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3-Morpholin-4-Yl-Propionic Acid

    • Product Name 3-Morpholin-4-Yl-Propionic Acid
    • Alias 3-(Morpholin-4-yl)propanoic acid
    • Einecs 412-900-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    699375

    Chemical Name 3-Morpholin-4-Yl-Propionic Acid
    Molecular Formula C7H13NO3
    Molecular Weight 159.18 g/mol
    Cas Number 26240-51-1
    Appearance White to off-white solid
    Melting Point 126-130°C
    Solubility Soluble in water
    Purity Typically >98%
    Pka Approx. 4.5 (carboxylic acid group)
    Smiles O=C(O)CCN1CCOCC1
    Inchi InChI=1S/C7H13NO3/c9-7(10)1-2-8-3-5-11-6-4-8/h1-6H2,(H,9,10)
    Synonyms 4-Morpholinopropionic acid

    As an accredited 3-Morpholin-4-Yl-Propionic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 3-Morpholin-4-Yl-Propionic Acid is supplied in a sealed, amber glass bottle with a tamper-evident label.
    Shipping 3-Morpholin-4-yl-propionic acid is securely packaged in sealed, chemical-resistant containers to ensure safety during transit. The shipment complies with all relevant regulations for chemical transport, including labeling and documentation. It is shipped via certified carriers, with care taken to avoid extreme temperatures and physical damage during delivery.
    Storage 3-Morpholin-4-yl-propionic acid should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from direct sunlight and incompatible substances such as strong oxidizers. Keep it at room temperature to preserve stability, and ensure proper labeling. Avoid moisture and extreme temperatures. Access should be limited to trained personnel, using appropriate safety precautions.
    Application of 3-Morpholin-4-Yl-Propionic Acid

    Applications of 3-Morpholin-4-Yl-Propionic Acid in Industrial Manufacturing

    3-Morpholin-4-Yl-Propionic Acid enables advanced molecular design across key chemical sectors, supporting manufacturers seeking stable intermediates, enhanced process reliability, and strict compliance with established industry protocols. As a global-scale producer, we serve only real-world applications where this compound forms a recognized and essential ingredient.

    1. Pharmaceutical Intermediate Synthesis

    This compound functions as a core building block in the synthesis of active pharmaceutical ingredients (APIs), especially for central nervous system agents and selected antitumor compounds. Process development chemists incorporate it into reaction sequences due to its functionalized morpholine structure, which supports high-yield, low-impurity routes under regulated environments.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients (APIs)
    • Current GMP (cGMP, 21 CFR Part 210/211)
    • EU GMP Directives
    • Ph. Eur., USP monograph references (where applicable for APIs utilizing this intermediate)

    Typical usage ratio

    • Usually 0.15–0.40 molar equivalents relative to target API, adjusted based on reaction stoichiometry and yield optimization in process development

    Downstream process integration

    • Introduced during multi-step organic synthesis, commonly within amidation, acylation, or heterocycle condensation steps; typically reacted under controlled pH and temperature with follow-up purification

    Final product types

    • Antidepressants
    • Antineoplastic intermediates
    • Experimental CNS compounds
    • Targeted small molecule APIs

    2. Specialty Agrochemical Intermediates

    The compound supports synthesis protocols for crop protection active components, particularly those requiring morpholine-derived side chains for improved stability and bioavailability. Agrochemical manufacturers value its reactivity profile, contributing to efficient multistep fabrication of systemic fungicides and selective herbicides.

    Industry compliance standards

    • FAO/WHO Codex Alimentarius agrochemical guidelines
    • ISO 9001-certified process traceability
    • REACH Regulation (EC) No 1907/2006
    • OECD Good Laboratory Practice (GLP), where required for registration studies

    Typical usage ratio

    • Ranges from 3% to 9% by mass relative to total batch input, typically optimized during pilot-scale development based on the desired side group loading

    Downstream process integration

    • Inserted after initial base structure assembly as a nucleophilic substituent in selective alkylation or condensation reactions; purification follows prior to final formulation

    Final product types

    • Systemic heterocyclic fungicides
    • Crop protection intermediates
    • Second-generation phenoxy herbicides

    3. Advanced Polymer Modification

    Polymer manufacturers use this compound as a functional additive to introduce morpholine moieties into polyamide and polyurethane chains, achieving electron-rich segments that improve hydrophilicity and modify mechanical flexibility. Applications focus on demanding performance contexts, such as specialty membrane and coating systems.

