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3-Methylquinoline

    • Product Name 3-Methylquinoline
    • Alias Quinoline, 3-methyl-
    • Einecs 202-594-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    427307

    Cas Number 91-63-4
    Molecular Formula C10H9N
    Molar Mass 143.19 g/mol
    Iupac Name 3-Methylquinoline
    Appearance Colorless to pale yellow liquid
    Melting Point -22 °C
    Boiling Point 242-243 °C
    Density 1.056 g/cm³
    Solubility In Water Slightly soluble
    Refractive Index 1.624
    Flash Point 101 °C
    Synonyms Quinoline, 3-methyl-

    As an accredited 3-Methylquinoline factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 3-Methylquinoline is packaged in a 100g amber glass bottle with a tight-seal cap and hazard labeling for safe storage.
    Shipping 3-Methylquinoline is shipped in tightly sealed containers to prevent leakage and contamination. The containers are appropriately labeled according to regulatory standards. During transport, the chemical is kept in a cool, well-ventilated area, away from sources of ignition, strong oxidizers, and incompatible materials to ensure safe handling and delivery.
    Storage 3-Methylquinoline should be stored in a tightly sealed container, in a cool, dry, well-ventilated area away from sources of ignition, heat, and incompatible substances such as strong oxidizers. The storage area should be labeled and compliant with chemical safety regulations. Protect from light and moisture. Use secondary containment to prevent accidental spills or leaks.
    Application of 3-Methylquinoline

    Applications of 3-Methylquinoline in Industrial Manufacturing

    3-Methylquinoline has established roles in advanced chemical production. We manufacture this raw material to support core processes in API synthesis, fine dye intermediates, specialty agrochemicals, high temperature lubricant additives, and analytical chemistry reagents. Each downstream field presents specific regulatory, formulation, and technical requirements, as detailed below.

    1. Pharmaceutical Intermediates for Active Pharmaceutical Ingredient Synthesis

    3-Methylquinoline serves as a key building block in the synthesis of antimalarial, antibacterial, and antiviral drug substances. Its aromatic nitrogen scaffold enables efficient production of various alkaloid analogs during targeted organic synthesis. Process chemists utilize our material in coupling and cyclization reactions for batch and continuous API production, supporting kilo- to ton-scale operations under GMP regimes. This direct integration requires strict QC and trace contamination control.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP–NF guidelines for pharmaceutical excipients and APIs
    • European Pharmacopoeia monographs for intermediates
    • REACH registered, with substance safety report

    Typical usage ratio

    • 2–8% by molar ratio in heterocyclic condensation steps, adjusted by target API molecule
    • Batch volume and use level specified in Drug Master Files (DMFs)

    Downstream process integration

    • Charged into reactor during initial condensation for quinoline-ring-based API cores
    • Utilized in N-alkylation and halogenation with regulated temperature and inert atmosphere
    • Purity specification at ≥99.0% to minimize byproduct formation
    • Subjected to final stage purification prior to formulation or pyrolysis

    Final product types

    • Synthetic quinoline anti-infectives (e.g. mefloquine, chloroquine intermediates)
    • Novel anti-tubercular pharmaceutical intermediates
    • Intermediates for CNS active molecules (e.g. dopamine system agents)
    • Precursors for quinoline-derived API impurities profile studies

    2. Dye and Pigment Intermediate Manufacturing

    Dye manufacturers use 3-Methylquinoline as a precursor for reactive and disperse azo dyes. Its methylated structure permits regioselective sulfonation, nitration, and coupling reactions, contributing chromophoric stability and enhanced lightfastness in high-performance pigments. This compound supports proprietary colorant synthesis routes for textiles, industrial coatings, inkjet pigments, and UV-resistant plastic dyes.

