Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
Follow us:

3-Chloro-N-(Chloroacetyl)-4-Fluoroaniline

    • Product Name 3-Chloro-N-(Chloroacetyl)-4-Fluoroaniline
    • Alias SCHEMBL819910
    • Einecs 409-260-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    461225

    Product Name 3-Chloro-N-(Chloroacetyl)-4-Fluoroaniline
    Molecular Formula C8H6Cl2FNO
    Molecular Weight 222.05 g/mol
    Cas Number 864179-51-5
    Appearance White to off-white solid
    Solubility Slightly soluble in organic solvents
    Purity Typically ≥98%
    Storage Conditions Store in a cool, dry place, tightly closed
    Synonyms N-(Chloroacetyl)-3-chloro-4-fluoroaniline
    Smiles ClCC(=O)NC1=CC(=C(C=C1)F)Cl
    Inchi InChI=1S/C8H6Cl2FNO/c9-4-8(13)12-6-2-1-5(11)7(10)3-6/h1-3H,4H2,(H,12,13)

    As an accredited 3-Chloro-N-(Chloroacetyl)-4-Fluoroaniline factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle with tamper-evident seal, labeled "3-Chloro-N-(Chloroacetyl)-4-Fluoroaniline, 25g," including hazard symbols and safety instructions.
    Shipping The chemical **3-Chloro-N-(Chloroacetyl)-4-Fluoroaniline** is shipped in tightly sealed, chemically resistant containers, clearly labeled with hazard information. It is transported under ambient conditions, away from incompatible substances, and in compliance with local and international regulations for hazardous materials. Proper documentation and handling protocols are strictly followed to ensure safety.
    Storage Store 3-Chloro-N-(Chloroacetyl)-4-Fluoroaniline in a tightly sealed container, in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers and bases. Keep away from direct sunlight and sources of ignition. Handle with appropriate personal protective equipment (PPE). Store at room temperature and protect from moisture. Follow all relevant safety and regulatory guidelines for hazardous chemicals.
    Application of 3-Chloro-N-(Chloroacetyl)-4-Fluoroaniline

    Applications of 3-Chloro-N-(Chloroacetyl)-4-Fluoroaniline in Industrial Manufacturing

    3-Chloro-N-(Chloroacetyl)-4-Fluoroaniline serves as a critical intermediate in several specialty and fine chemical industries. Our direct synthesis capability ensures consistently high purity and traceability for regulated sectors requiring batch-to-batch reproducibility. Below we highlight key downstream applications recognized and established within compliant manufacturing environments.

    1. Agrochemical Synthesis: Selective Herbicide Intermediate

    Within the agrochemical sector, this compound acts as a core building block for the preparation of selected chloroacetamide-based herbicides. Process engineers frequently deploy it during the condensation stage with various aromatic or heterocyclic partners, optimizing yield for high-selectivity post-emergence herbicides. Our production complies strictly with statutory residue and off-target activity regulations set by global authorities.

    Industry compliance standards

    • EPA 40 CFR Part 180 (U.S. pesticide residue tolerances)
    • EU Regulation (EC) No 1107/2009 on plant protection products
    • China GB 2763 food safety for maximum residue limits
    • ISO 9001 certified quality management system

    Typical usage ratio

    • 20–30% w/w of total active ingredient blend; optimize according to target weed spectrum and local regulatory limits on AI loading

    Downstream process integration

    • Enters as condensation partner after initial chlorination of aromatic feedstock
    • Subjected to controlled temperature and pH to maximize selectivity
    • QC samples withdrawn for LC-MS residue analysis throughout batch

    Final product types

    • Post-emergence grass and broadleaf herbicide concentrates (liquid, suspension, microcapsule)
    • Water-dispersible granules for crop protection
    • Tank-mix formulations for cereal crop weed management

    2. Pharmaceutical Intermediate: Fluorinated Phenyl Drug Scaffold

    The compound plays a pivotal role for API manufacturers, especially in the development of fluorinated phenyl-containing pharmaceuticals such as enzyme inhibitors and anti-inflammatory agents. Chemists employ it to introduce chlorine and fluorine groups into core scaffolds, supporting SAR explorations. All batches adhere to stringent GMP and ICH Q7 guidelines for intermediate handling and impurity traceability.

