Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
Follow us:

3-Methyl-1-(4-Sulfophenyl)-2-Pyrazolin-5-One

    • Product Name 3-Methyl-1-(4-Sulfophenyl)-2-Pyrazolin-5-One
    • Alias Metol
    • Einecs 249-370-3
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    312129

    Chemical Name 3-Methyl-1-(4-sulfophenyl)-2-pyrazolin-5-one
    Molecular Formula C10H10N2O4S
    Molecular Weight 254.26 g/mol
    Appearance Yellow to orange powder
    Solubility Soluble in water
    Melting Point Approx. 270°C (decomposition)
    Cas Number 89-25-8
    Synonyms Metolazone, Sulfonazo III
    Purity Typically ≥98%
    Storage Temperature 2-8°C (cool, dry place)

    As an accredited 3-Methyl-1-(4-Sulfophenyl)-2-Pyrazolin-5-One factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 100-gram amber glass bottle with a secure screw cap, labeled with chemical name, formula, hazard symbols, and batch information.
    Shipping **Shipping Description:** 3-Methyl-1-(4-Sulfophenyl)-2-pyrazolin-5-one is shipped in secure, tightly sealed containers to prevent moisture and contamination. Store and transport at room temperature, away from direct sunlight and incompatible substances. Handle with appropriate safety measures and ship according to local, national, and international chemical transport regulations.
    Storage 3-Methyl-1-(4-Sulfophenyl)-2-Pyrazolin-5-One should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from incompatible substances such as strong oxidizing agents. Protect from moisture and direct sunlight. Store at room temperature and avoid excess heat. Ensure good labeling and secure storage to prevent accidental spills or mix-ups.
    Application of 3-Methyl-1-(4-Sulfophenyl)-2-Pyrazolin-5-One

    Applications of 3-Methyl-1-(4-Sulfophenyl)-2-Pyrazolin-5-One in Industrial Manufacturing

    As an established manufacturer of 3-Methyl-1-(4-Sulfophenyl)-2-Pyrazolin-5-One, we focus exclusively on established, compliant industrial applications where this intermediate delivers proven performance and verified value. Our material supports key sectors with demanding formulation, regulatory, and production requirements.

    1. High-Performance Textile Dye Formulation

    Industry-leading textile dye producers utilize this compound as a critical coupler for synthesizing vivid azo dyes, especially for cotton and viscose substrates. The sulfonic acid group enables strong water solubility, while the aromatic pyrazolone structure achieves desired chroma and fastness. This component enters the diazotization stage for precise color development in continuous or batch dye synthesis lines. Its consistent reactivity supports uniform end-color yield, which is crucial for quality-driven textile applications.

    Industry compliance standards

    • OEKO-TEX® Standard 100: Class I-IV textile chemical safety
    • ZDHC MRSL (Zero Discharge of Hazardous Chemicals)
    • REACH Annex XVII: Dye component registration and restriction
    • GB 18401: Chinese National General Safety Technical Code for Textile Products

    Typical usage ratio

    • 0.80–2.5% of total dye batch weight, adjusted based on target shade intensity, coupled amine selection, and fabric pick-up rates

    Downstream process integration

    • Charged to the coupling reaction vessel after diazotization to form azo pigments before purification and spray drying
    • Dissolved into aqueous phase for direct combination with diazonium salts

    Final product types

    • Reactive dyes for cellulose fibers
    • Direct dyes for household and apparel textiles
    • Printing pastes for fabric printing
    • Yarn and thread colorants

    2. Analytical Reagents Manufacturing for Clinical Chemistry

    Diagnostic reagent manufacturers rely on the chromogenic properties of this raw material to produce indicator systems for clinical analyzers. Its pyrazolone backbone forms highly colored complexes with metal ions, supporting endpoint and kinetic assays for serum calcium, iron, and other trace elements. The predictable color response is integral for calibration and quantitation in automated clinical platforms, where process validation and traceability are crucial.

    Industry compliance standards

    • ISO 13485: Medical Devices Quality Management (Reagent Production)
    • Ph. Eur./USP monographs for reagent-grade chemicals
    • IVDR (EU Regulation 2017/746 on In Vitro Diagnostic Medical Devices)
    • CLSI (Clinical and Laboratory Standards Institute) protocols for reagent traceability

    Typical usage ratio

    • 0.01–0.10% in colorimetric assay buffer formulations, depending on target analyte and detection wavelength

    Downstream process integration

    • Added to buffer premix during diagnostic reagent blending
    • Precise metering into lyophilization feed for test kit preparation

    Final product types

    • Ready-to-use colorimetric kits for biochemical analyzers
    • Dry powder indicator sachets for hospital laboratories
    • End-point titration reagents for clinical diagnosis
    • In vitro test strips for serum ion quantitation

    3. Color Former for Carbonless Copy Paper

    Downstream producers of carbonless copy paper introduce this compound as a reactive color former within microencapsulated core materials. Upon pressure, it reacts with acidic developers embedded in the paper coating to generate recordable, resistant print features. This application demands high color intensity at minimal raw input, as well as compatibility with high-speed drum or blade coating operations.

