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3-Chloro-4-Fluorobenzamide

    • Product Name 3-Chloro-4-Fluorobenzamide
    • Alias 3-Chloro-4-fluorobenzamide
    • Einecs 'EINECS 629-643-7'
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    326479

    Productname 3-Chloro-4-Fluorobenzamide
    Casnumber 328-34-7
    Molecularformula C7H5ClFNO
    Molecularweight 173.57
    Appearance White to off-white solid
    Meltingpoint 122-125°C
    Purity Typically ≥98%
    Solubility Slightly soluble in water, soluble in organic solvents
    Density 1.44 g/cm³ (estimated)
    Smiles C1=CC(=C(C=C1F)Cl)C(=O)N
    Inchi InChI=1S/C7H5ClFNO/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3H,(H2,10,11)
    Synonyms 3-chloro-4-fluorobenzamide; m-Chloro-p-fluorobenzamide

    As an accredited 3-Chloro-4-Fluorobenzamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 250g of 3-Chloro-4-Fluorobenzamide packaged in a sealed, amber glass bottle with hazard labeling and tamper-evident cap.
    Shipping 3-Chloro-4-Fluorobenzamide is shipped in sealed, chemically resistant containers to prevent contamination and degradation. Packaging complies with international regulations for hazardous chemicals. The product is clearly labeled, cushioned against physical shocks, and accompanied by a safety data sheet (SDS). Shipping is typically via ground or air, depending on destination and urgency.
    Storage 3-Chloro-4-Fluorobenzamide should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers. Keep away from direct sunlight and sources of ignition. Store at room temperature and avoid excessive heat or moisture. Ensure proper labeling and use appropriate personal protective equipment when handling.
    Application of 3-Chloro-4-Fluorobenzamide

    Applications of 3-Chloro-4-Fluorobenzamide in Industrial Manufacturing

    As an original manufacturer with full-chain QC and proven process control, we supply 3-Chloro-4-Fluorobenzamide to multiple specialized downstream industries. The following application insights illustrate genuine, large-scale industrial uses, with technical detail on compliance, formula integration, and finished product types delivered by global end users.

    1. Pharmaceutical Intermediates for Anti-inflammatory Drug APIs

    3-Chloro-4-Fluorobenzamide finds direct application as a key intermediate in the synthesis of certain anti-inflammatory active pharmaceutical ingredients (APIs), where its halogen-substituted benzamide structure enables stepwise functionalization by leading API plants. During multi-stage organic synthesis, the material provides both positional selectivity and high yield for target molecules in regulated finished drug substances manufactured under strict cGMP controls.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • EU EMA GMP Guide Part II
    • US FDA 21 CFR Part 211 and Part 314
    • Applicable European Pharmacopoeia & United States Pharmacopeia monographs for finished APIs

    Typical usage ratio

    • Input ratio of 3-Chloro-4-Fluorobenzamide commonly ranges from 0.85 to 1.2 molar equivalents per API batch step, depending on final target molecule design and conversion efficiency.

    Downstream process integration

    • The compound is introduced as a pre-coupling intermediate after halogenation and before amide bond formation, typically in Stage-II of the multi-step pharmaceutical synthesis route, preceding purification and final salt formation steps.

    Final product types

    • Nonsteroidal anti-inflammatory drug (NSAID) APIs (e.g., modified benzamide derivatives)
    • Certain finished tablet and capsule drug products planned for global Rx markets

    2. Agrochemical Intermediate for Herbicide Synthesis

    Crop protection chemical manufacturers apply this molecule as an intermediate for selective benzamide-type herbicides. The structure serves to introduce distinct halide groups into new-generation herbicide actives, where both efficacy and crop safety profiles depend on controlled halogen orientation. Its role as a building-block intermediate supports consistent herbicide actives needed for large-acreage cereal and oilseed applications.

    Industry compliance standards

    • ISO 9001:2015 for chemical manufacturing processes
    • FAO/WHO Specifications and Evaluations for Agricultural Pesticides
    • REACH (EC) No 1907/2006—Registration, Evaluation, Authorization and Restriction of Chemicals
    • US EPA Registration requirements for technical-grade actives

    Typical usage ratio

    • Integrated at 1.0–1.3 equivalents relative to final active, stoichiometry tailored by downstream coupling and protection step efficiency in pilot and production scales.

    Downstream process integration

    • Charged following halogen exchange and ring activation sequence, performing as a coupling partner during core building of heterocyclic herbicide actives, preceding post-reaction purification via crystallization or column separation.

