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3-Chloro-4-Nitrotoluene

    • Product Name 3-Chloro-4-Nitrotoluene
    • Alias 3-Chloro-1-methyl-4-nitrobenzene
    • Einecs 221-635-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    260279

    Cas Number 89-60-1
    Molecular Formula C7H6ClNO2
    Molecular Weight 171.58 g/mol
    Appearance Yellow to orange solid
    Melting Point 54-56 °C
    Boiling Point 272 °C
    Density 1.41 g/cm3
    Solubility In Water Insoluble
    Flash Point 130 °C
    Purity Typically ≥98%
    Smiles CC1=C(C=C(C=C1)Cl)[N+](=O)[O-]
    Registry Number UN 2811
    Refractive Index 1.587 (estimated)
    Synonyms 3-Chloro-4-methylnitrobenzene
    Storage Conditions Store in a cool, dry, well-ventilated place

    As an accredited 3-Chloro-4-Nitrotoluene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 3-Chloro-4-Nitrotoluene is securely packed in a 500g amber glass bottle, labeled with hazard symbols and handling instructions.
    Shipping 3-Chloro-4-Nitrotoluene is shipped as a hazardous material. It should be packed in tightly sealed, chemical-resistant containers, and clearly labeled. Ship via a certified carrier, complying with all local and international regulations (such as DOT, IATA, or IMDG). Handle with care to avoid leaks or exposure during transit.
    Storage 3-Chloro-4-nitrotoluene should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from incompatible substances like strong oxidizers and reducing agents. Protect from heat, moisture, and direct sunlight. The storage area should be equipped with proper ventilation and spill containment measures. Clearly label the container and keep it away from ignition sources.
    Application of 3-Chloro-4-Nitrotoluene

    Applications of 3-Chloro-4-Nitrotoluene in Industrial Manufacturing

    As a primary producer of 3-Chloro-4-Nitrotoluene, we supply this specialized intermediate to several mature industrial sectors where its unique functional groups enable direct downstream synthesis. Our material supports regulated production processes in advanced chemical manufacturing routes. Below we outline the principle applications, each focused on a well-established segment with clear compliance, formulation, processing, and product links.

    1. Agrochemical Synthesis: Herbicide Intermediate

    Agrochemical formulators use this compound in the synthesis of selective herbicides, especially those based on nitroaromatic frameworks where chlorine substitution confers improved field stability and efficacy. Chemical process designers often prefer this intermediate due to its reliable reactivity and compatibility with current catalyst and solvent systems. The chloronitrotoluene scaffold enters late-stage condensation or coupling steps, directly influencing the biological profile of the resulting molecules.

    Industry compliance standards

    • ISO 9001:2015 for production consistency
    • REACH Annex XVII for use in agricultural chemicals
    • US EPA 40 CFR Part 180 for pesticide active ingredient tolerances
    • EU Plant Protection Products Regulation (EC) No 1107/2009

    Typical usage ratio

    • 10–20% weight basis per batch, adjusted based on targeted herbicide analog; variation depends on desired chain extension and substitution pattern in downstream synthesis

    Downstream process integration

    • Introduced after primary aromatic nitration, used in condensation with amines or phenols
    • Step incorporated prior to final oxidative cyclization or sulfonation, depending on herbicide family
    • Tolerance for elevated reaction temperatures and process solvents (DMF, toluene)

    Final product types

    • Triazinone-based selective herbicides
    • Nitrophenyl-urea herbicide actives
    • Substituted aniline growth inhibitors

    2. Dye and Pigment Manufacture: Nitro Aromatic Coupling Agent

    Colorant manufacturers select 3-Chloro-4-Nitrotoluene for the construction of azo and anthraquinone dyes. Its position-specific substitution delivers high-fastness chromophores with increased demand in textile and polymer coloration. The nitro group drives diazotization reactions, while the chloro substituent can either remain for durability or undergo further substitution to diversify shade profiles in subsequent processing.

