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3-Mercapto-1-Hexanol

    • Product Name 3-Mercapto-1-Hexanol
    • Alias 3-sulfanylhexan-1-ol
    • Einecs 224-580-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    572827

    Cas Number 51755-83-0
    Molecular Formula C6H14OS
    Molecular Weight 134.24 g/mol
    Iupac Name 3-mercaptohexan-1-ol
    Appearance Colorless to pale yellow liquid
    Odor Powerful, grapefruit, tropical, sulfurous
    Boiling Point 208-210 °C
    Density 0.988 g/mL at 25 °C
    Refractive Index 1.483-1.485
    Solubility Slightly soluble in water, soluble in organic solvents

    As an accredited 3-Mercapto-1-Hexanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 3-Mercapto-1-Hexanol, 25g, supplied in a sealed amber glass bottle with tamper-evident cap and hazard labeling.
    Shipping 3-Mercapto-1-Hexanol is shipped in tightly sealed, chemically resistant containers, typically under inert gas. The package is clearly labeled and handled according to hazardous material regulations, due to its strong odor and potential toxicity. Appropriate documentation and safety data sheets accompany the shipment to ensure full compliance with transport regulations.
    Storage 3-Mercapto-1-Hexanol should be stored in a cool, dry, well-ventilated area away from sources of ignition and incompatible substances such as oxidizing agents. Keep the container tightly closed and protected from light and moisture. Use appropriate chemical-resistant containers, and ensure proper labeling. Handle in accordance with good industrial hygiene and safety practices. Store at recommended temperatures as specified by the supplier.
    Application of 3-Mercapto-1-Hexanol

    Applications of 3-Mercapto-1-Hexanol in Industrial Manufacturing

    3-Mercapto-1-hexanol serves as a specialized functional intermediate in highly regulated fine chemical, fragrance, and advanced materials sectors. As the direct manufacturer, we supply this product to customers with stringent technical and compliance demands for use in sophisticated downstream processes. Below are focused industrial application scenarios where 3-Mercapto-1-hexanol demonstrates unique value and regulatory fit.

    1. Aroma Chemical Synthesis for Flavors and Fragrances

    Commercial fragrance houses use 3-Mercapto-1-hexanol as a sulfur-containing precursor in the synthesis of high-impact aroma compounds—particularly for tropical, green, and grapefruit notes. As part of the thiol chemistry toolset, it enters at the aldehyde condensation or mercaptan functionalization step, depending on the target molecule. Its purity and odor threshold make it integral in the creation of premium, trace-component signatures in food and personal care flavorings, as well as in fine perfumery. End users demand regulatory documentation for application in products destined for consumer markets worldwide.

    Industry compliance standards

    • IFRA Code of Practice for Fragrance Ingredients
    • EU Regulation (EC) No 1223/2009 on Cosmetic Products
    • US FDA 21 CFR 172.515 (Flavoring Substances and Adjuvants)
    • ISO 9235: Aromatic Natural Raw Materials — Definition, Classification and Nomenclature

    Typical usage ratio

    • Final fragrance concentrate: 0.01–0.10%; can adjust lower for high-impact or threshold applications
    • Flavor compounds: ≤5 ppm in finished beverage or food, per regional regulatory limits

    Downstream process integration

    • Added during the controlled thiolation or reduction step of aroma intermediate synthesis
    • Handled under inert gas during compounding to preserve reactivity and prevent oxidation

    Final product types

    • Fine fragrances for personal care and luxury goods
    • Beverage and confectionery flavorings
    • Household cleaner scents
    • Natural-identical flavor concentrates

    2. Polymer Chain Transfer Agent in Advanced Resin Production

    Chemical formulators employ 3-Mercapto-1-hexanol as a chain transfer agent within the polymerization of styrenics, acrylates, and specialty engineering plastics. Its mercapto functionality regulates molecular weight and narrows polydispersity through transfer reactions, supporting the engineering of polymers for medical device coatings, electronics, and automotive assemblies. The alcohol functionality imparts compatibility with waterborne or alcohol-based systems. Strict process controls and documentation are essential for downstream use in regulated resin systems.

