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3-Butoxypropionitrile

    • Product Name 3-Butoxypropionitrile
    • Alias 3-Butoxypropanenitrile
    • Einecs 203-689-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    507432

    Cas Number 6280-79-1
    Molecular Formula C7H13NO
    Molecular Weight 127.18 g/mol
    Appearance Colorless liquid
    Boiling Point 201-203 °C
    Density 0.923 g/cm3 at 25 °C
    Refractive Index 1.422-1.424 at 20 °C
    Flash Point 92 °C (closed cup)
    Solubility In Water Miscible
    Chemical Structure CH3CH2CH2OCH2CH2CN

    As an accredited 3-Butoxypropionitrile factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle with secure screw cap, labeled "3-Butoxypropionitrile, 250 mL, for laboratory use only, handle with care."
    Shipping 3-Butoxypropionitrile is shipped as a liquid chemical, typically in tightly sealed containers made of compatible materials such as glass or high-density polyethylene. It should be stored and transported in a cool, well-ventilated area, away from sources of ignition and incompatible substances. Proper labeling and adherence to relevant transport regulations are required.
    Storage 3-Butoxypropionitrile should be stored in a cool, dry, and well-ventilated area, away from sources of ignition, heat, and incompatible substances such as strong oxidizers and acids. Keep the container tightly closed when not in use. Use chemically resistant containers and avoid contact with moisture. Prevent buildup of vapors and ensure proper labeling to prevent accidental exposure or misuse.
    Application of 3-Butoxypropionitrile

    Applications of 3-Butoxypropionitrile in Industrial Manufacturing

    As a direct producer of 3-Butoxypropionitrile, we support global manufacturers in high-precision downstream sectors that require reliable specialty nitriles. The following sections outline real application scenarios verified by consistent industrial practice, including compliance context, recommended formulation ratios, integration into operational workflows, and the specific types of finished goods produced by our customers worldwide.

    1. Agrochemical Intermediate Synthesis

    Agrochemical manufacturers employ 3-Butoxypropionitrile as an essential intermediate during the multi-step synthesis of selective herbicides and advanced insecticidal compounds, leveraging its high purity and controlled reactivity to support heterocyclic and nitrile-coupling reactions. The purity profile meets residue limits required for active ingredient synthesis in regulatory submissions, and the material is tailored for efficient conversion during alkylation or amination routes, where precise stoichiometry impacts both yield and downstream purification cost.

    Industry compliance standards

    • ISO 9001:2015 Quality Management System for chemical synthesis
    • REACH Registration (European Union) for raw material import and handling
    • US EPA TSCA Inventory Certification for approved actives
    • China Pesticide Registration Guidance (GB 20811-2007)

    Typical usage ratio

    • Formulators use 3-Butoxypropionitrile at 0.02–0.08 molar equivalence relative to the main halide or amine co-reactant; the ratio varies by the chain length of the target herbicide or insecticide skeleton.

    Downstream process integration

    • The compound enters at the nitrile introduction stage after core ring assembly and precedes catalytic reduction or hydrogenation steps in batch processes, often in closed reactors to minimize volatilization.

    Final product types

    • S-triazine herbicides (e.g., ametryn, simazine derivatives)
    • Pyridine-based insecticides
    • Chloroacetanilide herbicide intermediates
    • Custom contract-manufactured agrochemical APIs

    2. Pharmaceutical Building Block Production

    API manufacturers source 3-Butoxypropionitrile for its role in controlled cyanoethylation and subsequent downstream conversion via hydrolysis or amidation to access precursor moieties essential in antihypertensive, antidiabetic, and CNS drug candidates. The source material must conform to strict impurity profiles and batch traceability, offering secure registration documents and validated Certificate of Analysis for DMF or CEP filings.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP/NF General Chapters for raw material specification
    • EDQM CEP Section 3.2.S.2.3 (EU)
    • 21 CFR Part 211, US FDA cGMP for finished pharmaceuticals

    Typical usage ratio

    • Introduced at 0.5–2.0% molar ratio in relation to the total weight of pharmaceutical precursor batch, depending on the pathway and targeted yield; concentrations align with downstream toxicity/purity cutoffs.

    Downstream process integration

    • Dosed during the alkylation or cyanoethylation stage, typically in a solvent system supporting selective conversion, and followed by intermediate workup and chromatography purification.