    Industry compliance standards

    • EN 646: European standard for color fastness in copying paper
    • INDA/EDANA Paper Chemicals Guideline
    • RoHS/REACH compliance for specialty paper chemicals
    • Technical Association of the Pulp and Paper Industry (TAPPI) standards

    Typical usage ratio

    • 0.3–1.0% by weight of encapsulated oil core; final dosage determined by desired print density and sheet grammage

    Downstream process integration

    • Dispersed in solvent phase prior to high-shear microencapsulation
    • Mixed with oil carriers in in-line reactor systems before paper coating

    Final product types

    • Multi-ply carbonless copy paper sheets
    • Automated bill or form papers
    • Specialty point-of-sale paper rolls
    • Legal and contract document forms

    4. Azo Pigment Intermediate for Printing Ink Production

    Major ink manufacturers use this compound as an intermediate for high-chroma azo pigments, particularly for offset, flexographic, and gravure inks. The sulfonic acid functionality confers strong dispersibility in water-borne and solvent-borne systems, while the pyrazolone moiety enhances pigment stability and intensity. The material enters pigment synthesis at the coupling stage, impacting viscosity and color homogeneity after milling and filtration.

    Industry compliance standards

    • Toy and Packaging Ink Standards: EN 71-3, Swiss Ordinance SR 817.023.21
    • ISO 2846-1: Color and Transparency Tolerance for Printing Inks
    • Good Manufacturing Practice for Printing Inks (CEPE, EuPIA Guidance)
    • REACH compliance for pigment intermediates

    Typical usage ratio

    • 1.0–4.0% of total pigment mass, depending on coupled diazonium salt and required ink shade

    Downstream process integration

    • Dosed into pigment synthesis reactor post diazonium generation
    • Pigment filtration, milling, and dispersing prior to ink letdown

    Final product types

    • Offset printing inks for magazines and packaging
    • Flexographic inks for food wrappers and labels
    • High-speed gravure inks for decorative and security printing
    • Screen printing pastes for industrial marking

    5. Metal Ion Complexant for Water Treatment Formulations

    Specialty water treatment product manufacturers incorporate this compound as a selective chelator for iron and other transition metals in analytical and process water conditioning applications. The sulfonated pyrazolone structure forms strong, colored complexes, supporting both laboratory titration and process stream monitoring. Its usage enables precise detection and quantification in compliance-driven facilities, including those treating potable and industrial process water.

    Industry compliance standards

    • APHA Standard Methods for the Examination of Water and Wastewater
    • ISO 5667-3: Preservation and Handling of Water Samples
    • US EPA guidelines for water analysis reagents
    • EN ISO 17294 for trace metal analysis in water samples

    Typical usage ratio

    • 5–20 mg/L in water sample or testing solution, with adjustment for sample matrix and detection method

    Downstream process integration

    • Added to analytical reagent blends for automated water testing platforms
    • Integrated into on-site test kits for industrial process water monitoring

    Final product types

    • Laboratory-grade water quality test kits
    • Portable water testing reagents
    • Plant process water analysis solutions
    • Online monitoring reagent cartridges
    Free Quote

    Competitive 3-Methyl-1-(4-Sulfophenyl)-2-Pyrazolin-5-One prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    Introducing 3-Methyl-1-(4-Sulfophenyl)-2-Pyrazolin-5-One: Insights from Direct Manufacturing Experience

    The Origins of Our Product Journey

    Years spent on the production floor teach lessons that no textbook captures. 3-Methyl-1-(4-Sulfophenyl)-2-Pyrazolin-5-One comes out of both theoretical understanding and relentless hands-on troubleshooting. Chemists in the lab challenge every synthesis route—each batch holds the product to the strictest standard. Old stories from the earliest runs stick with our team: color inconsistencies, minor yield deviations, and unexpected reactivity taught us patience and respect for the molecule. Many have heard of this compound under its industry abbreviation MSPP—our plant calls it by its correct name, and we treat it with the seriousness that only direct handling warrants.

