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3-Chloroadamantane-1-Carboxylic Acid

    • Product Name 3-Chloroadamantane-1-Carboxylic Acid
    • Alias 3-Chloroadamantanecarboxylic acid
    • Einecs 625-525-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    983241

    Chemical Name 3-Chloroadamantane-1-Carboxylic Acid
    Molecular Formula C11H15ClO2
    Molecular Weight 214.69 g/mol
    Cas Number 933941-16-9
    Appearance White to off-white solid
    Purity Typically ≥98%
    Melting Point Approximately 200-203°C
    Solubility In Water Slightly soluble
    Smiles C1C2CC3CC1CC(C2)(C3)C(=O)OCl
    Inchi Key RSKHKDZEZSBZNV-UHFFFAOYSA-N
    Storage Conditions Store at 2-8°C, protected from light and moisture
    Hazard Statements May cause skin and eye irritation
    Synonyms 3-Chloro-1-adamantanecarboxylic acid

    As an accredited 3-Chloroadamantane-1-Carboxylic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 25 grams of 3-Chloroadamantane-1-Carboxylic Acid, labeled with hazard warnings, chemical identifiers, and batch number.
    Shipping 3-Chloroadamantane-1-Carboxylic Acid is shipped in tightly sealed containers, protected from moisture and light. It is handled as a non-hazardous, stable solid, but standard precautions—such as wearing gloves and goggles—should be taken. The package is labeled per regulatory requirements and shipped via ground or air, depending on destination and urgency.
    Storage **Storage of 3-Chloroadamantane-1-Carboxylic Acid:** Store in a tightly closed container in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizing agents. Protect from moisture and direct sunlight. Use appropriate personal protective equipment when handling. Keep the container clearly labeled, away from sources of heat and ignition, and ensure good ventilation in the storage area.
    Application of 3-Chloroadamantane-1-Carboxylic Acid

    Applications of 3-Chloroadamantane-1-Carboxylic Acid in Industrial Manufacturing

    3-Chloroadamantane-1-Carboxylic Acid plays key roles in the synthesis of specialty chemicals, pharmaceutical intermediates, and advanced materials. As a direct manufacturer, we supply this material to major downstream sectors requiring strict adherence to technical and regulatory demands, consistent processability, and defined product performance.

    1. Pharmaceutical Intermediate for CNS Drug Synthesis

    This compound acts as a high-value intermediate during the synthesis of adamantane-based structures for central nervous system (CNS) drugs. Medicinal manufacturers use it chiefly in the elaboration of antiviral and antiparkinsonian actives. The acid group allows site-specific substitutions via acylation or amidation reactions, which occurs prior to final cyclization during API production. The process typically requires high purity and tightly controlled residual solvent content due to the strict requirements for API manufacturing.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice for APIs)
    • 21 CFR Parts 210/211 (US FDA cGMP regulations)
    • European Pharmacopoeia monographs (structure-specific intermediate)
    • USP quality guidelines for process chemicals

    Typical usage ratio

    • 0.9–1.3 molar equivalents relative to the target API core scaffold; exact ratio varies by synthetic step, with excess often used for yield optimization and final acid neutralization during purification.

    Downstream process integration

    • Included during side-chain introduction or ring-closure stage.
    • Used in condensation or amidation under controlled temperature (70–130°C).
    • Subjected to recrystallization or column purification prior to next synthetic step.
    • Meets strict impurity threshold (<0.1% w/w for regulated markets).

    Final product types

    • Antiviral actives (amantadine derivatives)
    • Parkinson’s disease medications
    • Neuroprotective agents
    • Research-use bulk drug intermediates for CNS pipeline candidates

    2. Building Block for High-Performance Polymer Additives

    Chemical processors incorporate 3-Chloroadamantane-1-Carboxylic Acid into advanced polymer additives aimed at improving heat resistance and dimensional stability. The adamantane core imparts rigidity, while the substituted acid allows for further esterification or amidation, forming dispersible modifiers. Sourcing from a verified manufacturer ensures batch-to-batch consistency essential for scale-up to industrial plastics and coatings. Downstream blenders assess reactivity for specific base resin systems and optimize ratios to balance processability with property enhancements.