    Industry compliance standards

    • ISO 9001-certified quality management for specialty polymers
    • RoHS Directive (2011/65/EU) for electronics-related materials
    • ASTM D638 for tensile properties of plastics
    • REACH Annex XVII (as relevant to polymer additives)

    Typical usage ratio

    • 0.5–3.0 wt% based on total monomer or pre-polymer mass; dosage refined according to desired hydrophilic–hydrophobic balance and mechanical specification

    Downstream process integration

    • Fed into pre-polymer mix or direct addition during copolymerization, followed by extrusion, curing, or casting depending on downstream product requirements

    Final product types

    • Polyamide-based filtration membranes
    • Antistatic polyurethane coatings
    • High-performance fiber modifiers

    4. Fine Chemical and Analytical Reagent Manufacturing

    Specialty fine chemical producers utilize this molecule as a precursor or side-chain source for custom reagents and analytical standards, notably in HPLC sample preparation and buffer development. The propionic acid tether and morpholine ring contribute specific polarity and solubility profiles demanded in synthesis of reference materials.

    Industry compliance standards

    • ISO 17034 for reference material producers
    • ISO/IEC 17025 for analytical laboratory chemicals
    • EU CLP Regulation (EC) No 1272/2008 for chemical labelling
    • Standard test methods (e.g., ASTM, AOAC, as applicable)

    Typical usage ratio

    • Employed at 0.1–1.0 mmol scale per batch for analytical standards; quantity chosen according to final concentration and formulation volume needed

    Downstream process integration

    • Dosed during acylation or derivatization steps for reagent kits, purity-certified by HPLC or GC, and further processed into single-use vials or buffer packs

    Final product types

    • Certified analytical standards
    • Chromatography mobile phase modifiers
    • Specialty derivatization agents for bioanalysis

    5. Biochemical Research Tool Compound Synthesis

    In biotech labs and custom synthesis operations, researchers select this compound to construct probe molecules and linker-modified biomolecules for assay development and target validation. Its precisely spaced morpholine ring permits predictable interaction in conjugation chemistries.

    Industry compliance standards

    • ISO 9001 and ISO 13485 (for medical research materials)
    • OECD GLP for regulated research applications
    • Material transfer requirements under Nagoya Protocol, where genetic resources are involved
    • Applicable GHS chemical safety labelling systems

    Typical usage ratio

    • Added at defined stoichiometric excess (1.1–1.3x vs. target ligand) to ensure complete conjugation during coupling or derivatization; quantity tailored for batch size and probe design

    Downstream process integration

    • Introduced in late-stage coupling reactions, followed by HPLC purification and lyophilization prior to formulation into assay kits, enzyme substrates, or labeled biomolecules

    Final product types

    • Functionalized assay probes
    • Protein or oligonucleotide conjugates
    • Custom biochemical kits and test panels
    Free Quote

    Competitive 3-Morpholin-4-Yl-Propionic Acid prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

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    Email: admin@sinochem-nanjing.com

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    Certification & Compliance
    More Introduction

    3-Morpholin-4-Yl-Propionic Acid: Nurturing Reliable Chemistry Through Real Manufacturing Experience

    Introducing Our 3-Morpholin-4-Yl-Propionic Acid

    In every batch that leaves our production floor, 3-Morpholin-4-Yl-Propionic Acid stands for a legacy of careful hands-on manufacturing. Unlike finished compounds flowing off-the-shelf without distinction, this molecule emerges through years of refining process parameters, raw material sourcing, and no-nonsense quality checks. In our lab, every drum of 3-Morpholin-4-Yl-Propionic Acid tells a story—of people who took turns night and day watching for purity, and who know the way even the trace moisture affects stability during storage and shipping. For chemists and formulating engineers, the difference comes through in the clean profile at every checkpoint, consistent appearance, and measured balances between reactivity and shelf stability.

    Model and Specifications

    Our current production run meets pharmaceutical and fine chemical standards. Chemical structure uses the morpholine ring, attached to the propionic acid moiety. Careful attention addresses issues during synthesis, including moisture management and batch heating. We control for water content, color impurity, and residual solvent through rigorous analytics at every critical process step. We keep particle size within a narrow distribution ideal for both solid and dissolved-phase handling during downstream reactions. Shelf-life testing, always conducted on finished lots, tracks stability under normal and stressed storage, ensuring customers receive a material that’s ready for further formulation and scale-up work.