    Industry compliance standards

    • ISO 9001:2015/ISO 14001:2015 Quality and Environmental Management
    • USP Class VI – Medical Device Polymer Standards (for devices)
    • REACH Regulation (EC) No 1907/2006 for Monomer/Polymer Use
    • RoHS Directive (2011/65/EU) for Electronic Materials

    Typical usage ratio

    • 0.05–0.5% by weight of total monomer feed; adjust by target polymer chain length
    • Lower ratios for high-molecular-weight resins; higher for improved flow and processability

    Downstream process integration

    • Metered addition to the monomer batch prior to initiation
    • Dosed during free-radical or controlled-living polymerization under nitrogen atmosphere

    Final product types

    • Medical-grade acrylic and styrenic resins
    • Automotive clear-coat polymers
    • Antistatic coatings for electronics
    • High-performance waterborne adhesives

    3. Intermediate for Pharmaceutical Synthesis

    Pharmaceutical manufacturers use 3-Mercapto-1-hexanol as a building block in the synthesis of key heterocycles and API precursors. The thiol/alcohol dual reactivity enables selective substitution and cyclization reactions critical to forming sulfur- or oxygen-heterocyclic rings in new chemical entities. Controlled use requires full documentation and traceability for GMP compliance during preclinical and clinical production phases.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • US FDA CFR Title 21 Part 211 (Current GMP for Finished Pharmaceuticals)
    • EU EudraLex Volume 4 (Good Manufacturing Practice Guidelines)
    • USP-NF and Ph. Eur. Monographs where applicable

    Typical usage ratio

    • 0.2–2.5 molar equivalents per target intermediate, adjusted by stepwise protection/deprotection requirements
    • Exact charge determined via route development studies

    Downstream process integration

    • Introduced at the nucleophilic addition/cyclization step during multi-stage API synthesis
    • Incorporated under nitrogen to limit oxidative by-product formation during high-purity reactions

    Final product types

    • Sulfur-heterocycle pharmaceutical intermediates
    • Pain management and anti-inflammatory APIs
    • Antiviral and CNS-active compounds
    • High-value diagnostic reagent building blocks

    4. Functional Modifier in Silver and Precious Metal Electroplating

    Electroplating specialists incorporate 3-Mercapto-1-hexanol as an additive in silver and alloy bath formulations to improve brightness, grain refinement, and bath stability. The mercapto group anchors to the metal surface, controlling deposit morphology, while the hexanol moiety enhances solubility and reduces defects. Strict adherence to formulation limits and process cleanliness ensures safe and efficient use in electronics and jewelry finishing plants.

    Industry compliance standards

    • ISO 4527:2003 – Electrodeposited Coatings of Silver
    • IEC 62321 – Requirement for the Restriction of Hazardous Substances (RoHS)
    • ASTM B700 – Standard for Electrodeposited Silver Coatings
    • EN 1811:2011 – Nickel Release Limit Standards for Jewelry

    Typical usage ratio

    • 2–20 mg/L in total electroplating bath solution
    • Carefully titrated during setup and makeup solution preparation; inline monitoring recommended

    Downstream process integration

    • Diluted into primary or auxiliary additive tanks before bath charge-up
    • Monitored by QC during operation to avoid over-accumulation affecting deposit properties

    Final product types

    • Microelectronic connector finishes for printed circuit boards
    • Jewelry and decorative silver coatings
    • Precision optical device housings
    • Switch and relay contacts for electrical systems
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    Certification & Compliance
    More Introduction

    Introducing 3-Mercapto-1-Hexanol: Perspective from the Manufacturer’s Floor

    Our Take on 3-Mercapto-1-Hexanol Production and Application

    Working day in and day out with 3-Mercapto-1-Hexanol, the processes, challenges, and the unique features of this compound become obvious. We produce it at a scale that lets us watch trends in demand, user concerns, and changes in processing techniques up close. Instead of running through a dry list of properties, let's focus on what truly matters for those who use or rely on this compound in their work.