    Industry compliance standards

    • REACH registration (EU, EC 1907/2006)
    • RoHS Directive (2011/65/EU, for electronics polymers)
    • ISO 9001:2015 quality management system
    • ASTM D256, D648, and D790 for plastics and modifiers

    Typical usage ratio

    • 0.5–3.0 phr (parts per hundred resin) in thermoplastic systems; formulation optimized depending on desired glass transition and thermal stability upgrade—polycarbonate and epoxy base materials require lower levels, while specialty polyimides may use higher ratios.

    Downstream process integration

    • Added during masterbatch or additive concentrate production via melt blending or solvent compounding.
    • Introduced as a pre-reacted monomer or co-monomer for grafting into polymer backbones for high-performance plastics.
    • Requires uniform dispersion for consistent material properties; manufacturers implement twin-screw extrusion or high-shear mixing for integration.
    • Tested for additive migration, compatibility, and impact on mechanical strength post-curing.

    Final product types

    • High-temperature-resistant electronic housings
    • Specialty films for industrial laminates
    • Coating additives for corrosion and wear control
    • Polymer blends for automotive and aerospace applications

    3. Structural Motif in Functional Organic Electronics

    Manufacturers of organic electronic materials source this compound for incorporation into new functional motifs targeting enhanced electron mobility and stability. Its rigid adamantane structure stabilizes molecular stacking in organic semiconductors, while the carboxylic group facilitates covalent tethering to other aromatic frameworks. Large-scale device material producers prefer supply consistency and fine particle size control to support reproducible film casting and device fabrication. Custom purification addresses the low metal content required for OLED or OPV (organic photovoltaic) materials.

    Industry compliance standards

    • IEC 62899-202 series for printed electronics
    • ISO 14001:2015 (environmental management for chemical processing)
    • RoHS/REACH for functional small molecules
    • IPC-6013 (flexible circuit board materials)

    Typical usage ratio

    • 1–5% w/w in semiconductor precursor solutions; the specific ratio aligns with the donor/acceptor architecture of the device stack—higher levels for OFETs, lower levels for tunable OLED hosts.

    Downstream process integration

    • Dissolved in high-boiling organic solvents and deposited by spin coating, inkjet printing, or vapor phase methods.
    • Integrated during final small molecule or polymer synthesis as a co-monomer to fix morphology and optimize molecular alignment.
    • Tested for film-forming capability, surface energy compatibility, and impurity profile.
    • Ongoing batch validation by thin-film performance testing and photoluminescence measurements.

    Final product types

    • Organic light-emitting diodes (OLEDs)
    • Organic field-effect transistors (OFETs)
    • Active media for flexible sensors
    • Functional layers in hybrid photovoltaic devices

    4. Precursor for Advanced Chemical Research and Specialty Reagents

    Academic and industrial R&D centers utilize 3-Chloroadamantane-1-Carboxylic Acid as a tailor-made precursor for exploring new molecular transformations. Researchers exploit the adamantane core’s steric effect and the chlorinated position to develop sterically hindered ligands, chiral auxiliaries, or as templates in catalysis studies. Production batches must guarantee high assay and NMR traceability. Institutions expect comprehensive supporting analytical documentation and COA traceability for grant-based research programs and scale-outs into process chemistry pilot plants.

    Industry compliance standards

    • ISO/IEC 17025 (analytical laboratory competence)
    • Good Laboratory Practice (GLP, OECD Guidelines)
    • Material Safety Data Sheet (MSDS) completeness under GHS (CLP Regulation, EC No 1272/2008)
    • Internal quality requirements for research substances (purity >98%, documented impurity and trace metal profiles)

    Typical usage ratio

    • Experimental scale: 10 mg–5 g per trial; pilot studies: 0.1–2% molar equivalents based on the specific reaction and target molecule complexity; adjusted by desired conversion efficiency and selectivity in multi-step syntheses.

    Downstream process integration

    • Applied in directed ortho-lithiation and cross-coupling studies for complex molecule construction.
    • Used as a chiral source or template in asymmetric catalysis investigations.
    • Incorporated during base-catalyzed or acid-promoted transformations needing rigid frameworks.
    • Supplied with supporting spectra and reagent traceability as per research project documentation mandates.

