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3-Isopropoxyaniline

    • Product Name 3-Isopropoxyaniline
    • Alias m-Isopropoxyaniline
    • Einecs 211-876-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    988161

    Cas Number 585-25-1
    Molecular Formula C9H13NO
    Molecular Weight 151.21
    Iupac Name 3-(Propan-2-yloxy)aniline
    Synonyms m-Isopropoxyaniline; 1-Amino-3-isopropoxybenzene
    Appearance Colorless to pale yellow liquid
    Boiling Point 258-259 °C
    Density 1.037 g/cm³ at 25°C
    Solubility Slightly soluble in water; soluble in organic solvents
    Flash Point 124 °C
    Refractive Index 1.555
    Smiles CC(C)Oc1cccc(N)c1

    As an accredited 3-Isopropoxyaniline factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 100 grams of 3-Isopropoxyaniline, sealed with a screw cap and labeled with chemical information and safety warnings.
    Shipping 3-Isopropoxyaniline is shipped in tightly sealed containers to prevent leakage and contamination, typically under ambient conditions. It should be handled as a hazardous chemical, following standard chemical transport regulations. Packaging is clearly labeled, with transport documentation compliant with local and international safety guidelines for safe handling and delivery.
    Storage 3-Isopropoxyaniline should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers and acids. Protect the chemical from light and moisture. Ensure that storage areas are equipped with proper spill containment and that the container is clearly labeled. Keep away from sources of ignition and heat.
    Application of 3-Isopropoxyaniline

    Applications of 3-Isopropoxyaniline in Industrial Manufacturing

    Our 3-Isopropoxyaniline, produced in compliance with stringent quality systems, supports several advanced chemical manufacturing sectors relying on precise intermediates for specialty product synthesis. Below, we detail distinct application scenarios, technical compliance, and the integration path from formulation to end product.

    1. Synthesis of Agrochemical Active Ingredients

    Agrochemical manufacturers deploy 3-Isopropoxyaniline as a key intermediate for the production of selective herbicides, where the isopropoxy substituent enables targeted synthesis of specific amide and urea derivatives. Major use occurs during the coupling step for constructing core frameworks of active molecules, which undergo subsequent functionalization to achieve the desired biological selectivity. Careful dosage adjustment and quality checks are implemented throughout to comply with regulatory residue limits and ensure batch reproducibility in large-scale reaction vessels.

    Industry compliance standards

    • FAO/WHO Joint Meeting on Pesticide Specifications (JMPS)
    • EU Regulation No 1107/2009 for plant protection products
    • US EPA technical grade active ingredient guidelines
    • ISO 9001:2015 quality management system

    Typical usage ratio

    • 0.5–2.5 molar equivalents per molecule of agrochemical core intermediate; adjusted for stoichiometry and impurity profile control

    Downstream process integration

    • Introduced early in condensation or acylation reaction with chloroformates or isocyanates
    • Subjected to recrystallization and quality verification before conversion to final active
    • Blended with catalyst and solvents in controlled reactors

    Final product types

    • Pre- and post-emergent herbicides targeting broadleaf weeds
    • Formulations for cereals, rice, and corn applications
    • Granular flowable concentrates and suspension concentrate herbicide products

    2. Pharmaceutical Intermediate for Antihypertensive Drug Synthesis

    Formulators in API manufacturing use 3-Isopropoxyaniline for constructing aromatic amine backbones in multi-step synthesis routes for specific antihypertensive agents. The compound’s controlled purity and defined reactivity facilitate regioselective steps like nucleophilic aromatic substitution and amide formation, which are crucial for maintaining structural fidelity in complex heterocycles. Our manufacturing process aligns with cGMP requirements, and end users routinely verify intermediate purity before downstream processing.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • European Pharmacopoeia (Ph. Eur.) specifications for intermediates
    • US FDA cGMP for drug substances (21 CFR Part 211)
    • Comprehensive impurity profiles per USP <1086>

    Typical usage ratio

    • 0.8–1.2 molar equivalents relative to coupling partners; ratio refined based on process validation batches and target yield optimization

    Downstream process integration

    • Engages in amide bond formation or directed ortho-metalation in active ingredient synthesis
    • Processed in jacketed stainless steel reactors under isolated air conditions
    • Fully characterized before release to finishing and purification lines

