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3-Bromocyclohexene

    • Product Name 3-Bromocyclohexene
    • Alias 3-Bromocyclohex-1-ene
    • Einecs 212-226-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    118542

    Iupac Name 3-Bromocyclohexene
    Cas Number 4108-20-7
    Molecular Formula C6H9Br
    Molar Mass 161.04 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 174-176 °C
    Melting Point -38 °C
    Density 1.374 g/cm³
    Refractive Index 1.529
    Flash Point 55 °C
    Solubility In Water Insoluble
    Smiles C1CC=CC(C1)Br

    As an accredited 3-Bromocyclohexene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 100 mL, labeled with "3-Bromocyclohexene," hazard symbols, chemical formula, and handling/storage instructions.
    Shipping 3-Bromocyclohexene is shipped in tightly sealed containers, protected from light and moisture. It should be stored in a cool, dry, and well-ventilated area, away from sources of ignition. Proper labeling and handling according to hazardous material regulations are required during transport to ensure safety and prevent leaks or spills.
    Storage 3-Bromocyclohexene should be stored in a tightly sealed container, in a cool, dry, well-ventilated area away from sources of ignition, heat, and direct sunlight. Keep it segregated from strong oxidizing agents and bases. Store at room temperature and avoid moisture contact. Proper chemical storage cabinetry and clear labeling are recommended to prevent accidental misuse or exposure.
    Application of 3-Bromocyclohexene

    Applications of 3-Bromocyclohexene in Industrial Manufacturing

    As a manufacturer of 3-Bromocyclohexene, we support the specialized requirements of multiple downstream industries using this intermediate in real, compliant production environments. The following application scenarios outline how our material integrates into established chemical manufacturing routes, with focus on applicable compliance frameworks, realistic dosing, actual downstream processes, and the specific types of finished products produced.

    1. Pharmaceutical Building Block in Active Pharmaceutical Ingredient (API) Synthesis

    Pharmaceutical companies employ 3-Bromocyclohexene as a key intermediate for preparing substituted cyclohexene derivatives incorporated into several APIs, especially in central nervous system and cardiovascular therapies. The compound serves as a brominated synthon for regioselective cyclization, alkylation, and other functionalization steps critical to the API's core structure. Process development requires close management of material purity and trace by-products to comply with sector regulations.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice (GMP) for Active Pharmaceutical Ingredients
    • US Pharmacopeia (USP)
    • European Pharmacopeia (Ph. Eur.)
    • FDA 21 CFR Part 211 (Finished Pharmaceuticals)

    Typical usage ratio

    • 0.8-1.1 molar equivalents as a reactant, relative to target moiety; adjusted for conversion efficiency and downstream purity requirements.

    Downstream process integration

    • Charged in early-to-mid-stage step for cyclization or Suzuki coupling to introduce the functionalized cyclohexene core; undergoes dehydrohalogenation or cross-coupling, followed by further purification and derivatization towards API finalization.

    Final product types

    • Bulk pharmaceutical intermediates
    • Small molecule drugs targeting neurological or metabolic pathways
    • Precursor molecules for specialty APIs

    2. Agrochemical Intermediate for Protective Agents and Growth Regulators

    Manufacturers in the agrochemical sector integrate 3-Bromocyclohexene during the synthesis of specialized growth regulators and protective agents, where the cycloalkyl structure forms part of the active ingredient for improved crop resistance or growth modulation. Synthesis involves nucleophilic substitution or catalytic coupling with other organic substrates, usually in multi-step batch production.

    Industry compliance standards

    • FAO/WHO Codex Alimentarius (Pesticide Residues Guidelines)
    • OECD Principles of Good Laboratory Practice (GLP)
    • REACH Regulation (EC No. 1907/2006)
    • ISO 9001:2015 Quality Management Systems

    Typical usage ratio

    • 0.5-1.3 molar equivalents, optimized pending desired yield and process loss rates, as guided by downstream conversion efficiency.

    Downstream process integration

    • Entry point following initial raw material derivatization; reacts under controlled temperature and catalyst dosage to obtain target cyclohexene-based agrochemicals; further purified post-synthesis to meet residue limits and formulation standards.

    Final product types

    • Herbicide intermediates
    • Plant growth regulators
    • Fungicide precursor compounds
    • Acaricide building blocks

    3. Specialty Chemicals for Polymer Modification and Performance Materials

    Producers of specialty polymers and performance materials employ 3-Bromocyclohexene as a functional modifier to introduce brominated cyclic structures into polymer chains, targeting improved flame retardancy, impact resistance, or compatibility in thermoset and thermoplastic matrices. The compound features in grafting, copolymerization, or post-polymerization modifications, especially where controlling the density and uniformity of bromine substitution is essential for the target application.

