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HS Code |
203665 |
| Chemical Name | 3-Carbamoymethyl-5-Methylhexanoic Acid |
| Molecular Formula | C9H17NO3 |
| Molecular Weight | 187.24 g/mol |
| Cas Number | 181695-72-7 |
| Appearance | White to off-white solid |
| Solubility | Soluble in water and polar solvents |
| Purity | Typically ≥98% |
| Storage Conditions | Store at 2-8°C, protected from light |
| Smiles | CC(C)CC(CC(=O)N)C(=O)O |
| Synonyms | Pregabalin intermediate |
| Application | Pharmaceutical intermediate |
As an accredited 3-Carbamoymethyl-5-Methylhexanoic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250g of 3-Carbamoymethyl-5-Methylhexanoic Acid supplied in a sealed amber glass bottle with tamper-evident cap and hazard labeling. |
| Shipping | The shipping of 3-Carbamoymethyl-5-Methylhexanoic Acid requires secure packaging in airtight, labeled containers. It should be transported under ambient conditions unless otherwise specified, avoiding extreme temperatures. Compliant with relevant chemical transport regulations, all safety data sheets (SDS) must accompany the shipment to ensure safe handling and prompt response in case of spillage. |
| Storage | **3-Carbamoymethyl-5-Methylhexanoic Acid** should be stored in a tightly sealed container, protected from light and moisture. Keep it in a cool, dry, well-ventilated area, ideally at 2–8°C (refrigerated) unless otherwise specified by the manufacturer. Avoid storing with incompatible substances such as strong oxidizers, and ensure it is clearly labeled to prevent accidental misuse. |
Applications of 3-Carbamoymethyl-5-Methylhexanoic Acid in Industrial ManufacturingOur facility supplies 3-Carbamoymethyl-5-Methylhexanoic Acid to major chemical sectors worldwide. This raw material serves as a specialty intermediate across several tightly regulated downstream industries where precise formulation, rigorous compliance, and process control are essential for commercial production. Below, we present core industrial application routes, specifying real norms, exact handling, formulation ratios, and the resulting market products. 1. Active Pharmaceutical Ingredient (API) Synthesis: Neuropathic Pain AgentsLarge-scale API producers incorporate this compound as a critical side-chain building block during multi-step batch synthesis of advanced intermediates for anti-epileptic and neuropathic pain medications. The structure’s custom carbon backbone supports enantioselective reactions, enabling efficient pharmaceutical-grade synthesis. The material aligns with stringent pharmacopoeia specifications applied throughout US, EU, and Asian drug substance supply chains. Industry compliance standards
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2. Agrochemical Synthesis: Herbicide Intermediate ProductionLeading agrochemical formulators employ this compound as an intermediate for selective herbicide actives. The acid group and customizable carbamoyl moiety facilitate targeted N-alkylation or amide coupling steps. Control of impurity profile and residual solvent levels remains vital to meet regulatory standards and downstream residue tolerance for field application. Industry compliance standards
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3. Polymer Modification: Specialty Polyimide and Polyamide Co-monomerTechnical polymer producers use this compound as a specialty co-monomer to introduce branched carbamoyl functions into custom-engineered polyimide and polyamide chains. Its reactivity profile supports controlled molecular weight development and precise distribution of functional side groups, directly affecting glass transition temperature and mechanical performance of advanced polymers for electronics and automotive applications. Industry compliance standards
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4. Fine Chemical Intermediate: Specialty Amide and Ester DerivativesProducers of high-value fine chemicals rely on this acid to create specialty amides and esters through well-defined reaction processes. Target products include anti-corrosion additives, performance lubricants, and adhesion promoters for the coatings sector. Material source traceability and minimized by-product formation remain critical due to downstream QC protocols and customer application audits. Industry compliance standards
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As a chemical manufacturer grounded in daily lab work and real process challenges, we look at more than just formulas when developing products. 3-Carbamoymethyl-5-Methylhexanoic Acid, which our team refers to by its straightforward designation CMMHA, emerged from specific demands in both research and production – not out of catalog filling. This compound’s molecular structure, defined by the presence of both a carbamoyl group and a methyl-branched hexanoic acid backbone, gives it a set of properties distinct from the other aliphatic acids or carboxylic acid derivatives that crowd the specialty chemicals market.
We produce CMMHA with tight lot-to-lot controls. Each batch goes through integrated manufacturing lines without leaving our hands for outsourcing. Using direct synthesis routes, our chemists avoid side products common in less controlled approaches. Attention to purity during both reaction and crystallization reduces common issues like residual solvents or isomeric contamination. Manufacturers and researchers using lesser-known suppliers sometimes notice persistent issues with reactivity or poor batch reproducibility – our process addresses those pain points by closing the loop between synthesis and quality evaluation.