    Final product types

    • Bulk pharmaceutical active ingredients for antihypertensive medications
    • Finished tablets and injectable drug forms after further synthesis and purification

    3. Production of Liquid Crystal Monomers for Display Technologies

    Advanced materials suppliers use our 3-Isopropoxyaniline as a precursor in the synthesis of anisotropic liquid crystal monomers. Its electron-donating substituents fine-tune the dielectric and optical anisotropy of terminal groups, crucial for high-contrast, fast-switching matrix displays. The material enters precise Friedel–Crafts alkylation and subsequent polymerization processes, and its trace impurity content must consistently fall below internationally recognized limits to guarantee display uniformity and prevent color drift over display lifetimes.

    Industry compliance standards

    • IEC 61747 (International Standard for Liquid Crystal Displays)
    • RoHS Directive (EU) 2011/65/EU on restricted substances
    • REACH SVHC compliance for specialty monomers
    • JIS C6105 for purity in electronic material intermediates

    Typical usage ratio

    • 1.0–1.3 molar equivalents as a terminal monomer unit; adjusted for the degree of polymerization in the formulation recipe

    Downstream process integration

    • Enters aromatic substitution or etherification during liquid crystal monomer assembly
    • Monomer purification by high-vacuum distillation and column chromatography
    • Feeds into final LC mixture blends ahead of thin-film cell application

    Final product types

    • Twisted nematic and super-twisted nematic liquid crystal mixtures
    • Columnar and discotic phase materials for advanced displays
    • IPS and FFS cellphone and television LCD panel substrates

    4. Dye and Pigment Intermediate for Specialty Colorants

    Dye and pigment factories utilize 3-Isopropoxyaniline as a coupling component for synthesizing high-performance azo, anthraquinone, and other specialty colorants used in industrial coatings, textiles, and plastics. Purity and isomeric consistency are critical for batch-to-batch color reliability and resistance properties, especially when formulating pigments for automotive and industrial applications. Our production enables direct integration into diazotization or condensation steps, supporting stringent color fastness and migration requirements of end-use regulations.

    Industry compliance standards

    • OEKO-TEX STANDARD 100 for restricted substances in textiles
    • EN 71-3 for safety of toys’ colorants
    • GMP for food-contact pigments (EC No 1935/2004)
    • Standard methods for colorant quality ISO 787/1

    Typical usage ratio

    • 5–15% mass ratio in dye synthesis batches; proportion varies with target color depth and reaction pathway

    Downstream process integration

    • Acts as amine-linked coupling agent in azo dye diazotization steps
    • Processed in batch reactors with carefully controlled pH and temperature
    • Subjected to milling, dispersing, and spray-drying for final powdered or dispersible pigments

    Final product types

    • Early-stage dye intermediates for direct and disperse dyes
    • Resin-bound pigments for automotive or industrial coatings
    • Color batches for plastics compounding and fibers

    5. Polymer Modifier in High-Performance Resin Development

    Polymer compounders and formulators add 3-Isopropoxyaniline as a reactive chain stopper or branch agent in specialty polyamide, epoxy, and polyurethane resin systems. Its role as an aromatic amine with controlled steric effects enables tuning of glass transition temperature, hardness, and flexibility. The compound is charged at a defined stage in the reactive extrusion or in situ polymerization process, where it alters chain architecture and molecular weight distribution. Manufacturers conduct comprehensive material balances and in-process QC to ensure consistent incorporation and meet downstream regulatory demands for advanced engineering polymers.

    Industry compliance standards

    • ISO 9001 and IATF 16949 for automotive polymer quality
    • UL Yellow Card listing for electrical insulation polymers
    • REACH and RoHS compliant material supply for consumer durables and electronics
    • FDA CFR 21 177.1580 for indirect food-contact applications (where applicable)

    Typical usage ratio

    • 0.2–2% by weight depending on polymer type and target modification index; exact level tested in pilot lines before production scale-up

    Downstream process integration

    • Dosed during prepolymer charging or melt-phase step-growth reaction
    • Tracked by NMR and GPC techniques for structural proof throughout synthesis
    • Batch-specific formulation sheets for traceability and QA sign-off

    Final product types

    • High-heat polyamide injection molding compounds
    • Polyurethane elastomers for automotive bushings and housings
    • Electrical-grade epoxy encapsulants and resins
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    Certification & Compliance
    More Introduction

