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3-Ethylamino-4-Methylphenol

    • Product Name 3-Ethylamino-4-Methylphenol
    • Alias EMAP
    • Einecs 258-222-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    420469

    Chemical Name 3-Ethylamino-4-Methylphenol
    Molecular Formula C9H13NO
    Molar Mass 151.21 g/mol
    Appearance Solid (may be off-white or light-colored)
    Solubility In Water Moderate (expected for substituted phenols)
    Cas Number 25308-94-1
    Pubchem Cid 74865
    Smiles CCNC1=CC(=C(C=C1)O)C
    Inchi InChI=1S/C9H13NO/c1-3-10-8-4-5-9(11)7(2)6-8/h4-6,11,10H,3H2,1-2H3
    Synonyms 2-Methyl-6-(ethylamino)phenol
    Functional Groups Phenol, ethylamino, methyl

    As an accredited 3-Ethylamino-4-Methylphenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 250g of 3-Ethylamino-4-Methylphenol is supplied in a sealed amber glass bottle with a printed hazard label and tamper-evident cap.
    Shipping 3-Ethylamino-4-Methylphenol is shipped in tightly sealed, chemical-resistant containers to prevent leaks and contamination. Packages are clearly labeled and handled according to applicable safety and regulatory guidelines. Shipping typically follows ground or air transport with appropriate documentation, ensuring protection from heat, moisture, and incompatible substances throughout transit.
    Storage Store **3-Ethylamino-4-Methylphenol** in a tightly sealed container, away from light and moisture, in a cool, dry, and well-ventilated area. Keep away from incompatible materials such as strong oxidizing agents. Follow appropriate safety guidelines, label containers clearly, and ensure safety equipment is available in storage and handling areas. Store at room temperature unless specified otherwise by the manufacturer.
    Application of 3-Ethylamino-4-Methylphenol

    Applications of 3-Ethylamino-4-Methylphenol in Industrial Manufacturing

    As a manufacturer dedicated to supplying high-purity specialty chemical intermediates, we strictly control the quality of 3-Ethylamino-4-Methylphenol for integration into established industrial sectors. Below we outline the primary downstream application scenarios where this compound plays a critical role in formulation development and processing of advanced products. Each segment is supported by current industry standards and specifications, with practical formulation approaches and key final products based on real-world manufacturing requirements.

    1. Oxidative Hair Dye Intermediates for Professional Hair Colorants

    Professional hair dye manufacturers incorporate this compound as a core intermediate in oxidation colorant systems, targeting formulation stability and controlled color development, particularly within brown and warm shade ranges. During the process, its balanced reactivity enables nuanced shade control, minimizing irritant by-products and improving final product shelf life. Inclusion at specified concentrations ensures the protection of cuticle integrity while securing desired color outcome uniformity.

    Industry compliance standards

    • European Cosmetic Regulation (EC) No 1223/2009
    • Cosmetic Ingredient Review (CIR) safety assessment procedures
    • U.S. FDA 21 CFR 73.2396—Hair Dyes, Coal-Tar Hair Dye Exemption
    • Japanese Ministry of Health, Labour and Welfare: Standards for Cosmetics

    Typical usage ratio

    • Generally added at 0.1%–1.2% of total formula weight, with precise ratio calibrated per shade target and oxidative system concentration

    Downstream process integration

    • Dissolved into aqueous or glycol vehicle during pre-mixing, then introduced prior to the controlled addition of oxidizing agent (hydrogen peroxide) during batch blending under inert conditions

    Final product types

    • Professional salon permanent hair color creams
    • Demi-permanent hair color developers
    • Home-use oxidative hair dye kits
    • Personalized shade mixing bases for commercial coloring services

    2. Fine Chemical Synthesis of Advanced Organic Pigments

    Organic pigment manufacturers use this compound during condensation and coupling stages for creating high-value pigments with enhanced chromaticity and solvent-fast properties. Its unique amine profile enables tailored molecular structures, supporting the production of saturated tones for specialized coatings and high-performance inks. Controlled integration minimizes impurity formation and supports precision purification steps for pigment intermediates.