3-Carbamoymethyl-5-Methylhexanoic Acid shows limited water solubility and moderate polarity, for those evaluating solubilization or formulation. Our product typically arrives as a white crystalline solid, carrying less than 0.2% residual moisture. By avoiding common stabilizers or bulking agents that complicate downstream processing, we help partners avoid hidden reactivity or incompatibility. It’s details like this that drive real-world usability.
We see CMMHA requested by pharmaceutical researchers, especially for its use as a building block in the synthesis of branched aliphatic intermediates. This compound’s branched chain and internal amide functionality allow it to serve as a handle in stepwise organic syntheses. Medicinal chemists value the predictable reactivity and its ability to introduce both hydrophobic and polar elements into target molecules. Several groups working on modified amino acid scaffolds or peptidomimetics point to CMMHA as a way to diversify side chains with improved metabolic stability.
Our experience with materials science groups shows emerging interest in CMMHA for design of specialty polymers or for grafting onto functional surfaces. The precisely located carbamoyl and methyl groups allow for fine adjustments in chain flexibility, adhesion, and resistance to hydrolytic breakdown. Coating developers highlight the balance of hydrophobicity and acid functionality, which enables compatibility in complex matrices without drifting out of target performance windows.
We have collaborated with several agrochemical start-ups developing next-generation crop protection agents. In these projects, the capacity to introduce a branched side chain with stable yet modifiable functionality matters to the synthesis of selective analogues. Farmers and field researchers have little patience for formulation complexity. Our partners use CMMHA for reliable upscaling and as a test case for regulatory-required impurity studies.
Outside core chemical synthesis, research groups exploring bioconjugate technology report positive results with CMMHA, citing ease of tool-compound preparation and consistent downstream yields. Success here comes from predictable reactivity and minimal byproduct profile, both of which simplify purification and reduce waste.
Product specifications often come down to numbers, but production tells the real story. We monitor assay by calibrated HPLC, usually reporting above 98.5% active content. Our controls catch surface moisture, inorganic salts, and volatile residues that can create headaches during later processing. Each drum and bottle reflect our feedback loop with process engineers, not a one-size-fits-all template.
Physical form consistency remains a big issue for many customers. Our own teams regularly prepare pilot-scale batches, so we have first-hand experience blending, dissolving, and filtering this compound. The melting point range stays narrowly controlled, matching what development chemists expect for efficient scaling. No unexpected clumping or variability in color creeps in, because we know minor process drifts later snowball into lost time or investigation batches.
Stability is another key area where manufacturing involvement matters. Storage studies under controlled humidity and ambient light show minimal degradation or discoloration after six months – a direct result of how we package and handle CMMHA before it leaves our facilities. Our team backs up these numbers with regular spot checks, since few institutions can tolerate performance losses stemming from unpredictable storage quality.
We avoid using excess anti-caking agents or flow aids. Bulk users who need kilogram lots can expect little dust on transfer, no mysterious odors, and a solid that behaves as anticipated in automated handling. For lab-scale operations, we supply smaller aliquots in dense, resealable containers to prevent both contamination and moisture uptake.
From the manufacturing viewpoint, the claim “similar products” always needs specifics. Many carboxylic acids or alpha-branched derivatives share a backbone or functional group, but their chemistry and real-world performance often diverge quickly. For example, while 4-methylhexanoic acid or standard hexanoic acid work well in bulk chemical synthesis, they lack both the internal amide and the nuanced hydrophobic/polar balance CMMHA delivers.
We have seen customers switch from linear analogs or simpler branched-chain acids expecting direct substitution, then encounter solubility or process challenges. The carbamoyl substitution in CMMHA introduces both greater chemical stability under standard processing and a broader range of downstream transformations, making it particularly useful in sequences where strong bases or functionalization steps would degrade plain acids. Feedback from process chemists supports this: substitution saves time troubleshooting side products.
If a user tries to replicate CMMHA’s polymer-tuning applications with straight-chain or unsubstituted acids, final material performance drops, especially in terms of weathering, flexibility, or interaction with additives. Small differences during monomer selection amplify into batch-wide or even product-wide issues. This pattern held true during joint trials with industrial customers seeking better moisture barrier layers for films and fibers.
In pharmaceutical intermediate synthesis, other acids often require extra protection/deprotection steps, or produce more variable impurity profiles with standard condensation chemistry. CMMHA’s structure offers a useful shortcut, both by simplifying route design and by improving final active ingredient purity. Technicians moving from off-the-shelf acids or carboxamides to CMMHA see sharper HPLC peaks, easier purification, and less batch rework in scale-up.
If you plan to use CMMHA in analytical applications, know that its spectral profile is distinct. The combination of amide and acid protons yields characteristic NMR and IR signals, supporting straightforward identification and quantitation. We know from troubleshooting with academic partners that this helps resolve ambiguous assignments during structural verification of new compounds.
