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(3-Chlorophenyl)(Phenyl)Methanone

    • Product Name (3-Chlorophenyl)(Phenyl)Methanone
    • Einecs 216-412-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    143984

    Chemical Name (3-Chlorophenyl)(Phenyl)Methanone
    Synonyms 3-Chlorobenzophenone
    Molecular Formula C13H9ClO
    Molecular Weight 216.67
    Cas Number 2292-59-9
    Appearance White to off-white crystalline solid
    Melting Point 50-54°C
    Boiling Point 348°C
    Density 1.23 g/cm³
    Solubility In Water Insoluble
    Flash Point 160°C
    Smiles C1=CC=C(C=C1)C(=O)C2=CC(=CC=C2)Cl

    As an accredited (3-Chlorophenyl)(Phenyl)Methanone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle, 100g quantity, sealed with a screw cap, labeled with chemical name, CAS number, hazard warnings, and handling instructions.
    Shipping (3-Chlorophenyl)(Phenyl)Methanone is shipped in tightly sealed containers, protected from light, moisture, and incompatible materials. Transportation complies with all relevant hazardous material regulations. Appropriate labeling, documentation, and handling procedures are ensured to maintain safety during transit. Temperature control may be applied if required to preserve product stability.
    Storage (3-Chlorophenyl)(phenyl)methanone should be stored in a cool, dry, and well-ventilated area, away from direct sunlight and incompatible substances such as strong oxidizers. Keep the chemical in a tightly sealed container, preferably made of glass or compatible plastic. Ensure the storage area is secure and clearly labeled, and limit access to authorized personnel only.
    Application of (3-Chlorophenyl)(Phenyl)Methanone

    Applications of (3-Chlorophenyl)(Phenyl)Methanone in Industrial Manufacturing

    As a chemical manufacturer specializing in aromatic ketones, we supply (3-Chlorophenyl)(Phenyl)Methanone directly to sectors with regulated, high-integration needs. Below are key industry applications, including sector-specific compliance requirements, formulation dosages, downstream use points, and end product types.

    1. Pharmaceutical Intermediate Synthesis

    Major pharmaceutical producers utilize this compound as a pivotal intermediate in the synthesis of multiple non-steroidal anti-inflammatory drugs (NSAIDs) and select antihypertensive agents. Standard manufacturing processes incorporate this molecule during early-stage condensation and Friedel–Crafts acylation, forming critical core structures within patented active pharmaceutical ingredients. Consistency in purity and traceability aligns with batch release protocols for both regulated markets and export-oriented fill-and-finish operations.

    Industry compliance standards

    • Current Good Manufacturing Practice (cGMP, 21 CFR Parts 210/211)
    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • Ph. Eur. and USP raw material monograph referencing
    • REACH Annex VII registration (Europe) and US DMF submission tiers

    Typical usage ratio

    • 5–15% by mole in drug intermediate synthesis; adjusted for downstream yield optimization or impurity management

    Downstream process integration

    • Introduced during initial condensation or acylation steps in API route design
    • Quality checked for residual solvents, chloroarene content, and related impurities at pre-isolation phase

    Final product types

    • NSAID APIs such as diclofenac analogues (regulated formulations)
    • Select beta-blockers as antihypertensive actives
    • Intermediate bulk actives for contract development use
    • Generic pharmaceutical intermediates for global supply markets

    2. Agrochemical Active Ingredient Development

    Leading agrochemical formulators integrate the molecule as a building block in the manufacture of certain selective herbicides and fungicides with aryl-ketone moieties. The molecule’s halogenated aromatic profile supports specific crop protection chemistries where stability to UV and resistance to microbial breakdown are required. Controlled batchwise synthesis in pilot reactor suites ensures compliance with agricultural environmental protocols, residue limits, and downstream field formulation testing.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products (FAO/WHO)
    • ISO 9001:2015 for agrochemical raw material supply
    • EU Regulation (EC) No 1107/2009 – Plant Protection Products
    • US EPA 40 CFR Part 180 – Tolerance Limits for Pesticide Residues

