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3-Bromophthalide

    • Product Name 3-Bromophthalide
    • Einecs 211-637-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    216293

    Chemicalname 3-Bromophthalide
    Casnumber 3741-34-6
    Molecularformula C8H5BrO2
    Molecularweight 213.03 g/mol
    Appearance White to off-white crystalline solid
    Meltingpoint 74-77 °C
    Purity Typically ≥98%
    Solubility Soluble in organic solvents such as ethanol, methanol, and acetone
    Density 1.715 g/cm³
    Synonyms 3-Bromo-1(3H)-isobenzofuranone
    Inchikey IJUCRRKUCAZYBT-UHFFFAOYSA-N
    Smiles Brc1cccc2c1C(=O)OC2
    Storageconditions Store at room temperature, keep container tightly closed

    As an accredited 3-Bromophthalide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 25 grams of 3-Bromophthalide, tightly sealed with a screw cap, labeled with hazard warnings and handling instructions.
    Shipping 3-Bromophthalide is shipped in tightly sealed, chemically resistant containers to prevent moisture and contamination. The packaging complies with hazardous material regulations, clearly labeled with appropriate safety warnings. During transit, it is handled as a regulated substance, avoiding exposure to heat or direct sunlight, ensuring safe and compliant delivery to the recipient.
    Storage 3-Bromophthalide should be stored in a tightly sealed container, protected from light and moisture, in a cool, dry, and well-ventilated area. It should be kept away from sources of ignition, incompatible substances, and strong oxidizers. Properly label the container and handle it using appropriate personal protective equipment to prevent inhalation or contact with skin and eyes.
    Application of 3-Bromophthalide

    Applications of 3-Bromophthalide in Industrial Manufacturing

    3-Bromophthalide serves as a critical intermediate in a range of industrial processes, especially where precision synthesis and regulatory-approved performance are essential. As a dedicated chemical raw material manufacturer, we provide 3-Bromophthalide to industry partners who require consistent quality and batch-to-batch reproducibility in their downstream formulations. Below are key real-world application areas, with specific details on compliance obligations, incorporation ratios, process integration, and finished product types.

    1. Agrochemical Synthesis—Herbicide Intermediate

    Major global agrochemical producers utilize 3-Bromophthalide for the targeted synthesis of selective herbicide actives. Reactivity at the bromine-functionalized position allows for precision organic transformations crucial to meeting regulatory impurity profiles. Formulators rely on accurate dosage calibration and controlled processing to comply with agricultural chemical standards in export markets.

    Industry compliance standards

    • FAO/WHO: Specifications for Plant Protection Products
    • Chinese GB 2763 Pesticide MRLs
    • US EPA: Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA)
    • EU Regulation (EC) No 1107/2009—Approval of Active Substances

    Typical usage ratio

    • Dosage ranges from 0.5–3.0% w/w of the total synthetic batch, depending on target herbicide structure and scale-up metrics. Adjustments require pilot reaction yield optimization and impurity control data.

    Downstream process integration

    • Introduced during the halogenation or phthalide cyclization early stage in the multi-step synthesis of herbicidal active ingredients. Real-time monitoring ensures endpoint purity, followed by sequential coupling or hydrolysis steps.

    Final product types

    • Technical-grade herbicidal actives
    • Suspension concentrate herbicides
    • Soluble concentrate herbicides
    • Pre-mix bulk herbicide formulations

    2. Pharmaceutical Intermediate—API Precursor

    3-Bromophthalide functions as a strategic building block in the synthesis of benzofuran or phthalide-based APIs, where controlled substitution is mandatory to achieve pharmacopeial standards. Pharmaceutical process engineers require consistent input material to meet global registration dossiers and maintain cGMP documentation during active pharmaceutical ingredient (API) manufacture.

