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3-Methylthiopropanol

    • Product Name 3-Methylthiopropanol
    • Alias 3-Mercaptopropan-1-ol
    • Einecs 221-579-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    613739

    Name 3-Methylthiopropanol
    Chemical Formula C4H10OS
    Molecular Weight 106.19 g/mol
    Cas Number 505-10-2
    Appearance Colorless to pale yellow liquid
    Odor Strong, garlic-like
    Boiling Point 151-152 °C
    Melting Point -90 °C
    Density 0.988 g/cm3 at 20 °C
    Refractive Index 1.4730 at 20 °C
    Solubility In Water Miscible
    Flash Point 64 °C (closed cup)
    Autoignition Temperature 420 °C
    Vapor Pressure 1 mmHg at 34 °C
    Pubchem Cid 11818

    As an accredited 3-Methylthiopropanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 3-Methylthiopropanol is packaged in a 100 mL amber glass bottle with a secure screw cap, labeled for laboratory use.
    Shipping 3-Methylthiopropanol is shipped in tightly sealed containers to prevent leaks and evaporation, typically under cool, dry conditions. It should be clearly labeled, handled with protective equipment, and kept away from incompatible substances. Compliant with relevant hazardous material transport regulations, suitable packaging ensures safety during transit and storage.
    Storage 3-Methylthiopropanol should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from sources of ignition and incompatible substances such as strong oxidizing agents. Protect it from direct sunlight and moisture. Ensure proper labeling and secure storage to prevent accidental release. Follow all relevant local regulations and safety guidelines for handling and storage.
    Application of 3-Methylthiopropanol

    Applications of 3-Methylthiopropanol in Industrial Manufacturing

    3-Methylthiopropanol is a sulfur-containing alcohol widely utilized in specialty chemical production, flavors and fragrances, agrochemical synthesis, pharmaceutical intermediates, and fine chemical processes. As an established upstream supplier, we ensure consistent quality and purity, enabling efficient and compliant downstream operations in regulated markets.

    1. Flavor and Fragrance Intermediates for Food and Beverage

    3-Methylthiopropanol serves as a key building block in the synthesis of sulfur-containing aroma compounds such as thioesters and thioethers, which impart meat, cheese, onion, and savory notes in food flavorings. Manufacturers rely on this intermediate to create complex, natural-identical aroma profiles. We support food-grade supply with stringent attention to residual solvents and by-product controls to meet food additive purity specifications. Production environments require closed, inerted systems with specialized handling to ensure safety and quality. The value chain typically incorporates our material at esterification or thiol-etherification stages before compounding into formulations for liquid flavor bases or encapsulated powder blends.

    Industry compliance standards

    • EU Regulation (EC) No 1334/2008 on flavorings and certain food ingredients
    • US FDA 21 CFR Part 172 – Food Additives Permitted for Direct Addition
    • FEMA GRAS status, FEMA No. 3470 for related compounds
    • ISO 22000 Food Safety Management System in flavor ingredient manufacturing

    Typical usage ratio

    • Applied at 0.05–0.2% in concentrated flavor formulations by weight
    • Dosed to achieve target ppm thresholds in finished food products based on sensory consistency and local regulations

    Downstream process integration

    • Introduced after distillation in thiol chemistry lines
    • Reacted with acid chlorides for thioester synthesis during batch or continuous operation
    • Monitored for elimination of residual free thiol by GC or HPLC prior to flavor compounding

    Final product types

    • Meat, cheese, onion, and roasted savory flavor premixes
    • Beverage base flavors with sulfur nuance
    • Encapsulated flavor granules for snacks and seasoning blends

    2. Synthesis of Sulfur-Containing Pharmaceuticals

    Downstream pharmaceutical manufacturers use 3-Methylthiopropanol as an intermediate in the preparation of active pharmaceutical ingredients (APIs) with a thiol or sulfur moiety, which can contribute to antimicrobial or enzyme-inhibitor functionalities. It is usually involved at early synthetic steps such as alkylation, thioether formation, or oxidation to sulfones or sulfoxides under tightly controlled GMP environments. Our material undergoes rigorous impurity profiling, and we offer batch traceability and support for regulatory filings. This application requires precise addition and closed-loop handling to avoid contamination, with chemical transformations integrated into multi-step synthesis campaigns.