    Industry compliance standards

    • Oeko-Tex Standard 100 for finished textile dyes
    • ZDHC MRSL for restricted substances in textile wet processing
    • EN 71-7 for colorants in toys and children’s articles
    • ISO 14001 for environmental management during dye synthesis

    Typical usage ratio

    • 15–30% by weight in diazo coupling reactions; exact dosage determined by target dye structure and molar reactivity

    Downstream process integration

    • Feeds into nitro reduction or direct diazotization units
    • Used for mono- or polycoupling with aromatic amines for extended chromophore design
    • Intermediate carried forward into metal complex dye generation or sulfonation for water solubility

    Final product types

    • Disperse dyes for polyester textiles
    • Acid dyes for nylon and wool
    • Solvent-soluble pigments for synthetic fibers

    3. Pharmaceutical Intermediate: API Synthesis Precursor

    APIs utilizing nitro- and chloro-aromatic motifs source this raw material as a key precursor for heterocycle formation. It appears in routes of antihypertensive, antimicrobial, or analgesic compounds where selectivity and traceability are mandatory. Production managers in pharmaceutical synthesis require stringent analytical control and documentation, enforcing robust material traceability from initial charging through to final purification steps.

    Industry compliance standards

    • ICH Q7 GMP for active pharmaceutical ingredients
    • Ph. Eur. and USP monographs for intermediate characterization
    • FDA 21 CFR Part 210/211 for drug manufacturing controls
    • ALCOA+ data integrity principles

    Typical usage ratio

    • Ranges from 5–15% molar basis according to the target heterocycle/biologically active scaffold; adjusted based on target yield and impurity management

    Downstream process integration

    • Charged post-nitration, immediately preceding reduction and cyclization with nitrogen nucleophiles
    • Often involved in catalytic hydrogenation or chlorination steps to provide the final functionalized intermediate
    • Requires high-purity, low-residue input to avoid downstream contamination

    Final product types

    • Sulfonamide antibiotic precursors
    • Pyrimidine-based antihypertensive drug actives
    • Nitroaniline analgesic intermediates

    4. Specialty Chemical Manufacturing: Halonitro Derivative Production

    Producers of halonitro derivatives, essential for fine chemical and material modification, utilize this compound as a building block for custom halogenation or reduction products. Specialty segment users emphasize tight molecular weight and isomeric precision, using rigorous analytical verification to support proprietary downstream transformations in electronics, coatings, or polymer additives.

    Industry compliance standards

    • ISO 9001 quality management for specialty chemicals
    • Responsible Care management systems for industrial safety
    • REACH registration for all supplied downstream uses
    • GHS/CLP labeling and transport compliance under ADR/IMDG

    Typical usage ratio

    • 5–25% by mass per reaction, adapted to molecular engineering targets and process batch scale; ratio tuned to minimize side-product formation

    Downstream process integration

    • Feeds directly into batch reactors for halogenation (Br, F substitution) or selective reduction to diamines
    • Processed under anhydrous or inert atmosphere for controlled reactivity
    • Requires continuous inline monitoring for reaction completeness and color index

    Final product types

    • High-purity halonitro building blocks for electronics
    • Reactive polymer additives for flame retardancy
    • Surface-active agents in specialty coatings

    5. Optical Brightener Intermediate: Benzoxazole Synthesis

    Manufacturers of optical brighteners integrate this compound into benzoxazole core synthesis, a vital intermediate for plastic, textile, and paper whitening agents. The process leverages both the nitro and chloro functionalities to form substituted heterocycles after multi-stage condensation and cyclization with amino acids or phenol derivatives, enabling precise molecular tuning for UV absorbance.

    Industry compliance standards

    • EN ISO 818 for paper and board - determination of optical properties
    • China GB 9685 additive permitted list (for food packaging exposure)
    • OECD Good Laboratory Practice (GLP) for analytical support
    • Textile Eco-Passport (Oeko-Tex) for optical brightener safety

    Typical usage ratio

    • 10–25% by molar proportion in the key condensation/cyclization stage; adjustment based on desired UV absorbance and fluorescence yield

    Downstream process integration

    • Condensation with ortho-aminophenols in solvent phase reactors
    • Cyclization under acid catalysis with heating step to form final benzoxazole ring
    • Purification by recrystallization or column chromatography for color consistency

    Final product types

    • Plastic brighteners for PET and PS resins
    • Optical brightener additives in laundry detergents
    • Paper whitening agents for high-gloss print media
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    Certification & Compliance
    More Introduction

    3-Chloro-4-Nitrotoluene: Practical Strength Rooted in Chemical Manufacturing

    Real-World Experiences with 3-Chloro-4-Nitrotoluene

    Over the past several decades, the chemical industry has seen a growing demand for specialty nitroaromatics. Our team manufactures 3-Chloro-4-Nitrotoluene (CAS 89-60-1) in-house, using tightly controlled processes that have evolved through years of hands-on production, not just theory from design tables. We continuously work to reduce impurities and streamline crystalline separation during synthesis because we know even a small quality shift can complicate downstream reactions for our customers. Through steady feedback loops with long-term clients and vigilance in laboratory controls, we have fine-tuned the color index, minimized byproducts, and kept to tight melting point ranges. These improvements did not emerge overnight but came from recalibrating equipment, refining filtration, and, at times, stepping back to troubleshoot an entire batch when minor problems cropped up. Our knowledge lives in these details—it is in the calloused hands that adjust batch parameters and the keen eyes watching crystallization tanks late into the night.

