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3-Chloro-2-Nitrobenzoic Acid

    • Product Name 3-Chloro-2-Nitrobenzoic Acid
    • Alias 3-Chloro-o-nitrobenzoic acid
    • Einecs 223-281-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    412361

    Chemical Name 3-Chloro-2-Nitrobenzoic Acid
    Cas Number 635-09-0
    Molecular Formula C7H4ClNO4
    Molecular Weight 201.56
    Appearance Yellow crystalline powder
    Melting Point 151-154°C
    Solubility In Water Slightly soluble
    Density 1.65 g/cm3 (approximate)
    Purity Typically ≥98%
    Storage Conditions Store in a cool, dry place
    Smiles C1=CC(=C(C(=C1Cl)C(=O)O)[N+](=O)[O-])

    As an accredited 3-Chloro-2-Nitrobenzoic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 25g amber glass bottle featuring a white tamper-evident cap, labeled: “3-Chloro-2-Nitrobenzoic Acid, analytical grade, 25g.”
    Shipping 3-Chloro-2-Nitrobenzoic Acid is shipped in tightly sealed containers, protected from light, moisture, and incompatible substances. It should be packed according to hazardous material regulations, typically with appropriate labeling and documentation. Ensure upright positioning, cushioning to prevent breakage, and temperature control if required. Handle with gloves and safety precautions during transport.
    Storage 3-Chloro-2-Nitrobenzoic Acid should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from incompatible substances such as strong bases and reducing agents. Protect from light, heat, and sources of ignition. Ensure the storage area is equipped for handling corrosive and toxic chemicals, and label containers clearly to prevent accidental misuse.
    Application of 3-Chloro-2-Nitrobenzoic Acid

    Applications of 3-Chloro-2-Nitrobenzoic Acid in Industrial Manufacturing

    As a leading manufacturer and supplier of 3-Chloro-2-Nitrobenzoic Acid, we support a focused range of downstream sectors that demand precision in formulation and regulatory alignment. Our technical support team works closely with end users to ensure effective integration into their production lines. The following sections detail practical applications and parameters for our material, structured to guide industrial customers in making informed sourcing and process decisions.

    1. Agrochemical Intermediates for Herbicide Synthesis

    This raw material acts as a coupling intermediate for manufacturing systemic herbicides, especially in the class of substituted benzoic acid-based products. Its function relies on precise aromatic substitution during active ingredient synthesis, with performance and yield depending on both the input quality and integration timing in multi-step organic syntheses. End users value its highly controlled impurity profile to minimize downstream side reactions and meet global residue requirements on finished agrochemicals.

    Industry compliance standards

    • FAO/WHO International Code of Conduct on Pesticide Management
    • EU Regulation (EC) No 1107/2009 for Plant Protection Products
    • ISO 9001:2015 Quality Management for Agrochemical Production
    • China ICAMA registration technical requirements

    Typical usage ratio

    • Typically dosed at 0.8–1.3 molar equivalents for condensation with amines or phenols, adjusted based on desired herbicide active structure and molar mass targets in the synthetic route.

    Downstream process integration

    • Fed into aromatic nucleophilic substitution or amidation steps following the completion of ring nitration. Process introduces strict temperature control to ensure high-purity conversion before subsequent coupling and post-reaction workup.

    Final product types

    • Aromatic carboxylic acid-based herbicide actives (selective and non-selective)
    • Pre-emergent weed control products
    • Bulk intermediates for custom pesticide formulations

    2. Pharmaceutical Intermediate in API Synthesis (Non-Steroidal Anti-Inflammatory Derivatives)

    This compound serves as a regulated intermediate in the multi-step synthesis of certain non-steroidal anti-inflammatory drug molecular scaffolds. Production sites require rigorous tracking and traceability due to its status as a controlled starting material for pharma APIs, demanding validated analytical testing and full batch documentation. Process engineers closely monitor the purity of this intermediate to reduce downstream purification costs and meet regulatory DQ/IQ/OQ expectations.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • EU GMP: EudraLex Volume 4
    • Pharmacopoeia (USP, EP, JP) monograph requirements for related substances
    • FDA cGMP guidelines for API intermediates

    Typical usage ratio

    • Used at 1.0 equivalent for the designated coupling step, adjusted according to target API yield and process step efficiency, with process optimization for waste minimization and purity assurance in scale-up batches.