    What Sets 3-Mercapto-1-Hexanol Apart in the Chemical Toolbox

    Straight from the production line, 3-Mercapto-1-Hexanol doesn’t have the notoriety of some other thiol-containing compounds, but those who need it don’t see it as a substitute. Developed through specialized synthetic routes, its molecular structure—highlighted by both a thiol and a hydroxyl group—lends itself to specificity in many industrial and research applications. Unlike options that either carry only thiol or only hydroxyl groups, this molecule combines reactivity and solubility in a way that can’t always be replaced by alternatives.

    Colleagues who work with sulfur chemistry and flavor design understand why the subtle balance between the hexanol backbone and the mercapto group brings a difference in reactivity and odor that doesn’t go unnoticed. Many competitors in the market produce compounds that appear on spec sheets as interchangeable, but running a reaction or formulation with 3-Mercapto-1-Hexanol often reveals contrasts in yield, side-product formation, or even shelf stability.

    Model and Quality Control Direct from Our Facility

    Every batch of 3-Mercapto-1-Hexanol we ship carries a clear trace back to our reactor systems. Synthetic control over purity stands as a matter of pride here, not just a bullet point for compliance. Over years of process refinement, we track impurities and side reactions carefully. For example, we monitor isomer distributions and make sure free sulfur content never creeps above trace amounts.

    On our plant floor, technicians run GC-MS tests for every lot. Down the line, we’ve tailored our distillation and purification stages so that end users get consistent color, aroma, and reactivity. Few outside manufacturing realize how a slight elevation in thiol content from decomposition can throw off downstream processes in either a fine fragrance or a specialty polymer synthesis. Here, we’ve seen user partnerships last because we address these nuances before drums leave our site.

    Experience in Scale-Up and Logistics

    Lab-scale synthesis often looks straightforward, but as anyone who transitions to industrial scale learns, volatility, odor management, and storage challenge us daily. From our experience, packaging is never a throwaway detail. 3-Mercapto-1-Hexanol, despite a stable backbone, gives off a sulfurous odor that escapes through suboptimal seals. Years back, we invested in double-sealed, inert-lined containers that help keep both product and warehouse staff in good condition.

    Our logistics team keeps an eye on regional storage regulations. We ship under the controlled temperatures recommended by our internal quality group, rather than just the minimum regulatory guidelines. Odor and purity stay more reliable this way, and customers who run sensitive flavors or pharmaceuticals see the difference.

    Why Customers Rely on This Product for Flavors and Beyond

    Even a small misstep in the purity of 3-Mercapto-1-Hexanol turns into a flavor note that can derail a launch or a batch review in a food company. The thiol group delivers characteristic tropical and passionfruit aromas that perfumers and food chemists reach for when nothing else will do. Trials with similar thiols often fail to bring the layered aroma or reactivity.

    We hear from formulators who use our material in tiny concentrations but still insist on single-digit ppm purity specs. Some competitors can supply a broader range of volatiles, but a purity slip or cross-contamination with other mercaptans ruins an application. Through our feedback loops, we learned that flavor chemists rely on rapid support if batch odors shift, so we keep communication lines open and technical teams on call.

    Research chemists chase after the unique nucleophilicity of this compound's sulfur atom combined with the solubility boost from its alcohol group. It comes up in thiol-ene click chemistry and specialty surfactant production. Over the years, we collaborated with several researchers working on controlled-release matrices and specialty protective coatings. Their feedback drove our production improvements, especially on minimizing trace solvents that could inhibit their reactions.