    Industry compliance standards

    • ICH Q7 – Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • EU GMP Part II – Basic Requirements for Active Substances
    • Relevant monographs in USP/NF or Ph. Eur for intermediates under impurity specifications
    • REACH Registration, Evaluation, and Authorization compliance for European supply chains

    Typical usage ratio

    • Generally dosed in a 1:1.05 molar ratio with core reactants at the relevant synthetic step
    • Adjusted based on substrate reactivity; excess limited to 5-10% over stoichiometry to control by-products

    Downstream process integration

    • Charged to reactors following initial raw material charge and solvent loading
    • Subjected to continuous monitoring of conversion rates and by-product formation
    • Integrated with solvent recovery and closed-containment systems for worker safety and GMP audit trails

    Final product types

    • Sulfur-based antibiotic intermediates
    • API precursors for anti-infective and cardiovascular drugs
    • Chiral thioether compounds for proprietary pharmaceutical candidates

    3. Intermediate for Agrochemical Active Ingredients

    Producers of herbicides, fungicides, and insecticides utilize 3-Methylthiopropanol to construct molecules with targeted biological activity involving sulfur-based moieties. Our supply supports controlled synthesis of thiocarbamates, dithiocarbamates, and related bioactive structures. The raw material is introduced during key alkylation or addition reactions and must meet narrow impurity and sulfur content limits to guarantee consistent field performance of downstream agrochemical products. We recommend process containment and vapor recovery technologies for safe plant operation given the compound’s odor threshold and volatility in large-scale manufacturing.

    Industry compliance standards

    • FAO/WHO Specifications for Agricultural Pesticides
    • ISO 9001:2015 Quality Management for Production Sites
    • OECD Guidelines for the Testing of Chemicals and workplace safety
    • REACH compliance for international supply

    Typical usage ratio

    • Employed at 8–15% by weight in thiocarbamate precursor synthesis
    • Exact ratio based on desired sulfur incorporation and substrate conversion, with minor excess to ensure full reaction

    Downstream process integration

    • Fed during continuous or semi-batch alkylation processes with other chloro/intermediate reactants
    • Monitored by GC-MS for absence of unreacted alcohol prior to final product isolation
    • Waste streams treated for sulfide content upstream of biological treatment

    Final product types

    • Thiocarbamate herbicides for rice and cereal crops
    • Dithiocarbamate fungicidal agents for fruits and vegetables
    • Other sulfur donor agrochemical intermediates

    4. Raw Material for Fine Chemical Syntheses (Thioethers and Thioesters)

    Chemical manufacturers harness 3-Methylthiopropanol to introduce methylthio and propanol functionalities in the targeted synthesis of thioether and thioester derivatives for polymers, lubricants, and specialty modifier chemistries. Its controlled reactivity and defined sulfur functionality allow formulation flexibility in low-odor, stable end-products. Fine chemical process engineers dose the alcohol after solvent and catalyst charging, with careful control of temperature to avoid unwanted side reactions. Application-specific purification by distillation or extraction ensures product purity meets downstream performance specifications for molecular dispersants, antiwear additives, or custom-engineered intermediates.

    Industry compliance standards

    • ISO 9001:2015 and ISO 14001 Environmental Management in specialty chemical production
    • REACH pre-registration for non-exempted substances
    • Occupational health and exposure limits per ACGIH guidelines
    • Documented batch records and in-process QC checks for contract manufacturing

    Typical usage ratio

    • Dosed at 1.1–1.2 equivalents relative to halogen reactant in thioether syntheses
    • Adjusted based on desired chain length and sulfur density in polymer formulations

    Downstream process integration

    • Added in agitated reactors during catalyst pre-charge or as post-addition in multi-step sequences
    • Followed by temperature ramp and inert gas sparging to drive completion
    • In-process analytics via GC/FID confirm product formation and conversion rate

    Final product types

    • Alkyl thioether additives for lubricants and metalworking fluids
    • Thioester-based stabilizers for polymer modifications
    • Custom sulfur intermediates for contract fine chemical markets
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    Certification & Compliance
    More Introduction

    Introducing 3-Methylthiopropanol: Reliable Flavor Chemistry from a Manufacturer’s Perspective

