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3-Chloro-2-Butanone

    • Product Name 3-Chloro-2-Butanone
    • Alias 3-Chloroethyl methyl ketone
    • Einecs 209-954-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    671866

    Chemicalname 3-Chloro-2-Butanone
    Casnumber 4091-39-8
    Molecularformula C4H7ClO
    Molecularweight 106.55 g/mol
    Appearance Colorless to pale yellow liquid
    Boilingpoint 117-119 °C
    Meltingpoint -23 °C
    Density 1.09 g/cm³ at 25°C
    Refractiveindex 1.426
    Flashpoint 32 °C
    Solubilityinwater Moderately soluble
    Synonyms 3-Chlorobutan-2-one
    Smiles CC(=O)CCCl
    Inchi InChI=1S/C4H7ClO/c1-3(6)2-4-5/h2,4H2,1H3
    Odor Pungent

    As an accredited 3-Chloro-2-Butanone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle, 100 mL, tightly sealed with a screw cap, labeled with hazard warnings and chemical details, protective outer packaging.
    Shipping 3-Chloro-2-Butanone should be shipped in tightly sealed containers, kept in a cool, dry, and well-ventilated area, away from incompatible substances. It must comply with hazardous material regulations, featuring proper labeling and documentation. During transport, suitable protective packaging is essential to prevent leaks and exposure, ensuring safety for handlers and the environment.
    Storage 3-Chloro-2-butanone should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from sources of ignition, heat, and direct sunlight. Keep it separate from incompatible substances such as strong oxidizers, acids, and bases. Properly label the container and store it in a designated area for hazardous chemicals, ensuring safety measures are in place.
    Application of 3-Chloro-2-Butanone

    Applications of 3-Chloro-2-Butanone in Industrial Manufacturing

    3-Chloro-2-butanone serves as a vital intermediate for several industrial sectors, supporting both large-scale synthesis and specialized downstream production processes. As a manufacturer with extensive experience in supply chain traceability and technical support, we address compliance, formulation, process integration, and end-use requirements for our global partners. The following core application scenarios outline precise and field-proven roles of this product in real-world downstream operations.

    1. Pharmaceutical Intermediate for Antibiotic Synthesis

    3-Chloro-2-butanone acts as a key building block in synthesizing third-generation cephalosporin antibiotics, particularly during the preparation of 7-aminocephalosporanic acid (7-ACA) derivatives. The material enters enzymatic or chemical acylation steps where precision in purity and compliance is mandatory. Formulators adjust charge ratios to optimize yield while minimizing residuals to meet pharmaceutical regulations. The downstream process frequently involves reaction under controlled temperature and pH, followed by purification steps monitored via validated analytical methods, resulting in high-purity active pharmaceutical ingredients (APIs).

    Industry compliance standards

    • ICH Q7 GMP Guidelines
    • US FDA 21 CFR Part 210/211
    • European Pharmacopoeia (EP) Monographs
    • Chinese Pharmacopoeia (ChP) Quality Standards for APIs

    Typical usage ratio

    • 0.12–0.25 molar equivalent per unit 7-ACA, adjusted based on target derivative and process yield efficiency

    Downstream process integration

    • Incorporated into the acylation reaction vessel after initial substrate dissolution; precise timing of addition ensures effective substitution for downstream β-lactam ring modification

    Final product types

    • Cefotaxime API
    • Ceftriaxone API
    • Other 7-ACA–based cephalosporin APIs

    2. Agrochemical Intermediate for Pyrethroid Insecticide Synthesis

    In the agricultural sector, 3-chloro-2-butanone is crucial for the synthesis of certain pyrethroid intermediates. Downstream manufacturers utilize this material in reacting with carboxylic acids or alcohols for ring formation or chlorination sequences, forming essential halogenated compounds required for next-generation insecticides. Strict adherence to agrochemical active ingredient standards is necessary due to residue and toxicology regulations across export markets. Quality managers verify batch consistency through GC and NMR analysis before bulk formulation into finished actives.