    What Sets 3-Morpholin-4-Yl-Propionic Acid Apart

    Throughout two decades of handling similar morpholinic acids, we’ve learned that even minor differences in precursor selection and process temperature stamp an invisible signature on the final product. People coming to us often share frustration: past lots from the open market occasionally promised purity claims, but batch-to-batch reactivity, solubility, and even color would shift without warning. Our team draws from these lived mishaps to keep each production and QC run grounded in traceability. If a contaminant sneaks past batch one, it gets flagged and tracked, never repeated downstream. Our records stretch back years, so the manufacturing line draws on real performance, not just paperwork.

    Compared with standard propionic acids or simple morpholine derivatives, our 3-Morpholin-4-Yl-Propionic Acid holds on to a unique set of physicochemical properties. The morpholine ring offers flexibility to the molecule, and in practice plays out as slightly different solubility, boiling range, and solvent interaction. Chemists in our pilot lab mixed other obtainable grades in parallel reactions, revealing slower or unpredictable reaction rates, especially in conditions involving sensitive coupling reagents. Only our method, refined through more than 100 process runs, produced a reliable acid chloride intermediate without clogging, nor did it cause downstream amine degradation that would complicate product purification. Our focus on low-odour, pale color, and fine particulate handling makes large-scale blending and packaging smoother for industrial partners. Our approach stems from hands-on experience managing issues in real reactors, and from the tough lessons when just one out-of-specification can halt a customer trial for days.

    Practical Uses: Insights from the Shop Floor

    Lab notes pile high in our facility, charting how formulators put our 3-Morpholin-4-Yl-Propionic Acid to work. Within pharmaceutical intermediate production, the molecule stands out for two uses: efficient amidation and stable ester formation. Specialty biotech companies seek our batches for custom peptide coupling, taking advantage of its morpholine ring to modulate polarity while retaining a sturdy backbone in the propionic acid tail. We’ve walked clients through reaction monitoring, showing them how our standard product performs during the coupling step—no persistent baseline drift, no dissolving time-outs that ran reactions for extra hours. For customers working under cGMP protocols, our processes deliver supporting analytical documentation stretching back through replicate batches, providing the predictability to scale from gram to kilo quantities with few performance hiccups. We’ve also shipped to agricultural R&D customers, who value a more flexible morpholinic acid for pilot syntheses of crop actives, reporting smoother solubilization in process solvents and easier waste handling after acid quench steps compared with traditional shorter-chain acids.

    The story doesn’t stop with synthesis. Some industrial partners have told us that, due to our product’s consistently measured melting and boiling points, they can push their reaction throughput higher without worrying whether new deliveries will react differently. We’ve seen people try similar products from other sources and struggle through phase separation or persistent cloudiness in test solutions, especially with recycled solvents or large volume batches. By controlling trace impurities that traditional production ignores—phenolics, trace base, and volatiles—we keep each drum ready for direct charging into main line reactors.

    Quality Backed by Real-World Experience

    We know how stressful a critical raw material shortage feels, especially if a result depends on a single batch’s consistency. Our team leans on deep production data to offer flexible lot sizes, arrange expedited production, and help partners navigate regulatory compliance if their end use calls for technical or pharma-grade documentation. Regular root-cause reviews and post-mortem on each deviation—a practice started after a trashed pilot lot years ago—means lessons from each run get embedded straight into new manufacturing protocols. Our blend of raw chemical handling and regular feedback from the plant floor means less time spent troubleshooting in the field or patching substandard product after delivery.

    Comparative Perspective: Why Choice of Manufacturer Matters

    It’s tough to capture every subtlety in a certificate of analysis. Years spent watching batches fail over trace contaminants have taught us that quality only happens through boots-on-the-ground vigilance. For example, someone approached us about inconsistency issues with another supplier’s 3-Morpholin-4-Yl-Propionic Acid—reaction times in their system would swing without warning, forcing days of troubleshooting. We broke down the competitor’s product and tracked impurities, finding micro-traces of unreacted morpholine ring derivative and short alkyl acid byproducts. Switching over to our material, their process stabilized, and they didn’t lose any further production days to mystery downtime.

    Every month, new customers bring in samples from global traders and resellers, drawn by attractive pricing and vague guarantees. Repeated lab checks show a pattern: appearance might look similar, but their product’s performance in actual chemistry reveals batch instability, inconsistent acid value, or even excessive water that risks hydrolysis in sensitive formulations. Our direct-from-manufacturer approach grows from feedback and actual production headaches, not just regulatory requirements. Our in-house process means we answer for each batch—no deflecting, no hiding behind certificates with asterisks or untransparent documentation. And when questions arise, plant chemists and production folk come straight to the table, speaking from hard-won experience instead of copying boilerplate text.