    The Essence of 3-Methylthiopropanol in Flavor Creation

    Over the years in our chemical manufacturing facility, we've learned how subtle differences in molecular structure make or break the flavor of finished consumer goods. 3-Methylthiopropanol stands out as one of those molecules you turn to for its unique balance between liveliness and authenticity. Our batches maintain consistent purity through direct synthesis rather than dilution or chemical recovery. Typically, customers who rely on reliable, food-grade concentration prefer our 3-Methylthiopropanol at 98% minimum assay, colorless and clear, with a well-recognized molecular formula of C4H10OS. This is not a case of swapping one alcohol for another—every characteristic, from odor threshold to volatility, influences the entire production chain.

    Where We See 3-Methylthiopropanol Prove Its Worth

    Working alongside seasoned applications specialists, we know that this compound isn't just another minor note in the flavorist’s toolkit. Its profile—complex, onion-like, meaty—is essential for building depth in both savory and roasted notes. Soup bases, seasoning powders, processed meats, instant noodles all depend on the proper structure and quality of building blocks like this molecule. The delicacy of certain formulations, for instance where regulatory restrictions demand trace-level precision, pushes us to maintain tight quality controls. By producing our own feedstock streams, we don’t depend on secondary markets, so each batch meets tight compositional and impurity specs.

    But the real key isn’t what textbooks say—it's what food technologists and formulation chemists have confirmed in their sensory panels or GC-MS screens. There’s nothing abstract about complementing cysteine-derived savory flavors or contributing to foundational Maillard reaction systems; chefs and producers notice the result on the palate. Blending or imitating with less pure, off-spec types from smaller processors inevitably imparts off-notes and batch-to-batch drift. We have watched claims of “equivalence” break down once the application moves from lab scale to production. It comes down to predictable aroma release, minimal background, and high reactivity with complementary ingredients.

    Product Origins: Control over Inputs and Reactions

    Our facilities have refined thioalcohol syntheses longer than many downstream brands have existed. Early years brought plenty of headaches: unfiltered raw materials, unstable catalyst systems, and issues with trace by-products clogging further processing. After investing in dedicated high-purity reactors and automated in-line quality control, we now deliver orders knowing exactly what leaves our gates. This lets product developers work with predictable behaviors at room temperature or under food-relevant heating. No strange solvent residues. No masking agents to tame sulfur peaks. Just reliable, fresh material every time.

    Managing Specifications for Real-World Performance

    Our technical team always encourages partners to check specs against application trials, because “on-paper” purity sometimes hides issues with color, clarity, or instability. Through direct batch-to-batch monitoring, we've determined that keeping water and residual chloride well below 0.05% is not just a target but a necessity. The slightest move above this limit triggers undesirable notes—especially in products newly reformulated for salt reduction or natural claims.

    Every drum receives visual, olfactory, and chromatographic tests—no exceptions. By focusing on both the main component and trace impurity profile, we're able to ship material that fits seamlessly into high-stakes food processes. You won’t find traces of unrelated solvents or unreacted intermediates that complicate scale-up. Regular shipments to global clients have proven that controlling specification drift makes or breaks shelf-stable seasoning products. It doesn’t hurt that this transparency often opens new project opportunities, as technically-minded food companies grow tired of inconsistent third-party materials and swapping out grades when things go wrong.

    Compliance and Transparency: Trust Gained Over Decades

    Food and flavor industry regulations require predictable, traceable, and highly pure aromatic chemicals. This is not paperwork for its own sake but reflects hard lessons learned across accidents and failures in our sector. Material we supply meets global requirements, but more importantly, it holds up under strict final food-use testing—especially for detectable sulfur compounds.

    We don't treat regulatory processes as obstacles. Our record-keeping and batch traceability mean downstream audits or ingredient recalls don’t turn into searching for a paper trail. More than a few flavor houses have come to us after losing a customer because supply-chain complexity and unreliable smaller vendors left their product lines at risk. Many find that our clear, direct supply path eliminates much of this uncertainty. We take part in the final review of compositional declarations and migration studies, especially for new product launches or geographic expansion, so surprises stay out of finished consumer goods and regulatory filings.