    3-Isopropoxyaniline: Reliable Performance from a Dedicated Chemical Manufacturer

    Understanding 3-Isopropoxyaniline from the Production Floor

    Walk through any chemical plant that specializes in aromatic compounds, and you start to appreciate the nuances behind everyday molecules like 3-Isopropoxyaniline. We have spent years fine-tuning our production process to deliver this compound consistently to customers—often those who won’t settle for inconsistencies or waste time with vague origin stories. As a manufacturer deeply embedded in quality control and real-time process monitoring, we know what it takes not just to meet, but to exceed the benchmarks that matter most to downstream formulators, research teams, and bulk chemical consumers. This isn’t a bulk commodity. 3-Isopropoxyaniline demands precision at every stage, beginning with raw material sourcing and running through the delicate balance of heat, pressure, pH, and separation. Any skip here means headaches later for those using this molecule.

    Model and Specifications—Built for Demanding Chemistries

    Our process yields 3-Isopropoxyaniline with high purity—typically exceeding 99%—and controlled moisture content to prevent downstream reactivity issues. We recognize that solvent traces or residual metal catalysts can spark performance issues in pharma, specialty dye, or electronic applications. That’s why every batch is analyzed by gas chromatography and NMR, not only to confirm identity but to provide real transparency. Samples from each synthesis pass through a series of in-plant checks for melting point, color, and solubility. Any deviation signals required recalibration. This is not a check-the-box exercise; it is the backbone of our operation.

    We deliver this compound as a clear to pale yellow liquid or solid, depending on storage and ambient temperature. Packed in high-integrity drums or as bespoke smaller lots, our product stays free from contamination—ensured by rigorous cleaning protocols and nitrogen purging where needed. Large-scale buyers—whether Asian pharmaceutical companies or European catalyst developers—report consistently low batch-to-batch variability because our staff take personal ownership of product consistency.

    Usage Across Sectors—Real-World Role of 3-Isopropoxyaniline

    Customers rely on 3-Isopropoxyaniline to build advanced intermediates for colorants, pharmaceuticals, and agrochemicals. We see experienced formulation chemists in Europe use it as a precursor for azo dyes that demand high tinctorial strength and stability. In Indian research labs, teams pursue new crystalline forms of antihypertensive APIs, and our compound offers a flexible aniline core with a predictable reactivity profile. Many teams value 3-Isopropoxyaniline because its isopropoxy substitution on the aromatic ring tunes electron density, enabling unique coupling and condensation pathways that aren’t available from standard aniline or N-alkylaniline analogues. We field questions almost weekly from R&D managers exploring whether this specificity can simplify their synthetic routes, and it does—cutting both cost and reaction steps in the right context.

    Electronics manufacturers also turn to our plant for this compound. Here, subtle changes in molecular structure give way to major improvements in charge carrier mobility and thermal endurance for functional polymers and resins. Our technical support staff engage directly with formulation teams to solve bottlenecks and hit tight purity specs. Pharmaceutical users—some of whom must answer to global health authorities—know our documentation trail stands up to audit, with full traceability.

    Why the Real Difference Comes from the Manufacturer’s Bench

    Not all aniline derivatives are created equal. Many commercial players secure inferior lots from brokers or contract manufacturers, only to struggle with inconsistent yields and purification headaches. We take control upstream. By integrating backward into our aniline feedstock chain, we optimize the quality of every precursor. The process, which avoids ambient oxygen contamination and keeps exothermic side reactions in check, leads to a cleaner product from the start. Colleagues at customer sites have told us how much time and money they’ve saved by shifting to a source that actually understands what’s behind a certificate of analysis, rather than just issuing a slip of paper.

    Some suppliers take shortcuts with catalyst recovery, or ignore insidious metal residues that hamper scale-up reactions. We never go down that path. We design our process to minimize unwanted side products—like over-alkylated anilines or ring-substituted impurities—through careful monitoring and integrated purification. This allows users to skip repeated recrystallization steps downstream, and, in many cases, run reactions at larger scale without excessive loss. Our facilities run on validated protocols, and we maintain environmental compliance at every turn, not only out of regulatory compulsion, but as a reflection of pride in craft.

