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3-Hydroxybenzhydrazide

    • Product Name 3-Hydroxybenzhydrazide
    • Alias m-Hydroxybenzhydrazide
    • Einecs 238-876-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    183667

    Chemical Name 3-Hydroxybenzhydrazide
    Molecular Formula C7H8N2O2
    Molecular Weight 152.15 g/mol
    Cas Number 16618-39-4
    Appearance White to off-white solid
    Melting Point 197-200°C
    Solubility Soluble in water and ethanol
    Storage Conditions Store in a cool, dry place, tightly closed
    Synonyms m-Hydroxybenzhydrazide
    Pubchem Cid 199346
    Smiles C1=CC(=CC(=C1O)C(=O)NN)O
    Inchikey YUZDRLXZMZXWDQ-UHFFFAOYSA-N

    As an accredited 3-Hydroxybenzhydrazide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 3-Hydroxybenzhydrazide, 25g: Supplied in a sealed amber glass bottle, labeled with hazard symbols, chemical details, purity, and storage instructions.
    Shipping 3-Hydroxybenzhydrazide should be shipped in tightly sealed containers, protected from moisture, heat, and direct sunlight. Transport in compliance with local and international regulations for hazardous chemicals. Ensure appropriate labeling, packaging, and documentation. Use secondary containment to prevent spills, and utilize temperature control if recommended by the product’s safety data sheet (SDS).
    Storage 3-Hydroxybenzhydrazide should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers. Protect from light and moisture. Ensure storage area is free from ignition sources and labeled appropriately. Follow all relevant safety protocols, including using secondary containment to prevent spills or leaks.
    Application of 3-Hydroxybenzhydrazide

    Applications of 3-Hydroxybenzhydrazide in Industrial Manufacturing

    As a manufacturer of 3-Hydroxybenzhydrazide, we supply this key intermediate to diverse chemical sectors. Below, we detail real downstream application scenarios where our material supports specialized formulations, precise process integration, and compliance with stringent industry standards.

    1. Pharmaceutical Active Ingredient Synthesis

    Pharmaceutical companies employ 3-Hydroxybenzhydrazide as an intermediate in synthesizing hydrazide-based APIs, particularly in anti-tubercular and antibacterial therapies. The compound’s reactivity allows controlled formation of hydrazone and heterocyclic scaffolds integral to drug development pipelines. Quality assurance requires rigorous impurity profiling and validated batch records throughout multi-step syntheses. Manufacturers fine-tune the reaction stage and ratio based on the API’s target molecular structure, ensuring consistency for regulatory filing and commercial-scale production.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients
    • United States Pharmacopeia (USP) General Chapter <797>
    • European Pharmacopoeia (Ph. Eur.) specifications
    • FDA 21 CFR Part 210/211 for API manufacturing

    Typical usage ratio

    • 20–35% molar ratio as coupling partner in hydrazone formation
    • Precise adjustment according to stoichiometric demands and process validation results

    Downstream process integration

    • Introduced in stage two or three of multi-step synthesis, following protected carboxylic acid activation
    • In situ reaction with aldehyde or ketone intermediates under controlled solvent and temperature conditions
    • Assessed by HPLC and NMR during in-process control to monitor transformation completeness

    Final product types

    • Hydrazone-based antimicrobials
    • Tuberculostatic pharmaceutical actives
    • Intermediates for heterocyclic API cores
    • Drug substance candidates for pre-clinical testing

    2. Agricultural Fungicide and Pesticide Synthesis

    Agrochemical producers incorporate 3-Hydroxybenzhydrazide to synthesize systemic fungicides and insecticides, exploiting its hydrazide motif to generate potent active compounds through condensation reactions and subsequent cyclization. Production lines demand consistent supply for seasonal campaigns, with comprehensive batch documentation and traceability throughout. The pesticide registration process mandates extensive impurity and residue profiling, with production lots closely tracked.