    Solving Common Challenges

    Every plant faces challenges: equipment breakdown, sudden swings in demand, and raw material hiccups. In the world of propionic acids and morpholine derivatives, unpredictable response in scale-up remains one of the worst. We encountered this ourselves early on—during a series of pilot batches, a subtle contaminant from recycled solvent triggered cloud formation in the reaction mix, delaying product completion by days. Since then, our team doubled down, introducing multi-stage solvent purification, tracking every temperature ramp, and installing better in-line monitoring tools. The result: our partners rarely need to repeat or discard batches due to supplier-side stability issues. We trade stories with customers about those panic nights spent re-formulating a scale-up batch, and then set up backup inventory and clear process change documentation so neither side gets caught out again.

    Another challenge comes from downstream compatibility. Our product’s controlled particle distribution prevents dust or inconsistent pour rates during solid charging in large reactors. Unlike older grades on the market that left sticky residues or particulate clusters hindering dissolution, our refinements let users handle bulk bags with standard flow equipment, reducing the risk of operator exposure or material loss. Regular plant visits and feedback sessions identify pinch points where handling gets tricky—our team developed real tweaks to drying, packaging, and logistics, so customers spend less time wrestling with the product and more time getting reactions running.

    Building Trust Through Data and Transparency

    Reliable chemicals come from open discussion and clear record-keeping, not just claims. We keep a multi-year archive of batch records—complete with performance stats, root-cause notes, and corrective steps—from every 3-Morpholin-4-Yl-Propionic Acid production, available for partners looking to understand how each lot evolved. Feedback cycles bring in practical reports from R&D and plant users, identifying not just chemical specs met, but also operational tweaks in particle handling, packaging, and in-line quality controls. It’s routine for our technical crew to ship reference standards to new clients alongside full analytical sheets, giving their labs a measurable benchmark and a baseline for troubleshooting every incoming lot. We treat every inquiry as a two-way knowledge exchange, not a sales routine; long-term partners stick with us because when problems pop up, they reach someone who’s handled the actual batch, not a middleman or script reader. Our integrity anchors every outgoing drum—we ship only what passed our own shop-floor criteria, and we never push questionable lots onto the market to chase monthly targets.

    Shaping the Chemical Supply Chain for the Next Generation

    As industry regulatory standards continue to evolve, expectations from manufacturers increase. We invest in data logging, inline quality analytics, and root-cause improvement programs driven by real-world production data. On-site teams at our plant regularly interface with compliance auditors, sharing process change logs, deviation reports, and monthly corrective actions. Every regulatory change pushes us to re-examine our batch records, organize new process validation runs, and train the next round of operators in the lessons learned from every hiccup and improvement. Instead of prioritizing volume throughput, we focus on stability in supply, flexibility in lot sizing, and tight traceability. This approach saves our customers days of downtime and expensive troubleshooting further down the line.

    The Difference in Technical Partnership

    One thing sets us apart as direct chemical manufacturers: hands-on involvement with every lot, and a readiness to answer for difficult moments. During customer plant visits, we walk partners through the granular reality of how each production run went—what problems cropped up, how QC responded, and how the final product matched published specs. In one case, a partner revealed a persistent drift in acid value readings—our technical lead worked together with theirs, ran parallel test blinding, and together we uncovered ultra-trace background acid vapor contamination as the culprit. With that knowledge shared, their formulation stabilized. We view every transaction as the start of a longer working relationship, not the end; troubleshooting, technical advisement, and process audits become a part of regular collaboration. Because our technical background stems from years of shop-floor involvement, we respond to problems in language customers speak—not canned answers, but practical recommendations built from onsite problem-solving.

    Conclusion: Real Manufacturing, Real Solutions

    3-Morpholin-4-Yl-Propionic Acid, in the way we produce it, represents more than a molecule on a spec sheet. Every batch draws from working knowledge honed over years, real challenges experienced, and actual partnership with customers facing their own production realities. Through constant data tracking, transparent communication, and willingness to learn from every production cycle, we bridge gaps between raw chemical manufacturing and practical downstream performance. We welcome every technical inquiry, ready to share data, troubleshooting insights, and to help customers find solutions that keep their processes running steady—because we’ve been there, and we know what a consistent, high-quality intermediate can mean for productivity and peace of mind.