    Industry compliance standards

    • Current Good Manufacturing Practice (cGMP): ICH Q7, 21 CFR Parts 210/211
    • Ph. Eur., USP-NF, ChP (as applicable by API destination)
    • European Medicines Agency (EMA) Guidelines
    • Drug Master File (DMF) requirements in regulated markets

    Typical usage ratio

    • Applied at 0.8–2.2 molar equivalents in condensation or alkylation steps; variation determined by stoichiometry and side-reaction screening during pilot plant scale-up.

    Downstream process integration

    • Charged as a key intermediate at the step prior to core heterocycle formation or phthalide ring modification; followed by purification, crystallization, or chromatographic separation according to the registered process.

    Final product types

    • Carefully characterized API intermediates
    • Finished phthalide-based active substances
    • Pharmaceutical-grade reference standards
    • cGMP-compliant final drug substances

    3. Dye and Pigment Manufacturing—Anthraquinone Derivatives

    Specialty dye manufacturers incorporate 3-Bromophthalide into the condensation and halogenation steps for high-purity anthraquinone pigment synthesis. The brominated phthalide facilitates structural modifications that yield color variance, light-fastness, and compliance with international textile and plastics safety requirements.

    Industry compliance standards

    • DIN EN 71-3: Toy Safety for Heavy Metals in Pigments
    • Oeko-Tex Standard 100 (applicable restricted substances)
    • REACH Annex XVII: Registration, Evaluation, and Restriction of Chemicals
    • ISO 105-X11: Color Fastness to Light and Washing

    Typical usage ratio

    • Normally introduced at 1–4% of batch mass for pigment-grade preparations, precision-tuned based on batch color targets and downstream application requirements.

    Downstream process integration

    • Added at the controlled condensation stage, enabling uniform bromine incorporation. Process technicians implement sequential reflux and purification to minimize by-product contents and guarantee performance in end-use polymers or coatings.

    Final product types

    • Anthraquinone-based pigments
    • Disperse and solvent dyes for plastics
    • High-lightfast colorants for textiles
    • Specialty ink colorants

    4. Fine Chemical Synthesis—Laboratory Reagents & Analytical Standards

    Producers of certified laboratory reagents and analytical standards utilize 3-Bromophthalide in the preparation of traceable reference compounds and specialized fine chemicals. Stringent lot-specific purity assessments and analytical documentation support its consistent use in QC and R&D environments under laboratory and semi-industrial scales.

    Industry compliance standards

    • ISO 17034:2016 for Reference Material Producers
    • ISO/IEC 17025:2017 Laboratory Accreditation
    • ACS Reagent Grade specifications (where relevant)
    • Local chemical safety and handling standards

    Typical usage ratio

    • Variable, typically adjusted between 0.1–5 g per 100 g of target product depending on reaction pathway and analytical method development needs.

    Downstream process integration

    • Dosed as a substrate or reaction intermediate during custom synthesis, reference material preparation, or as part of derivatization workflows for analytical method calibration.

    Final product types

    • Reference standards for analytical calibration
    • Certified laboratory fine chemicals
    • Synthesis intermediates for R&D
    • Calibration solutions for QC applications
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    Competitive 3-Bromophthalide prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    3-Bromophthalide: A Trusted Ingredient Built on Experience

    Every day in our plant, we see the fundamental role 3-Bromophthalide plays in specialty chemical manufacturing. This compound doesn’t headline most industrial news, but behind the scenes it quietly keeps processes running and end-users satisfied. Synthetic chemists and manufacturers come to us with specific goals—whether for fine chemicals, pharmaceutical building blocks, or advanced dye intermediates—and 3-Bromophthalide is often their go-to. Our experience over decades shows why.

    Steadfast Performance in Real-World Applications

    We manufacture 3-Bromophthalide under model BP-0618, following strict process controls that deliver consistent assay and quality metrics by industry standards. Customers in pharmaceuticals and fine chemicals value this reliability. Each batch receives thorough analytical verification, typically achieving a purity above 98%, with minimal moisture content and impurities maintained well below critical thresholds. Specialists comment that their synthetic routes with our 3-Bromophthalide run cleaner, require less post-process scrubbing, and deliver higher conversion rates in target molecules. For us, performance comes down to these day-to-day observations on the shop floor and feedback from direct users.