    Final product types

    • Alkyl nitrile pharmaceutical intermediates
    • Hydrolyzed carboxylic acid precursors
    • API precursors for cardiovascular/antidiabetic drugs
    • Specialty fine chemical actives

    3. Specialty Paints and Coating Additive Manufacturing

    High-performance coatings manufacturers utilize 3-Butoxypropionitrile as a reactive solvent or co-monomer for synthesizing binder resins and functionalized acrylic/nitrile copolymers. This enables precise control of resin glass transition temperature (Tg) and solvent resistance profile, critical for advanced vehicle OEM and industrial maintenance coatings subjected to stringent volatility and residue acceptance criteria.

    Industry compliance standards

    • ASTM D5402 (Solvent Resistance of Organic Coatings)
    • EU Regulation 1907/2006 (REACH)—List of Registered Substances
    • US EPA 40 CFR Part 63 (National Emission Standards for Hazardous Air Pollutants for Surface Coating)
    • ISO 9001:2015 Certificate for Quality Management in paints/inks

    Typical usage ratio

    • Formulated at 0.1–2.5% by weight in binder resin phase, adjusted based on end-use film requirements and desired solvent evaporation rates during application or curing.

    Downstream process integration

    • Added during the monomer blending stage in copolymerization of specialty resins, often in combination with acrylates, and further processed by batch distillation and thin-film evaporation; can also function as a tail solvent in pigment dispersion.

    Final product types

    • High-gloss automotive topcoats
    • Heavy-duty industrial anti-corrosion coatings
    • Adhesive-crosslinking binder resins
    • Specialty solventborne coatings for electronics casings

    4. Electronic Chemical Processing for Printed Circuit Board Manufacturing

    PCB fabrication plants employ 3-Butoxypropionitrile as a controlled-polarity solvent and intermediate in the preparation of photoresist stripping and cleaning agents. The unique solvent characteristics support effective removal of polymerized residues from copper-clad laminates while meeting residue standards for microelectronic trace-level acceptance. Our plant delivers the material in electronic-grade specifications, ensuring low metallic and ionic contaminant content that meets downstream qualification criteria for Class 2 and Class 3 electronic assemblies.

    Industry compliance standards

    • IPC-4101B Base Materials for Rigid and Multilayer Printed Boards
    • J-STD-001 (Requirements for Soldered Electrical & Electronic Assemblies)
    • RoHS 3 (2015/863/EU) Hazardous Substances Restriction
    • ISO 9001:2015 Quality Assurance for electronics manufacturing

    Typical usage ratio

    • Blended at 0.3–2.0% within proprietary cleaning agent formulations; the proportion depends on copper surface area, type of photoresist used, and cycle time for automated wash systems.

    Downstream process integration

    • Utilized post-imaging and surface development as a step in automated or manual cleaning baths, where it combines with amine or glycol-based stripping agents to remove organic films and residues before lamination or soldermask application.

    Final product types

    • Copper laminate cleaning solutions
    • Printed circuit board pre-treatment agents
    • Microelectronic grade photoresist removers
    • Precision component cleaner blends
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    Certification & Compliance
    More Introduction

    3-Butoxypropionitrile: A Closer Look from the Manufacturer’s Perspective

    Understanding 3-Butoxypropionitrile in Our Process

    The name 3-Butoxypropionitrile (CAS: 3775-73-3) comes up often in both specialty and bulk chemical orders, but people rarely stop to consider exactly why it stays reliable in demanding applications. From an operator’s view, 3-Butoxypropionitrile isn’t just another bottle on the shelf. We’ve refined its manufacturing over years of process tuning and strict raw material controls. That hard-won consistency in production separates it from the unpredictable profiles sometimes seen in network-purchased intermediates or resold alternatives.

    In our plant, the process begins with carefully selected n-butanol and acrylonitrile. Both get subject to rigorous pre-inspection—moisture and impurity control are non-negotiable if you want a stable yield. We learned early that any cut corners on input affect the downstream purity of the nitrile. Once we charge the reactors, our staff tracks temperature curves constantly. Subtle fluctuations can trigger unwanted polymer byproducts or lead to trace contamination.

    Filtering and fractionating the resulting crude product takes just as much attention. You can’t expect high-performance synthesis without pulling the heavy ends and off-odors out with precision. Our customers might not see the columns or hear the valves click shut, but every lot of 3-Butoxypropionitrile tells the story of those steps. The purity we achieve, typically above 99%, gives steady results batch after batch. That’s something trading houses or repackagers can’t guarantee, since they juggle multiple upstream sources with shifting quality.

