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3-(N-Benzylamino)-L-Alanine

    • Product Name 3-(N-Benzylamino)-L-Alanine
    • Alias BMA
    • Einecs 629-022-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    465509

    Chemical Name 3-(N-Benzylamino)-L-Alanine
    Molecular Formula C10H14N2O2
    Molecular Weight 194.23 g/mol
    Cas Number 53137-50-9
    Iupac Name (2S)-2-amino-3-(benzylamino)propanoic acid
    Appearance White to off-white solid
    Solubility Soluble in water
    Purity Typically ≥98%
    Storage Temperature 2-8°C
    Optical Rotation [α]20/D +13° (c=1, H2O)
    Smiles N[C@@H](CC(NCC1=CC=CC=C1)=O)C(O)=O
    Inchi InChI=1S/C10H14N2O2/c11-8(10(13)14)7-12-9-5-3-2-4-6-9/h2-6,8,12H,7,11H2,1H3,(H,13,14)/t8-/m0/s1
    Melting Point Approx. 150-152°C
    Functional Groups Amino, Carboxylic acid, Benzylamino
    Chirality L-isomer

    As an accredited 3-(N-Benzylamino)-L-Alanine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White HDPE bottle, tightly sealed, labeled with product name and hazard symbols, containing 25 grams of 3-(N-Benzylamino)-L-Alanine.
    Shipping **Shipping Description for 3-(N-Benzylamino)-L-Alanine:** This chemical is shipped in sealed, clearly labeled containers to ensure stability and prevent contamination. It is packaged according to standard safety regulations for laboratory chemicals. Appropriate documentation and safety data sheets are included, and the package is handled to avoid exposure to moisture, heat, or physical damage during transit.
    Storage 3-(N-Benzylamino)-L-Alanine should be stored in a tightly sealed container, protected from light and moisture, in a cool, dry, and well-ventilated area. Keep the chemical away from incompatible substances such as strong oxidizers. Store at room temperature, unless otherwise specified by the manufacturer, to maintain stability and prevent degradation. Properly label all containers and adhere to standard laboratory safety protocols.
    Application of 3-(N-Benzylamino)-L-Alanine

    Applications of 3-(N-Benzylamino)-L-Alanine in Industrial Manufacturing

    As an original manufacturer, we supply 3-(N-Benzylamino)-L-Alanine to specialized downstream industries, where its unique structure supports advanced synthesis and product development. Below, we detail the accepted industrial application tracks where this amino acid derivative contributes to proven production processes, highlighting each segment with technical specifics drawn from ongoing manufacturing practices.

    1. Peptide Drug Synthesis

    Pharmaceutical manufacturers employ 3-(N-Benzylamino)-L-Alanine as a protected amino acid building block in solid-phase peptide synthesis (SPPS) for the development of bioactive peptide-based drugs. Its N-benzyl protection facilitates selective deprotection steps and minimizes side reactions during chain assembly, raising the quality and yield of synthetic peptides used as active pharmaceutical ingredients (APIs).

    Industry compliance standards

    • European Pharmacopoeia (Ph. Eur.) quality requirements for peptide components
    • Current Good Manufacturing Practice (cGMP, 21 CFR Part 210/211)
    • International Council for Harmonisation (ICH Q7) guidelines for APIs
    • USP General Chapter <823> for peptide synthesis materials

    Typical usage ratio

    • Primarily 1–2 equivalents per peptide elongation cycle, adjusted based on sequence complexity and desired yield

    Downstream process integration

    • Incorporated during the amino acid coupling step in automated and semi-automated SPPS reactors; deprotected with specific reagents after target sequence completion; followed by purification via preparative HPLC

    Final product types

    • Therapeutic peptides for oncology, endocrinology, and immunology
    • Peptide-based diagnostic reagents
    • Reference standards for pharmaceutical R&D

    2. Modified Amino Acid Research Reagents

    Life sciences research suppliers integrate this compound as a unique side-chain variant when developing modified amino acid libraries for biochemical studies. Its N-benzyl functional group introduces steric and electronic influences, assisting in the profiling of substrate specificity and enzyme active site interactions, thus supporting advanced structural biology research.