    Industry compliance standards

    • ISO 18451-1:2019—Pigments and Extenders
    • REACH (EC) No 1907/2006 substance registration—Europe
    • ASTM D3723—Analysis of Organic Colorants
    • DIN EN 71-3: Safety of Toys—Migration of certain elements

    Typical usage ratio

    • Utilized at 3%–10% relative to primary aromatic substrate, depending on pigment target structure, and reactant stoichiometry in coupling reactions

    Downstream process integration

    • Introduced during the primary aromatic amination stage or as part of the diazotization-coupling sequence for pigment precursor synthesis; solvent and temperature strictly monitored

    Final product types

    • High-performance organic pigments for gravure and flexographic printing inks
    • Dispersions for automotive OEM and refinish coatings
    • UV-curable pigment pastes for electronics
    • Specialty industrial paints for plastic and metal substrates

    3. Active Ingredient for Permanent Makeup (PMU) Coloring Agents

    Permanent makeup formulation labs incorporate this amine-phenol as a controlled dye precursor in PMU ink systems, leveraging its stability under dermal application conditions. Its compatibility with cosmetic-grade oxidants grants regulated pigment formation while addressing hypoallergenic requirements for professional PMU artists. Stringent traceability supports compliance with evolving cosmetic pigment regulations in the EU and U.S. markets.

    Industry compliance standards

    • EU Regulation (EU) 2022/692 restricting tattoo and permanent makeup substances
    • FDA Draft Guidance for Tattoo Inks and PMU Pigments
    • ISO 22716: Good Manufacturing Practices for Cosmetics
    • CTFA/PCPC INCI registration

    Typical usage ratio

    • Formulated at 0.05%–0.8% in pigment blend, based on color saturation requirements and validated safety limits for dermal exposure

    Downstream process integration

    • Blended with other amine-based dye precursors in sterile aqueous dispersions, following standardized pigment synthesis and filtration prior to aseptic filling

    Final product types

    • PMU eyebrow microblading inks
    • Lip tint tattoo pigment systems
    • Eyeliner PMU colorants
    • Corrective color tattoo bases

    4. Intermediary for API Synthesis in Dermatological Hair Treatments

    In pharmaceutical manufacturing, R&D and bulk API producers apply this raw material as an intermediate in the stepwise synthesis of actives for topical hair growth and pigment-restoration therapies. Its functional groups facilitate targeted chemical modifications, supporting impurity profile control and batch reproducibility under GMP protocols. Each synthesis adheres to validated process maps and impurity specifications for regulatory submission in regulated markets.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice Guidance for Active Pharmaceutical Ingredients
    • United States Pharmacopeia (USP) General Monographs
    • European Pharmacopoeia (Ph. Eur.) substance requirements
    • US FDA DMF (Drug Master File) submission standards

    Typical usage ratio

    • Added from 1.5–8 mol% of total substrate load, adjusted for downstream functionalization pathway and kinetic/reaction yield targets

    Downstream process integration

    • Fed into staged stepwise amination or coupling reactions for key intermediate formation; critical step QC and subsequent purification ensure downstream API quality

    Final product types

    • Dermatological hair regrowth active ingredients
    • Topical anti-graying serum APIs
    • Prescription pigment restoration formulas
    • Bulk intermediates for specialty pharmaceutical integration

    5. Precursor for High-Resolution Analytical Reagents in Diagnostic Kits

    Producers of diagnostic and analytical reagents employ this compound for the synthesis of colorimetric indicator agents and reference standards. Its robust chromophore generation under controlled oxidation supports rapid and sensitive detection in biochemical test kits, especially for hair and skin assessment methods. Purity and batch traceability ensure consistent performance during clinical assay production and standardized kit filling.