    From Nitroaromatic Synthesis to Practical Use

    3-Chloro-4-Nitrotoluene is much more than a structural formula—our operators understand the practical realities of scale-up from research bench to industrial reactor. We run routine checks on every lot, monitoring attributes from purity to hue, because we recognize that a dye intermediate’s unpredictability or a minor off-note in an agrochemical precursor can frustrate end-users and shut down entire production lines. In every vial we ship, whether drums or bags, you find a layered story of vigilance: solvent choices that ease downstream reduction, catalyst loadings adapted to minimize tar, and temperature cycles monitored minute by minute. That level of precision is rooted in years of hands-on troubleshooting, not just textbook references.

    How This Product Differs in Application

    Our 3-Chloro-4-Nitrotoluene unlocks different synthesis routes compared to similar toluene-based nitro intermediates. Its structure favors diazotization and coupling, making it a preferred starting point in the manufacture of certain yellow azo dyes and high-performance pigments. The chlorine and nitro substituents set up the aromatic ring for enhanced regioselectivity when other groups are introduced. Many end users come to us after trialing other isomers such as 2-Chloro-4-Nitrotoluene or the simple 4-Nitrotoluene, only to find stubborn side reactions or difficult separations. In contrast, our product’s balanced molecular properties minimize these problems, cutting down post-reaction cleanup efforts and improving yields for downstream steps like reduction or nucleophilic substitution.

    Key Features: From Operator’s Bench to Factory Floor

    Every kilogram we ship meets clarity and purity levels developed after thousands of process iterations. Through frequent interaction with large-volume dye, pigment, and pharmaceutical companies—not just the paperwork—they’ve pushed us to shrink moisture content, address particle size consistency, and close the door on inconsistencies that can arise from fluctuations in raw toluene or nitric acid supply. We gain little by hiding the rough spots: one year, a supplier’s change in hydrochloric acid concentration caused a surge in colored contaminants, so we had to suspend output and rework batch parameters. That meant calling up several long-standing customers, explaining the delay, and swallowing extra test runs until confidence was restored. Their patience was earned and has guided our current focus on transparency—product shipments are never blind boxes.

    Comparison to Other Nitroaromatic Compounds

    Despite their similarities, 3-Chloro-4-Nitrotoluene behaves differently from close cousins like 2-Chloro-5-Nitrotoluene or 2-Chloro-4-Nitrotoluene, both common in commercial dye intermediates manufacturing. Our lab studies show that positional isomers won’t consistently deliver the same yield or color purity in certain pigment syntheses, especially those requiring high color fastness or UV stability. Even modest differences in physical constants can cause issues during precipitation, oil dispersal, or solvent selection. For decades, customers have outlined comparative case studies highlighting lower byproduct formation with our product during specific coupling reactions, while lesser-known isomers led to resin discoloration or filter clogging. These advantages come from empirical results witnessed on workshops, not marketing promises.

    Our Approach to Consistency and Safety

    Decades of operating batch and continuous lines have taught us that perfect results start with carefully sourced raw materials and disciplined maintenance on all pumps, filters, and reactors. Production is run under controlled temperature and pH, not just for efficiency but because flares in energy input affect the crystalline size and can cause batch-to-batch variation. Daily inspection routines pick up early warning signs—line pressure surges, unplanned condensation, anomalous gas evolution. We never outsource these controls or skimp on staff training, because automation alone can't replace the intuition developed on the shop floor after years of seeing subtle changes in reaction color or viscosity. When we say our product is safe for chemical processing, what matters is the confidence our operators and quality managers possess, built on firsthand knowledge of exothermic nitro processes and risk prevention programs enforced to the letter.

