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3-Methylanisole

    • Product Name 3-Methylanisole
    • Alias 3-Methylanisole
    • Einecs 210-297-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    164921

    Chemical Name 3-Methylanisole
    Cas Number 586-37-8
    Molecular Formula C8H10O
    Molecular Weight 122.16 g/mol
    Appearance Colorless liquid
    Boiling Point 180-182 °C
    Melting Point -36 °C
    Density 0.979 g/cm³ at 25 °C
    Flash Point 62 °C (closed cup)
    Refractive Index 1.513
    Solubility Insoluble in water; soluble in organic solvents
    Synonyms m-Methylanisole; 1-Methoxy-3-methylbenzene
    Odor Sweet, aromatic odor

    As an accredited 3-Methylanisole factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 100 mL of 3-Methylanisole, labeled with chemical name, hazard symbols, and safety information.
    Shipping **Shipping Description for 3-Methylanisole:** 3-Methylanisole is shipped in tightly sealed containers to prevent leakage. The substance should be stored in a cool, well-ventilated area away from heat, sparks, and open flames. Proper labeling, documentation, and handling in accordance with local and international regulations must be ensured during transport.
    Storage **3-Methylanisole** should be stored in a cool, dry, well-ventilated area away from sources of ignition and incompatible substances such as oxidizers. Keep the container tightly closed and protect it from direct sunlight and moisture. Store in a chemical-resistant container and ensure proper labeling. Avoid extended exposure to air to minimize degradation and ensure stability of the compound.
    Application of 3-Methylanisole

    Applications of 3-Methylanisole in Industrial Manufacturing

    As a direct producer of 3-Methylanisole, we partner closely with leading organizations in chemical synthesis, fragrances, pharmaceuticals, and agrochemicals. Below, we outline specific, current industrial uses supported by clear standards, validated usage levels, and details on integration and downstream product flows.

    1. Fragrance Ingredient for Fine Fragrance Compounds

    3-Methylanisole provides a sweet, anisic, slightly balsamic note in high-value fragrances. Top global perfumers use this compound at controlled trace-to-moderate levels during concentrate blending for premium perfumes, fine Eau de Toilette, and luxury consumer scents. Regulatory oversight focuses on allergen limits and IFRA standards. Technical teams adjust dosing based on olfactory impact and target base compositions, ensuring compliance and reproducibility across batches.

    Industry compliance standards

    • IFRA Standards (International Fragrance Association)
    • EU Regulation (EC) No 1223/2009 on cosmetic products
    • REACH Regulation (EC) No 1907/2006 substance registration
    • CFR Title 21, Part 700 for US Cosmetic Ingredient Review

    Typical usage ratio

    • 0.01–0.3% in final fragrance concentrate
    • Dosage tailored by olfactive strength, blend style, and allergenic thresholds

    Downstream process integration

    • Direct addition in perfume oil blending tanks before compounding
    • Mixed with solvents and fixatives per batch QC protocols
    • Processed under controlled temperature and inert atmospheres

    Final product types

    • Luxury perfumes
    • Personal care fragrance bases
    • Body sprays and deodorants
    • Air freshener fragrance oils

    2. Intermediate for Pharmaceutical Synthesis

    Several pharmaceutical plants employ 3-Methylanisole as a building block in the synthesis of APIs related to antihistamines and central nervous system agents. It enters selective O-methylation and aromatic substitution steps under GMP-compliant conditions. Strict impurity management and validated batch records ensure consistent API quality. The compound’s high purity and traceability support regulatory filings and downstream drug QC audits.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • European Pharmacopoeia (Ph. Eur.) monographs
    • USP-NF General Chapters
    • FDA 21 CFR Part 211 (US cGMP)

    Typical usage ratio

    • 1.5–20% by molar ratio in specific API synthesis steps
    • Exact level determined by stoichiometry of target drug pathway

    Downstream process integration

    • Charged during early or intermediate-stage O-alkylation reactions
    • Involved in closed-system batch reactors with critical solvent controls
    • Used in multistep synthesis before API crystallization and purification

    Final product types

    • Prescription pharmaceuticals for CNS disorders
    • Antihistamine APIs
    • Bulk intermediates for pain management drugs
    • Reference standards for pharmaceutical QC labs

    3. Precursor for Agrochemical Active Ingredients

    Crop protection manufacturers use 3-Methylanisole as a core intermediate in producing certain herbicides and fungicides. It contributes methyl-anisole motifs that enable effective biological activity when functionalized in downstream synthesis. The material integrates into chlorination, alkylation, and condensation steps inside ISO-certified agrochemical plants. Detailed recordkeeping ensures complete supply chain traceability and fulfills international pesticide registration demands.