    Real-World Challenges, Straight from Production

    Let’s be frank. No production story comes without hiccups. We’ve encountered everything from feedstock supply swings caused by geopolitical tensions, to process fouling where oxygen intrusion alters reactant profiles. Occasionally, shifts in energy pricing force us to revisit our cost structures and process sequencing to keep downstream pricing stable. Because we run our own reactors—not outsource them—our technical and operations personnel catch problems early, calibrate equipment quickly, and learn directly from root-cause investigations. Once, we staved off a potentially costly shutdown by tracking a subtle rise in batch color that indicated trace iron contamination. By identifying the point-of-entry, we swapped out a corroded transfer line and returned to full specification within days, posting detailed learnings onto our plant-wide knowledge base, so that slip wouldn’t repeat.

    Workflow digitalization now empowers us to log process data in real-time. Our control software tracks temperature, flow rates, and pH, with dashboard alerts to catch deviations instantly. Investing in this infrastructure requires commitment, but the payoff in product consistency and reduced waste is real. The lessons we learn at the sharp end of production—where a few tenths of a percent off-spec can mean thousands in customer recalls—drive us to improve season after season.

    We’ve Refined Our Approach—Here’s What Matters for Users

    Those new to 3-Isopropoxyaniline occasionally ask us why it outperforms cheaper substitutes or why they shouldn’t just rely on generics from trading companies. The answer is seen in the details. Even a slight change in trace impurity levels affects reactivity and product color. A run of batches from an unverified source often produces dark, off-spec material that stalls on chromatography purification, costing more in the long run than any initial savings from the purchase. In the dye industry, where final hue and colorfastness matter, variability is not welcome. In electronics, a minor deviation affects resistivity or curing. We carry the feedback from these sectors back into our plant, and update training or process settings based directly on customer complaints or praise.

    What also sets us apart is our open approach to technical support. If a customer needs custom cuts or advice on downstream handling, our team steps in. Some request differentiated isopropoxy orientation, shipment at adjusted pH, or help with post-delivery quality tests. Because we understand both the product and its applications, our support staff aren’t reading from scripts—they’ve handled the product dozens of times themselves.

    Comparing with Peer Products—Subtle Shifts That Matter

    Chemically, 3-Isopropoxyaniline stands out from its isomers and from typical parent anilines. The isopropoxy group on the meta-position delivers both steric bulk and electron-donating capability, altering its reactivity. Unlike ortho or para isomers, meta-substitution tunes how the core ring interacts with acylation or diazonium functionalization steps. Many researchers reach new catalytic or pharmacological targets by backbone tweaking, and meta isopropoxyaniline often opens up synthetic shortcuts, especially where regioselectivity is crucial. Our technical sales team spent several months with partners in Germany and Japan benchmarking direct performance against ortho-substituted alternatives, and reported higher yields and improved side-chain integrity for some regulated API syntheses.

    With regular aniline or less defined substituted analogues, users face regulatory headaches and higher purification burdens due to impurity carryover. We control for these risks by specifying advanced purification techniques and confirming spectral fingerprints prior to shipment. This level of scrutiny might feel excessive for low-value commodities, but here it separates reliable manufacturing from basic trading. In one customer’s words, “One drum with consistent specs simplifies processes more than five drums of untested alternatives.” That kind of endorsement only comes after years of iterative improvement, not afterthoughts or shortcuts.

    Opening the Doors to Customization

    Sometimes a textbook approach doesn’t cut it. Several advanced research groups have asked for tightly controlled physical forms, or inclusion of stabilizing agents to suit unique process pathways. We don’t shy away from those requests. Our R&D and process teams revisit equipment settings, recalibrate drying, or run pH controls—fine-tuning lots to customer-driven specifications. This is where vertical integration and knowledge of both upstream and downstream impacts matter. Want a batch with residual solvent below 50 ppm for a sensitive coupling reaction? We have piloted that variant more than once, learning in short cycles and updating QC protocols each run. This approach isn’t for the faint-hearted, but the benefits for tailored outcomes pay off for customers invested in premium, fit-for-purpose compounds.