    Typical usage ratio

    • 10–30% of the total molecular scaffold during pre-formulation synthesis depending on target field activity and environmental fate studies

    Downstream process integration

    • Incorporated at the first aromatic acylation step to form active ingredient backbones
    • Subjected to in-process purity testing for residual chlorinated aromatics

    Final product types

    • Triazole-based fungicide actives
    • Selective herbicide intermediate solids for field application formulations
    • Convertible pre-emergence herbicide concentrates
    • Bulk crop protection agents supplied to downstream formulating partners

    3. Specialty Dye and Pigment Manufacturing

    Industrial dye plants and pigment manufacturers utilize (3-Chlorophenyl)(Phenyl)Methanone as a key arylating component in the creation of high-performance dyes for plastics and fiber applications. The molecule’s structural halogenation enhances shade depth and migration resistance, critical for textile, automotive, and packaging market needs. Integration at the condensation and coupling stage controls chromophore integrity, and downstream partners set specifications for HAPs and aryl chloride residuals.

    Industry compliance standards

    • OEKO-TEX Standard 100 (Restricted Substances List)
    • GOTS – Global Organic Textile Standard chemical requirements
    • EU REACH Candidate List for Substances of Very High Concern (SVHC)
    • ISO 14001:2015 certified production for industrial colorants

    Typical usage ratio

    • 2–10% by mass in pigment pre-mix blends; adjusted per color strength requirement and migration control

    Downstream process integration

    • Engaged in condensation/coupling stage to form azo and anthraquinone Dyes
    • Quality screened for non-conforming halide content post-reaction

    Final product types

    • High-stability textile dyestuffs
    • Automotive-grade plastic pigments
    • Specialty masterbatch concentrates for fiber and film coloring
    • Performance colorants for coatings and inks

    4. Liquid Crystal and Electronic Intermediate Preparation

    Manufacturers of high-end liquid crystal materials and specialty electronics grades deploy the compound as a precursor in functionalized aryl ketone development. Precision-controlled synthesis ensures tight batch reproducibility vital for electronic device performance and reliability. The molecule enters processing under strict moisture and trace metal control, consistent with microelectronics and optoelectronic-grade specifications.

    Industry compliance standards

    • IEC 61249-2-21: Specification for Non-halogenated Epoxy Laminates (for LC and PCB devices)
    • RoHS Directive 2011/65/EU for hazardous materials in electronics
    • JEDEC JESD 625: Requirements for Handling Electrostatic Discharge (ESD) Sensitive Devices
    • ISO 9001:2015 for electronic component supply chain

    Typical usage ratio

    • 1–5% by weight as initial reactant in liquid crystal intermediate synthesis; ratio adapted per phase transition characteristics

    Downstream process integration

    • Activated under acid- or base-catalyzed functionalization in precursor molecule assembly
    • Strictly controlled at the dry-down and isolation stage for trace ionic contamination

    Final product types

    • Liquid crystal compounds for display panel manufacturers
    • Functionalized aryl intermediates for OLED and advanced optoelectronic devices
    • High dielectric aryl ketone building blocks for flexible PCB materials
    • Microelectronic-grade specialty chemicals for thin film deposition
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    Certification & Compliance
    More Introduction

    (3-Chlorophenyl)(Phenyl)Methanone: Expert Insights from the Manufacturer

    Direct from the Factory Floor: An Introduction

    Rolling out (3-Chlorophenyl)(phenyl)methanone from a chemical manufacturing plant brings together core process knowledge, solid hands-on experience, and constant dialogue with end-users. Our approach shapes how we produce chemicals like this one, commonly known in industry circles as a versatile intermediate for both R&D and full-scale production. Factory settings rarely enjoy the limelight, but here’s a ground-up perspective on (3-Chlorophenyl)(phenyl)methanone—what it is, how it acts, and why it stands apart from similar compounds.