    Downstream process integration

    • Fed directly into amidation or esterification during API precursor construction, often following reduction or selective halogenation steps. Careful control over residual halide and nitro group conversions is enforced to conform with API impurity profiles.

    Final product types

    • Non-steroidal anti-inflammatory drugs (e.g., certain benzoic acid series)
    • Key intermediates for analgesic API manufacturing
    • Synthetic building blocks for licensed pharmaceutical compounds

    3. Dyes and Pigments Manufacturing (Azo Dye Coupling Agent)

    This aromatic acid functions as a diazo coupling component in the synthesis of specialty dyes, particularly for textiles and plastics. Its electron-withdrawing substituents enable precise color tuning and improved color fastness in the resulting azo and anthraquinone pigments. Large-volume users require granular control over batch homogeneity and trace contaminants to avoid color inconsistencies in end-use applications.

    Industry compliance standards

    • REACH Regulation (EC No 1907/2006) for chemical substances
    • OEKO-TEX® Standard 100 – certification for restricted dye use
    • EN 71-3:2019 for migration of certain elements in toys (pigment safety)
    • ISO 9001:2015 for pigment and colorant manufacturing

    Typical usage ratio

    • Loaded at 1–5% by total mass of dye formulation, with modifications depending on required chromophore intensity and specific hue development in the coupling step.

    Downstream process integration

    • Incorporated post-diazotization of primary amines, enabling direct coupling to achieve target pigment shades. Mixing and filtration are closely monitored for uniform particle dispersion and consistent granule size in finishing operations.

    Final product types

    • Synthetic azo dyes (yellow, orange, and red pigments)
    • Plastic masterbatch colorants for polymers
    • Textile and leather dyes for industrial finishing

    4. Fine Chemical Synthesis of UV Absorber Precursors

    Manufacturers in the specialty additives sector utilize this compound during the benzoic acid ring functionalization phase, preceding final-stage transformations to UV-absorbing agents for coatings and plastics. Implementation in advanced additive lines requires consistency in physical form and solubility to maintain downstream process uniformity. Technicians adjust formulation ratios to balance UV protection and compatibility with target resin systems, influencing the ultimate stabilization performance in outdoor-exposed goods.

    Industry compliance standards

    • EU Regulation (EC) No 1223/2009 on cosmetic UV filters (if used indirectly in UV stabilizers for consumer goods)
    • ISO 9001:2015 for specialty chemical manufacturing
    • ASTM D3424 Standard Practice for Evaluating the Lightfastness of Colored Organic Pigments
    • RoHS Directive (EU 2015/863) for electronic casings with UV additive integration

    Typical usage ratio

    • Added at 2–5% in synthesis batches for UV absorber precursors, ratio can be raised up to 7% where deeper absorption characteristics or higher thermal stability margins are required by downstream processing.

    Downstream process integration

    • Processed during early-stage aromatic substitution, prior to final ring closures or etherification steps. Quality inspectors monitor for unreacted halide content to preserve downstream lightfastness indices.

    Final product types

    • UV-stabilized coatings for automotive plastics
    • Outdoor-use polymer films and sheets
    • Masterbatch additives for synthetic fibers

    5. Custom Electronics and Specialty Coatings (Benzoic Acid Derivative for Insulator Formulations)

    Producers of electronics-grade coatings use this raw material to construct specialized aromatic acids that improve the dielectric properties of insulating resins for printed circuit boards and advanced cabling. Its purity and precise substitution pattern directly control the end insulation performance and are subject to batch-specific approval for high-voltage or high-frequency electronic applications. Formulators routinely adjust addition levels based on specific electrical resistance and surface finish requirements dictated by downstream OEMs.

    Industry compliance standards

    • UL 94 Flammability Standard for plastics and insulators
    • IEC 60695-2-10: Glow-Wire Flammability specifications
    • IPC-4101E: Specification for base materials for rigid and multilayer printed boards
    • ISO 14001:2015 Environmental Management for electronics manufacturing

    Typical usage ratio

    • Ranges from 0.5–2% by weight within insulator resin formulations, optimized based on the specific dielectric constant and flame-retardant profile needed by the blend.