    Final product types

    • Technical-grade, halogenated benzamide core herbicide actives
    • Formulated EC, SC, or WP finished crop protection products for field use

    3. Intermediate in Specialty Aromatic Polymer Precursors

    Specialty polymers manufacturers employ this chemical as an aromatic amide precursor in the development of fluorinated engineering polymers. Its unique structure enables the introduction of both chlorine and fluorine atoms onto polymer backbones, supporting high-performance thermoplastic and thermoset resins needed for electronics, filtration, and chemical-resistant applications. Process consistency and monomer purity are critical for downstream polymer integrity and device performance.

    Industry compliance standards

    • ISO 9001/14001 for production and environmental controls
    • RoHS Directive 2011/65/EU for electronic device polymers
    • UL 94 for flame retardance (as applicable to resins)
    • Customer-specific QMS (Polymer and electronics OEM requirements)

    Typical usage ratio

    • Utilized at 0.6–1.0 mol fraction within co-polymerization or amide condensation processes, ratio set based on target polymer backbone and functional group density.

    Downstream process integration

    • Introduced during primary monomer feed in step-growth or condensation polymerization plants, forming part of the backbone before cross-linking, with careful monitoring for halide integration and chain propagation kinetics.

    Final product types

    • Fluorochloroaromatic engineering plastics and resins
    • Membranes and filter media for industrial and electronic applications
    • High-performance molded electronic components

    4. Active Component for Chemical Research and Compound Screening

    Contract research organizations (CROs) and pharmaceutical development laboratories use laboratory-grade 3-Chloro-4-Fluorobenzamide for targeted molecule synthesis and compound screening programs. Its specific structural motifs enable structure–activity relationship (SAR) investigations and design of novel biologically active compounds. Researchers rely on batch-to-batch consistency and tightly defined impurities for reproducibility and patent application work.

    Industry compliance standards

    • GLP (Good Laboratory Practice) OECD Principles
    • ISO/IEC 17025:2017 for accredited testing laboratories
    • GHS/CLP Regulation EC No 1272/2008 (classification, labeling, handling)
    • Material transfer and supply regulations for R&D chemicals (IATA, UN ADR)

    Typical usage ratio

    • Lab-scale amounts, typically 0.01–0.2 mol per synthetic route step, with adjustments according to library synthesis scale, specific SAR requirements, and screening targets.

    Downstream process integration

    • Added as a core reactant in early-stage SAR series or for modification of scaffolds in medicinal chemistry pipelines, prior to analytical QC and biological screening phases.

    Final product types

    • Molecule libraries for drug discovery
    • Reference standards and test articles for screening projects
    • Custom intermediates for patent filings and early IND submissions
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    Competitive 3-Chloro-4-Fluorobenzamide prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    3-Chloro-4-Fluorobenzamide: Reliable Quality, Straight From the Manufacturer

    Quality chemistry doesn’t start with the laboratory—it begins with the raw materials. In our plant, the story of 3-Chloro-4-Fluorobenzamide traces back to direct control over every reaction, every temperature ramp, every filtration. Customers bring us in when they want the assurance of provenance, not just good looks on a certificate. With this compound, attention to clean starting materials and tightly managed synthesis steps set the tone for what we put on the drum.

    Model and Consistency You Can Build On

    3-Chloro-4-Fluorobenzamide carries the integrity of a well-made product because we manage the whole process under one roof, from the chlorination and fluorination to the amide coupling itself. Across multiple batches—dozens every year—specifications remain consistent. A white to off-white crystalline powder, our material routinely meets top-end purity targets, verified through HPLC and NMR analysis performed in-house. No batch leaves our doors without full traceability, backed by retained samples and a record of every process parameter.

    Some customers worry about residual solvents or metal traces; our attention to detail comes from years refining our workups and washes. We test specifically for low ppm levels, and solvent residues fall well within tight internal cutoffs. This isn’t just box-ticking for documentation. Reliable consistency matters every time a customer scales up or designs a new process around our compound. Inconsistent material means headaches; our deliveries help others avoid them.

    Applications That Matter: Real Use in Real Synthesis

    End-uses for 3-Chloro-4-Fluorobenzamide aren’t just abstract. We’ve dealt with teams taking it straight into pharmaceutical intermediates, agrochemical research, advanced material science, and industrial R&D. In drug synthesis, our material gets taken up for the similarities it shares with related benzamide fragments that feature in kinase inhibitors or central nervous system research. The industrial demand often comes down to the electron-withdrawing pattern of its substituents—chemists appreciate that the para-fluoro and meta-chloro combination direct further functionalization steps efficiently.