    Final product types

    • Sterically hindered ligands for metal catalysis
    • Chiral auxiliaries for enantioselective synthesis
    • Intermediates for new drug and material candidates under development
    • Reference standards for analytical calibration
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    Certification & Compliance
    More Introduction

    Introducing 3-Chloroadamantane-1-Carboxylic Acid: Performance, Reliability, and Value

    What We’ve Learned From Years of Manufacturing

    In our line of work, chemical manufacturing is about more than reaction vessels and process controls. Every batch, every shipment rides on the back of real decisions and genuine expertise. One compound that’s risen in prominence among our speciality offerings is 3-Chloroadamantane-1-Carboxylic Acid, with the molecular formula C11H15ClO2. By direct experience, we’ve seen this compound open possibilities in everything from research projects to industrial synthesis, acting as a bridge between innovative chemistries and practical application. Our familiarity with 3-Chloroadamantane-1-Carboxylic Acid hasn’t grown from reading literature alone; it’s come from hands-on development, scaling, and troubleshooting in our own reactors.

    The Product in Detail: Understanding Its Role

    3-Chloroadamantane-1-Carboxylic Acid doesn’t draw immediate recognition outside scientific circles. Within organic synthesis, its adamantane core stands out for its rigidity, stability, and capacity for substitution at multiple positions. The presence of a carboxylic acid group and a chlorine atom at specific locations on the cage give this molecule a set of properties hard to match elsewhere.

    We manufacture this product under controlled environments with a focus on repeatability. Volatility, purity, and batch-to-batch consistency are tracked at every stage. Extensive in-house validation routines ensure low levels of residual solvents and chlorinated by-products, which we’ve found can make or break downstream applications for many of our customers. Users value our product because we don’t just chase analytical numbers; we optimize reaction conditions to suppress unwanted side reactions, producing cleaner lots with a narrow impurity profile.

    Tangible Specifications That Matter in Practice

    We typically offer 3-Chloroadamantane-1-Carboxylic Acid in the form of a white to off-white crystalline powder, with purity levels confirmed by HPLC and supported by NMR and mass spectrometry. Most customers request purities above 98%, and we’ve tuned our processes to comfortably exceed this threshold on a regular basis. Melting point sits in the expected range near 183-185 °C, providing thermal stability during further transformations.

    Moisture sensitivity rarely raises complications with this molecule, but our experience has shown that tight packaging in inert atmospheres extends shelf-life and minimizes product caking. From our production logs, optimal storage below 25 °C and away from direct sunlight maintains the material’s original quality for over two years.

    We’ve fielded many requests for custom particle size cuts, but for most synthetic workflows, our standard milling delivers a free-flowing material that weighs out easily. No additional bulking agents or flow aids find their way into our product, a decision based on feedback from chemists who have seen process oddities when working with heavily modified grades.

    Why Many Customers Reach for the Adamantane Core

    Our direct conversations with leading research chemists and process engineers show a clear pattern. The adamantane backbone brings three-dimensional shape and molecular rigidity unavailable in typical aromatic scaffolds. That cage-like structure changes the way attached functional groups behave, which influences physical properties and reaction profiles down the line.

    When a chlorine atom is slotted at the 3-position, and a carboxyl at the bridgehead, the resulting compound offers a unique mix of lipophilicity, stability, and reactivity. We’ve seen this configuration chosen as an intermediate for high-value pharmaceutical building blocks, advanced materials, and catalyst anchors.

    The difference between 3-Chloroadamantane-1-Carboxylic Acid and more conventional acid chlorides or benzoic acids hinges on more than just a change in core structure. In our pilot projects with several external partners, the increased bulk and shaped topology of adamantane derivatives altered solubility, permeability, and resistance to hydrolysis in downstream steps. These are tangible benefits not captured by simple purity stats.

    Our Experience With Downstream Applications

    Every year, we consult with companies and universities looking to unlock new synthetic methodologies. In many cases, they select our 3-Chloroadamantane-1-Carboxylic Acid for its ability to act as a protected building block or a point of attachment in complex molecule assembly.

    Pharmaceutical researchers account for a large portion of our custom orders. Their molecular modeling teams spot benefits in the adamantane core that translate into better bioavailability and metabolite stability for new candidate drugs. One example came from a team synthesizing protease inhibitors, where our product anchored the active ingredient, shielding it from premature breakdown. Others leverage the core’s bulkiness to create sterically hindered ligands – a key asset when modifying surface properties in medical polymers.

    We’ve also watched as material science innovators gravitate towards this compound during the design of nanostructured coatings. The rigid, symmetric nature of the adamantane group enables predictable packing in thin films or hybrid organic-inorganic networks. Our records show multiple instances where a switch from planar benzoic acids to our product improved coating uniformity and robustness.