    This product enters the process as a carefully measured solid, melting above 125°C, with our team ensuring every bag is uniform and particulate-free. We package it so it stores and transports safely, arriving at customer sites in the same condition as the day it left our filling station. There’s a practical wisdom to this—the less trouble our shipments give, the more productive chemists stay in the lab. Feedback from repeat customers focuses not just on technical specs but the workability: our product handles well, pours cleanly, and blends without issue, even in scaled-up runs.

    Consistency Rooted in Modern Synthesis

    In practice, a lot stands or falls with the reproducibility of a key intermediate. Our approach integrates up-to-date synthesis routes and real-time process analytics, minimizing batch variation. Using a closed-system bromination pathway, we’ve cut down on possible side reactions, which means reduced color bodies and unwanted by-products in the finished solid. Fatigue on the reactor line and attention to detail during filtration play roles no brochure can capture, but these have shaped our routines for years.

    Some users in pharmaceutical R&D run highly sensitive assays where trace contaminants can disrupt an entire project. We’ve worked hand in hand with their procurement teams, tweaking our methods to suppress specific impurities. Our registry of feedback reports highlights incremental improvements: lower residual solvents by switching to a dryer atmosphere at final crystallization, or cleaner filtration after revising our equipment cleaning protocols. These insights feed directly back into production, and lab teams see the change.

    What Sets Our 3-Bromophthalide Apart?

    We’ve had customers compare material from various global sources. Off-spec batches from poorly controlled sites bring unwanted surprises: discoloration, persistent odors, and a tendency to clump or cake. We use a drying and milling step that keeps granules free-flowing and easy to handle, and a double-filtration process strips out minor insolubles. Chemists who rely on our material appreciate the subtle difference; a smoother reaction profile saves rework and lets them stay on schedule.

    Local partners in dye and pigment manufacturing comment that our 3-Bromophthalide integrates better in condensation reactions. “Yields are up, fouling is down,” one foreman told us during an audit. These are the moments that underline why trace quality characteristics matter. Not every specification shows on a product data sheet, and firsthand experience confirms the best material for the job.

    Sourcing with Confidence—Knowledge Built in the Plant

    Across the years, we have seen customers affected by supplier shifts, regulatory changes, or procurement bottlenecks. Larger chemical operations and specialty manufacturers need short lead times and no guesswork about incoming quality. That’s why we continually invest—both in people and process technology. Training covers not only technical skills but also the ethos that runs through our business: supply good material that makes the customer’s job easier, and they’ll keep coming back.

    Plant engineers, synthesis experts, and logistics teams review every step, from in-process sampling to final drum loading. If a batch falls outside our internal quality flags, it doesn’t leave our site. Our power comes from the in-house knowledge base—operators who have run thousands of cycles, chemists who check for hidden impurities, and a lab that’s always improving analytics. Our business remains grounded in what works, not what marketing trends might say.

    Bridging Research and Scale-Up

    Research labs choose our 3-Bromophthalide for its predictability in test reactions. When new molecules come through in pharma development or specialty dye work, scale-up must not introduce risk. We work with lab managers and scale-up engineers to ensure our product maintains consistency beyond the gram scale. Feedback circles back to us when a pilot batch flows through exactly as predicted, and project timelines stay on track.

    Chemists on our customer support line talk shop with users, sharing best practices on handling, storage, and recipe optimization. Years of shared technical troubleshooting have built trust on both sides. A technical manager working in electronics synthesis remarked recently that reliable starting material heads off 90% of headaches. For those scaling up, we keep paperwork simple and our supply lines transparent, so no bottleneck breaks momentum.

    Meeting Specialized Demands

    Different customers assign unique roles to 3-Bromophthalide in their processes. For some, it’s the precursor to more complex aromatic acids in high-value pharma applications; for others, it encourages chromophore formation in advanced dyes or pigments. Scenarios often demand that we tweak drying, blending, or particle size distribution. We adjust not by broad-brush but by gathering customer specifics and adapting methodically. Our standard packaging fits bulk operations, but custom needs—smaller packouts, extra-purified lots, or technical documentation—find their way through our production queue too.