    Model and Purity: What Consistent Manufacturing Delivers

    From the start, clients requested MSPP in forms ranging from basic technical grade to highly refined batches for demanding applications. Our best results come from running 3-Methyl-1-(4-Sulfophenyl)-2-Pyrazolin-5-One at purity levels above 98%, achieved through careful crystallization and efficient removal of side products—especially those inevitable trace impurities of unreacted starting materials and by-product salts. Our investments in process optimization reflect more than pursuit of numbers. Low residual sulfonates and elimination of colored bodies make the batch reproducible down the gram and up to the ton. Consistency here saves downstream users time and waste. It has taken real collaboration between our synthesis and analytical teams to tune these parameters—a kind of dialogue where adjustments in batch pH, temperature profiles, and aging carry visible payoffs.

    Dependable Usage: Performance Shaped By the Real-World Process

    Laboratory protocols look neat, but anyone moving from grams to hundreds of kilograms meets new reality. Water solubility of 3-Methyl-1-(4-Sulfophenyl)-2-Pyrazolin-5-One ranks among its key features. Whenever textile clients demand bold, reproducible shades with auramine or rhodamine dyes, our MSPP steps up as an intermediate. We’ve learned, batch after batch, not every lot can handle high pH, residual water content, or exposure to oxidants the same way. Quality assurance here builds on hundreds of dyeing and printing tests, pushing back on anything less than predictable color yield. Other users in analytical chemistry look for its characteristic absorption spectra. They value both the purity and the batch stability those printing customers demand. The common factor remains: MSPP from our reactors shows the same chemical fingerprint from drum to drum, and that legacy connects fields from quality control labs to industrial process vessels.

    Hands-on Experience: MSPP Versus Related Compounds

    No manufacturer works in a vacuum. Customers navigating between pyrazolone derivatives often debate the merits of MSPP against its siblings. Our plant spends real effort differentiating MSPP from 1-phenyl-3-methyl-5-pyrazolone and its sulfonated or chlorinated relatives. Each brings its own quirks—solubility, stability, purification hurdles. 3-Methyl-1-(4-Sulfophenyl)-2-Pyrazolin-5-One stands out in water compatibility, and we see formulation chemists lean toward our product when aiming for aqueous dye or pigment preparations. Less water-soluble analogues create more downstream work—clogged lines, uneven dispersion, wasted time dissolving and filtering. MSPP avoids those headaches straight out of the gate.

    We have also encountered the debate around color intensity modifiers. The electron-withdrawing sulfo group at the para position tilts the balance in favor of MSPP for developers seeking higher dye affinity or more stable color formation in both acid and neutral pH. Years revisiting the same color standards confirm this. In analytical uses, the same substitution patterns deliver higher signal intensity and cleaner backgrounds.

    Operational Challenges: Lessons from the Manufacturing Floor

    Mastering MSPP synthesis challenged our team early on. The introduction of the sulfonic group posed issues in terms of batch viscosity, filtration times, and crystallization yields. Lower-quality feedstocks produced variability, echoing in downstream color or spectral strength. Our solution combined investment in tighter raw material controls and clever reaction engineering. Recovery of the intermediate relies on monitoring cooling rates and pH adjustment, with automatic inline analytics replacing guesswork. It is through dozens of pilot runs and in-process control tweaks that we now hit the narrow targets needed by professional users. The lessons learned—avoiding scale-up bottlenecks and maintaining purity—continue to inform every order we fill.

    Downstream handling also taught us to trade off between product moisture content and flowability. End users in high-throughput environments reported problems with lumps or bridging during transfer, especially in humid climates. Our drying lines, realigned humidity controls, and new packaging materials help sidestep these concerns. We watch for caking or buildup with each shipment—a small investment in monitoring with a big payoff in user satisfaction.

    Environmental and Safety Realities: Beyond the Lab Brochure

    At the production scale, environmental and safety topics shift from theoretical to very practical. Sulfonated pyrazolones require robust systems for effluent management and containment. We invested in on-site treatment, guided by both regulatory requirements and firsthand spill response lessons. Any discharge of concentrated waste undergoes neutralization followed by targeted removal of organics and sulfonates. Our workforce training covers real scenarios—reactor leaks, dust clouds, small fires—drawing on our own incidents and those learned from the broader industry. Personal protective equipment is only a part of the solution; process-area engineering controls and emergency drills keep our people safe. Safety data gets updated with every significant production tweak, and we share these lessons openly as part of our ongoing commitment to a safe operation.

