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3-Chloro-2-Hydroxypropanesulfonic Acid Sodium Salt

    • Product Name 3-Chloro-2-Hydroxypropanesulfonic Acid Sodium Salt
    • Alias Sodium chlorohydroxypropane sulfonate
    • Einecs 262-194-2
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    992970

    Chemical Name 3-Chloro-2-Hydroxypropanesulfonic Acid Sodium Salt
    Cas Number 126-83-0
    Molecular Formula C3H6ClNaO4S
    Molecular Weight 212.59
    Appearance White to off-white solid
    Solubility Soluble in water
    Melting Point Decomposes before melting
    Storage Conditions Store at room temperature, keep container tightly closed
    Ph Value Approx. 7 (1% solution in water)
    Synonyms Sodium 3-chloro-2-hydroxypropanesulfonate
    Ec Number 204-809-1

    As an accredited 3-Chloro-2-Hydroxypropanesulfonic Acid Sodium Salt factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White, HDPE bottle with tamper-evident cap, labeled "3-Chloro-2-Hydroxypropanesulfonic Acid Sodium Salt, 100g," displaying hazard and storage instructions.
    Shipping 3-Chloro-2-Hydroxypropanesulfonic Acid Sodium Salt is shipped in tightly sealed containers, protected from moisture and incompatible substances. Transport is conducted in compliance with relevant chemical safety regulations to prevent spills or leaks. The package includes labeling with hazard information and handling instructions to ensure safe delivery and storage.
    Storage **3-Chloro-2-Hydroxypropanesulfonic Acid Sodium Salt** should be stored in a tightly closed container, in a cool, dry, well-ventilated area, away from incompatible substances such as strong oxidizers and acids. Protect from moisture and direct sunlight. Store at room temperature, avoiding temperatures above 30°C. Ensure proper chemical labeling and access only by trained personnel following standard laboratory safety protocols.
    Application of 3-Chloro-2-Hydroxypropanesulfonic Acid Sodium Salt

    Applications of 3-Chloro-2-Hydroxypropanesulfonic Acid Sodium Salt in Industrial Manufacturing

    3-Chloro-2-Hydroxypropanesulfonic Acid Sodium Salt supports several high-volume downstream industrial sectors due to its functional group reactivity and solubility. The following application breakdown covers practiced manufacturing routes, with dedicated details relevant to formulators, engineers, and quality managers.

    1. Synthesis of Textile Dye Intermediates

    Textile chemical manufacturers employ this material as a sulfonating and hydroxy-chlorinating agent when producing dye linkers and advanced intermediates for reactive dye syntheses. Its use enables controlled introduction of sulfonate and chloro-hydroxy groups essential for dye fixation and improving wash fastness on cellulose fibers. The ingredient enters early aromatic substitution routes, providing high selectivity and cleaner side-stream profiles. Consistent batch quality and reproducibility directly impact the shade stability demanded by textile finishers.

    Industry compliance standards

    • OEKO-TEX® Standard 100 for restricted substances in textile dyes
    • ZDHC MRSL (Manufacturing Restricted Substances List)
    • EN ISO 14001 Environmental Management for dye plants
    • REACH Annex XVII (EU) for chemicals in coloration

    Typical usage ratio

    • Between 1.5% and 3.0% by weight in sulfonation stage, adjusted based on aromatic substrate reactivity, target substitution, and final dye concentration.

    Downstream process integration

    • Metering and blending during initial dye precursor sulfonation
    • Careful temperature and pH control for optimized functionalization
    • Continuous monitoring to ensure absence of free halides in effluent
    • Feeding into neutralization and filtration systems prior to drying

    Final product types

    • Reactive dyes for cellulosic textiles
    • Direct azo dye intermediates
    • Vinyl sulfone dye linkers
    • Bifunctional dye precursors for high fastness applications

    2. Pharmaceutical Intermediate Manufacturing

    Api producers select this salt during the synthesis of certain sulfonated and chlorinated intermediates, focusing on regulated small molecule APIs for cardiovascular, antirheumatic, and anti-infective classes. Its precise group transfer delivers critical building blocks where stringent trace impurity control is non-negotiable. Manufacturers rely on validated process steps to eliminate residual inorganics and ensure compliance with pharmacopeia monographs.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP–NF (United States Pharmacopeia–National Formulary) monographs for intermediate purity
    • EU EudraLex Volume 4 Part II for API synthesis
    • FDA 21 CFR Part 210/211 for process controls

    Typical usage ratio

    • 0.8–2.5 molar equivalent relative to the aromatic nucleus, defined by target functionalization and downstream isolation yield requirements.