    Position in Comparison With Other Sulfur-Alcohol Compounds

    Claims about interchangeable use of thiol-alcohols usually fall apart in active projects. We’ve received samples from suppliers of other products, sometimes cheaper or more abundant, that on paper, look close to 3-Mercapto-1-Hexanol. Real-world results show subtle and not-so-subtle differences in shelf life, ease of handling, and olfactory properties.

    For example, 2-Mercaptoethanol, used by some as a reducing agent or odorant, behaves quite differently in reactivity and odor profile. The longer hexanol chain in our product softens its volatility and shifts its scent to an area valued in different flavor spaces. The reactivity window is more controlled, making side reactions less likely in delicate formulations. Other mercaptoalcohols with a shorter chain often struggle with higher volatility, stricter storage constraints, and off-odors that creep in and affect products downstream.

    Technicians at our facility emphasize that, for applications needing this particular carbon chain length and substitution pattern, a substitute rarely matches. Surplus 4-mercapto-butanol from another source wound up discarded by users when physical characteristics failed in trials, despite similar assay numbers.

    Why Manufacturing Transparency Matters With This Product

    Many customers need more than spec sheets—they want a view into the real production methods and controls behind a compound that can influence high-value goods. Over the last five years, we invited process engineers and customers onsite for audits and partnered on several continuous improvement initiatives. These days, we offer process data for each delivered batch, giving technical contacts a historical trail for every lot.

    Odor, color, and performance in use are the practical markers of quality for 3-Mercapto-1-Hexanol. Users rely on a direct channel to our site’s chemists, not only local salespeople. On rare occasions when an off-profile batch got flagged, we could link it back to a change in a purification column and resolve it by adjusting the wash process the same day. Such transparency has earned us repeat business, especially with stringent multinational buyers.

    Safety and Hands-On Handling

    Experience has taught us respect for the thiol family’s pungency. Staff always handle 3-Mercapto-1-Hexanol in ventilated areas, with gloves and eye protection. Routine exposure, even at low levels, saturates clothing and equipment. Our team runs regular drills on containment for accidental spills, and these protocols hold value for end users with sensitive manufacturing lines.

    Downstream, we recommend users avoid standard steel fittings; instead, PTFE gaskets and glass or compatible plasticware sidestep corrosion and odor retention issues. Colleagues from the food and cosmetic sectors have recounted incidents with lower-tier packaging that led to contamination and loss of material, which our packaging upgrades resolve.

    Fire risk remains moderate but cannot be neglected. We keep local storage below set temperature thresholds and share guidance with recipients on monitoring headspace vapor for buildup. Fielding user questions on this front, we’ve developed easy visual checks for leaks and equipment compatibility.

    Technical Support: Direct from the Manufacturing Team

    We have found that sending out a COA with just numbers does not always close the technical gap for downstream innovators working with this compound. By keeping application chemists and process engineers at the ready, we walk through troubleshooting, run small-batch simulations, and share data when a customer faces questions or gets irregular results.

    Sometimes, an unusual odor spike or slight color change triggers a collaborative deep dive, not only into the delivered batch but into storage, blending, and application conditions. We hosted joint lab sessions with industrial users to pinpoint instabilities, which led to recipe adaptations that benefited both sides. This hands-on approach proves that expertise built in manufacturing drives real value post-shipment.

    Environmental Impact and Sustainable Processing

    As with many sulfur-based compounds, effluent concerns guide our manufacturing design. We invested in closed-system transfers and vapor recovery units years ago, learning quickly that runoff and vented vapors raise both regulatory flags and real environmental risks. Every kilogram accounted for translates into cleaner record-keeping and less downstream impact.

    We partner with local treatment stations and monitor both air and water discharges. In one routine plant review, shifting a pre-purification step reduced our VOC footprint and improved workplace conditions. For our community and business partners, these details make a difference and encourage us to go beyond minimum requirements.

    Across the industry, those who want to ensure responsible sourcing ask for assurances on handling both waste and energy use. By sharing our own data on solvent recovery, batch yields, and energy consumption, we help drive higher standards across the market.