    Specification Details and Why They Matter

    Chemical buyers frequently ask about moisture, color, and assay content. In a laboratory or production setting, these minor differences can snowball into major headaches. For our 3-Butoxypropionitrile, we keep water content under 0.1% by Karl Fischer titration and assure visual clarity in every drum. As a nitrile, it naturally resists hydrolysis, yet the presence of water can still lead to slow breakdown or formation of unwanted byproducts during storage, especially at elevated temperatures or in open-air systems.

    Another critical factor is residual starting material. A faint odor of n-butanol or acrylonitrile means incomplete reaction or suboptimal distillation. We monitor those levels closely, using gas chromatography rather than relying on “typical” production standards. Analytical transparency has become a hallmark of our plant’s routine. This approach stems from years of troubleshooting issues for users in electronic materials or fine chemical intermediates—one off-spec batch can shut down a multi-million-dollar process. We treat every drum as if the user’s reputation rides on it, because we have lived through costly recalls from less careful suppliers.

    Each batch of 3-Butoxypropionitrile leaves our facility with a certificate reflecting GC purity, moisture, specific gravity, and color standard. We work directly with customers to tweak those details as needed for their downstream processing. Our facility holds ISO 9001 certification, but real credibility in the specialty solvents and intermediates space comes from consistency, not paperwork.

    What 3-Butoxypropionitrile Does and Where It Excels

    In practical terms, 3-Butoxypropionitrile often acts as a building block more than a finished good. The structure—a propionitrile with a butoxy group—adds flexibility, chemical robustness, and some handy solubility traits. It dissolves in polar and nonpolar media, which gives customers breathing room in process solvent blends. Coatings formulators value that flexibility because the product helps modify flow, adhesion, and leveling, without the volatility of lower-molecular-weight nitriles.

    Outside of coatings, we have customers using 3-Butoxypropionitrile in pharmaceutical synthesis. Its ready nitrile functionality fits well in reactions needing carbon-chain extension or specific amine derivatives. Here, clean starting points mean smoother purifications at later stages. If a pharma group runs into unknown colored byproducts or stubborn residues, it’s almost always a trace impurity in the input—our built-in controls reduce that risk.

    Electronic chemical makers have also knocked on our door, looking for alternatives to short-chain solvents that can’t deliver needed solvency or flash points. The higher carbon count and ether linkage in our 3-Butoxypropionitrile provide just enough boiling range to keep it stable under harsh conditions. They tell us the alternative (lower-boiling nitriles, like acetonitrile or propionitrile) evaporates too quickly and can disrupt process consistency, especially in closed-system manufacturing or during high-shear mixing.

    Some call this a “niche” product, but for those running continuous synthesis or sensitive surface treatments, the margin for error drops to zero. Our product stays clear and within spec, drum after drum. The real test is not whether a sample clears QC, but whether the final formulation or process runs without fail for the user.

    Distinctions Compared to Other Nitriles and Solvents

    Some buyers ask why they should look at 3-Butoxypropionitrile when cheaper short-chain nitriles are everywhere. The difference lies in what happens under load. In a reaction setting, crowded with other reagents, smaller nitriles like acetonitrile or propionitrile often create volatility management problems. Users grapple with evaporation losses, lingering odors, and regulatory headaches over flammability.

    The butoxy group changes the game. It moderates the interaction between the nitrile group and the backbone, creating a solvent with higher boiling point and lower vapor pressure. In coating systems, this provides a slower, more controlled release—producers report fewer pinholes and longer open times for spreading and curing. With regulatory limits on total VOC emissions tightening worldwide, every gram of volatility you can remove from the process counts.

    For users aiming at chemical synthesis, the ether function in 3-Butoxypropionitrile grants selective solubility to target substrates and intermediates. We’ve seen customer methods succeed with this product where straight-chain, unmodified nitriles fall short, either through hydrolysis, reactivity, or incomplete solution behavior. Tailoring process solvents isn’t just about cost per kilo—it’s about how the solvent interacts during a full reaction cycle.

    We value transparency with our users. Some plants see fit to simply re-drum or rename a product, blending or diluting after the fact to meet price points. Our direct control, from input selection through final QC, means the label matches the actual content. Reliability here protects both your business and our reputation.