    Industry compliance standards

    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • EU GMP Guidelines, Part II
    • US FDA 21 CFR Part 211 (finished pharmaceuticals)
    • USP/NF reference standards and monographs (as relevant to API project)

    Typical usage ratio

    • 0.5–3 molar equiv. relative to nucleophilic partner in stepwise synthesis; adjusted during scale-up for yield and impurity profiles

    Downstream process integration

    • Incorporated during core formation via nucleophilic aromatic substitution
    • Parallel impurity profiling and in-process HPLC monitoring
    • Hand-off to API synthesis after crystallization and solvent exchange

    Final product types

    • Non-steroidal anti-inflammatory intermediates
    • Fluorinated kinase inhibitor building blocks
    • Advanced pharmaceutical intermediates for clinical trial APIs

    3. Specialty Dye and Pigment Manufacturing

    Dye and pigment manufacturers integrate this compound to synthesize novel azo and anthraquinone dyes with enhanced lightfastness and chemical stability. The dual halogen and fluoro functionalities enable the creation of specialty shades for technical textiles and security inks. Our facility delivers high-purity lots to support both mass tonnage and batch-tinting operations.

    Industry compliance standards

    • ISO 9001 (Colorant Quality Systems)
    • OEKO-TEX Standard 100 (Textile chemical safety requirements)
    • EU REACH Annex XVII for restricted aromatic amines
    • ZDHC MRSL V3.0 (Zero Discharge of Hazardous Chemicals List)

    Typical usage ratio

    • 1–15% w/w in dye intermediate synthesis, based on chromophore extension and color depth requirements

    Downstream process integration

    • Employed during coupling steps with diazonium salts or naphthol derivatives
    • Subjected to pH cycling and temperature holding for color consistency
    • Wet cake processed to isolate final chromogenic entity

    Final product types

    • High-performance textile dyes for polyester and polyamide fibers
    • Technical pigments for plastic and automotive coatings
    • Invisible/UV security inks for document authentication

    4. Advanced Materials: Electronic Chemical Precursors

    Within the electronics chemical sector, the molecule is a precursor for creating functional aromatic fluorinated intermediates essential for specialty polymers and photoresists. Material scientists integrate it into synthetic routes for fine-tuning thermal and dielectric properties. Each production lot is monitored for trace metals and ionic contaminants in line with semiconductor requirements.

    Industry compliance standards

    • SEMI C93.1: Specification for High Purity Chemicals for Microlithography
    • IEC 62474 (Material declaration for electrical/electronic products)
    • RoHS Directive 2011/65/EU compliance for hazardous substances
    • ISO 14001 environmental management

    Typical usage ratio

    • 2–8% by weight in precursor blend for specialty polymerization, varies by end-use dielectric and flexibility benchmarks

    Downstream process integration

    • Introduced during monomer feed blending prior to polymerization
    • Monitored for residual halide and fluorine content post-synthesis
    • Transferred via high-purity dedicated lines to avoid cross-contamination

    Final product types

    • High dielectric constant fluoropolymers for printed circuit boards
    • Photoresist materials for photolithographic patterning
    • Low-κ insulating films for semiconductor fabrication
    Free Quote

    Competitive 3-Chloro-N-(Chloroacetyl)-4-Fluoroaniline prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    3-Chloro-N-(Chloroacetyl)-4-Fluoroaniline: Precision, Reliability, and Experience Behind Every Batch

    Introduction

    At our production site, every bag and drum of 3-Chloro-N-(Chloroacetyl)-4-Fluoroaniline follows the same simple philosophy: nothing beats accuracy you can rely on. This isn’t just about a finished chemical; it’s decades of manufacturing know-how working alongside technicians who know the process inside out. The compound, known for its distinctive dual halogenation pattern combined with a fluorinated aromatic ring, provides unique reactive value to professionals demanding something more than off-the-shelf chemicals.

    Market pressure for efficiency and purity doesn’t come from nowhere. It’s shaped by real downstream consequences—cost control, control of byproducts, consistent yields, and stricter regulatory scrutiny. We’ve seen projects go sideways when input materials lack the uniformity that only comes from experience-led manufacturing. We design our runs of 3-Chloro-N-(Chloroacetyl)-4-Fluoroaniline to minimize these headaches long before drums leave our warehouse.

    Product Overview and Specifications

    3-Chloro-N-(Chloroacetyl)-4-Fluoroaniline stands out with a carefully managed synthesis that keeps control over all critical variables—temperature, reaction time, feed ratios—because anything less shows up in the analytics. Every run features HPLC and GC checks, so any profile drifting from our tight standards gets flagged for full review. The compound carries a crisp, off-white crystalline solid or powder profile, usually clocking above 98% purity. We deliver material in a range of particle sizes, from fine powder for solution-phase applications to slightly larger crystals for those who value lower dust.

