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HS Code |
663640 |
| Chemicalname | 3-Chloro-2-nitroaniline |
| Molecularformula | C6H5ClN2O2 |
| Molecularweight | 172.57 g/mol |
| Casnumber | 601-77-4 |
| Appearance | Yellow to brown crystalline powder |
| Meltingpoint | 92-96 °C |
| Boilingpoint | Decomposes before boiling |
| Solubilityinwater | Slightly soluble |
| Density | 1.51 g/cm3 |
| Purity | Typically ≥98% |
| Smiles | CC1=CC(=C(N)C=C1Cl)[N+](=O)[O-] |
| Inchikey | AQKUGYZRKMOPQO-UHFFFAOYSA-N |
| Storagetemperature | Store at room temperature |
| Hazardclass | Irritant |
As an accredited 3-Chloro-2-Nitroaniline factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle, tightly sealed, labeled "3-Chloro-2-Nitroaniline, 100 grams," with hazard symbols and handling instructions on the exterior. |
| Shipping | 3-Chloro-2-Nitroaniline is shipped in tightly sealed, labeled containers to prevent moisture, light, and contamination. It is classified as a hazardous material due to its toxic and potentially irritating properties. Shipping follows regulatory requirements, with appropriate safety documentation, hazard labeling, and precautions for handling and accidental spillage during transit. |
| Storage | 3-Chloro-2-nitroaniline should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from sources of ignition, strong oxidizers, and incompatible substances. Protect from moisture and direct sunlight. Store separately from food and feedstuffs. Use secondary containment to prevent spills and ensure proper chemical labeling for safety and regulatory compliance. |
Applications of 3-Chloro-2-Nitroaniline in Industrial ManufacturingAs an established manufacturer of 3-Chloro-2-Nitroaniline, we supply this high-purity intermediate to trusted partners in key downstream industries. Below, we outline substantiated use cases across four principal application sectors, supported by real-world regulatory references, technical dosage ranges, integration within customer production lines, and end-product profiles. 1. Pharmaceutical Intermediate – Active Pharmaceutical Ingredient (API) SynthesisMany pharmaceutical companies utilize this material as a core building block in the synthesis of selective APIs. It figures prominently in multi-stage synthesis routes, particularly for certain antibacterial and antihypertensive agents. Its chlorinated aromatic structure facilitates substitution reactions, making it valuable to medicinal chemists seeking targeted molecular scaffolds. We supply this grade to strict cGMP production sites, with careful handling under validated cleaning procedures and automated metering. Industry compliance standards
Typical usage ratio
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2. Agrochemical Synthesis – Herbicide and Pesticide ManufacturingWithin the crop protection sector, this compound is processed as a key intermediate, particularly in the synthesis of chloroaniline-derived herbicides and select nitroaromatic pesticides. Formulation chemists utilize its molecular stability and reactivity during downstream sulfonation and acylation reactions, with batch traceability and solvent residue control as a primary risk management focus. Industry compliance standards
Typical usage ratio
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3. Dye and Pigment Industry – Disperse and Acid Dye SynthesisColorants manufacturers incorporate this raw material in targeted azo-coupling reactions to create green-yellow, brown, and specialty reactive dyes. Its nitro and chloro functionality enables precise introduction into diazotization cycles, ensuring controlled chromophore development. Production engineers focus on closed-transfer system operation and hazardous area management, typically using automated dosing and short-path distillation to maximize throughput while minimizing by-product formation. Industry compliance standards
Typical usage ratio
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4. Specialty Chemical Manufacturing – Polymer Additives and StabilizersProducers of engineered polymers and plastic compounds rely on this compound as a controlled intermediate in the creation of heat- and light-stabilizing additives. Its chemical profile allows for incorporation into hindered amine or aromatic amide moieties used in high-performance thermosets. Quality teams monitor dosage precisely during in-situ blending to avoid unwanted polymer matrix coloration and to maintain consistent additive reactivity. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
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After years in the chemical industry, working hands-on with aromatic intermediates, our approach to manufacturing 3-Chloro-2-Nitroaniline remains grounded in precision and responsibility. We have watched the landscape shift: regulations tighten, environmental responsibility climb, and end-user requirements broaden. In this environment, our experience shapes every batch, every quality checkpoint, and every future improvement. This compound stands as a staple within dye and pigment synthesis, fostering consistency where the world expects it and dependability where the market relies on it.