    Downstream process integration

    • Charged during sulfonation or halogenation of aromatic pharmaceutical precursors
    • Intermediate purification by crystallization and solvent extraction
    • On-line HPLC monitoring for impurity profiling
    • Sequential neutralization and removal in aqueous workup

    Final product types

    • Sulfonated phenol derivatives as drug intermediates
    • ACE inhibitor intermediate scaffolds
    • Chlorinated sulfonic acids for bulk synthesis
    • Antirheumatic API intermediates

    3. Electroplating and Metal Treatment Additives

    Surface finishing formulators incorporate the sodium salt variant as a catalyst and secondary sulfonating component in chrome-free electroplating baths. It functions to enhance metal surface activation, regulate metal ion dispersion, and inhibit undesired side reductions. The additive improves adhesion strength between base metal substrates and organic topcoats, supporting faster deposition rates and improved corrosion protection. Real-time dosing ensures uniform treatment, adapted to substrate geometry and throughput.

    Industry compliance standards

    • ASTM B633 for electrodeposited coatings of zinc on iron and steel
    • ISO 4527 Methodology for decorative and functional plating
    • RoHS Directive (EU) for hexavalent chromium replacement
    • REACH-compliant electroplating bath formulations

    Typical usage ratio

    • 0.2–1.0 g/L in plating bath, adjusted based on line speed, bath renewal, and treated surface area.

    Downstream process integration

    • Direct addition to metal activation stage
    • Automated bath monitoring for ionic strength balance
    • Post-plating rinse optimization to minimize carryover
    • Electrochemical recovery system compatibility check

    Final product types

    • Corrosion-resistant automotive components
    • Electroplated architectural hardware
    • Consumer electronics housings
    • Machinery parts with improved surface hardness

    4. Water Treatment Chemical Synthesis

    Specialty chemical blenders use 3-chloro-2-hydroxypropanesulfonic acid sodium salt during the formulation of sulfonated complexing agents and chelators for municipal and industrial water treatment. This input allows precise engineering of scale inhibitors and dispersants targeting calcium, iron, and heavy metal ions. Its controlled reactivity profile yields stable products with low residual byproducts, crucial for compliance with potable water standards and efficient plant operation.

    Industry compliance standards

    • NSF/ANSI 60: Drinking Water Treatment Chemicals – Health Effects
    • AWWA B200/B202 standards for chemical quality and usage
    • EN 15040 for water treatment chemical performance
    • ISO 9001:2015 for quality management in chemical manufacture

    Typical usage ratio

    • 0.5–1.7% mass fraction for chelant synthesis, tuned to target ionic profile and process yield.

    Downstream process integration

    • Batch addition into chelation reagent reactors
    • Neutralization and phase separation for reducing free acid content
    • Filtration and sanitation prior to storage and shipping
    • QC validation for complexing capacity before dispatch

    Final product types

    • Phosphonate-free antiscalant agents
    • Dispersant blends for cooling towers and boilers
    • Municipal potable water chelators
    • Condensate line scale control solutions

    5. Production of Anionic Surfactant Precursors

    Manufacturers of high-performance surfactants use the compound as a key feedstock for introducing sulfonic acid groups into propylene oxide-derived molecules. Its application supports the generation of anionic surfactant bases for industrial detergents, textile auxiliaries, and oilfield additives. Process engineers exploit its solubility and controlled group release to maximize throughput and minimize unreacted chlorinated byproducts.

    Industry compliance standards

    • EU Detergents Regulation (EC) No 648/2004 for surfactant content and biodegradability
    • ISO 9001 certified quality management for surfactant manufacturing
    • EPA 40 CFR 799 for TSCA surfactant registration
    • OECD Test Guideline 301 for aquatic degradability

    Typical usage ratio

    • 1.2–2.0 molar equivalents per mole propylene oxide oligomer chain, depending on degree of sulfonation and end-use rheology.

