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3-Hydroxyphenylurea

    • Product Name 3-Hydroxyphenylurea
    • Alias m-Hydroxyphenylurea
    • Einecs 229-374-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    456840

    Iupac Name 1-(3-hydroxyphenyl)urea
    Molecular Formula C7H8N2O2
    Molecular Weight 152.15 g/mol
    Cas Number 6268-41-7
    Appearance White to off-white crystalline powder
    Melting Point 196-198°C
    Solubility In Water Slightly soluble
    Boiling Point Decomposes before boiling
    Smiles C1=CC(=CC(=C1)O)NC(=O)N

    As an accredited 3-Hydroxyphenylurea factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 250-gram amber glass bottle with a secure screw cap, labeled “3-Hydroxyphenylurea,” including hazard symbols and batch information.
    Shipping 3-Hydroxyphenylurea is shipped in tightly sealed, chemically resistant containers to prevent moisture ingress and contamination. It should be transported under ambient conditions, away from incompatible substances. Appropriate hazard labeling and documentation are included to comply with regulatory requirements, ensuring safe handling during transit.
    Storage 3-Hydroxyphenylurea should be stored in a tightly closed container in a cool, dry, and well-ventilated area. Protect it from moisture, direct sunlight, and incompatible substances such as strong oxidizing agents. Store at room temperature and ensure the storage area is clearly labeled. Follow all relevant safety protocols for handling and storage to prevent contamination or accidental exposure.
    Application of 3-Hydroxyphenylurea

    Applications of 3-Hydroxyphenylurea in Industrial Manufacturing

    As a specialized factory with dedicated research and quality control capabilities, we focus on supplying 3-Hydroxyphenylurea for its established roles across several high-precision chemical sectors. Below, we present the material’s real-world adoption and integration in certified downstream industries, outlining compliance expectations, formulation guidelines, entry points during production, and typical finished products.

    1. Agrochemical Intermediate Synthesis (Herbicide Manufacturing)

    Major agrochemical producers utilize 3-Hydroxyphenylurea in formulating selective herbicides for cereal and broadleaf crops. It acts as a structural intermediate during the creation of urea and phenylurea herbicidal compounds, where precise conversion of input materials is essential for meeting both regulatory residue limits and custom efficacy profiles. The formulation process often involves targeted reactions under controlled temperatures and pH levels to ensure purity and safety for agricultural end use.

    Industry compliance standards

    • FAO/WHO Specifications for Agricultural Pesticides
    • EU Regulation (EC) No 1107/2009 (Plant Protection Products)
    • US EPA 40 CFR Part 180 (Pesticide Residues Tolerances)
    • ISO 9001:2015 (Quality Management for Agrochemicals)

    Typical usage ratio

    • 2.5%–8% by weight in intermediate synthesis batches, adjusted according to target molecule design and desired herbicide concentration.

    Downstream process integration

    • Added after primary amine protection and during aromatic urea condensation stage in multi-step synthesis before purification and crystallization.

    Final product types

    • Phenylurea-based herbicide active ingredients (such as linuron, diuron intermediates)
    • Granular and suspension concentrate herbicide formulations

    2. Pharmaceutical API Intermediate (Antihypertensive Agents)

    In the pharmaceutical sector, 3-Hydroxyphenylurea serves as a precursor for some aromatic urea-linked APIs, specifically in antihypertensive drug development. Regulatory-driven API production requires analytical traceability for every batch, with 3-Hydroxyphenylurea entering amidation and coupling steps to produce active structures conforming to global pharmacopeial standards.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • United States Pharmacopeia (USP)
    • European Pharmacopoeia (Ph. Eur.)
    • Good Manufacturing Practice (GMP) certification

    Typical usage ratio

    • 0.4–2 molar equivalents relative to starting aromatic core, determined by process yield targets and impurity profiles in multi-step syntheses.

    Downstream process integration

    • Introduced at the urea derivatization or acylation stage in complex multi-step API synthesis, coordinated with solvent selection and reflux timing to maximize conversion.