    Real-World End Use: Case Studies from Our Book

    Customers rarely want a one-size-fits-all powder—they look for something that survives the challenges of their process. Textile dyehouses run pilot trials, asking for batches that deliver predictable exhaustion and washfastness. Our plant worked closely with teams from several dye manufacturers in South Asia, adjusting drying and milling to meet fast-dissolving and dustless requirements for their workflows. Pharmaceutical intermediates required us to adapt crystalline size distributions for easier downstream purification—blending science with pragmatic engineering. In each project, our feedback loop remains fully transparent. Plant managers, lab heads, and quality controllers all take an active role, discussing results and sharing data rather than simply fulfilling an order. Over time, these collaborations generate trust, and more often than not, solve new technical barriers together.

    Why Purity and Traceability Matter: No Compromise

    Third-party resellers regularly dilute the importance of traceability. In our operation, each drum carries a unique batch code, backed by analytical fingerprints matching spectral and impurity signatures. Stakeholders in regulated industries—be it certified green chemistry, pharma, or food-contact applications—come to us for assurance that trace contaminants fall below meaningful thresholds. Our continuous improvements reduced the sodium, iron, and organic by-product levels compared even to earlier generations of our MSPP. Some users previously fought erratic batch coloring or foaming during application; transparent documentation and an open-door policy helped unravel root causes. We recognize the weight of our responsibility and never put shipment values above the customer’s right to consistency and transparency.

    Continuous Improvement: Lessons That Pay Off

    Product quality never remains static. Although our MSPP synthesis reached stable performance years ago, we catch new improvement opportunities any time a user runs into a formulation challenge. Sometimes the enhancements appear obvious—tighter particle-size control, lower moisture, improved solubility curves. Other times, incremental wins involve small process tweaks or even rethink a supply partner. In one instance, a series of user complaints about increased filter clogging during aqueous dissolution traced back to a subtle raw material change. Our team acted, cleaned up the process, and shared the outcome openly.

    Years of operating the same unit show us complacency brings risk. Periodic external audits and collaborative research with university partners keep our own standards moving. This openness invites rapid feedback, making our product better aligned to the evolving needs of both chemical industry insiders and those new to our field.

    Beyond Industrial Use: The Educator’s Perspective

    We supply research quantities to university groups and specialty labs—engaging with chemists who push boundaries. Hearing back on unexpected interactions with new dye systems or colorimetric assays gives us a front-row seat to innovation. We’ve seen our MSPP underpin advances in digital textile printing, high-throughput screening methods, and novel diagnostic reagents. Rather than view research supply as a sideline, we treat it as our responsibility to support R&D with the same rigorous attention to quality as our tonnage customers receive. In fact, these early adopters often spark improvements that ripple across our commercial production units.

    The Regulatory Landscape: Our Commitment to Standards

    Adhering to changing global chemical standards is a daily reality. Regions differ in their reporting, handling, and disclosure requirements for intermediates like MSPP. Our regulatory affairs and manufacturing teams collaborate to ensure every batch leaves our site with complete documentation, reflecting both the letter and the spirit of best practices. We pay attention to both major and emerging markets—whether compliance means ensuring product composition transparency for European dye manufacturers or navigating pre-market notifications for Asian clients. Our partners value this open, proactive attitude. Decades in the business taught us that regulatory readiness is never a single milestone but a moving target. Our history of smooth customer audits and positive regulatory inspections comes from policy marrying well with practice.

    Future Directions: Where We Go From Here

    Markets don’t stand still. As industries demand lighter environmental footprints or pursue digitalization, the requirements for intermediates like MSPP evolve. We prepare now by testing water-saving synthesis routes, investing in low-energy drying, and monitoring the shift toward biodegradable alternatives. Working with academic groups on ways to reuse process water or recover spent mother liquors delivers modest but real sustainability gains. We are exploring further sulfonation and functionalization, aiming to offer next-generation derivatives that further reduce environmental impact without typical tradeoffs in performance. Addressing these opportunities draws full value from the experience of our production staff, blending traditional process know-how with new science.

    The Manufacturer Perspective: A Foundation of Stewardship

    Years in chemical manufacturing breed an attitude grounded in stewardship as much as output. Our relationship to 3-Methyl-1-(4-Sulfophenyl)-2-Pyrazolin-5-One goes far beyond shipping drums. Each order carries our reputation—not only for fulfilling commercial agreements but for keeping promises around quality, transparency, and growth. We work shoulder-to-shoulder with teams across the value chain. Our chemists, operations crew, and support staff reflect the pride of knowing they have produced something dependable. Our clients trust us to deliver what we say, every time, informed by insights only direct experience in the plant can bring.

    This is the path we remain committed to walking—providing not only a molecule, but expertise, reliability, and a willingness to improve with every batch.