    Industry compliance standards

    • FAO/WHO Specifications for Pesticide Active Ingredients
    • China GB/T 1602 Pesticide Quality Standards
    • REACH Regulation (EC) 1907/2006 for chemical registration
    • OECD Guidelines for the Testing of Chemicals

    Typical usage ratio

    • 0.08–0.19 molar ratio relative to acid or alcohol reagents; variations depend on downstream conversion yield and environmental release controls

    Downstream process integration

    • Added during the intermediate condensation or halogen exchange steps, allowing precise molecular modification within multistep insecticide syntheses

    Final product types

    • Cyhalothrin and related pyrethroid actives
    • Intermediate halogenated ketone compounds for crop protection products

    3. Fine Chemical Intermediate for Perfume Ketone Synthesis

    Fragrance industry manufacturers deploy 3-chloro-2-butanone in controlled ketone synthesis for perfume intermediates, specifically for generating rare methylated or chlorinated notes. Integration occurs via aldol condensation pathways or nucleophilic substitution, requiring strict management of endotoxin and impurity parameters to comply with international perfumery standards. Operators select batch or continuous reactors depending on annual volume, with real-time chromatographic detection for batch release.

    Industry compliance standards

    • IFRA (International Fragrance Association) Code of Practice
    • ISO 9235:2013 (Aromatic Natural Raw Materials for the Perfume Industry)
    • REACH Regulation for chemical safety

    Typical usage ratio

    • 1.5–6.0% by mass in targeted ketone intermediate reaction mixtures; adjusted based on desired fragrance profile intensity and downstream purification capabilities

    Downstream process integration

    • Introduced after initial aldehyde activation to trigger controlled condensation, yielding targeted ketone intermediates for further distillation and purification

    Final product types

    • Methyl ketone-based perfume bases
    • Specialty chlorinated fragrance notes utilized in luxury perfumery

    4. Intermediate for High-Performance Polymer Synthesis

    Polymer and materials manufacturers use 3-chloro-2-butanone to introduce reactive functional groups during monomer modification, setting the stage for advanced polymer architectures. The product is essential in the synthesis of specialty acrylic and epoxy resins, where its bifunctional structure enables precise cross-linking. Technicians monitor viscosity and reactivity throughout addition, complying with international plastics and resin manufacturing standards. Post-integration, the resulting resins display tailored solubility and mechanical resilience for demanding end-use sectors.

    Industry compliance standards

    • ISO 9001 Quality Management System for chemical processing
    • US EPA 40 CFR Parts 79/80 (for polymer component registration, where applicable)
    • EU Regulation (EC) 1907/2006 (REACH) for industrial polymers

    Typical usage ratio

    • 0.5–2.8% by mass of total monomer or prepolymer charge, adjusted for targeted cross-link density and mechanical property requirements

    Downstream process integration

    • Added at the functional group modification or pre-polymerization stage, enabling subsequent copolymerization, chain extension, or cross-linking reactions

    Final product types

    • Performance acrylic resins for coatings
    • Specialty epoxy systems for electronics and adhesives
    • Modified copolymers for high-durability industrial parts

    5. Intermediate for Specialty Dye and Pigment Manufacturing

    Leading dye and pigment producers employ 3-chloro-2-butanone to synthesize key chromophoric intermediates by facilitating controlled halogenation in precursor molecules. These reactions require precise dosing to ensure product purity and batch repeatability in pigment manufacturing. Manufacturers target strict compliance with global colorant safety and purity standards, implementing in-line HPLC monitoring to minimize batch-to-batch deviations.

    Industry compliance standards

    • OEKO-TEX Standard 100 for textile colorants
    • EN 71-3 Safety of Toys for pigment safety
    • ISO 18314-3 for colorant purity analysis

    Typical usage ratio

    • 0.2–1.1% relative to main chromophore precursor based on the depth of halogen incorporation required

    Downstream process integration

    • Participates in the halogenation or ring-closure reaction stage, immediately downstream of primary precursors under controlled conditions to regulate color and solubility characteristics

    Final product types

    • Specialty azo and anthraquinone dyes
    • Chlorinated pigment intermediates for plastics, inks, and coatings
    Free Quote

    Competitive 3-Chloro-2-Butanone prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    3-Chloro-2-Butanone: Reliable Chemistry from an Established Manufacturer

    Producing 3-Chloro-2-Butanone in our facilities means more than filling an order. Every batch builds on years working with specialty ketones. The capabilities, experience, and process controls that we’ve developed inform every decision, from raw material purchasing to purification. In handling chloro-ketones like this one, our chemists focus on key parameters: maintaining manageable impurity profiles, accurate moisture content, and precise control over chlorination. This hands-on approach delivers material that meets the performance goals of complex downstream applications.