    Industry compliance standards

    • OEKO-TEX Standard 100 for textile dye substances safety
    • EU REACH Annex XVII (restriction for aromatic amines in colorants)
    • ISO 9001 quality management in dye manufacturing
    • ZDHC Manufacturing Restricted Substances List for garment sector

    Typical usage ratio

    • 5–12% by weight as primary heteroaromatic intermediate in dye precondensate
    • Adjusted according to targeted shade depth and batch scale

    Downstream process integration

    • Added to sulfonation or nitration reactors for introduction of functional groups
    • Engaged in subsequent diazotization and coupling with phenol or aniline derivatives to yield final dye structure
    • Process temperature maintained between 55–85°C to limit oxidation
    • Precipitated, filtered, and subjected to vacuum drying prior to pigment dispersion

    Final product types

    • Reactive dyes for cellulose fibers
    • Disperse dyes for polyester textiles
    • Yellow, orange, and red pigments for inks and plastics
    • UV-stabilized colorants for technical coatings

    3. Agrochemical Active Ingredient Development

    Formulators deploy 3-Methylquinoline in the multi-step synthesis of crop protection active ingredients, particularly insecticide and fungicide families based on the quinoline skeleton. Controlled catalyst and base activation allow selective ring substitutions, producing molecules with tailored pesticidal selectivity. These transformations require management of reaction time, solvent choice, and effluent for downstream optimization.

    Industry compliance standards

    • FAO/WHO International Code of Conduct on Pesticide Management
    • EPA 40 CFR Part 180 (tolerances for pesticide residues)
    • China GB 4839-2009 (pesticide technical specifications)
    • ISO 17025 laboratory accreditation for residue analysis

    Typical usage ratio

    • 3–9% w/w in quinoline-based pesticide intermediate manufacturing, altered by active structure
    • Ratio determined by stoichiometry of core cyclization or substitution

    Downstream process integration

    • Blended into reactor in early-stage cyclization for active scaffold formation
    • Processed through sequential halogenation, formylation, or esterification steps
    • In-process control for residual quinolines before product extraction
    • Byproduct management in secondary amine waste treatment

    Final product types

    • Systemic fungicides for rice, wheat, and fruit crops
    • Contact insecticides and miticides for vegetable production
    • Precursor intermediates for anthelmintic veterinary products
    • Plant growth regulator intermediates

    4. High Temperature Lubricant Additive Synthesis

    Lubricant formulators require 3-Methylquinoline to construct high-temperature antioxidants and anti-wear additives for synthetic oils, industrial greases, and specialized hydraulic fluids. Its aromatic and nitrogen moieties enable reaction with alkylating and phenolic agents to yield stable quinolinol derivatives, which inhibit thermal oxidation and extend service life under extreme operating conditions.

    Industry compliance standards

    • ASTM D5763 Standard Specification for engine oil additives
    • SAE J183 specification for crankcase lubricants
    • REACH registration for substances used in closed and open gear applications
    • ISO 21469:2006 for lubricants used in incidental food contact machinery (where applicable)

    Typical usage ratio

    • 0.2–1.2% by weight as additive precursor in concentrated packages
    • Adjusted for final viscosity, oxidative stability, or compatibility with base stock

    Downstream process integration

    • Reacted in alkylation or Mannich condensation with paraffin or phenolic compounds
    • Purified additive package post-reaction through distillation and molecular sieving
    • QC checks for nitrogen impurity and color index prior to base oil blending
    • Blended into synthetic lubricants, gear oils, or conveyor greases at manufacturer site

    Final product types

    • High-performance engine and transmission oils
    • Extreme pressure gear lubricants for steel plants and mines
    • Anti-oxidant enriched greases for heat transfer and open gear
    • Industrial hydraulic fluids for heavy-duty mechanical systems

    5. Analytical Chemistry Reference Reagent Manufacturing

    Reference standard suppliers employ 3-Methylquinoline as a calibration reagent and impurity marker in analytical method development. Its defined structure and high purity permit use in HPLC, GC/MS, and NMR laboratories for instrument calibration and residual analysis, especially in pharmaceutical or environmental labs requiring trace-level detection.