    Using 3-Methylthiopropanol Against Common Market Alternatives

    Producers new to savory flavor chemistry quickly realize not all aliphatic thioalcohols are created equal. Often, the urge to substitute arises from cost or availability pressures: consider replacing 3-Methylthiopropanol with 2-methylthiopropionaldehyde or similar mercaptan-alcohols. Over thirty years running technical evaluations for multinational food groups have shown us these substitutions rarely work. We’ve seen product launches derailed by minor sensory differences—sometimes no more than a slightly metallic or musty after-effect masking as “heat-stability” or “process improvement.”

    True 3-Methylthiopropanol, synthesized under controlled conditions, brings a rounded flavor lift where other analogs bring harshness or imbalance. Its natural presence in cooked onions and garlic makes it nearly impossible to fake in cost-driven imitations. In the lab, we can run GC-MS fingerprints side by side: lower purity grades or alternative thioalcohols show irregular peaks, suggesting background compounds that don’t clear at formulation time. Each spike or unfamilar note can unravel a carefully-tuned flavor profile. End users—especially those in culinary applications—notice this at the dinner table. Once a chef points out “off” taste, there’s no salvaging that batch.

    From the Tank to the Customer’s Table

    Manufacturing 3-Methylthiopropanol creates more work than many realize: reaction exotherm management, sulfur waste disposal, and close attention to glassware and pipeline materials. Any lax attitude introduces contaminants, undermining months of R&D and marketing for downstream brands. Our focus remains fixed on delivering a tight, food-acceptable product line—without “stretching” specifications to accommodate easier cheap runs. This is a matter of pride for our workforce; many have spent entire careers learning what small impurities slip through basic distillation controls and how to eliminate them effectively.

    Customers tell us that they value being able to pour from our drums into their production systems with no last-minute tweaks or repeated test kitchen rounds. No flavorist or QC technician likes scrapping a batch due to unidentified volatile compounds from a new supply source. We advise all partners to compare direct analytical spectra and keep a sensory reference library—looking at both organoleptic matching and long-term storage stability as part of approval protocols. Product failures are painful to trace back when they stem from two-liter sample substitutions or unlicensed traders cutting batches with unknown carriers.

    Why Continuous Manufacturing Drives Consistency

    Batch production of aroma chemicals—especially sulfur-containing molecules—can introduce small but crucial variations. We invested in continuous flow reactors calibrated by real-time analytics. Instead of waiting for end-of-batch deviation tests, our team monitors every parameter in-process, making rapid adjustments to reactant addition, catalyst purity, and temperature. This active control limits batch-to-batch color change or subtle shifts in odor intensity, which can devastate blended flavor profiles and contribute to yearly QA headaches for food brands.

    Running continuous systems at scale requires technical staff who understand both the chemical and the food sides of the business. New operators start on pilot lines, learning to pick out background aromatics by nose and instrument. We do not hand over reactor control until training and experience combine in judgment. Equipment is dedicated and cleaned to avoid cross-contamination with unrelated sulfur compounds—a common risk in companies who handle diverse aroma chemical portfolios. Our visitors from flavor companies often comment on the ‘freshness’ and clarity upon material arrival, which correlates with both quality control and manufacturing discipline.

    Meeting Increasing Demands in Application R&D

    The market is moving. Every year, consumers demand “clean label” products, and food brands ask for simplified ingredient statements and removal of allergens or ambiguous terms. 3-Methylthiopropanol fits into these strategies due to its established natural presence in typical cooked, savory sources. R&D partners test our material in matrixes ranging from vegan protein snacks to traditional instant soups. The feedback: the right grade works across formulations, holding up under varied storage and heating regimes.

    Historical, region-specific flavor notes—such as the roasted backbone of East Asian soy sauces or the “umami punch” in bouillon—depend on delivering these volatile components without major off-odors or instability. Any unexpected background note can alienate loyal customers, especially in established brands. As a supplier involved from the pilot phase, we observe blending experiments in customer labs and supply smaller packs for initial commercial runs. Direct insight from those test kitchens feeds back into our process improvement cycles, which keeps output predictable regardless of raw material origin fluctuations.