    Consistent Quality Through Proven Methods

    3-Chloro-2-Butanone offers a unique reactivity profile—it brings together the mild electrophilicity of its ketone group with the utility of a chlorinated secondary carbon. Some users focus on the moderate boiling point, which enables controlled introduction in multi-step syntheses. Others rely on specific color and clarity criteria, especially when making high-purity intermediates for pharmaceuticals or advanced materials. To satisfy these expectations, we use a direct chlorination process with reliable in-process checks. We know chlorine derivatives can suffer from instability, so we pack and ship this liquid with genuine care. Our teams check for small lots, scale-up runs, and larger volumes, ensuring every shipment is representative of what experienced chemists require.

    Application-Focused Manufacturing Experience

    Our technical group works with customers to understand how they actually use 3-Chloro-2-Butanone—whether as an intermediate for pharmaceutical ketones, an alkylating agent, or a synthon for heterocyclic chemistry. We recognize the concerns that show up in real-world plants: batch-to-batch variation, off-odors, contamination from chlorination byproducts. Over years developing this product, we’ve refined methods to limit formation of over-chlorinated species and minimize unknowns that cause headaches during downstream reactions. Every feedback loop with customer R&D sharpens our specifications and process design. This lived experience—seeing how our material performs not just in the lab but in larger-scale operations—informs the improvements we put in place.

    Key Specifications that Matter in Practice

    Chemists in industry rarely demand theoretical perfection. They need reliable content, clear identity checks, and physical properties that enable safe handling and reliable process integration. For 3-Chloro-2-Butanone, our standard assay is by gas chromatography, which pinpoints purity while highlighting key byproducts that could impact the intended synthesis route. Water and volatile impurities draw close attention, because moisture can throw off yields and create corrosion in storage equipment. By monitoring these specs batch by batch, we avoid the surprises that can shut down a reaction or delay a campaign. Our staff have run these controls thousands of times and know the value of accuracy as well as the cost of a trace contaminant.

    Why Customers Call for 3-Chloro-2-Butanone

    Three decades of experience inform our conversations with formulators and process engineers. The popularity of 3-Chloro-2-Butanone isn’t about novelty. It’s about reactivity and specificity—the compound adds a chloro function where it’s needed without excessive rearrangement or side reactions seen with less controlled reagents. In transition metal catalysis, this molecule can serve as a tailored handle, introducing exact functionalities compared to bulkier or less selective alternatives. Formulators working on niche anti-microbial products sometimes request it because it couples strong activity with tunable volatility, letting them dial in the performance without uncontrolled off-gassing. Others value its compatibility with established solvent and processing systems; it blends into common workups and crystallizations.

    Supporting Large-Scale and Laboratory Use

    Scaling from research to production always exposes new challenges. On the kilo scale, 3-Chloro-2-Butanone’s reactivity must be managed to prevent losses or safety hazards. Compatibility with standard plant materials and solvents matters—chlorinated ketones can attack the wrong gaskets or corrode certain metal lines. We advise customers on storage—how to keep the product dry, avoid UV exposure, and maintain seal integrity in drums or canisters. Our team has wrestled with leaks, unexpected phase separations, or dropped purity, and has used that knowledge to upgrade packaging, labeling, and documentation in practical, site-friendly ways. With a view across the laboratory, pilot plant, and integrated production, suggestions we make come directly from the floor, not just from documents or supplier recommendations.

    Not All Chloro-Ketones Are Equal—Choosing the Right Product

    Some companies new to halogenated ketones expect 3-Chloro-2-Butanone to behave just like its isomers or closely related structures. In practice, even minor changes in substitution position or chain length shift boiling points, stability, chemical compatibility, and reactivity. 2-Chloro-1-butanone, for instance, shows a different set of hazards and suits alternate synthesis routes. 3-Chloro-2-Butanone, by contrast, fits reactions where regioselectivity and balanced reactivity come first. Our quality testing exposes these differences. Users consistently report smoother batch processing and less byproduct formation compared to products sourced from generic catalog houses or made by older methods. Technical support requests from customers unfamiliar with its handling highlight why our attention to the small stuff (odors, viscosity, label clarity) can actually save costs and downtime.