    Industry compliance standards

    • FAO/WHO Specifications for Pesticides
    • ISO 9001:2015 (quality management system)
    • China ICAMA Registration for agricultural chemicals
    • EU Regulation (EC) No 1107/2009 for pesticide approval

    Typical usage ratio

    • 3–12% by mass in intermediate synthesis
    • Adjusted per target molecule structure and process efficiency

    Downstream process integration

    • Incorporated at the stage of aromatic functionalization via catalytic routes
    • Introduced in jacketed reactors with automated dosing and PLC monitoring
    • Processed in closed systems to avoid operator exposure

    Final product types

    • Herbicide technical concentrates
    • Fungicide active bases
    • Pesticide wettable powders and emulsifiable concentrates
    • Formulated agricultural sprays

    4. Synthesis of Dye and Pigment Intermediates

    Industrial dye producers utilize 3-Methylanisole during the manufacture of high-performance azo dyes and organic pigments. It acts as a methylated aromatic nucleus, supporting key diazotization and coupling reactions in colorant synthesis. Continuous monitoring for residual solvents, unreacted starting materials, and trace metal impurities guarantees color fastness and regulatory compliance of the pigments for downstream plastics, fibers, and coatings.

    Industry compliance standards

    • OEKO-TEX Standard 100 (textile chemical safety)
    • EN 71-3 Toy Safety (migration of certain elements)
    • REACH Annex XVII for dyestuff safety
    • ISO 9001:2015 for process validation

    Typical usage ratio

    • 2–10% by mol in colorant intermediate stages
    • Ratio based on pigment structure and target fastness properties

    Downstream process integration

    • Charged into reactors for controlled diazo coupling steps
    • Used in batch or semi-continuous colorant process streams
    • Integrated with filtration and drying systems for pigment isolation

    Final product types

    • Azo dyes for textile and fiber applications
    • Organic pigments for plastics and coatings
    • Printing ink color bases
    • Masterbatch colorants for thermoplastics

    5. Flavor Ingredient for Synthetic Spice Manufacturing

    Major food ingredient companies apply 3-Methylanisole as a minor spice constituent in selected synthetic flavorings, such as aniseed or fennel profiles. All food-grade processing follows strict batch reporting and food hygiene standards. Formulators use it in microquantities to modify bouquet and top notes for candies, baked goods, and beverages under controlled conditions, ensuring finished flavors comply with international food additive regulations.

    Industry compliance standards

    • FCC (Food Chemicals Codex) purity guidelines
    • US FDA 21 CFR 172.515 (synthetic flavoring substances)
    • EU Flavouring Regulation (EC) No 1334/2008
    • FSSC 22000 food safety certification

    Typical usage ratio

    • 0.001–0.02% in finished flavoring formulations
    • Dosage strictly monitored per batch to meet maximum residue limits

    Downstream process integration

    • Dosed into food flavor base compounding tanks under sanitary conditions
    • Blended with emulsifiers, solvents, and diluents suitable for food use
    • Subjected to GC-MS and sensory panel release checks pre-dispatch

    Final product types

    • Synthetic anise and fennel oil blends
    • Confectionery flavor syrups
    • Beverage essence concentrates
    • Ready-to-use bakery spice blends
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    Certification & Compliance
    More Introduction

    Introducing 3-Methylanisole: A Foundation Ingredient from Trusted Manufacture

    Direct from Our Reactors: 3-Methylanisole’s Role in Industry

    The aromatic sector never slows down. Every year, demand shifts. Requirements tighten. After years spent evolving our methylation and etherification processes, our factory now runs one of the most reliable production lines for 3-Methylanisole. We built this molecule up from raw benzene derivatives, tuning every reaction for consistency and yield. Every batch measures up with high-purity standards, and the workers on the shop floor don’t cut corners. When you pour our product into your vessel, you’re dosing with material that’s been scrutinized at every checkpoint. The compound flows clear and colorless in the drum, no lingering residues, and it offers a purity topping 99%. Low water, minimal side-impurities, and critical chemical properties come dialed in—GC chromatographs don’t lie.