    Insights from Decades of Production

    Manufacturing 3-Mercapto-1-Hexanol is not just running a standard recipe; it’s an ongoing cycle of monitoring, adaptation, and learning. No two years are quite the same. Shifts in feedstock pricing, improvements in process sensor technology, and field feedback all push us toward new iterations and better control.

    Years ago, one challenge hit with a sudden shortage of a key alcohol precursor, forcing us to pivot to a second synthesis route with tighter timelines. By keeping both our raw material supply chain flexible and our technical teams nimble, we stayed consistent in output and purity—customers barely noticed a difference on their end. This resilience comes not from luck, but from deep familiarity with the full lifecycle of 3-Mercapto-1-Hexanol.

    Feedback from users who switch from large commodity suppliers to our batch-crafted product usually points to fewer rejects, less downtime, and a more direct conversation with the team. Smaller-volume yet consistent workflow on our end lets us adapt rapidly to specification changes or one-off requests, which large commodity plants typically struggle to accommodate.

    Product Evolution: Meeting Future Needs

    The demands for 3-Mercapto-1-Hexanol shift over time. Years ago, it was a specialty for a handful of flavor companies. Now, researchers in advanced materials and green chemistry continually approach us to discuss new reactions and derivatives. Keeping our process development open to collaboration leads to faster innovation and lets us challenge our assumptions about what this compound can do.

    Our lab team is looking into greener synthesis pathways, reduced solvent use, and on-site recycling. As we run pilot trials of alternative routes, sharing interim results with trusted customers pays off in honest feedback and improved buy-in at the commercial stage. This way, improvements are not driven by market pressure alone, but also by shared priorities for safety, quality, and sustainability.

    As regulatory environments close in on legacy processes, we expect the standard for all sulfur alcohols—including ours—to climb. Staying engaged with environmental boards, regulatory bodies, and professional groups helps ensure we adapt before targets become obligations.

    Addressing Product Questions and Demands from the Field

    Most inquiries we field come from two ends of the spectrum: large users seeking steady supply at global scale and innovators with small, high-value projects. Both get a single channel straight into our production team. No question about trace components, application data, or process stability is too small. Decades in specialty manufacturing taught us that today’s pilot batch could be tomorrow’s high-volume standard.

    Feedback that loops directly from end users back to our process chemists often leads to small but crucial tweaks—whether in reaction conditions, distillation gradient, or analytical monitoring. We follow the nuances instead of ignoring outlier data. Reaction vessels, storage drums, and even the fans in our tank farm have changed based on safety and performance insights from application chemists and field users.

    Continuous Learning and Improvement

    Those who produce chemicals know that standing still means falling behind. Over the years, even seasoned staff here have seen mistakes turn into learning moments. For instance, testing a lower-cost shipping drum without full odor-barrier testing led to a series of customer complaints and forced us to rethink and replace much of our shipping inventory. Though costly, the lesson resulted in a new packaging protocol that significantly reduced product loss and kept customers loyal.

    Ongoing investment in staff development shapes our success. Teams receive cross-training so technical issues do not stall at any one point in the process, and we pull in outside subject matter experts as confidential consultants when a challenge hits a wall. Safety, product quality, and customer satisfaction get measured in results, not just goals.

    Final Product Values from the Manufacturing Perspective

    Experience, not just know-how, has shaped our view of 3-Mercapto-1-Hexanol. We pay attention to consistency, transparency, and technical support—not only because customers demand it, but because that’s how we build reputation in the market. By keeping these priorities at the core of our business, we give users—from food chemists to industrial formulators—confidence in each delivery.

    We remain accountable for every batch, recognize concerns with honest answers, and work in the open where it matters—from root cause investigations to day-to-day logistics. Anyone seeking a sulfur-alcohol compound for performance and reliability finds that product and process depth by coming straight to us, the source.