    Industry compliance standards

    • UL 94 (Flammability Standard for Plastics)
    • RoHS Directive (2011/65/EU, for electrical/electronic equipment)
    • ISO 14001 Environmental Management
    • ASTM D6866 (Polymer Content Testing)

    Typical usage ratio

    • 0.2–2.0 wt%, determined by desired bromine loading and product performance targets, with formula fine-tuned during pilot validation for each resin system.

    Downstream process integration

    • Mixed into pre-polymer stage or added during melt blending with initiators; participates in in situ modification, followed by curing or extrusion; subsequent compounding with fillers, pigments, and additives.

    Final product types

    • Flame-retardant thermoplastic granules
    • Modified epoxy resins
    • High-impact engineering plastics
    • Composite materials for electrical enclosures

    4. Synthesis Intermediate for Fragrance and Flavor Precursors

    Within the fine chemical fragrance and flavor industry, 3-Bromocyclohexene functions as an intermediate in the generation of cyclohexenyl ketones and alcohols, which ultimately impart woody or herbal notes to finished blends. Downstream transformation via Grignard or Friedel-Crafts pathways allows for tailored alkyl and acyl substitution, addressing strict purity needs for food-grade and perfumery use.

    Industry compliance standards

    • IFRA (International Fragrance Association) Code of Practice
    • FEMA GRAS list (Flavor and Extract Manufacturers Association)
    • ISO 9001:2015
    • EU Regulation (EC) No 1334/2008 on flavorings

    Typical usage ratio

    • 0.6-1.0 molar equivalents relative to core substrate, with loadings adjusted according to methylation or alkylation requirements in synthesis design.

    Downstream process integration

    • Added to reactor during initial condensation, followed by stepwise substitution and reduction; intermediate purified by distillation or chromatography before final derivatization to produce food-grade or perfumery components.

    Final product types

    • Cyclohexenyl alcohols for aroma compositions
    • Ketone-based fragrance bases
    • Flavor precursors for food industry
    • Essential oil extenders

    5. Fine Chemical Intermediate in Dye Synthesis

    Dye and pigment producers utilize 3-Bromocyclohexene as a reactive intermediate for synthesizing brominated cyclohexene derivatives, which serve as important building blocks in specialty dye formulations for inks and plastics. The material is typically involved in substitution or cycloaddition reactions to introduce color-imparting structures with precise shade or solubility characteristics.

    Industry compliance standards

    • REACH Regulation (EC No. 1907/2006) for chemical safety
    • ISO 787/24 (General Methods of Test for Pigments and Extenders)
    • Oeko-Tex Standard 100 (for textiles)
    • GMP as per ISO 22716 (where dyes are used in cosmetics)

    Typical usage ratio

    • 0.9-1.2 equivalents in targeted synthesis steps, adjusted for chromophore intensity and purity constraints for each downstream dye application.

    Downstream process integration

    • Employed during early condensation or substitution; follows with ring closure and azo-coupling, then isolation and milling to generate dye intermediates; subsequent formulation with solvents and dispersants for end-use deployment.

    Final product types

    • Specialty pigments for plastics
    • Disperse dyes for polyester fibers
    • Inkjet ink colorants
    • Color concentrates for masterbatch production
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    Certification & Compliance
    More Introduction

    Introducing 3-Bromocyclohexene: Applications, Quality Differences, and Our Perspective

    Understanding 3-Bromocyclohexene: Innovation in Chemical Synthesis

    At our production site, 3-Bromocyclohexene isn’t just a line on a product list—it’s a reflection of diligent process control, careful choice of raw materials, and decades of continuous improvement. Chemists value it for its six-membered ring and the strategic placement of that bromine atom—neither too exposed to risk degradation nor too hindered for coupling or functionalization. Over the past decade, we've refined our own reaction routes, ensuring high assay, low-impurity 3-Bromocyclohexene delivered reliably for complex transformations and robust scalable reactions.

    This chemical finds its way into laboratories and plants where precision matters. In many cross-coupling reactions—especially where chemists are aiming to introduce other functionalities onto a cyclohexene scaffold without the hassles brought by multiple donatable hydrogens—this compound fits snugly. Where alternative alkyl or aryl halides stumble, especially due to over-reactivity or problematic byproducts, cyclohexene’s stability comes through. Our observations have shown that for Suzuki and Heck reactions, the presence of a bromine, as opposed to a chlorine or iodine atom, strikes a well-documented balance between reactivity and selectivity. Yields trend higher, side products trend lower, and downstream purification is less of a bottleneck.