    Tuning Specifications to Application Needs

    The specifications we keep for 3-Chloro-4-Nitrotoluene respond to real task-specific needs. Color formers and intermediate producers often request material with sub-percent moisture and particle fineness for solution reactivity; pigment and pharmaceutical clients measure not only for the main compound but for trace-level chlorinated biphenyls or residual acids, which influence their own synthetic routes. Our plant operators customized batch crystallization and drying logic to lock in those parameters, going so far as to adjust filter aid selection and post-reaction wash cycles depending on final application requirements. We don’t rely on generic purity figures—last year, we invested in triple-validation HPLC runs per lot because a regular customer identified minute interference with their downstream hydrogenation step using standard pure material. That direct input led us to revalidate our protocols and recalibrate for their process, a change that now benefits all partners.

    Practical Handling and Real Logistics

    After years handling bulk nitroaromatic shipments, our staff learned that keeping material free from clumping or static requires more than just dry storage instructions. We line drums with double-barrier bags only after testing them against the humidity variance of different client regions. We have worked hand-in-hand with warehouse teams to combat odor and volatility during peak summer. Real-life bulk transfers don’t always follow the neat timing assumed by textbooks, and contamination risks lurk at every corner—so we coach our partners and drivers on best loading practices, address spillage fast, and maintain clear accountability from lab to dock. Security matters in chemical shipping, so all packages feature tamper-resistant seals and unique batch codes traceable through our manufacturing logs. No guesswork passes through our practice.

    Sustainability Concerns and Industry Adaptation

    Pressure is mounting across our industry to reduce chemical footprints, especially as downstream users confront stricter regulatory and sustainability benchmarks. Years ago, switching oxidation catalysts for lower-emission profiles felt risky, but we had to adapt as local regulators introduced limits on organochlorine emissions. We’ve introduced recycling loops for process solvent, brought on advanced scrubbers, and carry out continuous water monitoring not because it is fashionable but because lapses cost trust—and contracts. A significant challenge remains in waste acid neutralization; to tackle that, we built partnerships with downstream chemical recyclers for full-circle acid recovery. Our environmental team regularly audits carbon output for each manufacturing phase, not just to tick boxes, but so we can face client procurement officers with detailed assessments—proof that their suppliers share their sense of future obligation. Our practical approaches don’t rely on slogans but on steady steps that lower both risk and overhead.

    Learning Through Customer Feedback

    We continuously learn from the chemists and engineers who use our product day in, day out. When a large-scale pigment processor reported filter cake inconsistencies, we didn’t hand off the issue—we sent a process engineer to work with their plant team to find the source. Their insights led us to install micro-sieving arrays before final packaging, rooting out dust fractions that seemed invisible by standard analysis. On another occasion, an agrochemical partner described a color shift in a new formulation line: that feedback prompted us to revisit our feedstock supplier agreements and install in-line spectral analyzers for batch verification. These ongoing exchanges remind us that the real measure of our product rests on customer output, plant uptime, and minimal disruptions—not internal paperwork. Our history is marked by corrective actions made in partnership, not solo victories.

    Long-Term Differentiators for 3-Chloro-4-Nitrotoluene

    Working side by side with customers on multiple continents gives us a broad view of the challenges different industries face, from pigment blending to pharmaceutical synthesis. Over the years, one thing became clear—consistent product performance cut operational delays and reduced costly reworks. We charted stability data for storage conditions, crafted advisory sheets addressing region-specific weather extremes, and keep communications direct and honest about any upcoming process changes in advance of customer needs. A few manufacturers try to mask batch differences behind documentation; our practice is to share retention samples and batch run histories with clients, especially if they scale from lab to pilot plant. By providing access to technical teams and performance data, we remove friction for users integrating our material into regulated or high-throughput production lines.

    Supporting Innovation in Synthesis

    Chemical research environments move quickly. The structure of 3-Chloro-4-Nitrotoluene makes it a ready launchpad for new active compounds, particularly in veterinary medicine, crop protection, and specialty colorants. We’ve worked directly with R&D centers, supplying batches tailored for pilot runs. These collaborations often push us to experiment with even tighter purity specs, alternative solvent choices, or new crystallization profiles to accommodate next-generation syntheses. It’s not unusual for a project to require same-week retooling—our internal systems support such flexibility, making us a strong partner for innovation-focused companies. Supplying material for regulatory trial batches comes with its own regulatory headaches, and we invest in compliance data and custom certification to meet submission deadlines for our clients. Every successful trial cements long-term exchanges built on mutual trust and responsiveness.