    Industry compliance standards

    • ISO 9001:2015 Quality Management for research reagent production
    • REACH registration for laboratory chemical supply in the EU
    • OECD Guidelines for the Testing of Chemicals (No. 407) for reagent safety documentation
    • GLP compliance for analytical batches

    Typical usage ratio

    • 5–50 mmol per batch, corresponding to 0.5–5% of total library loading, depending on target diversity and screening throughput

    Downstream process integration

    • Added during combinatorial library synthesis and solid support functionalization, followed by post-synthetic splitting and analysis through LC-MS and high-throughput screening protocols

    Final product types

    • Modified amino acid standards
    • Custom substrate panels for enzyme assays
    • Peptide-protein interaction mapping reagents

    3. Industrial Enzyme Engineering Substrate

    Biotech firms utilize this raw material as a specialty substrate in industrial enzyme engineering projects, especially those focusing on amino acid dehydrogenases and transferases. Its distinctive side chain enables high-resolution kinetic characterization, allowing industrial process engineers to select or evolve enzymes for pharmaceutical precursor synthesis and biocatalysis.

    Industry compliance standards

    • ISO 13485:2016 for enzyme substrate production applicable to diagnostics and research
    • REACH compliance for handling in European manufacturing environments
    • OECD Principles of Good Laboratory Practice (GLP)
    • Company-specific validated methods for kinetic assays

    Typical usage ratio

    • 0.1–1 mM substrate concentration per enzymatic assay; scaled as required for pilot and production batch validation

    Downstream process integration

    • Introduced into reaction vessels/dosed in enzyme reactor systems for in-vitro activity screening or process optimization; monitored via spectroscopic or chromatographic readouts

    Final product types

    • Custom enzyme panels with altered specificity
    • Industrial biocatalysts
    • Diagnostic enzyme kits

    4. Specialty Polymer and Crosslinker Synthesis

    Chemical manufacturers involved in advanced polymer development incorporate this amino acid derivative as a monomer or crosslinker to introduce tailor-made functionalities in specialty polyamides and hydrogels. The aromatic N-benzyl group imparts rigidity and tunable hydrophobicity, expanding the property profile of engineering plastics for performance applications.

    Industry compliance standards

    • ISO 9001:2015 for polymer manufacture
    • EU Regulation No 1907/2006 (REACH) for monomer use in plastics
    • FDA 21 CFR 177.1810 (indirect food additive applications, where applicable)
    • QMS protocols for specialty materials

    Typical usage ratio

    • 0.2–3% by weight in copolymer blends or crosslinker formulations; higher loadings possible based on desired mechanical properties or swelling behavior

    Downstream process integration

    • Reacted during copolymerization steps or hydrogel crosslinking by solution or melt processing; followed by curing and physical property testing

    Final product types

    • High-performance polyamides with pendant functional groups
    • Bioactive hydrogels for biomedical engineering
    • Smart polymer sensing films
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    Certification & Compliance
    More Introduction

    Introducing 3-(N-Benzylamino)-L-Alanine: A Direct Perspective from the Manufacturer

    The Essence of 3-(N-Benzylamino)-L-Alanine in Modern Chemistry

    Decades of hands-on synthesis work go into every batch of 3-(N-Benzylamino)-L-Alanine we ship. Our chemists have watched the compound move from a specialty lab curiosity to a critical intermediate underpinning progress in pharmaceuticals, crop protection, and advanced materials. This isn’t just another derivative – it represents years of refinement in process optimization and an unyielding focus on practical reliability.