    Industry compliance standards

    • FAO/WHO Codex Alimentarius for pesticide active standards
    • European REACH Regulation (EC) No 1907/2006 for substance registration
    • EPA 40 CFR Part 158: Data requirements for pesticide registration (USA)
    • ISO 9001:2015 certified production system

    Typical usage ratio

    • 15–22% by weight relative to total reactant mass in heterocycle formation
    • Adjustable based on product line formulation, target hydrazide conversion, and environmental fate requirements

    Downstream process integration

    • Added during key condensation or cyclization step in active ingredient formation (e.g., triazole or pyrazole derivatives)
    • Monitored for endpoint conversion using GC-MS or LC-MS
    • Filtration and solvent swap for downstream formulation compatibility

    Final product types

    • Systemic grain fungicides
    • Seed treatment actives
    • Novel insecticide scaffolds
    • Pre-formulated agrochemical technical concentrates

    3. Polymer Crosslinking Agents for Resins and Coatings

    Formulators in the coatings and polymer industries utilize 3-Hydroxybenzhydrazide as a specialized crosslinking agent to improve chemical resistance and film durability. The unique hydrazide chemistry reacts with isocyanate or aldehyde moieties, enhancing network density in polyurethane or alkyd resin systems. Strict attention to VOC regulations and final thermal properties guide manufacturers in optimizing the choice and proportion of the additive during scale-up and mass production.

    Industry compliance standards

    • ISO 9001 Quality Management for coatings manufacturing
    • EU REACH compliance for substance safety
    • RoHS Directive (EU) 2011/65/EU for electronic coating applications
    • ASTM D16 and D4541 standards for coatings

    Typical usage ratio

    • 0.5–3.0% by resin solid weight depending on target crosslinking density
    • Fine-tuned based on accelerated aging and solvent resistance testing

    Downstream process integration

    • Blended with primary resin in pre-polymerization or post-additional step
    • Introduced during high-shear mixing before application of catalysts or further additives
    • Subjected to thermal curing or UV crosslinking in plant lines

    Final product types

    • Industrial protective coatings
    • Two-component epoxy primers
    • Heat- and solvent-resistant resin films
    • Automotive and appliance topcoats

    4. Analytical Reagent Manufacturing for Laboratory Testing

    Producers of analytical and diagnostic reagents employ 3-Hydroxybenzhydrazide for its selectivity in detecting and quantifying aldehydic functionalities. Analytical kit assembly lines require precise milligram- to gram-scale addition, typically under GMP and ISO certified conditions. Documentation must support traceability and minimize contamination for regulated laboratory applications. The raw material’s high purity helps assure analytical kit reliability for research, food safety, or clinical testing end users.

    Industry compliance standards

    • ISO 13485:2016 for manufacture of medical and analytical devices
    • Good Laboratory Practice (GLP), OECD Principles
    • FDA 21 CFR Part 820 for diagnostic reagent production (where applicable)
    • EN 13640 for in vitro diagnostic medical devices

    Typical usage ratio

    • 0.01–1.0% by solution weight for colorimetric reagent preparation
    • Adjusted according to method sensitivity, volume, and detection system

    Downstream process integration

    • Dissolved directly into pre-formulated solvent mixtures during kit assembly
    • Filtered and aliquoted under controlled environment
    • Batch QC by UV-Vis and HPLC for stability and response validation

    Final product types

    • Colorimetric aldehyde detection kits
    • Field testing kits for food/beverage safety
    • Analytical standards for laboratory QA/QC
    • Clinical diagnostic test components
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    Certification & Compliance
    More Introduction

    3-Hydroxybenzhydrazide: Direct from the Source

    Product Insight from the Plant Floor

    Every batch of 3-Hydroxybenzhydrazide we ship starts with active oversight and experienced technicians at each step. Years spent refining the process has shown us that quality control doesn’t just happen in the lab—it begins as soon as raw material orders arrive at our receiving dock. Careful handling reduces contamination risk, and our reactors never run until the final lineup checks are confirmed. Watching hydrazine hydrate react with 3-hydroxybenzoic acid, our operators can spot the difference between a smooth and a sluggish run, adjusting conditions on the fly to meet the color and purity standards our customers rely on.

    Structure, Model, and Purity: Our Approach

    In the daily operations of our plant, the details behind product models and specs mean more than what gets listed on a shipping label. Over the years, feedback showed a demand for a higher-purity hydrazide, so we updated our washing protocols and crystallization techniques. Today, we can routinely offer 3-Hydroxybenzhydrazide at a purity above 99%. Each drum comes stamped with the batch number and analysis sheet, and customers routinely visit our plant to watch production firsthand. The crystalline white powder, molecular formula C7H8N2O2, never leaves the plant before passing a battery of tests—melting point, assay by HPLC, moisture by Karl Fischer. We never blend with other batches that don’t pass, even if it would mean fewer rejects. This stricter approach translates to less unpredictability downstream for each of our partners.