    Final product types

    • Antihypertensive API intermediates containing a hydroxyphenylurea substructure
    • Final crystallized APIs for tablet and injectable formulations

    3. Specialty Dye and Pigment Synthesis

    Dye manufacturers employ 3-Hydroxyphenylurea as a functionalized precursor enabling synthesis of reactive dyes for fiber applications, particularly in the production of azo and anthraquinone systems. Its hydroxyl group provides targeted reactivity for color fastness improvements and covalent dye-fiber linkage, maximizing performance in textile processing and coloration stability under industrial washing protocols.

    Industry compliance standards

    • OEKO-TEX® Standard 100 (Textiles Safety)
    • REACH Regulation (EC) No 1907/2006 (Chemical Registration)
    • ISO 14001:2015 (Environmental Management for Chemical Production)
    • ZDH CEN/TS 10290 Dye Standard

    Typical usage ratio

    • 1.2%–7% by dry weight of total dye batch, depending on target chromophore synthesis and fiber affinity specification.

    Downstream process integration

    • Charged into the coupling phase, following diazotization and preceding sulfonation or halogenation, with batch blending in glass-lined reactors.

    Final product types

    • Reactive textile dyes for cotton and blended fibers
    • Water-soluble pigment concentrates for industrial printing

    4. Polymer Additive Formulation (Antioxidant Systems)

    Producers of engineering plastics and specialty resins select 3-Hydroxyphenylurea as a non-metallic chain-stabilizing additive, where its functional group structure aids in minimizing thermal and oxidative degradation during polymer extrusion and molding. Applied primarily in formulations where polymer clarity and extractables levels require careful monitoring, especially for electronic and medical-grade plastics.

    Industry compliance standards

    • FDA 21 CFR Parts 177 and 178 (Polymer Additive Safety for Food Contact Substances)
    • UL 94 (Plastics Flammability Standard)
    • IEC 60695-2-10 (Fire Hazard Testing for Plastics)
    • ISO 9001:2015 (Quality Management for Plastics)

    Typical usage ratio

    • 0.05%–0.8% by polymer weight, optimized via aging studies and extrusion temperature profiles to balance stability and processability.

    Downstream process integration

    • Pre-blended into polymer masterbatches prior to extrusion or compounding; disperses during melt mixing under inert gas or vacuum conditions.

    Final product types

    • High-performance polymer films for electronics
    • Injection-molded parts used in medical device housings and automotive interiors

    5. Performance Coating Modifier (Corrosion Inhibition)

    Industrial coatings manufacturers integrate 3-Hydroxyphenylurea as an active corrosion inhibitor used in protective layers for ferrous metal substrates. Its molecular configuration fosters adhesion and creates passivating films during waterborne and solvent-borne resin curing, which is essential for meeting salt spray and accelerated weathering standards in automotive and infrastructure finishing systems.

    Industry compliance standards

    • ASTM B117 (Salt Spray Corrosion Test for Coatings)
    • ISO 12944-6 (Protective Paint Systems for Steel Structures)
    • VOC content requirements per EU Directive 2004/42/EC
    • RoHS Directive 2011/65/EU (Hazardous Substances in Electronics Coatings)

    Typical usage ratio

    • 0.3%–2.2% by resin solids, balanced according to desired corrosion resistance interval and compatibility with other pigment/binder systems.

    Downstream process integration

    • Added during pigment dispersion or grind phase, ahead of resin dilution and crosslinker addition, ensuring uniform molecular interaction with substrate surface.

    Final product types

    • Waterborne and solventborne anti-corrosion primers
    • Protective coatings for automotive chassis and industrial equipment
    Free Quote

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    Certification & Compliance
    More Introduction

    3-Hydroxyphenylurea: Consistency and Value Shaped by Real Manufacturing

    Reliable Chemistry Rooted in Experience

    In our factory, every batch of 3-Hydroxyphenylurea draws on years of hands-on production and deep chemistry know-how. We produce this compound daily, and we understand the little things that make or break a good product—color, purity, and particle control all matter. The formula, C7H8N2O2, may seem simple, but behind that structure lies process discipline and a constant focus on quality. We know this molecule becomes more than just raw material; customers rely on predictable, repeatable results.

    Details That Set Production Apart

    Each run begins with tightly controlled synthesis conditions. Our team monitors every step from temperature and pH to reagent addition rate. We test every lot by HPLC and melting point analysis, routinely achieving purity above 99.5%—not some average, but a factory standard we protect batch after batch. Impurities impact performance, so we track not just the main byproducts but even minor isomers that show up in trace amounts. During filtration and drying, we follow strict time and temperature protocols. Our experience has taught us how small changes can lead to differences in solubility, off-colors, or residual moisture, so we treat each batch with an attention to detail that comes from actually running the reactors and checks ourselves.