    Supply Chain, Handling, and Real-World Performance

    There’s more to a chemical than a certificate or a drum. We’ve stood behind our 3-Butoxypropionitrile through dozens of shipping audits, cold-chain deliveries in winter, and client reviews during the hottest months. It packs in the same corrosion-resistant drums we validated for other mid-boiling nitriles and solvents. That feedback loop—designing packaging so the contents truly match the data—matters. Rush jobs and last-minute shipments stay within specification, avoiding the headaches of leaks or contamination that plagued early competitors using recycled barrels or unlined steel.

    Users in Europe, North America, and East Asia have different rules to follow, but the fundamentals remain the same. Clean handling, clear labeling, and a guarantee that the product inside is neither off-cut nor blended out. Our plant’s approach: check drum liner quality and gas-tight seals on every outgoing lot, not just the random sample. If you have ever received an oxidized or yellowed drum with swampy odors, you understand the pain of putting process on hold for days.

    Long supply chains amplify small mistakes. That’s why we keep full traceability of every batch, from raw input to final seal. In customer audits, we encourage full walks along our filling line and tank farms so clients can see firsthand how we operate. The reality of modern production means you can't leave anything to chance. Think of the impact of a poorly sealed container: one drum of off-spec product seldom lives in isolation—leaks migrate, odors spread, and process downtime climbs.

    PRACTICAL INSIGHTS FROM DECADES OF EXPERIENCE

    We didn’t pick up the right habits overnight. Watching batches come off-line, talking with end users, and troubleshooting failed syntheses taught us that tight spec and quality assurance help everyone from the operator to the finished goods packer. If a customer downstream runs an HPLC trace and sees extraneous peaks, guess where the questions come back? Our own batch logs, input records, and storage silos.

    A single problem in solvent performance, even if rare, costs several times more than any upfront savings from cut corners. Once, we fielded a late-night call from a coatings formulator whose product started gelling in a holding tank. Diagnostics pointed not at the resin but trace aldehydes—a known issue with less carefully distilled 3-Butoxypropionitrile from distant suppliers. The message: don’t just rely on numbers, visit your sources and validate handling all the way through. As a manufacturer, we value seeing our client’s challenges as our own.

    Every improvement in our process tracks back to real feedback. One glass manufacturer needed a narrowly defined conductivity and color range. We adjusted our filtration media and swapped out process lines to deliver. No off-the-shelf solution would work; only a process tailored upfront provided the result. This is where direct manufacturing control shines over multisource traders or brokers.

    Environmental and Regulatory Considerations

    Managing chemicals means looking past the immediate sale. Regulations for VOCs, workplace exposure, and final product residues get stricter every year. We monitor each batch of 3-Butoxypropionitrile not just for compliance with local standards, but to predict issues emerging as international rules evolve. Callouts from REACH, TSCA, and various Asian regulatory bodies shape how we produce, package, and label. We can provide full supporting documentation on request—no gaps, no blind spots.

    A lower vapor pressure and higher boiling point help plants reduce air emissions compared to some other nitrile solvents. Our own emissions monitoring, audited yearly by third parties, tracks both workplace and environmental exposure. We heed every feedback round with local environmental inspectors, improving both handling procedures and technical data to align with evolving restrictions.

    Waste management matters as well. We support several clients who reclaim spent solvents or recycle off-spec production for secondary use. Each kilo that stays out of landfill or incinerator serves both the planet and our operational discipline. While 3-Butoxypropionitrile remains a performance chemical, responsible use starts with giving clear, honest risk management advice based on decades of plant operations.

    Final Thoughts from the Production Floor

    People in the field know that product trust is built day by day. It grows every time a batch performs predictably, every time a line operator avoids a sticky pump or mystery film, every time a user reports zero odor or haze. Our crew has run, sampled, and shipped 3-Butoxypropionitrile across thousands of kilometers, adjusting methods for everything from art restoration formulations to light-sensitive circuit inks.

    Direct manufacturing isn’t about slogans; it’s about seeing the chemistry from reaction to user bottling to real-world performance. For every customer, the benefits stem from hard decisions made quietly on the plant floor: controlling inputs, setting higher QA hurdles, and investing in worker training that leaves nothing to chance. That's why when you order 3-Butoxypropionitrile from us, you don’t get a gamble or a guess—you get a commitment, built from years standing next to the process itself, listening and learning from each step in the chain.