    We don’t chase every market trend. Instead, we’ve built experience in what matters—production routes that limit exposure to hazardous byproducts, packaging that survives long-distance shipping, and an internal tracking system that logs complaints and resolutions. Supervisors meet monthly to discuss ways we can further cut waste or improve fill integrity. Each change follows a problem spotted in a real setting and a fix proven in-house.

    Differences That Define Value

    Not all 3-Bromophthalide is the same. Out in the field, we hear stories about inconsistent off-shore batches creating new headaches for buyers forced to double filter or recheck results. Our team focuses on the details: process purity, efficient batch-to-batch transfer, and close communication with downstream users. We know the practical impact of a smoother running process: higher yield, fewer plant stoppages, and simplified compliance.

    Our routine checks document granular differences. For example, our in-line FTIR verification and systematic moisture analysis set a tighter standard than most competitors publish. Soluble iron content, a common disruptor in pigment reactions, registers lower in our output than in almost all competitor-sourced samples we’ve tested. The broader business effect plays out through reduced downtime and more predictable product launches for end users.

    Supporting Evolving Industry Demands

    Environmental standards have tightened across markets. We stay proactive on compliance, from solvent recovery in production to secure transport documentation. Customers receive transparency in sources of raw material and details on our waste reduction initiatives. As a result, we help partners meet rising regulatory burdens more smoothly—letting them focus on core innovation instead of last-minute compliance scrambles.

    Market needs shift fast, but the fundamentals persist. Producers of specialty resins still need an intermediate that won’t seize or introduce unintended side products. Analytical chemists want minimal contaminants for their NMR and HPLC analytics. Our line operators adjust parameters based on historical data collected from hundreds of completed lots, catching potential deviations early. These working habits keep our 3-Bromophthalide ready to serve as a backbone for new product development or to bolster legacy processes.

    Building Relationships, Not Just Transactions

    Direct relationships with buyers and users of our 3-Bromophthalide have shaped our operation. Over time, we find that price negotiations matter less than the reassurance our reachability and technical expertise bring to the table. We believe users should get simple, truthful answers and prompt support that doesn’t bounce between departments. It builds loyalty and trust, much more than flashy sales pitches or shifting marketing claims.

    Some of our oldest business partners started with small volumes for trial runs, then scaled up as their confidence in the product and our reliability grew. Our technical teams share findings and process tips openly. We believe that small gestures—quick sampling, follow-up calls, and willingness to solve storage questions—add value beyond just moving inventory out the door. A culture of shared problem solving leads to more robust chemical operations all around, which benefits supplier and client alike.

    Looking Ahead with 3-Bromophthalide

    Industry demand for traceable, consistent, and clean starting materials rises year over year. We continue to upgrade our facilities to meet these expectations, both by introducing digital tracking tools and by training new operators through direct apprenticeship. Our plant stands as a place where young chemists and veteran process controllers work together, transforming simple aromatic intermediates into the foundation of modern technology and healthcare.

    3-Bromophthalide won’t appear in headlines, but it remains indispensable for specialty manufacturers. Its future pivots on the same principles that have sustained its past: peer-to-peer accountability, deep technical roots, and a willingness to solve each emerging challenge head-on. We see ourselves not as just a producer, but as a trusted contributor to every new advance our partners achieve with their finished products.

    Conclusion: Value Driven by Commitment

    Supplying 3-Bromophthalide is not just a matter of chemical synthesis. It’s a daily discipline grounded in technical accuracy, people who care, and respect for the hands-on realities of chemical manufacturing. We combine decades of craft with fresh insight and direct learning from customers facing market shifts, regulatory updates, and technological demands. As industries evolve, we stand ready to supply material that delivers, backed by a team committed to real-world solutions and sustainable growth.