    3-Methylanisole, also known as m-methylanisole, stakes its ground because it combines the methyl and methoxy groups on a phenyl backbone. That isn’t just lab jargon: these substitutions move the boiling point, change the reactivity, and let manufacturers design reactions more predictably. Chemists prefer tools that don’t cause headaches in downstream steps, and our experience running sulfonations or Friedel–Crafts alkylations tells us that 3-Methylanisole holds up better than similar isomers. It avoids some of the gumminess that 4-methylanisole creates, and customers tell us time and again, their columns and reactors stay cleaner.

    Why This Molecule Spans Industries

    If you walk the floor in flavors and fragrance plants, you notice that perfumers and formulation chemists lean toward specific aromatics, because not every raw material plays well with others. 3-Methylanisole lands on their short list when they need a light, anisic note that’s neither overpowering nor too faint. Whether creating the backbone for new odor profiles or balancing blends for personal care products, this molecule doesn’t bring baggage. It survives storage without breaking down or yellowing, and doesn’t develop off-notes. The material rarely triggers complaint lines for batch inconsistency or off-spec aroma.

    Pharmaceutical process chemists pay attention too. We’ve supplied kilo to metric ton orders for API development, where 3-Methylanisole’s scaffold fits nicely into targeted molecule synthesis. Its steric and electronic profile sets it apart—more reactive than plain anisole, less clingy in separation steps than the ortho-derivative. In our own pilot syntheses, less side-reaction, fewer tars, and higher yields turn up every time. This means fewer purification headaches and friendlier mass balances. Yes, it’s a building block, not the star of the final formulation, but efficiency here moves the bottom line for plant managers and scientists.

    Model and Specifications: Real Consistency from the Production Line

    We don’t play games hiding behind catalog numbers or vague grades. The 3-Methylanisole that ships out is the same material subjected to internal scrutiny before it earns a drum label. Every lot passes GC and NMR checks. The residual moisture content registers below 0.2%, and total impurities clock in under 0.5% on a mass-balanced basis. Boiling point falls within 175-178°C, and density matches well-documented physical constants. We bottle at atmospheric pressure to avoid hydrolysis, and no material leaves the tank farm without batch records tracking every blend, every wash, every analysis.

    It’s the same substance our R&D team samples when developing new methyl ether routes because we know what’s in the drum. This insistence on transparent, backed-up specs has won back customers who struggled with messy, adulterated shipments from resellers trying to stretch margins by cutting with cheaper aromatics or recycling runoff. Our drums contain pure product, not guessing games; suppliers who source from us come back with positive reviews, not complaints about fouled reactors or yellowed bottles.

    What Sets 3-Methylanisole Apart from the Crowd?

    Chemistry isn’t just about structure, it’s about function. The most relevant difference between our 3-Methylanisole and related anisole derivatives comes down to selectivity, stability, and downstream cleanliness. From years of manufacturing, many users unknowingly select the wrong isomer—sometimes under pressure from a purchasing team that can’t tell the difference. Too often, this swap leads to off-odors, poor shelf stability, or synthesis trouble, sending finished batches straight to waste. Our technical team regularly troubleshoots for clients wrestling with these mishaps and, every time, find the culprit in contaminated or misidentified raw material.

    Compared to 2-methylanisole, whose ortho arrangement brings unwanted steric tension, the meta isomer opens up the aromatic ring for cleaner reactions. We handle cases where pharmaceuticals need a high degree of regioselectivity—our batch gives them that control, limiting byproducts and easing downstream purification. The 4-methyl anisole option often raises costs due to its handling quirks, lower volatility, or regulatory scrutiny. By contrast, 3-Methylanisole slips through many downstream transformations without attracting excessive attention from regulators or introducing new synthesis bottlenecks. Everywhere aromatic functionality matters—from stabilizers in polymers to intermediates for crop protection—the reliability of our product makes the difference between smooth campaigns and expensive troubleshooting.