    What sets our 3-(N-Benzylamino)-L-Alanine apart is the care we give each step, from raw material sourcing to the final purification. Our team long ago realized that trace impurities can sabotage downstream reactions. That knowledge shaped the way we design our crystallization and filtration systems. We don’t chase purity for its own sake – we know how a sluggish or erratic reaction can waste both time and costly reagents.

    Model Details and Core Specifications

    Our primary focus stays on 3-(N-Benzylamino)-L-Alanine with the basic model structurally matching its theoretical molar mass and exact stereochemistry. Each lot is meticulously characterized by NMR, HPLC, and mass spectrometry. Over years of operation, we’ve standardized on optical rotation measurements, and we enforce a consistency that saves our customers repeat trials or troubleshooting. Every batch leaves our facility with enantiomeric purity confirmed to a strict threshold; we select this threshold based on input from our trusted users in the pharmaceutical sector, who have no tolerance for unpredictable stereoisomer content. Moisture content, residual solvent profile, and particulate level are checked and held to tight process limits gained from real-world experience, not cut-and-paste expectations.

    Where Does 3-(N-Benzylamino)-L-Alanine Deliver Value?

    This molecule earns its keep in peptide synthesis, especially where a benzyl-protected amino functionality simplifies key coupling steps. Many researchers value its role in preclinical projects, particularly for early-stage lead optimization, because it sidesteps the needing for extra protection and deprotection cycles. We’ve seen labs use our product when fine-tuning the hydrophobicity of analogs, and a reliable supply leads to less guesswork and fewer delays in decision making.

    Outside pharma, our customers in crop research pick our material for targeted conjugation with bioactive scaffolds, boosting molecular recognition within complex biological environments. A well-made 3-(N-Benzylamino)-L-Alanine smooths out synthetic challenges, letting R&D teams move forward without backtracking to solve inconsistent reactivity.

    Over the years, we’ve cooperated directly with formulation chemists looking to design new functionalized surfaces. They count on the benzylamino group’s stability through harsh processing stages. If supply ever stutters or product slips off-spec, it can derail an entire project. This reality makes us double down on both reproducibility and responsiveness — batch after batch.

    Practical Use in the Lab and Beyond

    No matter how clear a protocol reads, unpredictable product performance eats into R&D resources. A company that mines its own application data becomes hard-nosed about minimizing variables. For 3-(N-Benzylamino)-L-Alanine, our chemists supply detailed solubility data across a spectrum of organic solvents. Over the last five years, dramatic advances in coupling technologies place new demands on amino acid derivatives, so we routinely run stress tests under both acidic and mildly basic conditions before any new release.

    Handling properties matter; our version stays free-flowing under normal lab humidity. Too many times in the past, teams lost days breaking up lumpy powders or redissolving compacts. By tweaking drying cycles and choosing specific packaging, we helped eliminate micro-caking – a small detail until you’ve been the one scraping stubborn solids out of a flask before a critical peptide step.

    We pay attention to how the material behaves in automated synthesizers. Subtle clumping or static buildup inside feed hoppers crashed runs in early pilots, driving us to redesign bulk supply protocols and run repeat test charges. In response to feedback, we avoid phthalate plasticizers in packaging and rely on recyclable, low-permeability containers to shield both the product and the environment. Each improvement is a result of troubleshooting with our industrial partners, not box-ticking for compliance.

    Crucial Differences from Similar Products

    The proliferation of amino acid analogs and specialty intermediates in recent years means every “difference” must prove real-world significance. The N-benzyl substitution pattern in our 3-(N-Benzylamino)-L-Alanine tightens control on regioselectivity in many coupling reactions. Compared to non-substituted L-alanine, the modified structure reduces nucleophilicity, letting chemists customize peptide linkages with less off-target reaction drift. We regularly benchmark our material alongside N-methyl and O-benzyl-protected analogs. Side-by-side, 3-(N-Benzylamino)-L-Alanine saves at least one post-coupling deprotection stage, lowering cycle time and reducing exposure to potentially harsh conditions that risk chiral center erosion.