Direct synthesis and fine-tuning of 3-Chloro-2-Nitroaniline has taught us that purity and controlled impurity profiles matter more than any buzzword ever will. Whether for azo dye production, specialty colorants, or as part of more complex heterocyclic builds, our teams know that downstream processes are only as good as the quality of intermediates. We rely on continuous monitoring of moisture content, isomer content, chloride, and nitro purity—lessons carved out of rigorous quality control and customer feedback cycles. Every ounce of learning from our shop floor translates back into the next batch, ensuring consistent product behavior, fewer residues, and less rework.
In our own experience, the story often begins at the reactor, where contamination risks challenge the notion of a “standard” output. Isomeric purity anchors every run—if meta, ortho, or para isomers bleed into the final product, those subtle differences play out downstream, causing color drifts in dyes or potential instability in advanced pharmaceutical syntheses. We focus on isolating the 3-chloro-2-nitroaniline backbone, then confirm it through repeated analysis, guaranteeing that trace isomeric forms never stray past our chosen limits. Our long-standing technicians rely on instruments and unspoken know-how, both honed after years of environmental controls, temperature tracking, and column checks.
Each lot reflects the reality that micron-level solids make a significant difference. We routinely produce 3-Chloro-2-Nitroaniline with a melting point in the 125–130°C range, and our experience shows that deviations, even slightly, signal something off in raw materials or process parameters. Regular particle size checks let us offer both fine milled and slightly coarser types; different end-uses—like suspension dyes versus direct reductions—see distinct advantages from size control, determined through application feedback rather than guesswork. Moisture below 0.2%, a minimum assay of 99%, and low chloride content only make sense after seeing how each parameter shapes yield and equipment wear at the customer's facility.
Quality does not stop when the product leaves our plant. Any moisture pickup alters handling properties—clumping, caking, or even hydrolysis start to creep in with little warning. Over the years, we have partnered with packaging suppliers to find liners that actually keep ambient humidity out, and we use dedicated transfer lines that prevent cross-contamination with other nitro aromatics. Our logistics teams have seen what can go wrong; extra vigilance in transit and storage, including desiccated loading areas and quick processing, springs from seeing the impact of lapses on the shop floor of those who use our materials.
Our customers use 3-Chloro-2-Nitroaniline in a spectrum of ways, but most road-test the product in azo dye formation. Fine-tuning the reaction between diazonium salts and aromatic amines hinges on the reproducibility of the starting material. A stray impurity or off-target isomer throws off coupling speeds, affects yields, and inserts uncertainty that ripples through a production line. We know this, because we have fielded countless calls troubleshooting delayed color formation or odd residue—these stories shape our feedback loops in both synthesis and QC lab protocols.
Pharmaceutical researchers occasionally turn to this intermediate in building blocks for complex heterocycles or active pharma ingredients. Here, our responsibility runs deep: trace metal content, even in parts-per-million, unexpectedly influences later-stage reactions or bioactivity. We respond by double-purifying select lots, charging more for this extra step, because we have learned the costs of shortcuts through customer feedback and periodic regulatory audits. These choices help us stay in good standing with both safety experts and procurement teams who audit our supply chain.
Throughout years of partnerships, we have seen how 3-Chloro-2-Nitroaniline grades segment into niche requirements. Some dye houses only want our purest, low-residue grade, where a clear yellow to light brown powder ensures trouble-free performance in high-visibility applications like automotive fibers or engineered plastics. Others value cost over purity, requiring only that the raw material stays within conventional parameters. We keep channels open for both types of clients, and structure our offerings around what our process and quality backbone can support—not chasing requests that push our plant beyond safe boundaries. Years of market feedback taught us where to hold firm and where to adapt, always returning to process control and operator training as bottom lines.