    Standard and Custom Packing

    Product handling does not stop at synthesis. We ship the compound in polyethylene-lined fiber drums and sealed bags because we’ve seen how exposure to humidity changes its flow properties and can even encourage clumping. A good drum seal ensures our product behaves the same in your process as it did the day it left our plant. Over the years, we have worked directly with customers to provide alternate pack sizes, sometimes smaller lots for research or bulk containers for continuous reactors. This flexibility comes from having our own line, not from passing along someone else’s stock.

    Different Uses Call for Real Solutions

    This chemical sees heavy use as an intermediate for phenylurea herbicides. From our first days manufacturing, we noticed how variations in particle size can affect dissolving rates and system charging, especially in continuous feed systems. Some clients request a coarse grade for direct reactor charging, while others want finer powder for rapid dissolution in solvents. We tweak our milling steps because even the best chemistry can get lost if the product’s physical form does not match the customer’s end-use. That feedback goes straight to our production team, leading to improved results and fewer surprises during scale-up at the end user’s facility.

    3-Hydroxyphenylurea’s value goes far beyond agriculture. Cosmetic formulators sometimes ask about trace levels of heavy metals, so we test every output for iron, lead, nickel, and even residual solvents using our in-house GC. A regulatory team in pharmaceuticals may request detailed impurity profiles—aromatic amines, for example, need to fall below detection levels. We catch changes early, update our procedures, and test every release for these markers, not just the usual assay and moisture. The result is peace of mind for the purchaser, not a gamble on someone else’s specs.

    The Real Differences: Direct Control and Clarity

    Compared to generic, third-party offerings, our product stands apart because we manage every step from raw material sourcing through to the shipment dock. Many products on the market pass through multiple handlers, each adding time, cost, and often uncertainty. This chain of custody also increases the chance for contamination, mislabeling, or a mismatch in particle characteristics. We receive customer calls tracing a strange batch back through three resellers, often with no clear answers. Supplying directly from our own plant erases this chain and lets us give straight responses—customer to maker.

    Alternatives in the marketplace sometimes seem attractive due to price or availability claims. We have evaluated competitive samples in our own lab and have found unlabeled byproducts, inconsistent color, or moisture content showing exposure to uncontrolled environments. These differences are not theoretical; they affect performance in downstream reactions and can slow production. There are times when process troubleshooting uncovered that only a true, single-source manufacturer could speak knowledgeably about the molecular level issues that drive end-use performance. The reliability we deliver flows from years spent on plant floors, not just behind spreadsheets.

    Serving Specific Needs Through Real Dialogue

    Several of our regular buyers use 3-Hydroxyphenylurea in fine chemical synthesis, often as a building block for new phenyl derivatives or for research in polymer design. For these clients, the tiniest color shift signals a change in process parameters; off-white can mean unknown contaminants, which can poison catalysts or give false results in analysis. Our lab team works closely with them, running test syntheses, and sharing findings openly. Sometimes, scale-up creates its own hurdles. The bulk reaction might draw too much water from our powder, or a trace impurity binds up a key reactant. Our history in the chemical sector means we can suggest direct fixes—adjusted sample drying, tighter in-process controls, or a tweak to the post-reaction workup.

    Open feedback cycles benefit everyone. Recently, we partnered with an agrochemical developer trialing new urea-based actives. They needed a compound that dissolved predictably, with no settling or residue in pilot plant blending. Our team spent weeks adjusting granulation conditions until we reached a batch with zero residue. These are not off-the-shelf skills but hard-won abilities learned from direct dialogue with real production chemists—not brokers reading a flow chart.

    Safety, Authenticity, and Traceability

    Chemical safety goes far beyond following rules on a label. We have watched accidents unfold at other plants where off-spec material created unexpected hazards—dusting, vapor pressure spikes, or runaway reactions. Our commitment to making and documenting every lot prevents these problems upstream. Every bag includes batch history, process dates, and QC signatures. We can trace back every kilo to its reactor run, operator, and the raw inputs used that day. This protects our buyers and allows for rapid, informed response to questions about unexpected outcomes.

