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3-Chlorophenylglycolic Acid

    • Product Name 3-Chlorophenylglycolic Acid
    • Alias 3-(3-Chlorophenyl)-glycolic acid
    • Einecs 256-871-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    296743

    Chemical Name 3-Chlorophenylglycolic Acid
    Molecular Formula C8H7ClO3
    Molecular Weight 186.59 g/mol
    Cas Number 2261-01-4
    Appearance White to off-white crystalline powder
    Melting Point 141-144°C
    Solubility In Water Slightly soluble
    Pka 3.5 (estimated)
    Smiles C1=CC(=CC(=C1)Cl)C(C(=O)O)O
    Inchi InChI=1S/C8H7ClO3/c9-6-2-1-3-7(5-6)8(11)4-10/h1-3,5,8,10H,4H2,(H,11,12)
    Storage Conditions Store at room temperature, dry, and away from light

    As an accredited 3-Chlorophenylglycolic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 3-Chlorophenylglycolic Acid is supplied in a sealed amber glass bottle, containing 25 grams, with clear hazard and identification labeling.
    Shipping 3-Chlorophenylglycolic Acid is shipped in tightly sealed containers to prevent contamination and degradation. It is packed in accordance with regulatory guidelines for hazardous chemicals, typically inside cushioned, labeled packaging. The shipment includes safety documentation and must be stored and transported in cool, dry conditions away from incompatible materials.
    Storage 3-Chlorophenylglycolic Acid should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from incompatible substances such as strong oxidizers and bases. It should be protected from moisture and direct sunlight. Use appropriate chemical-resistant containers and store under ambient conditions unless otherwise specified by the manufacturer or safety data sheet.
    Application of 3-Chlorophenylglycolic Acid

    Applications of 3-Chlorophenylglycolic Acid in Industrial Manufacturing

    As an established manufacturer specializing in high-purity 3-Chlorophenylglycolic Acid, we support demanding industrial segments where strict compliance, formulation precision, and process control are essential. The following application scenarios illustrate direct integration into key downstream workflows, each with authentic industry requirements and production detail.

    1. Non-Steroidal Anti-Inflammatory Drug (NSAID) Intermediate Synthesis

    3-Chlorophenylglycolic Acid often functions as a core building block in the synthesis of specialty NSAIDs, including certain arylacetic acid derivatives. API manufacturers incorporate this material at the condensation or aryl acetic acid coupling stage, where its specific halogenation profile leads to enhanced molecular selectivity. Regulatory expectations for APIs demand strictly monitored precursor input and impurity control, impacting every batch release to pharmaceutical producers. Formulators select input quantities to manage reaction yields and downstream purification, while the compound’s unique reactivity ensures targeted molecular structures for tablet or capsule formation.

    Industry compliance standards

    • Current Good Manufacturing Practice (cGMP) as set by the US FDA (21 CFR Parts 210, 211)
    • ICH Q7 Guidelines for Active Pharmaceutical Ingredients
    • European Pharmacopoeia (Ph. Eur.) monographs for API-grade intermediates
    • Chinese Pharmacopoeia (ChP), input material testing and traceability provisions

    Typical usage ratio

    • 5–15% by molar mass relative to the target NSAID API, with the exact ratio adjusted based on desired side-chain substitution and batch scaling; higher ratios may compensate for lower reactivity in specific coupling reactions.

    Downstream process integration

    • Introduced during organic synthesis via esterification or amidation step; used after initial base structure assembly and before final purification and crystallization of the API.

    Final product types

    • Pharmaceutical-grade NSAIDs (tablets, capsules, injectables)
    • Bulk API shipments to contract development and manufacturing organizations (CDMOs)

    2. Specialty Agrochemical Synthesis

    Industrial crop protection formulators use this compound as an intermediate in the production of selective herbicides and certain systemic fungicides. The chemical’s halogenated aromatic core facilitates the functional group transformations required for synthesis of target molecules, such as substituted phenoxyacetates. The dosage depends on specific downstream crop protection chemistry and regulatory-driven residue limits, with materials traceability and batch audit forming part of agrochemical good laboratory practice frameworks.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • OECD Principles of Good Laboratory Practice (GLP)
    • REACH Registration (EC 1907/2006) for chemical intermediates
    • China Pesticide Registration Requirements (ICAMA)

    Typical usage ratio

    • 2–8% by total reactant mass in the active ingredient synthesis step; finalized depending on conversion rates and targeted product yield.