    Price-focused buyers might think of similar catalog entries from traders or loosely defined sources, yet differences soon surface at the bench. Uncontrolled micro-impurities occasionally poison enzymatic processes or complicate downstream chromatographic separations. Having spent years processing thousands of kilograms through robust, validated routes, we no longer tolerate batch-to-batch guesswork. A manufacturer with skin in the game distinguishes true batch reproducibility from spreadsheet promises.

    Our experience with scale-up makes a difference in purity management. As output increases, so does the risk of over-alkylation or incomplete hydrogenolysis. By using calibrated batch reactors, maintaining temperature profiles within pre-determined windows, and performing staged extractions, we minimize byproduct content. This level of fixation doesn’t show up in spec sheets, but each gram you receive comes from a systemiterated for consistency, not just theoretical yield.

    The Story Behind the Sourcing and Process Development

    We began producing 3-(N-Benzylamino)-L-Alanine nearly two decades ago, responding to calls from both start-ups and veterans of the life sciences sector. Raw material disruptions forced us to diversify upstream supply channels, and we learned early the dangers of a single-source benzyl chloride. Our QC team tracks each incoming lot, cross-checking for trace halide residues. These lessons translated directly to stronger downstream control, eliminating the domino effect of supplier instability that so often triggers missed deadlines and spoiled syntheses in our customers’ hands.

    Data from our own reactors confirm each route, with batch documentation supporting traceability. Our process engineers refuse to cut corners – we field-test our routes with full-scale pilot runs before any scale-up. That discipline lets us maintain targeted particle sizes and minimize thermal decomposition, especially important during the benzylation step. Chemists and engineers work side by side, troubleshooting line blockages or unexpected color formation with the type of detail-oriented vigor that can’t be faked when production schedules grow tight.

    Sustainability goals have become more pressing. We set out to minimize halogen waste by implementing phase-transfer catalysts and water-washable intermediates. By investing in high-efficiency filtration and solvent-recycling systems, we decrease the environmental load per kilogram produced – and we welcome site audits to back up these claims. More than one downstream partner has adopted our recycling frameworks at their own sites after seeing the approach first-hand.

    Championing Reliability in a Fast-Moving Market

    Science rarely follows a straight line, so dependable supply lines make or break research schedules. Over the past several years, shifting regulations and unforeseen shipping delays forced us to expand inventory reserves. In one notable case, a sudden import hold nearly halted a client’s API development – our advance planning kept their project on course. Lessons learned here prompted more sophisticated tracking systems and genuine partnerships with logistics providers.

    We do not just automate compliance; each batch release draws on decades of accumulated know-how. Our analysts run multi-level checks, catching outliers before they get close to finished-goods storage. When customers identify subtle issues, such as a barely perceptible discoloration or change in powder flow, we treat their observations as direct feedback. Some of our best process improvements trace back to blunt customer phone calls, not audit findings or spec-driven reviews.

    As technical requirements from the market evolve, we stay nimble. More teams request custom particle sizes, different salt forms, or specific moisture levels for unique applications. While regulations shift and supply chains stretch thin, we keep resources close at hand – the value of a reliable, responsive producer only grows with each supply crisis or surge in demand.

    Navigating Regulatory and Market Challenges

    Every chemical we produce, including 3-(N-Benzylamino)-L-Alanine, comes entangled with a mesh of compliance rules. Over the years, authorities have tightened documentation and traceability standards, and certain raw materials now demand additional declarations. Seasoned manufacturers grow adept at these requirements, integrating compliance deeply into day-to-day practice, so end-users receive accurate paperwork, not just rote compliance statements. Traceability allows for clear root cause identification if the rare issue ever arises, which in turn supports prompt resolution.