    We understand the importance of minimized residual solvents, which is why each batch includes full trace solvent analysis Reports don’t hide any outliers. Water content too high? That batch will never get packed out. Chloroacetyl and fluoro-functionalized compounds like this one see significant demand for their performance in coupling reactions and targeted syntheses, so meeting specification means long-term project stability for our partners.

    The Real-World Value: More Than Just a Reagent

    The market for anilines has seen a flood of mediocrity—low-reactivity side products, sloppily crystallized solids, fluctuating impurities, powders that cake or absorb moisture on contact. We stopped accepting those as ‘normal’ years ago. 3-Chloro-N-(Chloroacetyl)-4-Fluoroaniline delivers tightness in chemical profile. Our batches show a consistent melting range and low impurity baseline, reducing the risk that someone further down the supply chain has to chase contaminants or write off a production run because of unreliable upstream input.

    Each gram brings direct, honest value—something we’ve learned is non-negotiable for manufacturers who depend on predictable chemistry. Whether a customer is developing novel agrochemical actives or scaling up a pharmaceutical API intermediate, the operational value traces directly from careful, practical manufacturing.

    Applications: Chemistry That Delivers

    Practitioners in pharmaceuticals, specialty chemicals, and crop science turn to 3-Chloro-N-(Chloroacetyl)-4-Fluoroaniline for situations demanding both reactivity and selectivity. Its use in targeted acylation and amide formation steps gives chemists a handle on reaction predictability, even as complexity ratchets up in multi-step synthesis projects. Some customers rely on its chloroacetyl group for streamlined conjugation reactions, targeting small molecule pharmaceutical intermediates that require an exact chemical fingerprint.

    The presence of both chlorine and fluorine modifies the reactivity pattern of the aniline ring, giving process chemists more latitude to tune yields and moderate undesired side-reactions. We’ve seen this translate to fewer process upsets, and clearer in-process control points—a real advantage when timelines run tight and material budgets leave no room for waste.

    Why Our Manufacturing Experience Matters

    Decades of hands-on work with halogenated anilines taught us several hard-won lessons. Not every supplier that can provide a product code can deliver a true industrial-grade 3-Chloro-N-(Chloroacetyl)-4-Fluoroaniline. Many intermediates sound identical on paper, but impurities above a certain threshold introduce serious problems—catalyst poisoning, uneven crystallization, laborious purification steps downstream, and ultimately, reduced throughput. Many customers tell us stories where cutting corners led to hours of lost reactor time and missed delivery windows. Our approach: build quality into the process rather than chase it at the end with batch reworks or excessive reprocessing.

    Technical improvements over the years weren’t just upgrades for their own sake. They came from real operational pressure: developing closed process steps to prevent chlorination runaway, switching to high-purity feedstocks to minimize unknown side-product formation, and deploying on-line spectrometry to increase run-to-run reproducibility. We don’t accept just lab-scale purity, but production-scale consistency, batch after batch.

    Product Differences: Clarity in What We Deliver

    Not all aniline intermediates offer the unique halogenation and acyl substitution profile found here. Products with just a single halogen atom or lacking the fluoro group behave very differently during coupling reactions. A less substituted aniline lacks the electron-withdrawing punch the fluorine delivers; skipping the chloroacetyl group means forfeiting functionalization leverage in the final synthetic step. The difference comes out starkly during pilot scale: side-products spike, conversions drop, timelines stretch. Engineers on the ground notice results first—the right raw material cleans up a process, and turns a marginal project into a consistently manageable one.

    Other producers sometimes claim compatibility, but raw profiles show telltale signals—broad melting ranges, pooled brown oils among free-flowing powder, solvent residues above acceptability. We work with no-nonsense in-process analytical checkpoints, so what goes into our container matches the release criteria every time. That real-world difference ends up on production ledgers—fewer stopped batches and fewer troubleshooting calls right before a deadline.

    Handling and Storage: Lessons Learned in Practice

    The best product in the world gets wasted if storage and handling fail. Through years of warehousing, we learned what real-world packaging requires: strong, double-lined bags and inert atmosphere seals for bulk shipments, vapor barriers for long distance export. Temperature excursions and moisture creep are less of an abstract problem and more of a persistent reality in humid months. We track batches that move fastest, monitor shelf behavior, and adjust packaging based on what the field teaches us about transit damage or caking. Buying from manufacturers with a physical commitment to logistics means fewer surprises and keeps product right for direct charging into reactors or for pre-weighed dispensing at partner facilities.