    Downstream process integration

    • Added at the condensation or substitution phase as a source of chlorinated phenyl moiety; feeds into multi-step synthetic blocks prior to technical concentrate formation and formulation blending.

    Final product types

    • Selective herbicide actives for cereals and oilseeds
    • Systemic fungicides in suspension concentrate and emulsifiable concentrate formats

    3. Advanced Polymer and Resin Modification

    Producers of engineered polymer resins integrate this material to impart halogen resistance and fine-tune aromatic backbone properties in specialty polyesters and epoxy systems. Manufacturers incorporate it via pre-polymer charge or post-polymerization graft reactions, benefitting from carefully controlled monomer addition. Use rates reflect molecular weight targets and flame retardancy or crosslinking requirements, while QC protocols require thorough reaction monitoring and extraction analysis to verify complete conversion and limit residuals. Final thermoset articles meet demanding mechanical and chemical performance standards in electronics and automotive manufacturing.

    Industry compliance standards

    • UL 94 Flammability Standard for Plastics
    • EN ISO 178 (Flexural properties of plastics)
    • RoHS Directive 2011/65/EU – restrictions on hazardous substances
    • ISO 9001:2015 Quality Management in polymer compounding facilities

    Typical usage ratio

    • 0.5–3% by resin weight; dosage tuned based on degree of modification, molecular integration efficiency, and targeted dielectric or mechanical properties.

    Downstream process integration

    • Charged to the reaction vessel during oligomer formation in polyester or epoxide resin synthesis, or injected during melt blending of engineering plastics compounds.

    Final product types

    • Epoxy resins for printed circuit boards
    • Modified polyesters for reinforced composite systems
    • Halogen-resistant automotive housings and connectors

    4. Fine Chemical Building Block for Liquid Crystal Materials

    In the advanced materials sector, this compound acts as a precursor in manufacturing specialty liquid crystal components for flat-panel displays. It enters as a halogenated aromatic fragment during multi-step organic syntheses, often forming the backbone of esters, ethers, or biphenyl derivatives essential for display performance. Strict control of input ratios and impurity profiles is required due to the optical sensitivity of final products. Manufacturers scale batches with precision, optimizing input amounts relative to projected yield and purity thresholds set by electronics sector clients.

    Industry compliance standards

    • QC methodology in accordance with IEC 61747 standards for liquid crystal displays
    • RoHS Compliance (EU Directive 2002/95/EC)
    • ISO 17025 for testing laboratories (purity and performance testing)
    • Japanese Industrial Standards (JIS C 61126 – LCD components)

    Typical usage ratio

    • 1–6% by total precursor load in fine chemical synthesis routes; titrated to minimize byproduct formation and maximize target alignment of mesogenic groups.

    Downstream process integration

    • Employed at the intermediate coupling stage for the construction of mesogenic ether or ester linkages; used before distillation and purification of final liquid crystal intermediates.

    Final product types

    • Liquid crystal monomers for display applications
    • Biphenyl-based intermediate mixtures for active-matrix LCD panels
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    Certification & Compliance
    More Introduction

    3-Chlorophenylglycolic Acid: Direct from the Producer’s Line

    Working with Value: Our Approach to 3-Chlorophenylglycolic Acid

    Out on the factory floor, life moves according to the clock, the process, and the markets that rise and fall. In the chemical industry, every product tells a story through raw material sources, process adjustments, pricing realities, and the mix of end applications. 3-Chlorophenylglycolic acid falls into the category of specialty chemicals that only a handful of manufacturers handle with any degree of repeatable quality. Bringing this compound to market means more than hitting a numerical spec or ticking a purity box — it’s about ownership, repeatability, and the hard lessons learned through years wrestling with production variables.