    Downstream process integration

    • Stepwise addition in sulfonation reactor following chain extension
    • Alkaline neutralization to produce sodium salt form
    • Vacuum stripping for purge of excess reactants
    • In-line monitoring for endpoint control and byproduct minimization

    Final product types

    • Anionic surfactants for detergent blends
    • Textile wetting and dispersing agents
    • Oilfield demulsifier bases
    • Commercial-scale emulsifiers for agrochemical formulations
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    Certification & Compliance
    More Introduction

    3-Chloro-2-Hydroxypropanesulfonic Acid Sodium Salt: Fresh Insight from the Factory Floor

    Real-World Observations on a Specialist Reagent

    Manufacturing chemicals isn’t about quick decisions or guesswork; experience plays its part every day. In our facility, one of the most notable products coming from our reactors is 3-Chloro-2-Hydroxypropanesulfonic Acid Sodium Salt, with the common label of CHPS-Na. Behind the code and technical name stands a product that embodies the practical knowledge gained from regular hands-on production, strict testing, and problem-solving with partners from across the chemical supply chain.

    Understanding the Product Beyond the Label

    The sodium salt of 3-chloro-2-hydroxypropanesulfonic acid is more than just a specialty intermediate. On a molecular level, it offers a rare mix of reactivity and water solubility, giving formulators and downstream processors the unique handle they need when designing sulfonate chemistry. Every batch produced under our roof tells a story of strict purification, crystallization, and quality control. These steps ensure the material comes out meeting the necessary standards for advanced synthesis work, from pharmaceuticals to dye intermediates.

    Expertise-Driven Manufacturing Yields Reliable Consistency

    Over years of scaling up production, we have seen many variations in batches—whether from minor shifts in raw material quality or subtle temperature swings in reactors. The true value from a manufacturing standpoint comes in learning how to tune those processes, not just chasing certificate numbers but observing how changes ripple through yield, color, and purity. With 3-chloro-2-hydroxypropanesulfonic acid sodium salt, maintaining control over hydrolysis and side reactions demands daily skill. This isn’t a commodity item, and each consignment reflects care in process design and batch tracking—because accepting shortcuts leads to headaches for end users. We’ve watched customers face disruptions from poorly controlled material; by seeing these issues from both production and application angles, we focus on robust, reproducible output.

    Harnessing Experience for Application Advantages

    While countless chemicals mark themselves for theoretical uses on paper, the actual field performance reveals what’s possible. Our sodium-derivatized compound plays a central role as a sulfonating agent and an epoxy intermediate. The chlorohydrin structure brings together both nucleophilic and electrophilic centers, setting up a wide range of reactivity patterns in synthesis. Over many campaigns, research and customer feedback pointed us to key traits: effective incorporation into waterborne formulations, strong selectivity in ring-opening, and friendly behavior in automated production lines. Solubility matters more than any spec sheet promises—if the material aggregates, every blender along the chain suffers. By calibrating drying and sieving steps to resist caking without loading up on unnecessary anti-caking agents, we streamline both packing and user delivery.

    Distinctive Physical Traits: Factory Perspective

    Handling tons of bulk material each month sharpens attention to physical makeup. The sodium salt typically arrives as a free-flowing powder or slightly granular solid. Unlike many organic intermediates, it resists dusting under ordinary handling, and granule size stays stable throughout most blending and feeding equipment. Moisture content, always a concern in these hygroscopic products, stays low thanks to controlled drying cycles and watertight packaging lines. While it holds up in storage, long exposure to humid air or poorly sealed containers still threatens caking—this insight steadily improved our packaging design and warehouse practices. What might appear trivial to a trader or catalog writer makes a difference for plant operators, who need reliable material behavior in hoppers, conveyors, and small-pack repacking.