    Industry compliance standards

    • ISO 17034:2016 for reference material producers
    • USP <1225>, <621> for chromatographic system suitability
    • GLP (Good Laboratory Practice) for analytical reagent manufacturing
    • ISO/IEC 17025 for laboratory competency and QA

    Typical usage ratio

    • 1–20 mg/L as standard solution in analytical method development
    • Trace level mixtures designed per protocol for specific matrix validation

    Downstream process integration

    • Prepared as stock solution and supplied for HPLC, GC reference calibration
    • Bottled under ISO-classified cleanroom conditions
    • Packaged in ampoules or vials with certificate of analysis for laboratory use
    • Shipped to pharma, food, environmental, and industrial analytical labs

    Final product types

    • Pharmaceutical reference standards for quinoline impurities analysis
    • Analytical lab grade calibration reagents
    • Forensic toxicology standards
    • Traceable environmental monitoring reagents
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    Certification & Compliance
    More Introduction

    3-Methylquinoline: A Practical Specialty Chemical from Our Synthesis Lab

    For those of us focused on building a robust chemical toolbox, 3-methylquinoline offers a proven foundation for both research and scaling industrial projects. At our plant, we have spent years perfecting the synthesis and purification of this unique quinoline derivative. Through hands-on process improvements, careful feedstock selection, and detailed monitoring at every stage, we supply material that meets the demanding standards of pharmaceutical, agrochemical, and dye applications.

    Understanding 3-Methylquinoline

    By structure, 3-methylquinoline is part of the larger quinoline family. The presence of a methyl group at the third position changes the chemical’s performance in subtle but important ways compared to parent quinoline and other positional isomers. Our batches come with high purity, typically exceeding 99%, which matters for both consistent reactivity and predictable environmental profiles downstream.

    Distinguishing the differences from related compounds starts at the bench. Regular quinoline or 2-methylquinoline bring their own quirks in terms of solubility, boiling point, and behavior in catalytic cycles. Through bench and pilot trials, we have observed that the methyl group in 3-methylquinoline offers a gentle balance between volatility and stability. This helps in process integration, especially during reductive amination or selective functionalization sequences found across pharmaceutical and pigment industries.

    Sourcing Matters: How We Make 3-Methylquinoline Reliable

    Chemical manufacture doesn’t yield real results unless teams focus on repeatability. We recognize that even a modest impurity profile can derail a production batch of an active ingredient or lead to off-spec colorants. At the factory, our technical department begins with rigorously screened anilines and acroleins, then runs closed-loop distillation and chromatography so your research teams receive material consistent run after run. The color, odor, density, and residual solvent content tell the story of every synthesis, and every barrel we ship comes with batch-specific reporting. Users rely on these facts because failed runs cost time and money at scale.

    For many customers, sourcing high-quality niche compounds from the same manufacturer over time helps avoid surprises during regulatory review. Analysts often run our 3-methylquinoline against reference standards to confirm spectral data and impurity profiles. Years of feedback from pharmaceutical clients taught us not to cut corners with wash protocols, metals removal, and solvent stripping. In dye work, textile technologists pushed our team to drive down trace sulfur content, as even a fraction could cause discoloration or breakdown under bright light.

    Performance in the Lab and on the Factory Floor

    Anyone involved in product development knows efficiency starts well before kilogram-scale synthesis. For example, the UV absorbance properties of 3-methylquinoline make it a standout choice for building fluorescent probes or stabilizing specialty inks. The compound’s distinct profile reduces background interference in analytic runs, a key factor compared to related methylquinolines or unsubstituted quinoline. In smaller molecule pharma, intermediates leveraging 3-methylquinoline show superior yields for certain condensation and acylation steps, keeping waste lower and cycle times manageable.

    Processing does not stop with theoretical yields or spectral purity. Teams across our labs spend countless hours confirming that batches flow smoothly and mix properly in user applications, minimizing side reactions and fouling. Texture, melting point, and even the tiniest moisture content end up affecting downstream process reactors or formulation tanks. The aim has always been to bring a batch-to-batch consistency that other custom or imported routes struggle to match.

    Where 3-Methylquinoline Earns Its Keep

    We have witnessed how process chemists, researchers, and plant-scale technologists benefit from the unique balance of chemical stability and reactivity this compound brings. In pharmaceutical synthesis, the selectivity enabled by the methyl group helps with targeted functionalization, especially in multi-step chemical routes. Over the past decade, crop protection research has leaned on 3-methylquinoline-based intermediates during the search for novel actives. It performs as both a starting core for further construction and as a building block without the volatility or odor challenges often seen in other alkyl quinolines.