    Every lot carries a full traceability trail. We scan barcodes at each internal checkpoint and commit batch-level sample retains for backwards tracking if anything comes up downstream. Real-world challenges like customs hold-ups or warehouse humidity events led us to improve internal checklists rather than just ‘file away’ a report. Material that doesn’t pass outgoing stability checks gets quarantined, not shipped, so nobody faces a failed synthesis due to shelf instability or packaging error.

    Supporting Sustainable Chemistry

    Manufacturing halogenated intermediates involves environmental responsibility that’s become more pressing every year. Our plant design incorporates solvent recovery and closed recirculation where feasible. We minimize chlorinated effluent by integrating scrubbers and phase separation, pushing output streams through purification before anything leaves the site. Teams track every change in local and national disposal regulations, running pilot programs for solid waste minimization and exploring greener process routes.

    We’ve seen the impact of poor waste control, both economically and politically, across the industry. Local acceptance of chemical manufacturing hinges on more than compliance—it grows from proven long-term commitment. Regular inspections and investment in emission-minimizing upgrades lowered our permit fees and built real trust with the community. Every customer asking about regulatory burden or green chemistry points finds us ready with documentary traceability and experience-backed solutions.

    Process Support and Application Consultation

    Technical support stretches well past the point of sale. We’ve supported technicians and chemists on-site, not just with data sheets but with troubleshooting and continuous improvement calls. Chemists frequently run up against scaling issues—what works on a 2-liter bench can hit a wall in a 5000-liter reactor. Small things matter: agitation speeds, charging protocol, addition sequence, even reactor geometry. Our engineers cross-check incoming questions with actual plant data. This hands-on exchange solves more problems than any generic FAQ ever could. We don’t just move boxes; we invest time to see your process run clean, at yield, with no avoidable stops.

    If a new application needs minor modifications—alternate particle size, custom packaging, or specific certificates—feedback gets integrated into our next production window. Adaptability, built on top of a stable baseline process, produces the results our partners have grown to expect.

    Transparency in Sourcing and Quality Control

    Stories cross our desks every season about opaque supply chains causing real-world process collapses. Hidden outsourcing, unknown counterparty risk, low traceability—these issues wind up as emergency meetings for end users caught in a product shortfall or sudden quality issue. We hold direct control over every stage of our manufacturing—from the loading of base materials to the final packing check—because we’ve seen what breaks down when responsibility spreads too thinly.

    Every supplied lot ships with supporting analytical data, certifications based not on ‘checkbox compliance’ but on actual batch validation. In-process sampling at each critical stage guards against drift. Analytical equipment gets scheduled requalification, and out-of-spec data triggers root cause investigations instead of last-minute product reclassification. Paper trails and on-site audit readiness carry more weight in customer decisions than marketing claims ever could.

    Continuous Improvement and Reliability

    No process stays perfect forever. Over the years, we’ve seen where incremental improvements stack up: reaction charge order, temperature ramping profiles, cycle time shaving, and feedstock sourcing upgrades. We benchmark yields and impurity levels, feeding back learnings to the lab and the line, so every run improves at least on one small front. Operators track run-to-run data, flag split-off trends in impurity peaks, and recommend deviations only if a technical team vouches for safety and quality.

    Metrics from ERP and LIMS get reviewed weekly, not just for regulatory reporting but to keep an eye on strange fluctuations that may link to weather, incoming material variability, or operator shift changes. That kind of attention pays off over time—steadier product performance, satisfied repeat clients, and a real reduction in surprise costs from failed batches or unhappy end users.

    Conclusion: Reliability Grown from Experience

    The difference between 3-Chloro-N-(Chloroacetyl)-4-Fluoroaniline produced by specialists and intermediates offered by volume pushers comes through in the real-world confidence our customers gain. Projects stay on track, chemists sleep better, and costly late-stage failures drop away when you know the chemistry will behave. Years spent refining process, training teams, and building a culture where accountability means sending out only what we ourselves would want to run in our own pilot plant builds a model of reliability that speaks for itself.

    Decisions about raw materials don’t start or end with a price tag—they stand on proven routine, openness, and a stubborn refusal to cut corners. For us, each lot delivered is the product of hands-on work, technical improvement, and the quiet satisfaction of seeing years of experience pay off for someone else’s process.