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3-Benzoylpropionic Acid

    • Product Name 3-Benzoylpropionic Acid
    • Alias ethyl benzoylacetate
    • Einecs 211-673-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    533126

    Chemical Name 3-Benzoylpropionic Acid
    Synonyms Benzoylpropanoic acid, 3-Oxopropionic acid phenylmethyl ester
    Molecular Formula C10H10O3
    Molecular Weight 178.19 g/mol
    Cas Number 1073-57-8
    Appearance White to off-white crystalline powder
    Melting Point 98-102 °C
    Boiling Point 350.2 °C at 760 mmHg
    Solubility Soluble in organic solvents like ethanol and methanol, sparingly soluble in water
    Density 1.218 g/cm3
    Smiles C1=CC=C(C=C1)C(=O)CCC(=O)O

    As an accredited 3-Benzoylpropionic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 100 grams of 3-Benzoylpropionic Acid, labeled with product name, CAS number, safety symbols, and lot information.
    Shipping 3-Benzoylpropionic Acid is typically shipped in tightly sealed containers to prevent moisture absorption and contamination. Shipment complies with chemical safety regulations, including appropriate hazard labeling and documentation. Packages are cushioned to avoid breakage during transit and handled according to guidelines for transporting non-flammable, low-toxicity organic compounds. Temperature is usually maintained at ambient conditions.
    Storage Store 3-Benzoylpropionic acid in a tightly sealed container, placed in a cool, dry, and well-ventilated area. Keep away from sources of ignition, moisture, and direct sunlight. Segregate from incompatible substances such as strong oxidizers and bases. Clearly label the container, and handle using appropriate personal protective equipment to prevent inhalation and contact with skin or eyes.
    Application of 3-Benzoylpropionic Acid

    Applications of 3-Benzoylpropionic Acid in Industrial Manufacturing

    3-Benzoylpropionic Acid plays a significant role in specialized chemical industries as a value-added intermediate. Our direct production capabilities ensure reliable supply, controlled specifications, and traceability for high-volume manufacturers with strict compliance demands. Below, we detail key, substantiated downstream industrial scenarios where this compound is commonly formulated, processed, and transformed into finished goods with clear regulatory and operational requirements.

    1. Pharmaceutical Intermediates for Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

    Leading pharmaceutical producers leverage 3-Benzoylpropionic Acid as a critical building block in the synthesis of selective COX-2 inhibitor APIs such as etodolac and analogues. The compound’s ketone-acid motif enables precise condensation and cyclization during controlled synthesis stages, presenting high yields with well-characterized impurity profiles in cGMP environments.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • US FDA 21 CFR Part 211/210 (cGMP for Finished Pharmaceuticals)
    • European Pharmacopoeia Monographs (Ph. Eur.) related to NSAIDs
    • USP <467> Residual Solvents control for API intermediates

    Typical usage ratio

    • Used at 1.0–1.25 molar equivalents relative to the target COX-2 inhibitor scaffold; exact ratio determined by yield optimization and impurity controls during titration and cyclization steps.

    Downstream process integration

    • Introduced in the early-stage acylation or aldol condensation, followed by controlled cyclization or hydrogenation; batch or continuous reactors under validated SOPs.

    Final product types

    • API-grade etodolac and structurally related NSAIDs
    • Registered pharmaceutical intermediates
    • GMP-validated API synthesis stock

    2. Synthesis of Benzoyl-Containing Dyes and Pigments

    Manufacturers of specialty dyes use 3-Benzoylpropionic Acid as a precursor for producing high-purity benzoyl-containing chromophores applied in textile, paper, and plastics coloration. The compound’s functional groups facilitate selective coupling and condensation reactions, enabling downstream production of custom colorants with controlled lightfastness and solubility profiles.