    Industry compliance standards

    • ISO 13485:2016 for medical device quality management, including IVDs
    • US FDA Quality System Regulation (QSR) 21 CFR Part 820
    • CLSI guideline C24 (statistical quality control for clinical chemistry)
    • CE Marking requirements for IVD devices in the EU

    Typical usage ratio

    • Precisely dosed at 0.01–0.2% per diagnostic reagent volume; formulation based on analytical method detection requirements and colorimetric endpoint intensity

    Downstream process integration

    • Incorporated during indicator or dye coupling phase, followed by filtration and stabilization for liquid or dry kit formats, maintaining lot-to-lot chromophore consistency

    Final product types

    • Hair and skin melanin spot test solutions
    • Spectrophotometric calibration standards
    • Routine analytical laboratory color test kits
    • Custom in vitro diagnostic (IVD) blends for clinical platform developers
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    Certification & Compliance
    More Introduction

    Introducing 3-Ethylamino-4-Methylphenol: Insight from the Manufacturing Floor

    Understanding 3-Ethylamino-4-Methylphenol from Core Production

    Every batch of 3-Ethylamino-4-Methylphenol running through our reactors starts with a commitment to hands-on quality. As a chemical manufacturer, the approach begins long before the drums roll off the loading dock. In the plant, this phenolic intermediate has carved out a reliable presence, thanks largely to its steady demand from clients focused on performance dyes, pigments, and specialty material development. Every metric ton rolling out tells a story about tight process controls and a deep respect for purity and consistency.

    Based on our process, the model for 3-Ethylamino-4-Methylphenol sticks to a specification curve that our laboratory has put through 200+ validation steps across several years. Typical lot analysis shows an assay surpassing 99%, verified by HPLC and NMR, with a moisture level kept below 0.5% and impurity traces far beneath global regulatory triggers. These figures are not only for peace of mind—they protect downstream users during color synthesis and boost yields for any hair dye or pigment blend that incorporates this phenol structure.

    Throughout our lines, the physical appearance is always a mild off-white to pale yellow crystalline powder. Granule size remains tightly controlled, with less than 2% passing through as fines below 100 mesh. This means there is reassurance batch after batch, whether a client is scaling a batch for lab formulation or ramping up an industrial process. No need for extra screening on their end. All moisture-sensitive storage precautions are respected from synthesis to filling, cutting out degradation that often crops up in off-spec product sold on the spot market.

    How 3-Ethylamino-4-Methylphenol Fits Practical Applications

    We got our first push into manufacturing this grade when several international cosmetic brands needed a stable, low-allergen precursor for oxidative hair dye chemistries. The phenolic ring and ethylamino substitution combine to yield a key building block for color developer systems—those that hit permanent coloring goals without harsh metallic residues. Clients using older 4-aminophenol or other monoalkyl anilines report more cases of residual copper or increased fading. With 3-Ethylamino-4-Methylphenol, the pigment base forms more resilient oxidative bonds with less side reaction.

    Our crews have seen increasing orders from technical dye manufacturers looking to deepen their palette for fine textiles and leather finishing. In these cases, our product’s methyl group at the 4-position gives extra steric hindrance. This translates to less byproduct drift and purer color formations compared to straight amino-phenols. Textile chemists working at larger dye houses mention shorter filtration times and less color bleeding.

    Our laboratory highlights another edge rarely discussed in surface-level product fact sheets: 3-Ethylamino-4-Methylphenol resists yellowing over long-term storage, which matters especially for those making batches ahead of seasonal demand surges. We tested direct storage at elevated humidity and temperature. Even after six months, no crystallization or color breakdown surfaced in retained samples—an accomplishment competitors chasing lower production costs rarely match. This means our long-time customers will rarely face clumping or hazing in their own mixtures, saving weeks lost to failed blends.

    What Sets Manufacturing Practices Apart in Our Facility

    Every step, from the receipt of core precursors to finished product packing, takes place on-site. We took this approach after seeing years of market inconsistency from sub-contractors with lax controls, especially in solvent handling. Our own team controls every buffer addition, temperature swing, and filtration stage. This eliminates the variability often encountered in product sourced from unknown or distant suppliers.

    Our analytical team does not settle for only guideline checks. They emphasize internal parallel sampling during key synthesis points. This process trims risks of batch-to-batch contamination or cross-reaction products and keeps our impurity levels at benchmark minimums (a step above many public specifications). These smaller steps pay off noticeably, as customers routinely report zero detection of common side-products like para-aminophenol or excess free amines. This is not always the case with other phenol-based intermediates circulating in global markets.