    Colorant makers and dye formulators take advantage of the compound's strong chromophore base. Its stability under intense light and moderate pH allows longer shelf life for specialty dyes. Our dye industry partners report fewer failures in accelerated aging tests compared to alternatives. Less waste from batch-to-batch variation leads to lower costs and more consistent downstream color profiles in textiles or plastics.

    Some analytical chemistry teams have chosen 3-methylquinoline as an internal reference or component in fluorescence studies. Its emission and excitation wavelengths sit apart from common carrier solvents, making results easier to interpret. Research labs use this property to improve detection limits in biological assays and pollutant tracing work, as the compound does not overlap with many classic aromatic standards.

    Health, Safety, and Handling in Industrial Settings

    Long experience with quinoline derivatives has shaped our strict protocols. In high-volume settings, vapor containment and worker safety come first. We ensure our product ships tightly capped and clearly labeled, with full certificates on each drum and package. Storing at stable room temperature and avoiding open flames or oxidative environments prolongs shelf life and performance. Large plants trust us because we commit to regular audits and rigorously monitor residual solvent content to help meet evolving regulatory limits. Our staff keep up with the changing thresholds for workplace exposure under global standards such as REACH and U.S. TSCA—another point that sets dedicated manufacturers apart from traders or blenders.

    The physical form we offer—clear to pale yellow liquid—matches customer needs for fast and efficient transfer into reactors or blending tanks. Some users decide to filter again or dry under vacuum before use, though our post-processing already meets most handling requirements. Our safety team has worked directly with partners during scale-up phases so teams know what to expect in terms of odor, volatility, and compatibility. Each process review helps us deliver feedback back into our own operations, striving for continuous improvement with every delivery.

    Regulatory Trust and Building Long-Term Partnerships

    Years spent shipping 3-methylquinoline across various continents mean we know firsthand the importance of staying ahead of legal and customer expectations. Whether destined for pharmaceutical, agrochemical, or specialty chemical synthesis, this material shows up at registration desks everywhere. We have walked project managers through comprehensive impurity mapping, demonstrating the traceability of each ingredient batch and the stability of impurities across production cycles.

    Accessing a reliable supply of 3-methylquinoline sets research teams free from constant retesting and requalification. Several of our long-term pharmaceutical clients ran in-process validations using our product and scaled seamlessly from lab syntheses to pilot plant runs, citing time saved and fewer regulatory headaches. With real-world project success grounded in technical trust, we back every lot with data sets, analytical records, and collaborative support. If requirements change, our team adapts, whether that means adjusting specifications or shifting upstream sourcing to align with new environmental or toxicological findings.

    Comparing 3-Methylquinoline with Other Options

    Differences matter, especially in specialized chemistry. Even subtle changes between positional isomers have real logistical, chemical, and safety implications. 3-Methylquinoline carries a lower aromaticity than its parent quinoline, shifting solubility and reactivity profiles in useful ways. In high-performance liquid chromatography, its less polar nature means it behaves differently in separation tasks.

    On the practical side, users often mention the smoother handling of our 3-methylquinoline compared to technical-grade quinoline, which tends to come with more odor and greater volatility. We have recorded fewer issues with corrosion or vapor losses at typical storage and handling temperatures. These distinctions directly translate into cost savings; less product lost during transfer, fewer safety controls needed, and diminished risk of operator exposure.

    Trying to use alternative methylquinolines will shift reaction kinetics and may bring about extra downstream cleaning steps. The side products and tars generated also push up purification costs and challenge quality assurance teams. In preparation of fine chemicals or pharmaceutical intermediates, unpredictable impurity profiles increase the risk of out-of-spec batches. Over several audits and customer site visits, we have supported root-cause investigation teams as they compared our product with alternate sources, tracking both cost and quality improvements.