    Our Manufacturing Experience: Getting It Right from the Start

    Scaling up 3-Bromocyclohexene isn’t just a mathematical exercise. On paper, halogenation of cyclohexene looks simple, but managing subtle issues—hydrobromination side reactions, heat transfer, and solvent choice—separates high-purity output from product that brings headaches in downstream processing. In our plant, tight temperature control and an efficient quench protocol cut the formation of di-brominated or ring-opened byproducts to trace levels. Details matter: from the purity of cyclohexene sourced, the avenues taken for extraction, to the selection of finished-product drums that won’t leach impurities over months of storage.

    Years ago, a global shift in bromide sourcing standards forced us to rethink not just our bromination chemistry, but our storage and handling logistics. By layering in additional analytical checkpoints and adjusting our purification protocol, we eliminated a pattern of trace impurity carryover that previously impacted a handful of key pharma intermediates downstream. Our in-house team, drawn from both R&D and plant operations, meets regularly with our customers' technical staff to root out pain points. This ground-level feedback matters—batch specs are shaped by real user outcomes, not just internal benchmarks.

    Specifications and Quality Benchmarks

    Model numbers don’t tell the full story; practical chemists and production engineers often look past catalog codes and into documented experiences. Our standard 3-Bromocyclohexene consistently tests above 98% GC purity. The predominant impurity remains cyclohexene itself, attenuated by careful vacuum distillation and controlled crystallization steps. Water content sits low, typically under 0.05%. Metal and halide residues, often overlooked in less rigorous operations, fall well below the most stringent regulatory thresholds demanded by downstream pharmaceutical or agrochemical processes.

    We do not chase absolute perfectionism in a vacuum—each batch’s analytical package tracks impurity fingerprints, allowing users to anticipate effects on high-sensitivity catalytic steps. Instead of just listing “meets industry standards,” we talk with formulation chemists, so that our specs cover not only purity, but also physical form, yield consistency, and documented batch traceability.

    Why End-Uses Matter: Drawing from Industry Practice

    Our direct clients—process chemists in pharma, contract synthesis, and advanced materials—refer back to their experiences with variant halocycloalkenes when troubleshooting. Often, differences arise not between brands, but across lots made under different conditions. The unique structure of 3-Bromocyclohexene lets it function as a bridge between simple cyclic precursors and more elaborately substituted derivatives, so any main- or side-chain inconsistencies show up downstream. For example, the placement of bromine on the unsaturated six-membered ring enables selective functionalization that’s challenging and less predictable with open-chain or aromatic analogs.

    In our own collaborations, one clear advantage over 3-Chlorocyclohexene or 3-Iodocyclohexene lies in the reactivity profile. Bromine’s leaving group ability supports efficient coupling and substitution, without demanding extreme reaction conditions. Compared to the more volatile and sensitive 3-Iodocyclohexene—often trickier to store and less robust under extended reaction times—our product offers a blend of practical handling, moderate sensitivity, and shelf stability. It opens doors to leading catalysis and polymerization strategies stemming from that same olefin-bromine motif.

    We’ve worked with teams making both bulk specialty chemicals and high-value intermediates. Time and again, reproducible results hinge on subtle differences: residual acidity, batch to batch purity, or even shipping container choices for minimizing trace contamination. Our experience has shown that by focusing early on these aspects, we save our partners multiple hours in QA testing and repeated purification cycles.

    Distinct Features: How Our Product Stands Apart

    Unlike simple cyclohexenes or generic brominated aromatics, 3-Bromocyclohexene offers both a reactive alkene and a modifiable bromine function. Its structure isn’t prone to unwanted aromatization or polymerization under ambient storage—you’d be surprised how many so-called “off-the-shelf” products degrade after months of just sitting in ambient lighting or slightly humid conditions. Some imported lots, made under relaxed environmental controls or slower transit times, have shown trace polybrominated byproducts and peroxide formation. We solve this by monitoring peroxide and residual halide levels rigorously.

    Field feedback means everything to practical chemists under timeline pressure. Our own technical service team keeps a log of user reports—where substitution yields drop, we search for patterns in impurity profiles, not just a mismatch with a theoretical spec sheet. By adjusting process parameters, we have dialed in specific features—color stability, minimized odor, and improved thermal resistance—important for end-users performing multi-step synthesis or handling material in bulk.

    Solutions and Ongoing Advances

    The chemical industry rarely stands still. As regulatory frameworks get tougher and as customers shift toward next-generation catalysis, questions about trace contaminants, reproducibility, and shelf life become even more central. We have moved past the idea that a single “standard” grade suffices. Now, for certain recurring customers, we tailor minor aspects of the process: drying conditions, storage atmosphere, or even container linings. Sometimes, a seemingly minor tweak in the distillation endpoint temperature delivers significantly fewer residuals—small differences that pay big dividends in regulated sectors.

    Last year, one client’s feedback on gel formation during extended storage prompted a review of our quenching and filtration procedures. Rather than dismiss it as a storage peculiarity, our R&D group tracked the phenomenon to trace stabilizer depletion—a discovery that led to updated shelf-life labeling and a new protocol for inert gas backfilling. This kind of hands-on troubleshooting comes straight out of factory-floor observation and regular communication with users, not from chasing distant market trends.