    The global market faces more counterfeits and cut-corners every year. We've uncovered supposedly “identical” urea derivatives that failed even simple identity checks—melting points off by 8°C, IR spectrums showing extra absorption peaks. For safety and compliance, these deficiencies are not just quality issues but open doors to legal and environmental complications. Our process controls—clean-in-place cycles, solvent recovery tracking, operator training—reduce the risk of cross-contamination and provide a paper trail for every product leaving our facility.

    Supporting Regulatory and Custom Documentation

    Evolving regulation in different industries means technical data and documentation are not optional extras but central to every sale. Our technical and compliance staff prepare detailed dossiers on request—Kosher and Halal certifications for formulators, REACH or TSCA status for multinationals, COAs with impurity breakdowns by analytical method. These aren’t boilerplate forms. They reflect true factory conditions, batch records, and the analytical reports we generate for every shipment. Buyers get not just a substance but assurance—direct from our files, never made up or guessed based on a standard sheet.

    Pharmaceutical developers sometimes request residual solvent profiles or expanded heavy metals screenings, even if these go beyond typical agricultural needs. We readily run these using in-house LC-MS and IC, because we have built a lab culture anchored in detailed reality, not minimum requirements. Support does not end at the sale; product registration help, advice on customs declarations, and after-delivery batch verification remain central parts of our daily business.

    Shaping the Product with End Use in Mind

    Manufacturers that take shortcuts on drying, comminution, or packaging end up delivering inconsistent products that set users up for headaches. Years of hands-on experience have shown us how batch variance, caking, or unknown impurities can disrupt production and drive up hidden costs. Our technical staff know the effect that differences in surface area and particle size can have on dissolution rates in batch or continuous processes. So we take time to screen every run and, when needed, discuss custom particle sizes with buyers ahead of shipment.

    We understand that some industries need smaller, precisely packaged lots while others benefit from scale economies. By making every lot ourselves, we can label and prepare it according to strict inventory rotation practices, reducing the risks of aged stock or oxidative degradation. Offering steady, prompt logistics only comes when you control your own production calendar and know exactly how much you have available and when.

    The Value of Manufacturer’s Commitment

    Direct manufacturing allows us to respond to unexpected trends or regulatory changes with real options—such as tailoring documentation, modifying synthesis to exclude certain reactants, or providing accelerated aging data on request. Trends in environmental standards push everyone to do better. We have worked to lower solvent VOC emissions and track every input to ensure sustainable handling. These changes arise from ongoing investment in our own equipment and teams—not shortcuts taken by resellers looking to shave cents per kilo.

    Feedback from customers shapes both our products and our approach to service. Our best improvements have come not from chasing the cheapest input but from fixing real pain points as they arise in day-to-day production. We see ourselves as partners to every lab, factory, and developer using our 3-Hydroxyphenylurea; if a detail could affect your result, it matters to us long before it becomes an issue at the end of your process line.

    Looking Ahead: Sustaining Trust, Enabling Innovation

    Modern manufacturing is more than meeting a checklist of standards. Buyers ask tougher questions about sustainability, ethical sourcing, and long-term stability of supply. Our transparency—rooted in direct, documented production—gives buyers confidence. Whether the need is for better technical support, repeatable physical characteristics, or an end to supply chain guesswork, we provide clear answers and dependable deliveries because we live the chemistry ourselves.

    Trust forms the backbone of good business in specialty chemicals. As markets face cheap substitutes and shifting requirements, this trust cannot be bought on paper or delegated to anonymous intermediaries. Our commitment to making, testing, tracing, and improving every lot of 3-Hydroxyphenylurea allows customers to focus on their own growth. From everyday batch records to long-term partnerships, our roots as dedicated manufacturers set the tone—not just for our own business, but for every user who relies on true, reliable chemical products.

    Practical Knowledge, Consistent Delivery

    Customers looking for 3-Hydroxyphenylurea deserve more than a spec sheet or a promise. The difference comes through in every drum, every analysis, and every conversation we have with professionals who know what is at stake in their work. Our hands-on knowledge, from synthesis through shipment, shows up where it counts—in your process reliability, your final product quality, and the peace of mind that comes with trusted, direct supply.