    3-Methylthiopropanol in the Move toward Natural and Sustainable Production

    Efficiency and transparency have become key points for both chemical companies and food producers. For our part, we trace feedstock sources and refine purification steps to minimize waste. Over the past decade, we’ve reduced external solvent requirements and improved sulfur recovery through modular, closed systems. These aren’t afterthoughts but built-in components of reliable manufacturing, required by both environmental standards and customer trust.

    Fluctuations in global sulfur pricing and changes to import controls for precursors don’t have to mean inconsistent product or suddenly unavailable batches. We buffer supply with advanced purchase agreements and long-term storage of stabilized intermediates. This means R&D planning can remain on schedule without frantic ingredient changes at the eleventh hour. More than one customer has thanked our logistics team for keeping the pace during supply chain bottlenecks. Our laboratory process improvements, including non-chromatographic online purity checks, further drive down maintenance costs and finished product variability.

    Natural-Like Aroma: How We Maintain the Competitive Edge

    Natural flavor legislation has undergone changes worldwide. Today’s consumers scrutinize ingredient lists, and producers must prove that artificial flavorings do not compromise natural taste or health perceptions. Genuine 3-Methylthiopropanol, as produced by our reactors, mirrors the complexity of thermally processed onions or roasted roots, free from artificial enhancers or synthetic by-product fingerprints.

    Expert panels and trained sensory scientists corroborate our internal findings: our product’s taste and aroma release are nearly indistinguishable from those found in slow-cooked onions or plant-based stocks. Suppliers relying on less pure or side-product grades often introduce volatility or “burnt rubber” notes, which we simply do not see with high-specification manufacturing. This provides food developers with a clear route to premium ingredient statements, often supporting direct “onion-like” or “roast-type” front-of-pack claims.

    Troubleshooting and Long-Term Partnerships

    Food technology keeps evolving—today’s ready-meal or bouillon cube isn’t the same as it was ten years ago. Every reformulation for pricing, consumer taste, or shelf life involves a fresh round of chemical and sensory testing. We engage from early project phases, conducting stability and reaction studies, and staying open to feedback after product launches. If off-notes or instabilities show up, we work with process and QA teams to determine whether storage conditions, interaction with new packaging, or recipe tweaks are to blame.

    Partnership with a manufacturer, rather than a trader or packager, gives technical and commercial teams direct access to problem-solving resources. Our chemists, process engineers, and regulatory compliance staff contribute their experience in food production audits, documentation, and troubleshooting. The value of a direct relationship is proven each time ingredient standards shift or supply chains face disruption. This collaboration often helps multinational brands pass regional retailer audits and speed up approval cycles for new market launches.

    Flavor Stability and Life Cycle Analysis

    No compound acts alone in a flavor system, but the interaction between savory volatiles and bases or acids matters just as much as the headspace aroma. Over years of follow-up stability studies, we’ve learned that shelf stability comes down to three key variables: incoming material purity, isolation from oxygen and light, and minimizing background reactivity with other system ingredients. Our research teams constantly track storage life under a range of environmental conditions, optimizing packaging and recommending handling protocols to prevent sensory shifts.

    We also share life cycle data and environmental impact assessments with customers who request them. Many food producers evaluate environmental burden, not only batch-to-batch consistency, to meet internal sustainability targets. Continuous process upgrades and waste recovery efforts mean our material leaves a lighter footprint—from cradle to gate—than many industry alternatives. This helps partners demonstrate value to regulators, shareholders, and increasingly aware end-consumers.

    Final Take: Knowing the Source Makes the Difference

    Our facility teams have learned firsthand that supplying a high-impact raw material for food flavoring means living up to both tradition and innovation. Producers seeking depth, authenticity, and repeatability in their savory food and flavor systems look for more than basic chemical purity. The ability to provide clear, actionable spec sheets, consistent lot-to-lot output, and hands-on technical support separates reliable manufacturers from traders repackaging generic stock.

    We maintain ongoing dialog with both flavor houses and end-users, actively participating in application development and post-launch support. Each improvement in synthesis, quality control, and logistics shortens the path from concept to finished product on store shelves or restaurant tables. As the global food sector sets higher technical and ethical standards, we know that trust comes from proven, high-transparency manufacturing, not marketing spin or short-term pricing tricks. Our door is open to new collaborations and fresh product challenges—grounded in over three decades of dedicated sulfur chemistry expertise and real-world application feedback.