    Industry compliance standards

    • OEKO-TEX Standard 100 (chemicals in textile applications)
    • EU Regulation (EC) No 1907/2006 (REACH) for chemical safety
    • ISO 9001:2015 Quality Management Systems for pigment production
    • EN 71-3:2019 (Safety of Toys – migration of certain elements, for dyes in children’s products)

    Typical usage ratio

    • Typically incorporated at 3–8% by weight in chromophore precursor blends; adjusted according to targeted molecular structure and shade development during synthesis trials.

    Downstream process integration

    • Charged into coupling vessels post-nitration or halogenation; undergoes condensation with heterocyclic amines or anilines to form the colorant base, followed by purification and spray drying.

    Final product types

    • Benzoyl-derived azo dyes for synthetic and natural textile fibers
    • Specialty pigments for high-performance plastics
    • Paper dye intermediates
    • Custom colorant masterbatch components

    3. Fine Chemicals for Fragrance and Aroma Compound Synthesis

    Producers of aroma compounds integrate 3-Benzoylpropionic Acid as an intermediate for key transformations in the synthesis of musky and floral fragrance ingredients. Its aromatic and aliphatic structure supports selective esterification and reduction processes essential for creating stable olfactory notes in perfumery and flavor formulations.

    Industry compliance standards

    • IFRA Standards (International Fragrance Association regulations)
    • ISO 9235:2013 (Aromatic raw materials for the fragrance industry)
    • EU Flavouring Regulation (EC) No 1334/2008
    • Hazardous Substances Regulations for consumer fragrances

    Typical usage ratio

    • Applied at 5–10% by weight in aroma intermediate blends; actual percentage tailored for desired conversion rate and olfactory strength.

    Downstream process integration

    • Typically esterified or reduced in catalytic hydrogenation reactors at the intermediate formulation stage; purification achieved by fractional distillation for fragrance-grade raw materials.

    Final product types

    • Musky, benzoyl-derived aroma molecules for fine fragrances
    • Flavor ingredients for confectionery and beverage bases
    • Fragrance intermediates for toiletries and personal care

    4. Polymer Modifier in Specialty Polyesters and Copolymers

    Our material supports advanced polymer synthesis by introducing benzoylpropionic units into specialty polyester and copolymer backbones. This allows downstream processors to craft resins with tailored flexibility, thermal resistance, and surface activity. The carboxyl and ketone moieties offer multiple reactive sites critical for step-growth polymerization in high-end applications.

    Industry compliance standards

    • ISO 9001:2015 (Quality Management for polymer compounding)
    • RoHS 2011/65/EU (restriction of hazardous substances in electrical/electronic products)
    • FDA 21 CFR 177.1590 (Polymers for food contact in U.S. market, where applicable)
    • GB/T 19495.1-2004 (China national standard for polyesters used in engineering applications)

    Typical usage ratio

    • Incorporated at 0.5–4% by weight in polyester/copolymerization feeds; dosage optimized based on molecular weight target and modification extent.

    Downstream process integration

    • Fed into melt-phase or solution-phase reactors during initial polycondensation or subsequent copolymerization with glycols and dicarboxylic acids; process temperature and pressure controlled to maximize integration without unwanted branching.

    Final product types

    • Heat-stable polyester engineering plastics
    • Modified copolymers for specialty film and coating markets
    • Performance resin masterbatches for electronics and automotive parts

    5. Agrochemical Intermediate for Herbicidal Active Synthesis

    Established agrochemical formulators source 3-Benzoylpropionic Acid for the production of specific herbicide actives, particularly within the class of aromatic ketone-functionalized compounds. The molecular structure links effectively with various phenol and amine derivatives, underpinning the selective synthesis of targeted weed control agents with reproducible efficacy in the field.

    Industry compliance standards

    • FAO/WHO Specification for agricultural pesticide ingredients
    • ISO 9001:2015 (Agrochemical raw materials processing)
    • REACH authorization (EU 1907/2006) for agrochemical production and application
    • EPA Registration Guidelines (40 CFR Part 158, US market)

    Typical usage ratio

    • Dosage ranges from 1–2.5 mole equivalents in root-stage herbicidal synthesis pathways; adjusted to maximize conversion rate and minimize by-product formation during subsequent condensation.