    Batch Specifications: Meeting Targets Based on Practical Limits

    Specification sheets make promises about purity, water content, and typical assay ranges. In our hands, these aren’t just marketing targets; they become real world constraints. Standard assay by titration, supported by advanced chromatography for impurity tracking, hovers around 98% or above. Minor variations result from not only synthesis but also storage and atmospheric exposure. Sodium chloride stands as the primary byproduct, a remnant of the neutralization phase, and we monitor it tighter than most, given its potential impact on downstream ionic balances. Color rarely drifts past faintly off-white, but seasonal humidity sometimes shifts brightness a notch. Granule size distribution—often overlooked—remains in a tight window so users get consistent metering. These details live at the intersection of chemical science and practical plant knowledge, where specifications become a living thing, adjusted by direct production feedback.

    Product Differences: Sodium Salt Instead of Free Acid

    Common questions from buyers revolve around differences between our sodium salt form and the free acid variant of 3-chloro-2-hydroxypropanesulfonic acid. Experience shows the salt version greatly improves storage stability and handling safety. Free acid forms, even with stabilized storage, bring added risks—lower pH, higher corrosivity, and the need for more cautious feeding. Sodium salts simplify waste treatment for most operations, and water solubility increases, removing hurdles in blending. Laboratories sometimes demand the acid for specialty transformations, but for most industrial-scale synthesis or polymer modification, sodium salt answers nearly all technical needs. This difference in behavior, seen from plant to warehouse to application lab, gives the sodium variant a steady edge in day-to-day reliability.

    Supporting High-Tech and Bulk Segment Applications

    In the pharmaceutical world, 3-Chloro-2-Hydroxypropanesulfonic Acid Sodium Salt works as a valued building block for sulfonated intermediates. Its controlled reactivity streamlines installation of sulfonate groups on aromatic or aliphatic scaffolds, saving crucial steps during multi-stage syntheses. Dyes and surfactant manufacturers benefit from its dual-reactive sites—offering modification both at the chlorohydrin and the sulfonic acid handle. Our direct feedback comes from seeing how even minor differences in batch-to-batch purity or moisture can push back production times by hours, or compromise yields in long synthesis chains. The fact that this chemical offers such a stable platform is not accidental; it comes from process improvements born out of watching and fixing every practical problem, from raw tank fouling to ULPA filtering in sensitive applications.

    Worker Safety and Environmental Responsibility from the Ground Up

    Worker safety stands above all else in production. While sodium salts tend to present fewer hazards than many liquid intermediates, vigilance around dust and moisture load stays with us. Over the years, we have invested in closed transfer lines, dust collection zones, and strict PPE policies guided not just by theory, but by observations of how spills and leaks can occur—even with careful workers. This feeds into environmental stewardship, as we emphasize strict containment and wastewater pre-treatment right at the source, not simply downstream. Compliance is only part of the equation; by integrating robust monitoring at every valve, joint, and pump inlet, we see measurable improvements in emission reductions.

    Downstream Handling—Learning from Customer Use Patterns

    No chemical leaves our warehouses seen as “finished.” Every customer interaction gives us feedback on product handling, from off-loading trucks to opening sacks in batch reactors. Friction points—whether dusting, caking, or solubility lag—push us to tweak packaging layers and logistics. End users in high-throughput plants, especially in waterborne resins and specialty surfactants, share their pain points: delayed feed rates, losses from agglomeration, slower dissolution. Responding to these critiques, our engineering team runs small pilot packing lines and wetting tests, working alongside operators as products get transferred from drums to kettles. By doing so, we eliminate bottlenecks, continually sharpening delivery and usability.

    Comparisons with Competing Products: Real-World Outcomes

    Across dozens of projects, discrepancies between 3-chloro-2-hydroxypropanesulfonic acid sodium salt and functionally similar intermediates influence both chemistry and process economics. Substituting with alternative sulfochlorinated or sulfoalkylated species sometimes slashes performance in color stability or reactivity. Where our product stands out is its balance of gentle handling, high assay, and manageable storage requirements—which, from a manufacturer’s vantage, means fewer returns or process failures at the customer site. In polymer applications, side reactions and color drift trace almost always to upstream instability. Simple improvements such as more accurate pH control during neutralization and vigilant drying cycles show up immediately in customer yield and batch clarity.