    We make our 3-chlorophenylglycolic acid with deep knowledge gained by producing a whole range of chloroaromatic intermediates. Whenever we look at a new batch, we focus on physical consistency, minimizing impurities especially from incomplete halogenation or over-oxidation, and testing against the standards that chemists and downstream formulators actually need in day-to-day work. Lab specs often tell only a part of the story. Visual cues — color, flow behavior, even odor at the weighing bench — provide invisible markers for consistency that customers learn to trust after repeated interaction with the same supplier.

    Clear, Reliable Specifications: Putting Years of Process Refinement to Work

    Every batch starts with the right grade of starting material. The difference between source materials becomes clear during the first stages of synthesis, so we monitor each delivery and adjust process parameters accordingly. Our primary variant is typically offered at purity greater than 99 percent (as established by HPLC), moisture below 0.5 percent, and chloride ion content low enough to pass tough analytical scrutiny. Trace byproducts like 2-chlorophenyl derivatives or dimeric impurities tell on the process if not adequately controlled — real-world production shines a light on the claim behind every analytical printout.

    While there are competitors selling off-pattern grades recovered from side-streams or offering lower-purity technical product, our batches go through dedicated vessels, filtered and finished under inert atmosphere, and delivered with a COA based on in-house data — not just relabeled import. This stuff matters when you try to run a downstream Hofmann rearrangement, or you want to build toward a more elaborate pharma intermediate without risking waste or rework.

    Process Understanding: What Sets Direct Manufacturers Apart

    Over the years, both research and industrial buyers have given direct feedback on their frustrations dealing with traders and resellers — shipment quality shifts from lot to lot, documentation trails stop at the warehouse, and there’s little recourse when something fails downstream. As a manufacturer, our approach comes with a built-in feedback loop. Every failed batch is an internal problem to fix, not a passing liability. Our technical team tracks which reactor, which batch of starting 3-chlorobenzaldehyde, and which shipment route contributed to any deviation. Tolerances are not theoretical: we know how a two-degree shift in reaction temperature creates trace over-chlorination, or how using lower-quality acetone in workup can create background UV activity that shreds a customer’s chromatogram later.

    Many end users underestimate how much solvent residues or byproduct signatures affect their project timelines. In the realm of 3-chlorophenylglycolic acid, moisture and trace iron can produce color drift, and inconsistent pH can cause trouble in subsequent condensation reactions. We uphold strict attention to particle sizing — aiming for free-flowing crystalline powder, with minimal dust and clumping — so weighing at the bench or on automated lines happens without frustrating delays. It’s small details like this that keep production moving, especially at scale-up stages where delays can snowball into lost weeks.

    Usage in Real Industrial Contexts

    Years in production have shown that customers rely on 3-chlorophenylglycolic acid for several core end-uses. In pharmaceuticals and fine chemical synthesis, it’s a favored intermediate when building molecules where controlled substitution patterns matter for downstream reactivity. The compound’s carboxylic acid group lends well to transformation into esters or acids, and the chloro substitution offers routes for selective further substitution, crucial in customized building blocks for drug and agricultural pipelines.

    While theoretical chemists and purchasing agents see lists of available chemicals online, real process development teams discover early that not all lots work equally well across reaction schemes. Solubility, particle fineness, bench handling, and control over trace contaminants play out in yields and reproducibility. For hydrolysis, in-situ condensation, or amidation, our version has been preferred in lab and pilot plant settings that cannot afford downstream surprises.

    It also has uses in specialty coatings, adhesives, and materials development, although the pharmaceutical and research segments set the strictest requirements. Sometimes a variant tweaked for lower metallics or with enhanced purification is required for a new project. As a manufacturer, we’re able to offer these through simple adjustments and close communication, not through wishful posturing or unearned promises.

    Practical Differences: Real vs. Resold Product

    Every chemical starts with a source and a process. Sitting in meetings with industry partners, we hear plenty of stories about unpredictable quality and re-branded product that fails silently until a reactor run crashes. Those buying from resellers or distributors often never know which factory made their material. Our customers benefit from product that comes straight from origin — they get direct answers on batch genealogy, root cause on any deviation, and dialogue that translates into meaningful support.