    The plant setup favors all closed-system handling, from molecular sieves for drying to nitrogen-flushed hoppers. Few realize that open handling in other setups, especially where ambient moisture creeps in, can warp product form and reactivity. That turns into inconsistent shade results once the phenol integrates with dye precursors. By keeping every unit operation sealed, shelf life and downstream reaction viability maintain integrity across the entire global journey of each drum.

    Practical Differences from Other Phenolic Compounds

    Some may ask what really separates 3-Ethylamino-4-Methylphenol from other related chemicals on the market. The molecular balance between the ethylamino and methyl group means this phenolic sits at a unique sweet spot. For those in the dye business, switching from common 4-aminophenols or meta-substituted anilines, we see markedly less off-odor and better color retention in end-use applications. The advanced substitution pattern cuts down on secondary reactions that usually plague batches using more reactive, unprotected aminophenols.

    Compared to simple monoalkyl anilines, our product releases fewer volatile side components under processing stress. Worker health and end-user satisfaction depend on minimizing these impurities. Our records show employees in our production hall see improved air quality, as monitored by real-time sensors. Over the years, we have tracked a nearly 40% reduction in odor notices for new workers compared to older chemicals in the range.

    In practical surface treatment processes, this phenol offers chemical resilience against peroxide fading, making it a preferred option for advanced color developer lines used by luxury salon brands. The methyl group at the 4-position adds structural stability, reducing hydrolysis rates seen in products with weaker substitution. That difference becomes critical when finished cosmetic products face weeks of transit or months of shelf time in challenging climates.

    Direct Views from the Manufacturing Team

    Our teams talk each week about the challenges of maintaining consistent process control year-round. Seasonal shifts in local humidity or incoming raw material purity almost always impact phenol-based intermediates faster than expected. By investing in real-time monitoring at every reactor and filtration point, corrections happen on the spot, before any issue magnifies downstream. That same attention shows up in the lot-to-lot analyses sent to every customer. Reports from the field confirm our drum-to-drum repeatability.

    Some colleagues in the industry may opt for basic visual product checks or limited sampling. Through repeated in-line process chromatography, we confirm not only high assay percentages but also an absence of critical micro-impurities frequently missed by spot tests. This matters, especially for companies with strict tolerance budgets or those exporting to countries enforcing tighter chemical guidelines.

    Years of customer feedback taught us to keep open lines with industrial and formulation chemists. If an end-user starts experiencing even the slightest variance in finished product hue or texture, our in-house experts analyze recent manufacturing records and upstream raw materials. Often, the cause links to global fluctuations in crude supply or unexpected batch impurity from an outside source. With full vertical integration, we make fast corrections, swapping suppliers or refining purification steps as trends demand.

    Case Stories from Downstream Users

    One large cosmetic manufacturer shifted their entire color developer line to our 3-Ethylamino-4-Methylphenol after their original Asian supplier struggled with reproducibility. Their R&D chemists noticed that even at minor scale, our material demonstrated sharper oxidative kinetics and reduced unwanted byproducts. Filtration cycles used to require repeated polishing steps; after the switch, a single filtration delivered clear, uncontaminated intermediates for their color base.

    Another case comes from a technical dye house specializing in performance fibers. Their batch engineers watched as competing products often led to color gradation issues and increased stripping on heat-set washes. Testing our phenol, they saw finished colors persist over five machine washings, where competing dyes lost vibrancy after two. Tracking color stability, customer service claims from end-users dropped significantly after making the change.

    A research group specializing in next-generation inks tested our product against their own in-house synthesized 3-Ethylamino-4-Methylphenol. The observation emerged that our commercial sample featured both lower trace-metal contamination and better powder flowability—critical for high-precision inkjet applications. As a result, print head clogs declined, production speed picked up, and defect rates in the final prints fell.

    Meeting Regulatory and Sustainability Demands

    Chemical manufacturing lives alongside global change. Over the past decade, regulatory frameworks have tightened. Brands want phenolic compounds free of listed allergens, batch impurities, and with traceability across every drum. Our fully auditable process tracks raw material provenance, chemical additions, and packaging materials for every production lot. If a client audits for their own ISO or REACH documentation, every data trail stands up to inspection. Even trace impurity thresholds demanded by international cosmetic or dye legislation now form part of our internal metrics.