    End-Use Trends and Customer Narratives

    Over the years, we have watched market focuses shift, but usage of 3-Isopropoxyaniline remains resilient. Agrochemical innovators, now refining their next wave of crop protectants, rely on us for uninterrupted supply that meets both regional and global documentation needs. Pharmaceutical formulators, working under the eye of regulatory bodies, continually expect flawless material and fast turnaround on compliance paperwork. We work with auditing teams to deliver historical records, batch analyses, and comprehensive regulatory tracebacks. Few things unsettle a regulatory compliance meeting more than missing links between paperwork and real-world batches; our digital records system closes that gap.

    The colorant industry also leans on us. We have seen product launches delayed because of simple supply inconsistencies. One leading developer nearly abandoned a new chromophore project before uncovering that trace meta-substitution byproducts in cheaper alternatives caused systematic product browning. Their switch to our material—produced with controlled feedstock and monitoring—rescued not only the batch but the commercial timeline.

    We also prioritize responsible production. Ongoing debates about waste minimization and green chemistry reach all the way to our reactors. Achieving environmental benchmarks isn’t merely about paperwork; it’s a technical challenge. Our teams invest in waste reduction and solvent recovery, and our batch records track emissions, not just outputs. Participating in industry consortia ensures we benefit from community advances, stay on target for emissions protocols, and contribute to cleaner, safer chemical synthesis.

    Technical Dialogue Rather Than Sales Pitches

    One recurring observation among our buyers is the value of direct dialogue with the actual maker. Users frustrated with opaque supply chains appreciate straightforward access to technical managers, plant chemists, and QA staff who know batch histories inside and out. Sometimes the issue is as subtle as transport temperature or minor equipment shifts that affect downstream application. By closing the gap between floor-level insight and customer queries, we not only address complaints but turn them into catalysts for change.

    We discourage treating chemicals as simple line items on a spreadsheet. Deep familiarity with origin, storage conditions, and real-world behavior turns an ordinary purchasing decision into an investment that supports high-yield processes and product launches.

    Keys to a Consistently Trustworthy Supply Chain

    Our field teams and logistics partners work with a laser focus on securing supply continuity. Weather, port delays, transportation strikes, and regulatory policy changes all threaten predictable distribution, but we plan inventories and redundancy to avoid shortfalls. As a manufacturer, we commit stocks long before spot market whims dictate prices. This strategy brings peace of mind to major customers. For smaller users, our ability to break bulk and guarantee the same QC regimen across lots means labs receive uncompromised product, whether they’re running pilot trials or full production.

    We chase quality through on-site capacity expansions, investments in clean-in-place systems, and rigorous staff training programs. Our operators manage process bottlenecks and shutdown risks using real-world production analytics, constantly searching for improvements. Sometimes an apparently minor tweak in reactor loading cycle or solvent extraction improves overnight yields and consistency for months to come. We share these learning moments across the team, integrating lessons into standard operating procedures.

    Industry Context—Global and Local Trends

    Today’s chemical industry moves with global volatility: shifting geopolitical boundaries, rapid changes in regulatory expectations, and intensifying competition for high-value intermediates. Manufacturers able to offer resilient, transparent, and documented supply chains set themselves apart. 3-Isopropoxyaniline, once seen as a specialist’s tool, has taken on a new importance in cost-sensitive synthesis and next-generation research. We continue to monitor market trends, maintaining flexibility in batch size and purity. We deliver what works—not only for today, but for where our clients want to take their technology next.

    We never underestimate the pressures our customers face—from technical specs and sustainability targets, to cost controls and ever-shorter lead times. Our role is not just to supply molecules, but to support progress in the sector. Each time a formulator calls with a new challenge, we treat it as a genuine opportunity to push the chemistry further.

    Future Directions—Shaping Sustainable Manufacturing

    The road ahead centers on more than scale and cost. Stakeholders—from regulatory authorities to end-user R&D teams—push for traceability, minimized waste, and smarter energy use. We join industry consortia, implement new waste management strategies, and pilot greener alternatives to legacy solvents. As more chemists demand lifecycle data and transparency from upstream suppliers, our commitment deepens. We redesign process flows, experiment with enzyme catalysts alongside traditional tools, and publish any learning that nurtures a greener approach.

    By delivering 3-Isopropoxyaniline from a place of deep expertise, rigorous process control, and real-world technical support, we aim to build partnerships founded on trust and proven reliability. That’s the feedback we hear most often from our customers: real performance, delivered with accountability, again and again.