    Unlike commodity-grade benzamides, our version survives the scrutiny of methodical scientists, batch after batch. Users aren’t looking to shave a penny per kilo; they care about avoiding late-stage surprises. Stability through storage, predictable melting point, and reliable crystallinity mean samples perform the same way in California’s dry heat as in Germany’s damp air. In agricultural innovation, materials derived from our compound often head for screening as pre-emergent herbicide leads or fungicide candidates, making clean starting material critical to avoid false positives.

    Not Your Standard Benzamide: What Sets This Apart

    There’s no template formula for making a good intermediate, but experience teaches what not to cut, especially in high-substitution aromatic compounds. What makes 3-Chloro-4-Fluorobenzamide distinct isn’t just the substitution pattern; it’s the workmanship behind the process. Mono- and di-substituted analogs often carry byproduct contamination or strange polymorphs. Our reaction design avoids shortcuts. We refine the isolation steps to get single-species product, not a collection of near misses. It’s tempting to push yields at the expense of purity, but inexperience bites back when customers run into unexpected byproducts. Our refusal to blend sub-par batches has built trust with partners who need predictable performance in their research and processes.

    Comparing to other benzamides, especially those with bulkier groups or more electron-donating substituents, 3-Chloro-4-Fluorobenzamide stands out for versatility. It handles nucleophilic aromatic substitution and cross-coupling reactions better, with less side reaction noise. In our factory, we routinely test selectivity by simulating customer conditions—still finding no better substitute for the balance of reactivity and stability packed into this modest molecule.

    Production Experience: What Decades Have Taught Us

    Clients sometimes ask what makes our process different from the dozens of similar offers from traders or contract labs. The answer comes from years chasing higher yields, improved purity, and reliable logistics. By managing our own raw material sourcing—phenyl derivatives, clean amines, careful halogen reagents—we sidestep the unpredictable variation that comes from buying intermediates on spot markets.

    The isolation of 3-Chloro-4-Fluorobenzamide isn’t foolproof: patience, steady hands, and disciplined filtration make the difference. There’s no substituting for good glassware and trusted people watching each stage. In our experience, rushing any step introduces issues that can echo into the final spectra. We still see minor differences in crystal habit from changes in cooling rates, so each shift leaves notes for the next production run. These working methods, and a company culture that values process feedback, show in the analysis reports customers receive.

    Focus on Quality Control: Seeing Beyond Specifications

    Lab talk about 99% purity doesn’t matter if trace contaminants ruin a reaction down the line. Our approach was honed by listening to process chemists: hidden isomer peaks, trace halides, or mystery spots show up just when a downstream route approaches clinical scale. Building robust QC into everything—from glassware cleaning checks to dual-path drying—costs more, but the payoff comes when customers report zero issues batch-on-batch. We adapt methods based on customer feedback, not just penny-shaving managers, scrap-paper-slinging bureaucrats, or spreadsheet logic.

    Some electronic-grade manufacturers have tested our compound for applications beyond the classic pharmaceuticals, including as controlled building blocks for OLED research and advanced polymers. Here, minute differences in impurity profiles mean all the difference, and our hands-on policies fit the bill. It keeps us nimble but detail-driven, and we maintain open lines of communication with users throughout the world, even after sample throughput and routine supply start running smoothly.

    Customer Experience: Direct Support From the Source

    End users have our attention. Whether scaling from grams to multi-tonne drums, or troubleshooting stubborn downstream crystallizations, our technical support reaches real chemists, not distant sales reps. Direct feedback loops allow us to optimize not only for performance but also for practicalities: improved packaging materials, clearer shipping documents, tighter stability monitoring over time. If there’s a hiccup—a rare thing, but possible—we treat it as an opportunity to refine batch control, not just an incident to bury and forget.

    Memory holds valuable lessons: once, a customer flagged a trace impurity only detectable by extended dwell LC-MS—feedback our team built into the next cycle’s upstream wash protocol. This obsessive approach to tweaking the process, stepwise and thoroughly, comes from valuing relationships over short-term gain. Repeat clients teach us more about our job than textbooks or consultants ever could, which helps us stay recognized as a trusted manufacturing partner.