    Sustainable manufacturing pulls attention at every plant manager’s meeting. Our environmental loop returns most mother liquors for solvent recovery and minimizes atmospheric emissions by scrubbing vent lines and using high-efficiency particulate filters. Plant operators see monthly metrics on water, waste, and energy reduction—and watch as compliance with environmental policies draws repeated international certifications. This isn’t done for awards; rather, maintaining a future-proof operation makes every job in the plant more secure.

    During product transfer and drum filling, all staff receive regular training on containment and eco-friendly handling, not only to hit government marks but also to cut down on spillage and long-term containment risk. Technicians note strong reductions in chemical exposure as a direct effect of routine cross-checking and using closed-filling hoppers. Each drum of 3-Ethylamino-4-Methylphenol reflects the investment in safety and forward-thinking plant design as much as the compound itself.

    Decades of Field Experience Gaining Results

    Running a synthesis campaign for this phenolic intermediate may challenge even seasoned chemical engineers. Each modification along the route—from raw amine selection to reaction moderation—affects yield, cost, and impurity load. We stick with double purification through both acid-base and solvent extraction stages. The approach raises internal costs in the short run, but lifetime savings show up where our customers rarely need recalls or rushed returns.

    Field engineers from our team have supported clients during scale-ups and process troubleshooting. Several technical leads recall last-minute on-site visits, where stubborn filtration issues or sensitivity to temperature threatened critical product launches. In every case, direct guidance and rapid shipping from our own plant let clients hit their delivery deadlines, keeping our product in high demand even under global supply squeezes.

    Innovation continues to drive improvement. Our plant team has trialed greener alternative solvents, and early results reveal reduced operator risk and similar quality metrics. Collaborations with client process chemists ensure that switching process lines to these alternatives does not impact their own validations. Such changes filter down directly to our customers, offering not just a product, but a safer and more reliable base for new pigment and dye launches.

    Why Consistency and Traceability Matter for Users

    Purchasing 3-Ethylamino-4-Methylphenol from the original plant brings stronger peace of mind. Any batch shipped from our site carries a deep provenance: the batch record links every step, from each raw ingredient lot, through each process validation, straight to drum filling and final dispatch. This level of traceability ensures quick answers for any downstream quality queries, including full support from manufacturing chemists who intimately understand the material, the process, and the needs of both R&D and production managers.

    Large-scale buyers and formulators often face problems when they order off catalog from trading brokers. While the paperwork may look similar, hidden differences in product quality, impurity profile, and storage stability surface fast. Our long relationships with key cosmetic, dye, and pigment manufacturers have shown that long-term business always favors rigorous process documentation and open data exchange over one-off spot deals.

    Detailed conversations with technical managers show that the difference between a smooth production campaign and costly downtime often comes down to the small things: reproducible physical form, exact melting point, resistance to process moisture, and clear shipping documentation. Our goal remains to keep these details on point, so chemists and process plant teams can plan production calendars with far fewer headaches.

    Future Perspectives and Continuous Improvement

    A chemical—no matter how high the purity or robust the process—still exists inside a changing industry. Continuous process audits and customer dialogue remain the base for ongoing tweaks, improvements, and validations. Emerging applications for 3-Ethylamino-4-Methylphenol, such as advanced electronic inks and sustainable textile colorants, bring new process demands and analysis methods. Our lab extends its validation criteria and acts on customer-provided data, folding feedback straight into plant operations.

    We keep investing in people and technology. Batch supervisors share real-world examples and tweak batch protocols based on lived experience of temperature drift, packaging rupture, or newly observed impurity fractions. Young process chemists collect best practices from benchmarking trips to overseas plants and international technical symposia. Every crew member—from lab analyst to drum loader—brings decades of practice, skill, and a stake in continuous success. This environment keeps us close to both the product and the clients who trust us with their projects.

    In essence, for anyone needing consistent, clean, and proven 3-Ethylamino-4-Methylphenol, purchasing source-verified product from our manufacturing line means more than a simple supply agreement. It guarantees the hands-on touch of people who treat every drum as a reflection of their care for detail, safety, and client success. This real-world approach stands behind every order and has kept our partners coming back—year after year, decade after decade.