    Most plants can make a bottle of 3-Bromocyclohexene that looks clear today—keeping it clear, safely handled, and reliable for months is a bigger challenge. Our operations reflect that reality. We document stability under different storage and shipping conditions, especially for customers in regions with challenging logistics climates. This same attention to detail has shaped our reputation as a producer, not just a packager or bulk trader.

    Market Perspectives: Comparing and Contrasting with Other Products

    The tendency to treat all cyclic bromides as interchangeable only holds in catalogs, not in real-life chemistry. 3-Bromocyclohexene differs notably from its analogs—straight-chain bromoalkenes, for example, behave less predictably and often deliver broader impurity profiles. 3-Chlorocyclohexene handles a bit more gently, but the slower kinetics typically result in prolonged reaction times and extra purification cycles. Anyone trying to couple a Grignard reagent or a boronic acid onto a cyclohexene ring rapidly learns to value bromine’s sweet spot: neither too reactive to cause over-alkylation, nor too inert to require harsh conditions.

    From years of direct user feedback, we know that purity and batch-to-batch stability matter above all. High-purity 3-Bromocyclohexene furnishes more predictable results—less rework, fewer byproducts—and that translates to real economic gains for large-scale reactors and small R&D batches alike. By contrast, the “cheaper” low-spec grades from certain regions often carry invisible costs: clogged lines, lost hours, and diminished final yields.

    Our product stands out not just in terms of safer handling (with fewer volatiles and less problematic decomposition) but also because of the support that accompanies every delivery. Detailed CoAs, real-time traceability, and a willingness to audit and update specs as collaborations move forward underpin our standing. It's not only about bulk volume, but about confidence drawn from consistency—customers return because their teams avoid surprises batch after batch.

    Making a Difference as an Actual Manufacturer

    Making chemicals with integrity means more than filling orders. It involves continuous investment in training, upgrading equipment, and listening to the downstream impacts that sometimes only come to light after months of customer usage. By focusing on where our product ends up—be it a kilogram-scale pharmaceutical run or a hundred-metric-ton batch for advanced materials—we keep both eyes on performance, not just paperwork.

    Our on-site labs run extensive shelf life simulations and simulate a spectrum of processing stresses. This testing means we have firsthand knowledge of where the boundaries lie. In the field, we’ve observed formulations designed for complex molecule synthesis run smoother—and simply work better—when the incoming 3-Bromocyclohexene batch originates from our process line instead of the resale chain.

    We don’t just hear about issues; we live them. Whether it’s spotting odd peaks on a GC or getting a late-night email about off-color product, the reality of being a manufacturer means being accountable for every drop. We have revised entire workflows based on client feedback and internal audits, saving future projects from repeating yesterday’s problems. This kind of loop—problem, observation, correction, validation—defines our team and gives customers more than just a chemical supply.

    Supporting E-E-A-T: Firsthand Knowledge and Continuous Learning

    Expertise at our facility isn’t a marketing claim. Most of our managers and technicians have backgrounds rooted in years—sometimes decades—of on-site responsibilities. Experience means knowing not just “how” to make 3-Bromocyclohexene, but why every step along the way matters. We have seen the full arc: how a small tweak in bromination concentration leads to measurable changes in color stability six months later, or how routine instrument calibration can catch trace impurity shifts before they affect the entire lot.

    Authority means speaking from knowledge earned in daily practice. Many times our chemists work alongside end users to develop validation batches, creating feedback loops that drive both process innovation and risk management. Our commitment to reliability rests on this practical expertise, rather than on abstract assurances or catalog copy. Whether dealing with a pharmaceutical registration batch or a first-run specialty intermediate, our team puts effort into both outcome and documentation—removing the chance for manufacturing drift or spec ambiguities to impact customer projects.

    Final Thoughts: Moving the Industry Forward Together

    In the fast-changing field of synthetic chemistry and advanced materials, 3-Bromocyclohexene keeps its place because of both its proven value and the ability of real manufacturers to evolve with new challenges. We meet shifting industry demands—not by chasing buzzwords, but by listening, improving, and delivering. Our customers return not because we’re the only supplier, but because real differences show up in plant efficiency, product reliability, and total project outcomes.

    From raw material qualification to last-mile delivery, being the producer of 3-Bromocyclohexene carries a responsibility: to uphold standards, to learn from each interaction, and to maintain trust by turning knowledge into action. Our journey with this compound is ongoing, defined by the feedback and needs of those who blend it, transform it, and push the boundaries of what it can help create. We look forward to being part of that challenge, delivering performance—batch after batch—with the integrity that only real production experience brings.