    Model and Manufacturing Specifics

    The model that leaves our facility stems from a batch process designed for clarity of composition and repeatable purity. The molecule features a chlorinated phenyl group linked to a benzophenone scaffold, a structure well-recognized among chemists who build both active pharmaceutical ingredients and specialty fine chemicals. Over two decades, our crew has dialed in each step: from tight temperature control during Friedel-Crafts acylation to careful solvent recovery and final crystallization, every engineer on staff knows the stakes of rushing or cutting a corner.

    Catalogs can quote molecular weights and melting points, but in practice, what makes our product reliable starts with how we sustain narrow specification ranges. Each lot shows a minimum assay of 99.0%, and our own QC teams run NMR and HPLC checks far beyond the minimum regulatory bars. Purity grants sharper reactions and less downstream trouble, especially for customers synthesizing pharmaceuticals or complex polymers.

    Making Reliable Chemistry Happen

    Real-world users often approach us with project goals where (3-Chlorophenyl)(phenyl)methanone serves as a keystone. They may need it for coupling reactions to install specific moieties, or as a controlled starting material for anti-inflammatory drug research. Our blend of process experience and lab-scale flexibility makes it possible to supply from grams to metric tons, scaling without that notorious “pilot plant pinch.”

    Chlorinated aromatics have special demands for storage and handling. Working on the manufacturing line, our staff nurture a close understanding of the material’s flow properties, its stubborn tendency toward light-catalyzed decomposition, and the importance of correct packaging under inert atmosphere. Frequent customer questions center on shelf life and transport; by tracking actual performance through both warehouse and shipping runs—not just assuming ideal logistics—our teams have learned where most degradation occurs, and adapt the packaging accordingly.

    Comparing Against the Field: Why This Product?

    Plenty of aromatic ketones fill fine chemical catalogues, and (3-Chlorophenyl)(phenyl)methanone sits among familiar companions. For comparison, benzophenone itself—lacking the chlorine atom—remains more widely available, but dropping the halogen alters the compound’s reactivity profile. Chemists using our chlorinated version report greater selectivity in certain Suzuki and Heck couplings, as well as improved yields in specialized cross-couplings where electron density makes all the difference.

    Moving up or down the substitution pattern also paints a different landscape. Swapping chlorine for fluorine or moving it around the ring changes not just reactivity but regulatory treatment. We collaborate with clients—sometimes academic, often industrial—to trace these subtle differences through trial reactions. Our depth in custom synthesis allows running side-by-side studies, helping develop processes with a strong real-world foundation, not just literature promises.

    As manufacturers, the key differentiator stems not just from molecule, but from our “rooted” perspective. We oversee the entire journey: from sourcing chlorobenzene and benzoyl chloride, through multi-stage purification, to internal audits of waste reduction and solvent recovery. Downstream chemists value not only a tight purity spec—they lean heavily on traceability, ensured from lot coding to transportation documents.

    Many synthetic organic reactions develop headaches due to side-product contamination. By using freshly distilled solvents and high-grade catalysts, we aim to shed these headaches from our client’s workflows. Tighter particle size control and careful drying produce a solid that handles predictably on their end, reducing process downtime when charging the material to reactors or hoppers. Process reliability forms a practical dividing line in our field—factory experience spotlights this difference rather than just raw assay numbers.

    Balancing Production Scale with Environmental Responsibility

    Scaling production isn’t just about bigger tanks and more drums. Our industry still wrestles with environmental and personnel safety challenges, especially for aromatic chlorinated ketones. Each manufacturer faces persistent pressure to improve recovery and reduce emissions of organic solvents—much of the technology deployed in our plant came about from tight-lipped trial and error over many years. Waste handling processes have stepped up, with on-site distillation units reclaiming over 90% of the DMF and dichloromethane used in reaction and purification cycles.