    Improving Practices Through Transparency

    No manufacturer should treat feedback as an afterthought. Over the years, technical teams and operational leaders at our site have developed routines for open reporting—not only for defects but also for incremental improvements. That covers not only recordkeeping, but shared training from production shifts, maintenance crews, and quality technicians. Documentation alone never solves on-the-floor bottlenecks; quick meetings and feedback sessions do. One such example came from an uptick in returns tied to caking after extended storage. Rather than blaming weather or shipping, we ran in-house trials matching material age, packaging style, and storage conditions. Adjusting outer bags and including controlled desiccant layers cut returns, improved user satisfaction, and simplified internal transport. These hands-on alterations led directly to practical results—a lesson that technical improvement rarely lives in a vacuum.

    Modernization and Technology Upgrades

    Success in chemical manufacturing depends on adopting new technology and automation without losing focus on process fundamentals. As control systems become smarter and reactors more closely monitored, plant operators, instrument specialists, and R&D chemists must collaborate closely. Real-time analytics and digital sample logs have taken much of the guesswork out of assay measurement and impurity profile tracking for products like CHPS-Na. Upgrading material handling—from automated baggers to more flexible mixing tanks—eliminates old manual problems. Still, the touch of a skilled technician adjusting a valve or watching crystallization in real-time makes the crucial difference between a good and a great batch.

    Challenges Faced and Solutions Refined

    No process runs smoothly forever. At various times, issues from unpredictable feedstock purity to sudden utility failures have forced rapid adaptation. Reacting too quickly often brings more trouble; collected production data and plant logs now guide every troubleshooting round. In the case of sodium salt production, purity below target initially linked to slow reactor agitation during the introduction of the chlorinating agent. Noticing this, we changed the mechanical setup, adding a robust stirring system and revising feed rates. Resulting batches jumped in purity and throughput, directly impacting production targets. Physical mishaps—like accidental moisture leaks—prompted investments in smarter sensors and failsafe locking on hoppers. Learning by doing differs greatly from only running theoretical simulations.

    Collaboration Beyond Our Walls

    Field success relies on close partnerships—be it supply chain handlers, customers, or packaging designers. Our technical staff regularly participates in customer plant visits, conducting direct tests or troubleshooting in real operating environments. These sessions reveal unexpected issues: materials flowing poorly due to overlooked humidity shifts, or processing lines struggling with bag empties. This hands-on exchange means formulation tweaks or new packing standards arise not from distant R&D, but through day-to-day operation. Industry partnerships expand shared knowledge on new synthetic uses and safer handling methods, paving the way for mutual growth.

    Where This Sodium Salt Sits in the Chemical Landscape

    Out of the thousands of chemical specialties handled every year, 3-chloro-2-hydroxypropanesulfonic acid sodium salt stays relevant because, in process plants, it works reliably where many analogs falter. Its unique combination of chloride, hydroxyl, and sulfonate functions makes it a building block for new compounds—especially in environments that demand both water compatibility and carefully controlled reactivity. For dye-makers and surfactant houses, access to a product with stable granulation and resistant to humidity means less unplanned downtime. In pharma, a strong, reliable intermediate cuts risks downstream by lowering impurity carryover.

    Ongoing Development and Industry Feedback

    Continuous improvement cycles run deep in our operation. Each run teaches something new—whether about process bottlenecks or unexpected application benefits. We invest in ongoing training, R&D runs, and pilot campaigns, never assuming that the product can’t be better. Sometimes change means trialing new drying equipment on a pilot batch, or revisiting quality control checklists after unexpected returns. Regular review cycles with frontline workers and customers give us feedback loops no desk-bound program can match.

    Future Outlook: Staying Ahead Through Practical Solutions

    Chemical manufacturing never stands still. Demands from the market, changing regulatory landscapes, and advances in downstream formulations all push development. For our 3-chloro-2-hydroxypropanesulfonic acid sodium salt, ongoing work looks at ways to further drop impurity footprints, improve bulk-pack shipping resilience, and streamline integration with both automated and manual processes. There’s no substitute for hands-on problem-solving: every efficiency gained comes from watching actual production loads and true customer experience, then folding those lessons back into each process iteration. This chemical will keep evolving, shaped by real-world grit and factory-tested knowledge—not just theory or catalog promises.