    Working Safely with Chloro-Butanones: Manufacturer’s Practical Tips

    Anyone who spends time in a ketone synthesis area knows the unique odors and handling requirements of chlorinated intermediates like 3-Chloro-2-Butanone. This isn’t just about PPE and compliant storage. Trace acids, formation of unwanted tars, and volatile escape require vigilance. Our years making this compound taught us which transfer methods avoid static, which liners stand up to possible decomposition, and how to neutralize scrubber systems for occasional spills. We’ve published technical bulletins based not only on regulatory requirements but on what operators and maintenance crews encounter at the receiving dock or during blending.

    Our facility staff invest real effort in training new chemists on correct weigh-out and addition protocols. Months of small errors and near-misses drove us to design double-containment totes, color-coded valve stems, and batch-level barcoding. Tanks must stay below certain fill lines. Vacuum transfer beats pumping for long distances. These lessons, learned firsthand, let us share actionable recommendations with sites that purchase from us, reducing turnarounds and avoiding expensive flushes or wasted material.

    How Specification Impacts Synthesis Outcomes

    Decisions about purity, color, and assay aren’t just about regulatory compliance. They shape the yield, selectivity, and safety of every process step that relies on 3-Chloro-2-Butanone. We field stories from users who’ve chased down a faint yellow tint, only to trace it to improper drum lining or extended transit times. Others report a dip in assay by just fractions of a percent throwing off critical enolate formation or halogen exchange rates. We document these cases and use them to drive corrective actions at each link in the value chain. By controlling temperature, environmental exposure, and packaging tightness, we avoid risk-fraught variables. Our partners benefit from a compound with stable shelf life and predictable performance, not a roulette wheel of shifting assay numbers or mystery residues.

    Environmental and Supply Chain Responsibilities

    Handling chlorinated intermediates brings a responsibility bigger than any single shipment. We process waste streams using on-site, closed-loop treatment, reducing environmental impact and protecting water supplies in our community. By investing in emissions controls, we meet evolving regulatory requirements and create safer workplaces. Suppliers and partners expect transparency. We keep traceability records and audit our supply chain for each raw material that comes through the gate. These standards don't develop in a vacuum—they come from decades responding to both customer demands and societal expectations.

    We’ve found that customers working under stricter environmental standards benefit when manufacturers take sustainability seriously. Materials shipped in returnable containers cut waste costs and improve transport efficiency. We keep detailed records that let users provide required paperwork to their own customers, audit teams, or authorities. Sharing experience about best practices encourages not only compliance, but practical time and cost savings in large projects or campaigns.

    Future Developments: Your Needs Drive Our Roadmap

    As new sectors discover uses for 3-Chloro-2-Butanone, we listen carefully to requests for alternative grades, more concentrated forms, or customized blends. We have run pilot campaigns for ultra-low moisture and for specific byproduct profiles. Each request adds to a library of case studies showing how process variables impact performance in real-world equipment. Responsive manufacturers invest in flexibility, so chemists have the options they need for current and future process constraints.

    Looking back, many of our best upgrades started in customer plants: calls to reduce drum weights for easier handling, trials swapping bulk containers for unit-dose packaging, batch holds after detecting a new impurity. Our team welcomes these challenges, drawing on deep process knowledge to keep improving. What separates our product isn’t just its chemical structure, but a culture of listening, fixing problems fast, and sharing practical, actionable insights.

    Summary: More than Just Another Chloro-Ketone

    Our production of 3-Chloro-2-Butanone stands apart because it draws on decades of chemical engineering principles tested against day-to-day plant realities. From warehouse to laboratory to full-scale continuous processing, we supply a compound that meets the rigorous practical demands of working chemists. Close scrutiny of every lot, close partnership with users, and a cycle of feedback and innovation all play a role. What leaves our factory isn’t just a drum but a promise that the details matter—because that's what delivers success batch after batch and campaign after campaign.

    Choosing a Manufacturer with Deep Roots in Ketone Chemistry

    Selecting a supplier for 3-Chloro-2-Butanone requires more than comparing specification sheets. True value comes from trust built on real-world results and a readiness to adapt as process needs shift. Our team doesn't just sell a product—they support its safe, efficient, and reliable application in a broad range of industries. Years spent on continuous improvement, technical problem-solving, and transparent customer service have shaped our approach. Chemists who rely on high-integrity intermediates find a partner in us, not just a supplier.