Comparing this compound to other nitroanilines, subtle chemical shifts translate into big performance differences. Add a chloro atom at the 3-position, rearrange the nitro group, and suddenly reactivity, solubility, and colorfastness shift. We have learned where 3-Chloro-2-Nitroaniline hangs onto processing advantages: it offers distinct color tone potential in organic pigments, which isn’t always matched by unsubstituted or differently substituted nitroanilines. Its chlorinated position brings not just increased electron-withdrawing power, but also influences coupling behavior in creating deeper shades in dyestuffs or giving faster dye-fiber bonding in certain textile formulations.
Our experience suggests that for every end-use, the difference shows up in more than lab data. A subtle change in reduction kinetics, adjustment in solubility, and even the foaming profile in dye baths owes itself to where the chlorine and nitro groups sit. We have lost—and won—accounts over these details; knowledge built up from batch runs, not sales brochures, shapes how we present product options to technical teams looking for a better fit.
Our history has not been without challenges. Early on, sporadic color formation issues exposed the need for tighter monitoring of raw aniline input and acidification steps. We restructured our QA protocol, introducing twice-daily in-process checks, then expanded to near-line instrument verification. Each time a customer flagged an issue, we chased it down to root cause—whether from a subtle impurity in the starting nitrobenzene or a minor fluctuation in reactor temperature. Constant feedback doesn't just reveal process improvement opportunities, it keeps us honest about how close we are to target values.
Today, our product ships after passing multi-stage validation—melting point, water content, HPLC purity, and UV-visible consistency—all learned and reinforced by years of internal failures and successful customer signoff. Our experience underpins our openness: we disclose analytical methods on request, show real batch data, and welcome technical audits. This transparency comes from being consistently evaluated by those who depend on each shipment fitting tightly regulated recipes.
Chemical manufacturing, especially with aromatic nitro compounds, brings responsibility on many fronts. Our operations stay focused on safe management of nitration and chlorination steps, employing closed-loop reactors and dual-scrubber venting. Over the years, neighbors, regulators, and employees have all demanded tighter controls; our site improvements reflect each lesson learned—the time a minor release prompted better valve checks, or the shift to waterborne packaging after an incident during loading. Our teams keep up to date on solvent choices and effluent treatment, running regular scenario reviews and emergency drills. Investing in real improvements, carefully picking where and how raw materials enter the site, matters as much as any yield percentage boost.
Customers rely on us to trace batches from raw material receipt to final drum or bag. We link production logs, quality results, and shipment dates in integrated systems because repeated demands for granular supplier control made that necessary. Any recall, audit, or customer query can be tracked back in minutes—no thanks to theory, but to real investment in plant technology and operator training. Every supplier change, process tweak, and parameter adjustment receives daily review; our experience has been that tight recordkeeping trumps memory, preventing errors and smoothing regulatory review. When asked for lot histories, we deliver them without delay.
Our product sees use outside the obvious. Specialist coatings companies source 3-Chloro-2-Nitroaniline for intensive pigment design, seeking custom undertones or resistance characteristics not met by off-the-shelf colorants. Agriscience researchers have come to us for research-scale supply, trialing this compound as a building block in exploratory herbicide or fungicide synthesis. In each sector, our experience shows that small differences—like particle size distribution, mother liquor removal, or trace impurity control—mean several development cycles saved (or lost). Over time, we're asked for regulatory certificates: REACH, RoHS, or food-contact exclusions, built on actual manufacturing proof, not declarations constructed for ease.
Collaborative efforts with major and minor players have helped us align with sector-specific documentation. Technical data, toxicology reviews, or batch sample retention stems from daily requests—and seeing the impact of missing paperwork or delayed MSDS documents helps us keep paperwork and operations in sync.