    The “Why” Behind Our Focus on 3-Hydroxybenzhydrazide

    Chemistry isn’t just about making something react; it’s about understanding where and why certain molecules matter. Alongside common hydrazides, 3-Hydroxybenzhydrazide stands out for its reactivity in hydrazone formation and pharmaceutical intermediate work. Manufacturers in dye and pigment sectors come to us because the ortho-hydroxy group changes the electron distribution, unlocking reactions that plain benzhydrazide can’t handle. Some big-name pharmaceuticals need the specificity of the 3-hydroxy variant for active ingredient synthesis and API research. Our process delivers a product that performs consistently in pilot trials as well as commercial production.

    Uses That Matter—Stories from Our Buyers

    Feedback from returning clients taught us the real-world importance of product consistency. R&D chemists in Europe use our 3-Hydroxybenzhydrazide for NMR reference compounds due to its trace impurity profile. In India, one agrochemical group told us their process yields jumped over 10% after switching from generic imports to ours. Paint and dye manufacturers find the product less prone to off-color formation, especially when synthesizing sensitive azo compounds. Laboratory scaleups in Japan sent us detailed chromatograms, showing that our tighter impurity profile helped their downstream reactions. Years of these exchanges pushed us to abandon older, more variable routes in favor of a process that protects the ortho position, minimizing unwanted isomers.

    What Sets This Product Apart

    Plenty of companies offer hydrazide derivatives, but too many take shortcuts with reaction cleanups or compromise on drying to speed up turnaround times. We refuse to use aggressive drying that could decompose the hydrazide ring, so every batch gets full-spectrum analytical review. Control over particle size helps prevent dusting in automated handling setups and limits loss during transfer—issues we’ve solved together with customers. Strict adherence to temperature ramping and pH ensures there’s no residual hydrazine, a point many overlook when chasing cheap synthesis.

    Common Traps in the Market—and Our Solution

    Having tested competitor samples ourselves, we see how low-end products sometimes include benzoic acid or unreacted hydrazine in amounts that would never survive our QC. Subtle color changes—sometimes barely visible—warn us when something went wrong upstream. Each time we spot these signals, we halt line production, saving headaches for customers. Many buyers chasing only the specification sheet end up fighting batch-to-batch differences in their own processes and waste precious time troubleshooting impurities that could have been avoided. Our approach keeps feedback loops short between the manufacturing line and the end-user, with actual chemists on call for technical support.

    The Human Side of Production

    Every operator at our plant—some with over fifteen years on this line—takes pride in defect-free product. Regular hands-on training ensures that each one knows not just what the product is, but why QC checks matter during the various stages. If a staffer spots an out-of-range test value, flags get raised immediately. This team approach limits downtime and guarantees only top batches reach the filling room. We rely on physical observations as much as on automated data, because undetected microclumping or flow behavior can cause delays or defects further down a customer's production line.

    Traceability and Transparency—Keys to Trust

    Product traceability comes built into our philosophy. Each order leaves a digital and paper trail right to the source—raw materials verified by full CoA, in-process controls logged at every shift, and retained reference samples stored for comparison if questions arise later. Any customer can trace back to which batch and shift team handled their material. When customers have specific requirements—low moisture, unique particle sizing, alternate solvents during purification—we tackle these with transparency instead of rushed workarounds.

    Process Upgrades: Not All 3-Hydroxybenzhydrazide is the Same

    Our chemists have experimented extensively with reaction conditions that optimize purity and product lifespan. Older batch processes introduced side reactions that contemporary methods—like our modified solvent system and improved washing—nearly eliminate. By retooling our reactors for wider, gentler agitation, we reduce shear and keep particle breakage to a minimum. Vacuum drying at moderate temperatures avoids caking and decomposition. End users see the difference through reduced filter clogging, higher recovery on crystallization, and cleaner baseline chromatograms.

    Product in Action: Stories That Stick

    Several pharmaceutical developers sent feedback after successful clinical-phase syntheses, noting the reproducibility of active compound formation using our 3-Hydroxybenzhydrazide. Organic pigment producers rely on its robust color-forming capabilities in competitive export markets. Analytical labs trust the substance as a calibration reference because our batches display consistent melting point and spectral profile, order after order. These testimonials keep us focused on process control, not just paperwork.

    The Impact of Purity on Downstream Chemistry

    Contaminants at the level of tenths of a percent can stall entire research projects or require costly workarounds in purification. We monitor and act on even trace benzaldehyde or isomer contaminations, knowing these can poison catalysts or result in failed batch releases. Quality control means taking small details seriously, from solvent type to the order of reagent addition. Some clients who switched from bulk-market or gray-market sources to our line found that product shelf life extended months longer, giving their distribution channels flexibility and reliability.