    Working Through Global Supply Chain Challenges

    Volatility in global supply chains is a constant reality for manufacturing teams. Years ago, changes in international freight routing caused a pileup of containers on the coast, threatening to delay pigment shipments. Instead of deflecting with empty promises, our logistics crew worked through the gridlock, updating customers daily and re-routing smaller lots by ground transport at short-term expense. That experience led to ongoing improvements in our order tracking and contingency planning. Today we monitor major chemical transit corridors, weather changes, and port conditions in real time. Secure backup raw material stocks prevent shortages, and we contract with local carriers as insurance against long-distance delays. These practical steps were learned through occasional setbacks and never disappear from our risk checklists. Being ready for uncertainty defines the reliability of any chemical manufacturer serving international partners.

    Adaptations for Modern Manufacturing Demands

    Regulatory expectations and product traceability now reach every stage of our production. Customers expect batch histories, full audit trails on people and material, and ready answers to traceability questions. To meet those demands, we installed digital manufacturing execution systems that log every batch event—from start-of-day checks to filtration milestones and post-reaction readings. Our internal training has pivoted most staff from pen-and-paper entries to instant system reports, cutting human error and giving quality control more real-time oversight. If a user reports a performance issue, we can pull up precise reactor logs showing who handled the vessel, what test results were entered, and when material was cleared for shipment. Transparency is not just a promise here—it is logged in the digital backbone of our factory floor.

    Responsible Sourcing and Supply Chain Ethics

    Our buyers work directly with global feedstock suppliers, demanding verification documentation and consistent sampling, so each delivery meets both quality and ethical standards. For 3-Chloro-4-Nitrotoluene, traceability upstream is not just a matter of compliance; it shields us and our partners from disruptive price surges or adulteration with subpar reagents. Suppliers are regularly audited and held to strict sourcing standards, and we share those records with customers as needed. Responsible sourcing is not only about reputation but about keeping consistent product flowing through our own processes so end users face fewer headaches. The complexity of global sourcing only grows with each economic cycle, but our focus stays on clarity over volume.

    Regulatory Experience and Compliance Readiness

    It takes more than industry certifications to work with international agrochemical, colorant, and pharma partners. Regulatory regimes change quickly, and authorities now expect deeper product knowledge, batch documentation, and reporting on every lot delivered. Our regulatory experts have faced tough audits, both from multinational customers and government agencies. Instead of bracing for each new round nervously, we keep our technical literature, safety data, and environmental assessments always ready and current. Years of open inspection have shaped our systems for quick turnaround on questions—our teams expect to respond by drawing from first-hand plant data, not just filing cabinets. This readiness has turned pre-shipment checks and registrations into minor milestones, never roadblocks to customer timelines.

    The Role of 3-Chloro-4-Nitrotoluene in Downstream Success

    Success for users depends on predictable quality and ready support, not just base price or purity on paper. We’re proud to have helped clients cut impurity-driven reprocessing rates and boost yields. One pigment producer reported a ten percent uptick in plant throughput after switching from a blended competitor to our single-source batches—less downtime, fewer off-spec runs, and easier cleaning cycles between shifts. These gains only happen through clear dialogue between supplier and user and a willingness to trace and resolve problem lots, not pass them off. Our belief is daily, tangible benefits for the customer’s lines, not just paperwork achievements.

    Supporting Safe and Efficient Operations

    Process safety matters for us and downstream users alike. Our training culture emphasizes hazard recognition, dust management, explosion avoidance, and robust emergency shutdown protocols. Handling nitroaromatics for so long has engrained the importance of not just following rules but training operators to anticipate issues—color changes, unexpected foaming, equipment wear, and all the little clues that hint at brewing trouble. We work closely with customer EHS teams to develop batch-specific handling notes, not boilerplate checklists. Practical knowledge transfer helps our partners keep their teams safe and operations running smoothly.

    Partnership Built on Shared Knowledge and Results

    We see every repeat batch as an acknowledgment of shared risk and reward. Our commitment is not limited to selling material—over time, we have become a technical resource, a troubleshooter, and sometimes a critical backup during emergencies for our partners. Our support goes beyond sharing certificates; we send technical managers on-site, consult on batch optimization, and provide plant-specific documentation for regulatory reviews. That approach has built loyalty in a crowded field and lets us count global brands as regular partners.

    Conclusion: Depth Over Simplicity

    Anyone can offer 3-Chloro-4-Nitrotoluene by reference to purity and melting point sheets. Our difference comes from years of process improvement, technical service, and operational transparency built into every lot, for every application. Daily direct involvement with the raw chemistry underpins everything we ship. Our product stands not just for consistent input material but for reliable outcomes in color, pharmaceuticals, and crop protection—outcomes proven across decades of shared experience.