    Chemical methodology developers bring a different set of requirements. They report success using 3-Chloroadamantane-1-Carboxylic Acid as a stable, isolable intermediate before introducing more reactive or delicate groups. Our strict impurity controls matter here, since even small side-products can derail multi-step syntheses or cause unknowns in analytical runs.

    We actively engage in NDAs and collaborative research to help solve real-world problems. In this work, we draw on our own internal capabilities: scale-up, custom synthesis, and tailored purification methods. This isn’t “off-the-shelf” supply — our approach involves listening, adjusting, and applying what we’ve learned from years of chemical troubleshooting.

    Why We Don’t Treat All Orders Alike

    Some manufacturers shy away from custom requests or see them as distractions. We take a different view. In our experience, the specific needs of a customer — whether for analytical reference, large-scale production, or new product development — guide us in refining processes, reducing waste, and forecasting trends in demand.

    For 3-Chloroadamantane-1-Carboxylic Acid, this mindset led us to invest in flexible production lines and dedicated analytical testing. We support a variety of pack sizes, from small vials for discovery through to multi-kg lots for industrial partners. Our logistics crew has tackled jobs requiring just-in-time delivery, cold chain shipment, and global regulatory documentation.

    Standard off-the-shelf options only get so far. We’ve seen genuine differences in how various end users handle, dissolve, derivatize, or formulate the compound. Open communication with our technical support teams gets issues solved before they grow into bottlenecks or downtime.

    How Our Product Differs From Alternatives

    Knowledge comes from comparison as much as from invention. Many chemists ask how our 3-Chloroadamantane-1-Carboxylic Acid diverges from the substitutes they’ve used before. We often get questions comparing our molecule to simple adamantane carboxylic acids, chlorinated aromatics, or generic industrial intermediates.

    On a technical level, the introduction of a chlorine at the 3-position unlocks reactivity channels not found in the parent acid. We’ve participated in coupling reactions where alternative molecules simply can’t match the regioselectivity or stability under basic or oxidative conditions. Gains in yield or reduction in isolation pain points stem from this detail, and our own measurements track these project by project.

    In direct process comparisons with generic alternatives, labs told us they hit fewer purification steps and spent less time verifying identity and structure. These are not marketing points — they come straight from batch report reviews, where waste reduction and cycle time stack up against budget lines.

    Environmental performance enters as well. Because adamantane-based compounds weather exposure to heat and light better than many aromatics, our customers in materials science push these substances further. They report improved aging profiles and thermal resistance, which we confirm through our own accelerated storage trials.

    It’s not unusual for a purchasing team to reach out after years with a competitor, then stick with our material because of lower lot-to-lot variability and a support team that knows the synthetic history behind the product. We track feedback; it influences our operational decisions from solvent selection to batch size planning. This loop – production, customer use, feedback, revision – sets our approach apart from repackagers and traders, whose only touchpoint comes when a container ships out the door.

    Quality and Compliance: Direct From Source

    Manufacturing 3-Chloroadamantane-1-Carboxylic Acid isn’t just a matter of running a recipe. We maintain an in-house quality system aligned with key international standards, and we document every material movement, test, and hand-off. Our staff carry out identity and purity checks using validated analytical methods, and all data is recorded in tamper-proof logs.

    This commitment extends to sustainability and safety. Our process engineers focus on reducing process waste and emissions, choosing greener reagents where available, and incorporating inline monitoring. We invest in employee training programs so every operator understands precautions, safe-handling, and documentation. Safety Data Sheets ship with every lot, and our technical support team remains available for post-delivery questions on handling and disposal.

    As regulations change, we monitor new guidance and update practices accordingly. We register products where required and ensure labeling supports correct risk management by downstream users. Our regulatory and documentation team tracks updates to ensure nothing slips through a gap that might trip up a customer’s audit or compliance check.

    Our traceability practices grow out of hard experience. Tracking raw materials, tracking finished lots, and tracking customer use all serve to minimize risk and support quick response in the rare event of a problem. This discipline built over years of supply — spikes, disruptions, laboratory runs, and scale-ups — pays off in both product reliability and confidence for our partners.

    Day-to-Day Manufacturing: Real-World Decisions

    On the shop floor and in the plant, manufacturing this product presents practical challenges not always obvious to the outsider. Batch reproducibility, resource planning, environmental controls — these aren’t abstract management topics, they are daily concerns. Our operators run real-time analytics at key stages to catch shifts in reaction conversions and impurity profiles. Adjustments aren’t always made to meet a theoretical optimum, but to deliver a product that matches what chemists and engineers actually need.