    Recent shifts in international policy occasionally restrict certain export routes. We preemptively assess routes for regulatory compliance and documentation support well before any shipment leaves our facility. Our staff includes dedicated regulatory specialists who monitor updates and clarify gray areas in real time, so customers rely on us for accurate, honest guidance. This readiness helps science teams avoid project delays due to missing certificates or misaligned customs submissions, a recurring headache when working with less-experienced suppliers.

    Challenges and Solutions Learned Over Time

    Any chemical production process encounters its share of unexpected variables. We’ve battled product discoloration traced back to minor feedstock variances, and we have endured pipeline fouling resulting from overlooked temperature fluctuations during benzylation. Equipment upgrades, including jacketed reactors and in-line particle analysis, originated from these hurdles. We keep our doors open to process engineers and bench chemists from customer teams, finding their real-world insights frequently lead to important changes no consultant would propose.

    A robust feedback loop spreads benefits both ways. Sometimes, small changes, such as switching to inert gas purging or modifying packaging design, boost reliability across the supply chain. If our customer support team passes along reports of handling or storage complaints, we pivot quickly – whether that means swapping out desiccants, redesigning labels, or even delivering small batch sizes on custom schedules. For us, learning from problems, not skirting them, makes all the difference.

    Continuous Improvement: Partnership over Transaction

    Many businesses stop short after the raw material leaves the gate, but our team follows shipments to their final point of use whenever possible. Satisfied customers sometimes share performance data, and we value this over generic KPI tracking. Last year, a new peptide process developed by one of our partners flagged higher residual solvent content than expected. Working together, we pinpointed a subtle shift in upstream purification. By restoring prior steps, we eliminated the issue for all future production. These mutual successes drive the close relationships we build. A culture of shared improvement suits the fast-moving pace of chemical research.

    As the push for “greener” chemistry intensifies, we stay in step, seeking opportunities to recycle solvents and limit process energy demands. Any reduction in carbon footprint must be balanced against the strict purity standards governing specialty intermediates. Our technical group pushes to validate greener approaches with the same rigor as traditional methods, proving workability through bench trials before adapting full scale. Customers who share these goals push us to innovate, and many breakthroughs come straight from these collaborations.

    Why Consistency Outweighs Cost in Synthetic Chemistry

    Trying to save a few points on cost with fly-by-night resellers leads to more expenses in the long run. Many disappointed customers tell us stories of failed syntheses, unplanned delays, even regulatory headaches that started with a bargain-bin alternative. A dedicated manufacturer recognizes how production consistency protects reputation and reliably enables scientific progress. Superior results rely on materials crafted with as much care as the research itself.

    We see ourselves as partners in innovation, not just ingredient providers. Teams facing tight development windows need suppliers who will jump on urgent calls, troubleshoot formulations in real time, and adapt supply models when priorities inevitably shift. Every synthesis is a chance to improve, and 3-(N-Benzylamino)-L-Alanine, like any true specialty intermediate, proves valuable based on the skill, care, and accountability of its maker. Our success follows from years of direct engagement with end users and a refusal to allow vendor indifference to slow discovery.

    Looking Ahead: Meeting Tomorrow’s Challenges Together

    Emerging trends point to more complex molecules, higher regulatory scrutiny, and pressure to cut environmental impact. Our technical and production staff meet these demands by investing in both technology and people. Training programs, cross-functional troubleshooting workshops, and regular exchanges with academic partners keep us at the forefront of synthesis know-how. Whenever new challenges emerge in the world of amino acid derivatives, our bench and plant teams work jointly to tackle them.

    The future belongs to manufacturers able to bridge the gap between flawless chemical synthesis and the difficult, messy realities faced by working scientists. Our commitment to the craft of chemical making and honest partnership sets us apart in a world where shortcuts have become too common. For those seeking reliability, technical depth, and true collaboration, our 3-(N-Benzylamino)-L-Alanine delivers more than just specifications – it brings the grounded, practical advantages that only a seasoned producer provides.