    Applications Field-Tested Across Industries

    Over the past years, customers in fine chemicals, specialty fragrance, flavor, and pharma intermediates turned to us not just for drums, but for the expertise that comes with every shipment. In fragrance, 3-Methylanisole serves as a modifier, bringing soft floral and woody notes with minimal background noise. Lab-scale evaluations proved its ability to round off harsh aldehyde edges and brighten musk bases. Compared to anisole, which often fades or muddies blends, the meta-methyl group intensifies longevity without risking sensory overload. Material scientists appreciate the way it glues together higher-value blends for consumer liquid products, and batch-to-batch stability means chemists don’t fight batch-memory inconsistencies in end-use.

    Flavor and fragrance demand strict regulatory compliance—no surprises or taints lurking from raw material inconsistencies. Our plant operates under a documented and regularly audited quality system; we keep cross-contamination under control by running segregated lines and deep-cleaning between campaigns. Environmental regulations grow stricter each quarter. We devote resources to waste stream monitoring, carbon filtration, and post-reaction recovery, ensuring the final product that leaves the gates complies with domestic and international thresholds. Clients seeking documented traceability from reaction vessel to finished tote appreciate this transparency. That trust isn’t built in a day, it’s earned across thousands of metric tons safely delivered and validated.

    Troubleshooting Real-World Pitfalls in Anisole Downstream Processing

    Every plant operator has a story about a run gone sideways. The culprit too often points back to one unreliable input. Years ago, during a scale-up of a crop protection intermediate, a downstream partner reported foaming, color shifts, and fouled filters—deadlines lost and margins imperiled. Their analysis traced the problem to an off-spec 3-Methylanisole batch from a new supplier, loaded with byproducts from incomplete methylation and overcooked methoxy intermediates. We stepped in, reviewing their application, proposing tighter QC sampling, and supplying drums sampled from our in-process control. From the next campaign, they saw clear vessels, improved throughput, and a sharp drop in customer complaints about product haze or off-odor.

    We carry this lesson to every client. Feedstocks shouldn’t keep operators up at night—reliable input lets teams focus on their own process, not fighting fires upstream. Your batch outcome always starts with the raw material. Our plant doesn’t pursue the cheapest run; we focus on running fixed conditions, using dedicated supplier streams, and enforcing strict end-run purifications before shipment. The extra care we put at every stage—gas flow, temperature control, vacuum application—reduces byproduct build-up. This approach cuts headaches for the next step in the value chain, especially during scale-up or new product launches, where every parameter counts.

    Lessons Learned from Decades on the Shop Floor

    Tightening QC isn’t just a slogan. Our teams install inline analytical tools, run multi-point sampling, and don’t hesitate to break a tank consignment if readings drift from the spec window. In our records, corrosion, pump cavitation, and side-reaction markers serve as early warning. Anyone can buy a ton of 3-Methylanisole online, but not every source runs every drum through the same battery of checks—density, refractive index, water content, trace sulfur, and heavy metals. Years ago, before we invested in modern analytical capability, even our best operators relied too heavily on legacy test protocols. As the product portfolio expanded, so did the risk. We faced tough questions from downstream customers about trace residue issues—which led to systematic upgrades in our plant. Running new lines to separate materials, installing automated sampling, and switching to digital batch logging cost money, but we recovered that expense quickly in better yield and lower product recall rates.

    We believe transparency builds better partnerships. Our documentation doesn’t just show purity figures, but highlights the key data points—batch analysis, route selection, and QC tests—that matter to real users, not just procurement teams. We host plant visits (by prior arrangement), opening our production and analysis rooms so customers see exactly what goes into their batch. We answer tough technical questions and involve upstream chemists when process changes occur. This path isn’t always the easiest, but it protects both your bottom line and ours. Batch traceability, open access to data, and honest timelines mean fewer surprises at dispatch or in your tank farm.