    Distributors and brokers generally lack system-level traceability. What often travels through third and fourth hands may pick up moisture, oxygen, or even microbial load if not packaged and warehoused properly. Beyond just paperwork, product arriving directly from our factory skips those risks. If a customer runs a thermogravimetric analysis and spots volatility or trace thermal instability, we’re in a position to explain which part of the process led to such signals, what actions we’re taking, and what the next batch will look like as a result.

    We also do real-world compatibility and analytical testing in-house — covering UV, NMR, IR, and residual solvent analysis. Buyers operating at scale know how a tiny impurity at the intermediate stage can derail a project at API or agrochemical stage. Even packaging matters: we use liners and tamper-evident seals to guard against the sort of cross-contamination that comes from bulk repacking by non-specialists.

    Our experience says that end results speak clearest. Pharmaceutical researchers, for example, return with repeat orders and detailed notes on batch-to-batch consistency. Some have shared data showing how yield drift disappears when they shift from open-market product to direct-source material. Industrial teams often share photos of bright white product lines or successful crystallizations, evidence you can’t fake with a spreadsheet or a nice website.

    Supporting R&D and Scale-Up: Working Beyond the Standard Product

    Having produced 3-chlorophenylglycolic acid for years, we see most buyers start with off-the-shelf grades for R&D and move toward variant requests as projects mature. Sometimes it’s a need for extra low-ash content, or requests for specialized particle size ranges. We respond directly at the process level — changing filtration regimes, tweaking crystallization conditions, or introducing additional purification loops. Because we control every production stage, we don’t have to play telephone through multiple suppliers — solutions come straight from the person who runs the reaction or the person who packs the drum.

    This responsiveness becomes critical in projects that run into unexpected problems. If a late-stage scale-up stalls due to a previously invisible impurity, formula teams consult our analytical records and process history. We offer true transparency, sharing chromatographic traces, full residual solvent runs, and any data that matter for a regulatory or QA audit. Flexibility and direct support mean that customers are not stuck searching for scapegoats — they resolve issues efficiently, with allies on the production side.

    In-house R&D also exposes where market needs might change. We frequently review applications and align batches with niche needs, such as enhanced flow characteristics for automated powder feeders or even specific grades for use in chiral resolution studies. Because we are not beholden to anyone’s narrative but our own, every tweak in process comes from a real challenge on the ground.

    Regulatory and Quality: Accountability through Every Step

    Our facility follows strict housekeeping and documentation standards. All operational records, batch logs, and analytical files get kept for years, accessible if an end user or regulatory body ever asks questions. Once a customer asked for a full five-year historical review of trace metals trends; because we keep every notebook, we were able to deliver within hours. This type of reliability only exists at origin.

    We regularly update our standard operating procedures to anticipate evolving regulatory environments. Changes in allowed residuals or new safety recommendations translate into production updates. In the past, growing attention to halogenated byproducts prompted us to introduce an additional purification loop; that year, downstream clients working in regulated environments didn’t just get a checkbox ticked — their processes ran cleaner, smoother, and with fewer regulatory headaches.

    Auditors, both internal and external, walk our lines and interview operators, not just managers. Their reports guide our continuous improvement. For those needing support in preparing for FDA, EMA, or local inspections, our direct records and transparent QA relationships often make professional lives easier.

    Why Direct Manufacturing Delivers Trust in Specialty Chemicals

    Chemical supply takes more than moving drums from A to B. Every lot of 3-chlorophenylglycolic acid is built on stories — hard-won improvements after process slips, customer calls at midnight, lessons drawn from unexpected changes in raw material quality. In daily operations, pride comes less from polished mission statements and more from consistently positive feedback, repeat orders, and technical collaboration with those who use our product to build their own.

    Through decades of focus, we keep refining our practices, not only in reaction chemistry but also in how we talk with customers, how we report issues, and how we share responsibility. Problems get solved at origin. Improvements emerge from the day-to-day back-and-forth with those who every day wrestle molecules into high-value products. As direct producers, we eliminate uncertainty and offer continuity. Every batch tells the truth of our process — and our willingness to back up that work, always.