    Beyond Routine Analysis: Listening to the User

    Once, a key customer alerted us about unexpected haze formation during their proprietary crystallization step. Rather than pushing blame elsewhere, our technical chemist flew in to watch their process firsthand. Together, we pinpointed the issue—a trace impurity from our old upstream filtration cloth—leading us to re-specify all filtration supplies and eliminate the problem globally. This kind of collaboration only happens with real transparency from a manufacturer—not from intermediaries relaying messages secondhand.

    Risk Management: Storage and Delivery Matter

    Years of experience prove material quality can degrade after leaving production. Temperature spikes in transit, humidity creep, or container incompatibilities all chip away at shelf life. We package in airtight drums, each with real-time dataloggers for sensitive shipments. If a delivery route takes longer—customs, weather events, or unforeseen hold-ups—the datalogger history tells us if environmental controls held up during transit. Frequent QA checks spot offloads as soon as they arrive at customer docks, catching and isolating deviations before they hit the production line.

    Environmental and Regulatory Commitment

    Environmental stewardship cannot be a slogan on a webpage. At our plant, careful solvent recovery and process water recycling keep waste generation low. Regular audits ensure compliance with all handling and emissions regulations—both local mandates and export standards in our main trade zones. Responsible disposal of hydrazine byproducts and adherence to REACH and other global guidelines form a permanent part of our daily operations. We encourage customer plant visits to see these safeguards in practice.

    Technical Support—Built on Experience

    Our inside chemists have field backgrounds, filling the gap between theoretical knowledge and practical troubleshooting. Clients sometimes discover new applications—such as developing unique Schiff bases or experimental ligand scaffolds—and we can quickly run reference reactions in our pilot lab to optimize their conversion or suggest pathway tweaks. Some partners send us spent process streams for analysis to track downstream product fate. Years of technical back-and-forth have fed new improvements both in plant operations and in product documentation—translating into fewer surprises and lost hours for everyone.

    Differences from the Crowd—In Plain Terms

    Generic hydrazide suppliers often offer a product built for “good enough” rather than fit-for-purpose chemistry. Industrial buyers report fighting mystery impurities, out-of-spec batches, packaging breakdowns, or non-existent traceability. We face the reality that no documentation or claim can replace the trust that comes from open access to the whole chain of custody—from raw, to reaction, to final drum. That’s how we build long-term supply partnerships rather than one-off deals, especially for clients pursuing continuous processes where every kilogram counts.

    Practical Solutions to Manufacturing Hurdles

    Solving for real-world chemistry demands practical solutions. To tackle dusting, we deployed controlled granulation techniques that keep the product flowable for modern automated systems. For customers scaling pilot plants, we offer technical support on filtration, drying, and solvent compatibility, reducing lost yield and cleaning cycles. Where others compete on price alone, we focus on lifecycle cost—lower cleanup, longer shelf stability, and higher downstream conversion rates. With an open phone line for quick troubleshooting, chemists get direct advice on tweaks or alternatives based on actual experience with similar problems.

    Continuous Improvement—Our Real Mandate

    Actual manufacturing teaches lessons far beyond textbook chemistry. Process upgrades are driven not just by efficiency, but also by lessons learned at customer sites. Our R&D doesn’t pause once a “good enough” process is in place; trialing tweaks to agitation patterns, solvent swaps, or temperature sequencing always informs efforts to reduce impurity formation and boost active product recovery. Several innovations—including a revamped purification route—came straight from client-side feedback and post-delivery investigations. With each cycle and batch, the plant and its people grow more adept at dialing in the outputs that downstream chemists, formulators, and researchers demand.

    Conclusion: Why Buy from a Real Manufacturer?

    In an industry pressed by deadlines, competition, and technical constraints, product performance is built on manufacturing knowledge and a willingness to support customers through every hurdle. Endless documentation cannot replace actual open-door policies, where customers and chemists meet face-to-face to solve genuine process questions. Choosing 3-Hydroxybenzhydrazide direct from source means you work with a team tuned in to the realities of your business—not just the chemistry, but the packaging, compliance, supply assurance, and technical support that go with it. Each batch is shaped by years of real plant-floor know-how and a commitment to improvement, batch after batch, for every customer who counts on our product to keep their processes running clean and true.