    Downstream process integration

    • Material enters the pre-polymer feed phase, used during resin modification and cross-linking to achieve desired voltage withstand strength and surface smoothness. Quality control labs validate final blend by dielectric loss and migration testing.

    Final product types

    • Electronics coating resins for PCB applications
    • High-voltage cable insulation layers
    • Specialty films for sensitive components and device housing
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    Certification & Compliance
    More Introduction

    Understanding 3-Chloro-2-Nitrobenzoic Acid: Real World Insights from the Manufacturer

    Insight into the Product

    After decades on the production floor, seeing batch after batch of 3-Chloro-2-Nitrobenzoic Acid leave our reactors and move on to the next point in the supply chain, the value of a product goes beyond its chemical formula. Consistency, purity, and downstream applications speak louder than a line in a brochure. This compound, with its distinctive pale yellow appearance and sharply defined melting point, supports both established chemistries and projects where developers push the boundaries of specialty synthesis.

    Chemical Qualities and Production Standards

    Reliable manufacturing of 3-Chloro-2-Nitrobenzoic Acid demands hands-on knowledge of both raw input quality and process controls. Over time, we’ve seen how input variations – even subtle shifts in nitrochlorinated precursors – can impact the final assay and impurity content. Our standard batch runs produce material tested to exceed 99% purity by HPLC, usually backed by a tight melting range and spectral signatures that match reference standards. Trust forms when specifications mean the same thing every time, not just on paper but in practice.

    How This Product Fits Into the Chemical Landscape

    Experience in chemical manufacturing has shown that 3-Chloro-2-Nitrobenzoic Acid carves out its own space among intermediates. The balance of electron-withdrawing groups on the aromatic ring makes it valued for selective transformations. Customers working in specialty dyes, pharmaceutical intermediates, and agrochemical synthesis rely on our material as a substrate for further functionalization – where both the nitro and chloro substituents let chemists build complexity through reliable coupling and reduction chemistry.

    Chemists who run multi-step syntheses sometimes face the choice between 2-nitro or 4-chloro positions. Compared to similar benzoic acids, the 3-chloro-2-nitro variant strikes a different reactivity profile in nucleophilic substitution and reduction. We’ve seen our partners use it to open synthetic routes where other regioisomers stall or produce lower yield.

    Specifications that Reflect Real-World Demands

    Our product managers and technicians deal with practical requirements daily, not just nominal numbers on a report. The demand for tighter particle size distribution, reduced moisture content, and low trace metal contamination has grown as customer processes become more sensitive. Every shipment reflects calibration against years of experience tuning crystallization and filtration steps, not to mention the lessons learned through technical feedback from long-term clients.

    Batch-to-batch repeatability forms the core of successful long-term relationships. The recurring investments in in-line process analytics and automated dosing systems come from seeing firsthand the risks of out-of-spec batches. Each time an impurity profile trends up, our team reviews the reactor conditions and identifies sources of deviation – from solvent recovery to agitation speed – nipping problems before they scale.

    Differences Compared to Related Benzoic Acid Derivatives

    As a manufacturer, we navigate a catalog that includes both multi-halogenated and singly-substituted nitrobenzoic acids. Comparing 3-Chloro-2-Nitrobenzoic Acid to 4-chloro-3-nitrobenzoic or plain 2-nitrobenzoic acid, the differences show up both in the reaction flask and in the warehouse. The solubility curve of the 3-chloro-2-nitro compound favors certain solvent systems. Pricing reflects synthesis difficulty, with some positional isomers requiring additional process controls or purification steps.

    Chemists care about cost per mole and ease of downstream modification. Feedback from research and pilot plants indicates that the substitution pattern in 3-chloro-2-nitrobenzoic acid offers more predictable outcomes in metal-catalyzed cross couplings and reductive steps, an attribute that doesn’t always show up in generalized data. Our technical support often gets requests for guidance on using this compound as a building block for heterocyclic scaffolds, for which we share insights gathered through years of customer collaboration.

    Applications: The Transition from Lab to Industry

    Bench chemists start with grams in a beaker. Commercial teams look for kilos and up, packed without contamination, supported by documentation, and delivered on schedule. Both depend on a reliable upstream supply of the right intermediate. Through our own internal R&D and what we hear from our partners, 3-Chloro-2-Nitrobenzoic Acid often stands out in process development for routes leading to specialized agrochemicals, pigment bases, and pharmaceutical intermediates.