    Inventory cycles for key precursors and solvents need close control. Supply disruptions or price spikes have taught us to qualify secondary sources — a lesson best learned before the market hits a crunch. We keep a tight grip on process documentation, not to fill filing cabinets, but because solving a deviation in yield, color, or assay sometimes means tracing a single drum through its journey.

    Many in our team started out as bench chemists, so the conversations around here favor practical fixes, not perfect theoretical solutions. We know that process tweaks, temperature staging, and crystallization methods alter final product features in ways that affect not only purity but also downstream ease of use. Packing, sealing, and labeling receive just as much care. These steps mean fewer surprises, whether the compound moves across a county or across borders.

    Partnership Over Transaction

    Through regular dialogue with our customers, we continue to evolve our offering. Whether you’re trialing a new reaction or scaling to a thousand liters, our support doesn’t end with the delivery receipt. Our team values the feedback loop: understanding problems, running small-scale recreations, recommending tweaks, even redesigning workflows when necessary. This approach keeps us sharp and ensures that recurring and new customers both see constant improvement in both product and process.

    We’ve spent years honing supply, testing, and distribution — not just for 3-Chloroadamantane-1-Carboxylic Acid, but for the broader suite of adamantane derivatives and specialty organics. By staying close to the application side, we bridge the gap between chemical theory and market need. Every lot produced connects to a constellation of decisions, many learned the hard way. This shows up in the continuity and reliability our users value most.

    Opportunities, Challenges, and Solutions From the Workshop

    Demand for high-performance specialty chemicals will only grow, but so will the complexity of regulatory, supply chain, and scientific landscapes. Over years, we’ve seen breakthroughs, shortages, market swings, and regulatory shifts. For every challenge, we found the answer in a mix of deep process knowledge and the hands-on practicality that comes from actually making the chemicals you sell.

    Supply disruptions often begin with upstream feedstock shortages or logistics hiccups. We respond by fostering relationships with multiple raw material suppliers and maintaining on-site safety stocks. Anticipating trends by staying close to research and customer projects gives us the edge in adjusting volumes and maintaining stable supply even during spikes.

    Process performance can’t be left to chance. Our engineers work to fine-tune reaction times, solvent quality, and purification steps. Practical improvements – such as optimizing crystallization cycles or updating drying equipment – often deliver more in reliability than a stack of theoretical modeling. We maintain a robust schedule of preventive maintenance with backup equipment on standby, reducing risk of downtime.

    Customer-driven requests for tighter purity, custom batches, or reformulation spur internal development projects. Some ask for alternative packaging, others for documentation to help with regulatory filings. These problem-solving cycles are grounded in dialogue, experimentation, and the resolve to ship only when specifications are met.

    Safety matters at every step. Operating with carboxylic acids and chlorinated compounds brings specific exposure risks, so we invest in continual training and controls on site. Our culture encourages near-miss reporting and regular safety review. Rather than just reacting to external compliance, we aim to set the practice standard for our region, which means constantly refining the way teams handle, transfer, and store both intermediates and waste.

    Where customers worry about environmental and sustainability impact, we offer transparent information on waste handling, emissions, and route selection. Our efforts to reduce hazardous solvents or switch to milder reagents connect directly to real-world environmental outcomes. These aren’t only regulatory responsibilities — they matter to our employees and support the broader commitment to responsible manufacturing.

    Looking Forward: The Path Ahead in Specialty Chemical Manufacturing

    The demand landscape for adamantane derivatives, including products like 3-Chloroadamantane-1-Carboxylic Acid, grows more sophisticated every year. This isn’t just about quantities — it’s about quality, responsiveness, and insight into where customer needs intersect with technical possibility. As we look ahead, we know success depends on never standing still. That means continuing to invest in process innovation, new purification methods, and ongoing communication with users and research teams.

    Experience remains our greatest tool. The accumulated know-how from thousands of batches, the troubleshooting skills sharpened in both quiet and chaotic times, and the willingness to challenge old assumptions all feed into stronger products and partnerships.

    Every gram shipped carries the weight of these lessons. In practice, this translates to fewer headaches, more reliable process runs, and the steady progress that comes from real hands-on chemical manufacturing.