Our operation invests where customers notice gains. We added a secondary grinding stage after several reports of premature caking in certain climates. Switched filter media on input lines, closing down a contamination vector discovered only after seeing repeat complaints. Each site visit and plant audit bring fresh ideas back to our process development groups, closing gaps between theoretical product and real-world utility.
We maintain a feedback cycle with both technical and purchasing teams, encouraging visits, joint product testing, and formulation trials. In regions where our product moves through hot, humid supply chains, we've reinforced our commitment to weather-resistant packaging, testing options year after year. Many product revisions have been triggered by end-user feedback from unexpected quarters, drawing on honesty about batch-to-batch challenges.
Our process lines have to walk the tightrope: meeting high-purity market requirements while controlling cost drivers. Raw material sourcing, energy consumption, and waste management all feed into product availability and pricing. Managing unplanned downtime, whether caused by supply interruptions or regulatory audits, forms part of the challenge. Over decades, recognizing the direct effect of a single reactor outage on customers requiring guaranteed lead times has driven both investment and conservatism in forecasting. We prioritize open dialogue on lead times, lot sizes, and cost adjustments—always learning from angry or grateful feedback on shipment timelines.
Sustaining a role as a manufacturer for customers globally requires deeper expertise than chemical synthesis alone. Our product faces scrutiny under transportation, storage, handling, and environmental regulations. Evolving frameworks—from GHS labeling to regional import certifications—force regular update cycles in our labeling, SDS sheets, and technical documentation. We keep regulatory staff in close contact with production, forming onsite teams who flag compliance risks before products move to shipment. Successes are measured in audits passed without deficiency as much as by the clean yields that leave our reactors. Each lesson hard-learned balances innovation with due diligence.
Innovation does not stand still in specialty intermediates. We see more experienced formulators requesting slight tweaks: lower heavy metal traces, alternate granulations, or different packaging formats. Our willingness to pilot-reactor new variants, charter custom project pathways, and collaborate on scale-up anchors us in a position of reliability. Feedback from years of pilot plant work tells us that small changes in product characteristics ripple through to better product acceptance. Each collaborative project deepens our understanding and strengthens the trust that fuels return business.
Over the years, we have learned that strategic sourcing hinges on open producer dialogue. Technical questions, secondary documentation, and product performance feedback all reach the right hands faster when clients go to the manufacturer. We emphasize direct engagement, having seen how convoluted distributor chains erode both quality feedback and technical transparency. Our teams always take that extra call, exchange analytical data, and walk through potential improvements backed by in-plant knowledge.
3-Chloro-2-Nitroaniline’s place in the market continues to evolve. We observe rising demand driven by the expansion of specialty pigments, as well as regulatory-driven reformulation work in several advanced manufacturing segments. Our forecasting, investment in plant upgrades, and research partnerships stem from these signals. This drive has led us to explore greener synthesis, lower-impact process aids, and support for rapid regulatory documentation. Industry conversations shape our research priorities and keep us ahead of shifting requirements.
Years on the production floor have taught us that customer confidence builds from experience, not paperwork. Each lot of 3-Chloro-2-Nitroaniline we produce touches many hands before final shipment, and each hand knows the importance of their work. Quality results matter, but so do rapid response to issues, honest dialogue about constraints, and willingness to tweak processes for better fit. Our product has grown into a reliable, predictable backbone for countless industrial applications. All that work, every day, brings consistency to users at every stage, from dye plants to research labs.
Trust in chemical manufacturing grows from willingness to share methods, explain excursions, and adapt based on feedback. Through every challenge—contamination events, shipment delays, new specification requests—we have learned the value of transparency. We invite customer audits and take pride in presenting not just finished goods, but also the process, documentation, and people behind each drum shipped. Our product carries a record of care that shows in every analytical report, every technical consultation, and every repeat order.
The users of 3-Chloro-2-Nitroaniline expect more than a product that meets a test sheet. They expect the reliability and knowledge base of a manufacturer with decades at the reactor, a plant team working with hands and heads, and a promise of improvement. Each lot tells the story of experience earned, problems solved, and industry needs anticipated—one batch at a time.