    Replacing older energy sources with cleaner steam and implementing natural gas-fired boiler systems trimmed our carbon output. The work rarely makes headlines, but each improvement keeps us honest in the face of increasingly demanding environmental regulations. Long before compliance deadlines show up, production engineers log abatement data and work with staff chemists to troubleshoot leaks and inefficiencies. Years of feedback from local regulators and risk committees have shaped plant policy to anticipate—rather than simply react to—new safety targets.

    Listening to Industry Voices

    Many downstream companies open conversations not about what’s possible, but about what’s practical. One biopharma project team came to us after repeated failures with another supplier’s material, finding unexplainable yields and chromatographic headaches. Our hands-on plant chemist went through the synthesis history with them, pinpointed trace peroxide impurities, and switched up a purification step. Production runs after that saw consistent yield and purity, ultimately saving weeks of troubleshooting and wasted batch material on their flask side.

    Researchers in agricultural chemistry, another frequent user base, prize consistency more than anything else. They feed (3-Chlorophenyl)(phenyl)methanone into early-stage pesticide screens, running dozens of low-yielding reactions in parallel. Subtle impurities can skew these screens, leading to false negatives and wasted resources. By running products through both in-house analysis and outside contract labs, we maintain double-blind checks before a drum leaves the dock—an approach rooted in plant-floor pragmatism, not marketing gloss.

    Product Handling Lessons Learned

    (3-Chlorophenyl)(phenyl)methanone is stable under cool, dry storage with minimal exposure to UV light. Over years of full-facility management, technicians have flagged the slow shift in color that signals photodegradation—a warning that shows up long before certificates of analysis catch up. Simple lessons, like pulling drums from sunlight in loading bays and maintaining proper filling procedures, keep customers from encountering quality surprises months after purchase.

    We do not treat shelf life as a “once and done” spec. Scheduled re-testing and customer feedback feeds back into process tweaks—once, a report from a long-time client in Europe led us to switch anti-static liners to prevent trace moisture pickup during transit across humid port cities. Simple changes, made from listening to the people who open our containers each week, reinforce real reliability.

    Supply Chain Realities in a Live Plant Operation

    Maintaining a smooth flow of starting materials supports uninterrupted output of (3-Chlorophenyl)(phenyl)methanone. Occasionally, external supply shocks—temporary plant closures upstream or tightening of critical catalysts—force creative workarounds. Our operations team reviews contingency plans every quarter, in tandem with on-site logistics staff and trusted haulers. These measures do not keep delays from occurring, but limit their effect and keep customers looped in ahead of cycle times. Years in the field have shown that clear communication reduces last-minute surprises and missed production runs down the line.

    Recent bottlenecks in chlorobenzene supply led to a short-term push for alternate warehousing and expanded capacity at partner plants. By keeping a steady dialogue with raw material producers, and backing up with multiple shipping lanes, we safeguard continuity—not just for ourselves, but for each project downstream that banks on timely input.

    Another supply lesson: nothing replaces regular direct visits. Periodic site audits at our own and partner storage facilities let us spot early signs of contamination or mishandled stock—issues invisible in a digital ordering system. Fine-tuning packing lines to cut dust generation and reduce handling steps not only saves cost, but ensures each container delivers uncompromised quality.

    Facing Regulatory Requirements and Documentation

    Real E-E-A-T compliance does not come from reading codes and labeling protocols. Instead, regular interaction with industry safety groups and local regulatory bodies shaped our plant’s risk management approach. Each batch receives more than a certificate—it’s logged with material traceability from raw input to shipment. This tight record-keeping provides downstream users with the reassurance, and often the baseline documentation, vital to meet their own registration or submission requirements.