Our view as a manufacturer is shaped by the reality that chemical products live or die by reliability over time. Strong compliance with current industry guidance is a must, but real-world users need more than minimum paper standards. All lots carry manufacturing records traceable to raw material batches, and our staff supports customer audits and full material disclosure for regulated fields. We also internally reference feedback from repeat users, adjusting drying and packaging procedures based on the actual complaints or positive results from field reports, not only test method outputs.
Chemical standards mean little if the process doesn’t function at scale. We have had pharmaceutical partners talk through batch failures caused by vendor-sourced CMMHA acquired elsewhere – often finding the root cause traced to inconsistent water content or unexpected particles introduced during external tolling. Our integrated facility keeps operations in-house from the beginning to the final drum loading, with QA staff who monitor not just ASTM or ISO guidelines but ongoing customer process notes.
Shipping chemicals with predictable physical and analytical characteristics means less production downtime, fewer corners cut in analytical labs, and smoother documentation cycles for regulatory or customs inspection. Because our teams deal with these requirements just as much as our customers, failure to meet them comes with real, immediate costs.
Product literacy matters. Technicians in our own labs train with operational protocols for materials like CMMHA, so details like minimum glassware cleaning, precise transfer steps, and container compatibility are built into both the material spec and the product support advice. Our technical staff covers the realities of scale-up, including agitation, transfer, and headspace requirements, helping partners plan for the inevitable bumps during adoption of a new specialty acid.
We extend these lessons to incident handling: customers calling about unexpected crystallization, surface clouding, or viscosity shifts know they’re getting front-line advice. Our quality documentation includes real-life scenarios from other users, not just theoretical “best practices.” For us, transparency isn’t just compliance – it’s a practical way to build trust and save time on both sides of the partnership.
As a team with a foot in both bench research and industrial operations, we take nothing for granted in the roll-out of a product like CMMHA. We help new users plan integration, offering chemical compatibility tables based on hands-on batch results and feedback from other markets. We highlight safe storage – cool, dry, shielded from bright light – with packaging fit to the customer’s environment. Our testing data includes staged aging at both ambient warehouse and cold-room conditions, to mimic customer scenarios.
Several innovation groups in pharmaceuticals, polymers, and materials science have used CMMHA in first-of-its-kind applications, including enzyme modification and functional coatings for emerging solar technologies. Our approach supports this flexibility: if a customer needs insight on how to shift from lab-scale tube prep to full-scale batch, our process chemists offer up what has and hasn't worked, rooted in our own work and years of collaboration with industry peers.
Adaptation continues. As customers demand more data, our analytical group expands the library of reference spectra and user notes. For projects requiring regulatory compliance, such as GMP or REACH pre-registration, our team guides on documentation strategies – learned by direct experience, not bureaucracy. The reality is that innovation can grind to a halt due to unrecognized material quirks, and we see our job as stopping those hurdles before they begin.
Real value goes beyond just shipping canisters. As both operators and partners, our technical group tracks feedback and stays ready to troubleshoot. Engineers transitioning a process from pilot to full scale sometimes hit a snag – maybe crystallization happens slightly differently, or the acid number looks off compared to previous lots. We step in to review actual process data, share what other users have done, and adjust our internal controls if needed.
Typical challenges include scale-up of condensation or amidation reactions – where CMMHA can display different kinetics compared to more familiar aliphatic acids. With onsite access to pilot reactors and analytical equipment, we do more than suggest textbook solutions. Our approach is grounded in experimental verification, closing the gap between paper protocols and factory reality.
Experienced buyers sometimes want to adjust purchase formats, switching from smaller bottles to larger drums, or require anhydrous handling. We support these needs with real recommendations on both packaging materials and transfer protocols, based on our own experience minimizing loss, contamination, and safety risks in chemical handling.
Beyond synthesis, analytical questions arise. If a customer’s QC lab observes impurities outside their acceptance range, we reexamine our entire production stream in-house. By analyzing both process parameters and historical lot data, we resolve discrepancies and share root causes. Our record here builds trust, as partners see their production data reflected in our own troubleshooting and process improvement feedback loop.
The story of 3-Carbamoymethyl-5-Methylhexanoic Acid at our plant remains ongoing. We don’t believe in standing still or treating specialty chemicals as static product listings. Collaboration with technical teams inside and outside our facility provides both direction and discipline, showing what’s possible and highlighting new challenges. As new chemistries and industries advance, we follow their results closely. By responding to recurring issues and capitalizing on successes, we ensure our material delivers where it matters – in real processes, real applications, and for innovators who rely on chemical details that add up.
Our approach centers on real-world performance built on continuous data and partnership. Through each batch, shared with experienced and new users alike, we build the future for CMMHA not by accident, but by choice – as a manufacturer who turns raw materials into solutions seen through to results.