    Supporting Innovation Beyond Standard Applications

    Adaptability remains at the core of real manufacturing. Some of our partners explored new directions, incorporating 3-methylquinoline into optoelectronic and polymer chemistry. Its photostability and favorable electron-donating nature offer a base for synthetic chemists working on organic semiconductors or high-end pigment projects. The compound takes cross-coupling modifications well, and in recent years our technical team has helped custom synthesize derivatives based on evolving client blueprints.

    For scientific teams looking to broaden their experimental reach, a reliable supply of pure 3-methylquinoline frees up creative bandwidth. Rather than worrying about baseline purity or requalifying each shipment, researchers can focus effort on mechanism studies, scaling protocols, or formulating patents. We support these efforts with flexible shipping sizes and lots tailored to scale—small bottles for method development, larger drums for commercial runs—without sacrificing traceability or analytical backing.

    Environmental Responsibility Stitched into Every Batch

    Years ago, environmental compliance sat near the bottom of the production checklist for many chemical companies. That changed as local and global rules demanded better stewardship. Early on, our plant invested in solvent recovery and emission scrubbing. The processes that yield 3-methylquinoline now incorporate closed-loop water handling and in-line air monitoring. Every improvement, from pilot scale up to full production, goes through environmental risk review.

    As a manufacturer directly accountable for discharges and reporting, our team cuts no corners on waste management. Effluent and residuals meet both local discharge standards and stricter internal controls. We work with local authorities and independent laboratories to monitor releases, aiming for the lowest practical impact at every production point. This practice isn’t about regulatory fine print, but a recognition of our direct role in protecting neighboring land and water. Downstream users can confidently certify end products because we invest in robust compliance upstream.

    Real-World Experience: From R&D to Plant Scale

    Lab development never mimics factory life exactly. We bridge this gap for clients by providing real-time updates and technical exchange during project kickoff, process validation, or troubleshooting. Some pharmaceutical groups ask us to test the 3-methylquinoline in parallel with their first syntheses, reducing scale-up failures. Others in textile dyeing or pigment work lean on our analytical support, using retained samples for side-by-side comparisons.

    Those deep relationships yield unexpected benefits. Years of technical audit records, customer on-site visits, and continuous feedback shaped our process optimization—reducing solvent use by upwards of 20% in some units, and fine-tuning distillation profiles for better energy efficiency. Rather than constant change for its own sake, we make gradual, evidence-backed improvements reflecting operators’ input and user outcomes. This iterative cycle between manufacturer and user distinguishes a dedicated producer from generic commodity suppliers or traders.

    Choosing a Manufacturing Partner Who Understands the Details

    Every project team—industrial chemists, formulation scientists, analytical experts—benefits from closer relationships with true makers. Where traders or middlemen see a catalog number, we see years of hands-on trials, equipment tuning, and ongoing process improvement. Our facility maintains internal reference spectra for every lot, saving partners the hassle of repeated cross-verification. When product application requirements change, our technical team relays new parameters back to R&D, sharing test results and performance data openly.

    The end result for users is crystal-clear: less risk, more predictability, fewer process upsets. This reliability keeps pipelines on schedule and regulatory submissions moving forward. We take pride knowing our 3-methylquinoline runs smoothly in reactors day after day, contributing not only to the success of downstream innovators, but also to the safety and compliance practices that underpin the whole industry.

    Looking Forward: Commitment to Consistency and Responsiveness

    As specialty chemicals like 3-methylquinoline become even more central to next-generation discoveries, having a dependable producer matters more than ever. New applications in materials science, advanced printing, and therapeutics demand repeatable quality and transparent practices across the supply chain. Our role grows beyond the plant gates. From shipping lot selection to document support, technical troubleshooting, and compliance documentation, every action aims at strengthening trust.

    In the end, reliability grows not just from chemical expertise, but from the accumulated stories and hard-won experience of a team who does the work on the ground. We remain committed to delivering 3-methylquinoline that performs in practice as well as on paper, empowering our clients to achieve their best, safely and sustainably. As the industry evolves, so does our manufacturing process—rooted in technical skill, strengthened by every partnership, and ready to meet the next challenge head on.