    Plant employees take regular training on updated GHS labeling, waste disposal handling, and emergency response. Beyond documentation, supervisors stage mock drills and record lessons for continual safety improvement. Fielding customer questions about new workplace exposure limits or international classifications, we find that real familiarity with day-to-day plant safety builds trust, not just compliance paperwork.

    Supporting User Success: Beyond the Material

    Every container of (3-Chlorophenyl)(phenyl)methanone reflects a trail of continuous improvements and steady dialogue with users. We emphasize clarity in COA reporting, batch-specific trace contaminant disclosure, and fast response to questions about reordering or unusual end uses. While most requests follow familiar patterns, the greatest results come from listening closely to unexpected needs—like supplying lots in custom particle sizes for pilot reactors or adjusting packaging after changing national freight codes.

    Our technical team operates as a bridge between factory floor and customer bench, not just a support ticket. Addressing customer complaints sometimes means digging through production logs to uncover root causes, implementing plant changes, and following up through every subsequent run. Over time, that built-in accountability rewards both sides—users count on a ready fix and tailored recommendation, and our own production crew learns how changes affect actual performance in live chemical processes.

    We see many requests for copies of analytical results and stability data. Providing these documents, along with insight into manufacturing practices, gives downstream teams confidence—not by making claims, but by showing detailed factory know-how. This documentation cycle does not stop with shipment; customer feedback on batch performance feeds straight back into next production.

    A Broad Use Spectrum: Pharma, Agrochemicals, and Materials Science

    Over time, (3-Chlorophenyl)(phenyl)methanone has shown strong utility as a synthetic building block. Labs working on non-steroidal anti-inflammatory agents routinely screen new analogs using this ketone, capitalizing on the effect of chlorine to modify both potency and selectivity in finished APIs. Chemists in crop science value the compound for its stability and reactivity in constructing candidate molecules for pesticide and herbicide screening pipelines.

    Several material science teams, especially those developing polymers or optoelectronic precursors, source the molecule for its tunable electronic characteristics. The ability of the ketone to move electrons between rings (modulated by the chlorine atom) provides pathways for designing small-molecule semiconductors, specialty resins, or even photoactive coatings.

    Academic projects, pressed for reliable source material but often operating at modest scale, point to the importance of detailed batch records and willingness to provide support across scale—attributes that trace their roots not just to quality specs, but to years of experienced manufacturing practice.

    Continuous Improvement: Lessons from the Manufacturing Line

    The reality of making a specialty intermediate means finding small but crucial tweaks, year after year. Our plant team keeps records of changes to unit operations, like optimizing reaction times to cut side-product formation, or adjusting filtration media to improve throughput and minimize batch losses. Success in high-purity chemical production owes as much to steady on-the-floor observation as to upstream engineering controls.

    We encourage staff—from the night shift reactor operator to the on-call analytical chemist—to log unexpected process observations. Sometimes, a stray note about a new odor or a stubborn filter cake leads to systematic change. That open line between operations and QC groups forms the bedrock for consistency that users recognize in our (3-Chlorophenyl)(phenyl)methanone—and gives them real grounds for confidence.

    Final Thoughts: Building Trust Through Practical Know-How

    As a chemical manufacturer, our perspective on (3-Chlorophenyl)(phenyl)methanone comes from direct engagement with every stage of its creation. We place a premium on process integrity and open communication, taking in feedback and sharing lessons that keep each lot both predictable and usable down the line. Beyond purity alone, the true value comes from the connections—between plant staff, technical support, and end users—created in the course of making and shipping this product.

    People working with chemicals do not need polished sales pitches. They rely on information that comes from practical experience and plainspoken engagement. Manufacturing (3-Chlorophenyl)(phenyl)methanone year after year, we have seen what matters on the ground: fast turnaround on questions, clarity in handling and storage guidance, responsiveness to new needs, and a willingness to keep refining our process every step forward. This spirit defines what users receive from us—not an item off a shelf, but the benefits of a decades-honed partnership rooted in real chemical manufacturing.