    Its use in azo dye production leverages the electron-deficient ring for diazotization and coupling reactions, yielding products with high color strength and stability. In pharmaceuticals, the carefully controlled purity supports the synthesis of APIs where the introduction of functional groups downstream can’t tolerate unknown impurities. For those scaling up, every batch consistency matters. Our GMP-adjacent protocols, though not always required by every market, reflect a mindset that values traceability and data retention.

    Challenges and How We Address Them

    Working with nitrobenzoic acids brings handling hazards, not to mention environmental concerns. One lesson learned early: proactive waste stream monitoring and investment in scrubber technology reduces both risk and regulatory headaches. The manufacturing teams handling 3-Chloro-2-Nitrobenzoic Acid wear experience as much as safety gear; their insights about dust generation, storage stability, and dual filter maintenance contribute to steady improvements.

    Raw material sourcing can shift due to changing global supply chains. Our procurement department watches the market, pivoting to suppliers with verifiable quality systems. This provides resilience in the face of shipping delays or shortages. Documentation, from Certificate of Analysis to full traceability, responds to customer audit demands and regulatory bodies. We keep a back-catalog of analytical records, ready for examination, spanning years.

    Supporting Customers Beyond Supply

    Having worked with laboratories from start-ups to multinational corporations, we’ve learned efficiency doesn’t end at delivery. Guidance on storage, shelf life, and even the right filter media for slurries saves our clients both time and money. We invest in continuous improvement partnerships, welcoming joint troubleshooting sessions when something veers off-pattern in a customer’s plant.

    Technical documentation evolves, informed by the problems faced by our customers as processes transfer from pilot scale to full commercial production. Whether it’s sharing best practices for dissolving stubborn solids or tips on trace impurity removal, our input draws on failures as much as successes. Such practical perspectives only come from production floor experience, not generic handbooks.

    Sustainability and Future Direction

    Chemical production increasingly calls for resource stewardship along with product performance. From the earliest batches, we saw solvent management as more than compliance – cost and community impact both ride on our choices. Closed-loop solvent recovery reduces waste and eases regulatory reporting. Adjusting reaction conditions for milder temperatures and greener oxidizers took time; every change prompted new rounds of stability testing, in-process analysis, and final product review.

    We invest in lifecycle assessments. Every outgoing shipment of 3-Chloro-2-Nitrobenzoic Acid reflects decisions upstream: recycled drum use, careful waste segregation, and supplier audits. While the market focus often trains on immediate attributes like price and lead time, end-users increasingly ask for supply chain transparency. Having the right answers ready – based on verified actions – wins long-term trust. Our plant’s future incorporates more energy-efficient reactors and digital monitoring, not just to cut costs but to meet the expectations of customers and the communities around us.

    Pain Points and Continuous Improvement

    Controlling dust and managing safe storage remains one of the everyday realities of producing nitrobenzoic acids. Every shift, our logistics crew checks for package integrity – not just for compliance but against real risk of cross-contamination in multi-product warehouses. We keep detailed logs, continually training new operators and updating them as lessons from incidents elsewhere ripple through the industry.

    Customer feedback often points to the subtle differences between lots. We monitor for “invisible” issues that only show up in specific downstream applications – maybe a batch that dissolves a bit slower in an uncommon solvent, or one where trace oxygenates affect a later coupling yield. Resolving them means another investment in analytical capacity, more closely controlled process parameters, and sometimes retraining. We share what we learn, building not just a transaction but a two-way street of expertise.

    Why Choosing the Right Manufacturer Matters

    In the world of specialty chemical manufacturing, experience shapes both product and service. Customers choose 3-Chloro-2-Nitrobenzoic Acid not just for its chemical identity, but for the reliability, transparency, and support we deliver alongside each shipment. We invest in long-term relationships because we witness the value of understanding the “why” behind every order, every specification tweak, and every technical question. Our history is built not from marketing jargon, but from daily operations, lessons from setbacks, and progress in making processes safer, greener, and more reliable.

    For those who look beyond a line item on an order form, the pathway from manufacturing to market for 3-Chloro-2-Nitrobenzoic Acid comes shaped by real people, real processes, and a shared commitment to doing it better every time.