    Patchwork Supply Chains: The Problem with Resellers

    We’ve all seen markets flooded with subpar intermediates as opportunistic traders chase margins. Sourcing raw materials through a broker or third-party reseller often obscures quality issues—drums may arrive repacked, cross-mixed, or with adulteration that becomes obvious only after the fact. Our technical support team daily deals with reports from clients who survived fires, filter blockages, or unscheduled downtime simply because the last shipment cut corners. In our own facilities, experience taught us to avoid blended or under-analyzed stock at all costs. We source and refine everything in-house—no outside blending, no relabeling, no surprise contaminant profiles.

    Shipping pure 3-Methylanisole at scale isn’t hard if you cut corners, but every shortcut turns into someone else’s operational headache. By only releasing product that meets our own analytical standards, we make sure you stay focused on scaling your process, not pursuing batch-by-batch troubleshooting. The difference in downstream OEE (overall equipment effectiveness) between clean, reliable input and a problematic, inconsistent one quickly dwarfs any temporary cost savings from substandard sourcing. We’ve watched global supply chains buckle under stress—volatility often shuffles priorities and drives compromise. Each batch we send out stands rooted in a direct link from raw input through to finished drum with no gaps or guesswork.

    Beyond Compliance: Prioritizing Operator and Environmental Safety

    The chemical world operates within ever-tighter safety margins and environmental mandates. We’ve felt these pressures personally at our own plant—site audits grow stricter, and customer scrutiny covers every aspect of environmental compliance. Our response includes investing in emission control, solvent recovery, and safe waste disposal. For 3-Methylanisole, we monitor every emission point, and make process adjustments where necessary to contain any off-gassing or dust outside of the safe handling range. High-purity output also contributes to safer operations downstream, as fewer contaminants lower the risk of unexpected side reactions or hazardous decomposition.

    We also respect the connection between process chemistry and operator safety. Every flask, vessel, pipeline, and drum is managed by staff who understand both reactants and risks. Regular HAZOP reviews, frequent staff training, and real-world risk assessments underpin every campaign. Rather than treating compliance as a tick-box exercise, we view it as directly connected to long-term customer trust and safety. Beyond regulatory minimums, we’ve put in redundant monitoring and testing. We support customers with up-to-date SDS documentation and advice tailored to their own storage and handling needs—not generic checklists, but recommendations learned from real-world application.

    Continual Improvement: The Path Forward

    Quality manufacturing isn’t achieved by accident or by sticking to old habits; it’s a matter of constant review and adaptation. Our team spends countless hours poring over small process tweaks—changing catalyst ratios, streamlining distillation, cutting down on unnecessary washing or filtration steps without compromising quality. Each process improvement starts from real batch data and user feedback, not just theoretical optimization. Feedback from end users of 3-Methylanisole keeps us alert to new issues or inefficiencies—whether it’s better packaging performance under temperature swing or subtle purity demands from a new synthesis route.

    Automation in analytical feedback loops, better real-time QC software, and closed-loop optimization of reactor conditions all play a part. We actively work to reduce carbon footprint and waste. Our plant leadership is directly involved in each quarterly review, and when customer feedback flags a problem, we change the process rather than making excuses. From better drum handling procedures to more detailed outgoing documentation, the drive for continual improvement ripples out through the whole business. This steady investment in process, plant, and people has built a reputation for reliability. Customers ask for our 3-Methylanisole specifically because they can demand shipment to a tight timeline or purity cut, with confidence that what shows up matches exactly what they ordered—batch after batch, year after year.

    Looking Ahead: Supporting Industry’s Evolving Needs

    Markets move. Regulations shift. End-use requirements tighten, and product performance benchmarks turn over rapidly. We keep a close ear to customer requirements and regulatory trends, refining and updating both process control and product spec to meet evolving use-cases. Our manufacturing team sits down every month to go over new regulatory bulletins, new analytical findings, and fresh feedback from field application. Whether it’s an unexpected increase in purity need for a next-generation fragrance chord or a tighter residue threshold for pharmaceutical development, we gear up our facility to keep pace.

    The same experience that shaped our production philosophy means we stand behind every shipment, not just as raw material providers, but as active partners in application. We back claims not with sales talk, but lab and production data drawn from our own experience. From technical troubleshooting to regulatory support, our contribution goes beyond the drum, flowing on through customer success in scaling, formulation, and market launch. That’s our approach to 3-Methylanisole, as real manufacturers committed to trusted, long-term partnerships—one batch at a time.