    Packing, Shipping, and Keeping It Authentic

    Shipping isn’t an afterthought. We’ve learned shipping delays and rough handling can ruin a perfect batch, so we work with partners who show real respect for what’s in the drum. Our packaging stands up to temperature swings and long transit journeys, and label transparency means every lot is traceable back to raw materials. No relabeling, no mystery reselling—just chemistry as made, intact and real, from our manufacturing line to your bench or production suite.

    Stock levels are maintained to supply both recurring and project-based demands. Because we produce continuously, not intermittently, fast turnaround remains realistic for most order sizes. Express shipping on urgent requests happens without middleman delays. Knowledge of shipping regulations, careful declaration of chemical properties, and practical transit tracking keep us on the right side of both regulations and our customers’ scheduling needs.

    Challenges We’ve Faced—and Turned Into Strengths

    No product comes easy. Early in our history, issues with exothermic steps in the chlorination phase led to batch rejections. Rather than cut corners, we rebuilt our temperature control infrastructure and integrated redundant sensors—real money, real time, real improvement. Years later, competitors buying from offshore resellers still struggle with runaway batches, but we haven’t looked back.

    Worker expertise makes the real difference—years of cross-training mean night-shift operators recognize trouble signs without waiting for morning management. Legacy processes, documented and lived by, don’t change with trends. Customers tell us competitor material sometimes leaves unexplained color or odor. Our commitment to process hygiene means visual appearance lines up with pure spectra—consistency earned the hard way, not talked up through empty marketing phrases.

    Looking Forward: Where New Applications Are Growing

    New research trends push 3-Chloro-4-Fluorobenzamide into areas its original inventors couldn’t predict. Custom modifications on aromatic backbones lead to agrochemical tools that need clean, unambiguous starting blocks. Higher standards for impurity qualification enter the pharmaceutical space each year, demanding transparent reporting and ever-lower detection thresholds for related substances. Instead of seeing these as regulatory headaches, we’ve redesigned our internal protocols to gather process data at every stage and make it available to researchers integrating our product into regulated supply streams.

    Instrument advances have let us dial in even subtle variances between batches; understanding polymorphism means that academic collaborators and industrial partners can trust the material to behave predictably, no matter the application. Every quarter brings new conversations with downstream innovators—people using our benzamide in protein labeling, polymer end-group control, or unique sensor molecules. We welcome the challenge, taking the synthesis route as the starting gun, not the finish line.

    Why Direct Manufacturing Still Matters for Specialty Chemicals

    Traders and middlemen can move boxes, but only the hands-on manufacturer builds and maintains a system capable of consistent, scalable, and transparent supply. Our team sits with batch journals older than some of our customers, using experience to read between the lines of obscure LC peaks or unexpected IR stretches. Where a new regulation or a bottleneck threatens reliability, we modify processes in real time—sometimes overnight, sometimes over months—without waiting for direction from somewhere faraway.

    Customers come to us after disappointing experiences with anonymous resellers and dead-end supply chains. They stay because we adapt side-by-side, facing the down-to-earth realities of lab and plant work. Chemical solutions aren’t magic; they’re built molecule by molecule in the hands of professionals who care about every step, every gram, every request. The transparency and accountability of direct manufacturing take the romance out of the process and put hard evidence back in. This approach fits especially well for products like 3-Chloro-4-Fluorobenzamide, where the margin for error is thin and the need for trust is high.

    Supplying for the Next Decade

    Global markets move fast, and our flexibility is only possible because we control the core. No waiting on third parties for missing paperwork, no risk of surprise outages due to middleman miscounts. Our process data, sample archives, and team memory mean questions are answered quickly, whether from a purchasing department or a project manager lining up their next campaign. The rhythm of production and the discipline in tracking each lot keeps us responsive and accurate, not just “compliant.”

    That level of partnership matters as new technologies reshape demand for pure aromatic intermediates. Whether a customer needs a single trial kilo for a feasibility study or a supply for industrial demand extending years, we commit resources, technical expertise, and end-to-end transparency. It isn’t just the initial sale—it’s the long-term relationship proving that honest manufacturing makes for reliable science.

    Conclusion: A Foundation for Dependable Chemistry

    3-Chloro-4-Fluorobenzamide remains a reminder of what manufacturing at the source makes possible. Integrity starts in the reaction flask and follows each lot through production, packaging, and delivery. When working with us, buyers receive not just a pile of powder, but the cumulative insight and problem-solving that come from years behind the controls. We don’t just talk up our product—we live by it, and we look forward to helping others do the same, one batch at a time.