    Downstream process integration

    • Added during initial condensation reaction with phenolic or cyclic amine partners; followed by functional group transformation steps (e.g., acetylation, reduction) and multi-stage purification tailored to herbicide activity requirements.

    Final product types

    • Aromatic ketone-based herbicide actives for post-emergent application
    • Registered agrochemical intermediates for weed control blends
    • Raw materials for granules, EC (emulsifiable concentrate), and SC (suspension concentrate) formulations
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    Certification & Compliance
    More Introduction

    3-Benzoylpropionic Acid: A Practical Look from the Manufacturing Floor

    Where Our Work Meets Chemistry

    Chemical manufacturing rewards persistence. Every day brings new lessons and tighter standards. In our plant, 3-Benzoylpropionic Acid isn’t just inventory — it’s the result of careful handling, attention to safety, and a drive to supply what industries actually need. We’ve worked hard to make this compound a steady performer for pharmaceutical and fine chemical partners who expect more than just technical grade listings. The work’s not glamorous, but you don’t see repeat orders without real-world consistency. Here’s what drives our production.

    Core Product Model and Specifications

    We produce 3-Benzoylpropionic Acid using a bench-marked batch process that’s shaped by years of feedback from R&D chemists, process engineers, and regulatory teams on the downstream side. Chemically, the formula matches C10H10O3 with a molar mass of 178.19 g/mol. Our batches routinely score purity at or above 99 percent on HPLC, targeting colorless to pale yellow crystals for reliable reaction visibility. Moisture usually measures less than 0.5 percent, tracked by our in-line Karl Fischer titration. Each lot follows protocols to control trace byproducts, which matter when you scale up for APIs or performance additives. We follow strict packaging rules, usually double-layered PE lines inside fiber drums, to keep environmental exposure minimal through transit.

    Specific Uses and Real-World Application

    Discussion about 3-Benzoylpropionic Acid often circles back to its performance as a building block. Customers in pharma synthesis count on its ability to introduce a benzoyl side group or propionic chain during core coupling reactions. Large-volume requests come from those assembling hydrocodone, certain anti-inflammatory intermediates, or new benzene-based scaffolds that demand a stable precursor. Beyond small-molecule drug development, we’ve seen it work into functionalized polymers and specialty coatings, where a touch of carboxylic reactivity moves chain extension in the right direction.

    With over two decades on the shop floor, our technical team has flagged trends. This material gets selected when teams need something more manageable than multi-step Friedel–Crafts acylation. The acid group on the propionic chain lets design chemists install benzoyl groups efficiently—often with mild reagents and less aggressive conditions. We’ve supplied projects that move toward pesticide development, fragrance chemistry, and cross-linker research, especially when downstream purification relies on the unique crystallization properties this molecule offers. A single product lot might end up defining reaction scope for weeks before scale-up.

    Differences That Impact Results

    Ordering specialty acids seems straightforward until you’re troubleshooting tower fouling or ambiguous yields in a pilot reactor. Our batch 3-Benzoylpropionic Acid stands out because every kilogram passes through audits built by a team who understands process headaches. Inconsistent water content, strange isomer ratios, or faint yellowing will drive up time at every QA station—it’s a painful lesson we learned early from one-off runs that couldn’t deliver on alpha-to-beta purity ratios.

    Some rivals shortcut drying, some let solvent residues drift above 1 percent, hoping customers will adjust their own drying cycles. We run slow and steady crystallizations, then grind with a temperature-controlled mill to hit an average particle size that fits typical glassware and flow equipment. Chemists in medicinal research say our lots cut 10–15 percent off their pre-mixing prep, mainly because of predictable dissolution and filtration behavior. API makers tell us residual acetic acid or food-grade impurities can scuttle entire campaigns—our SOPs leave those far below detectable limits. The product’s shelf life rarely generates customer complaints, even from those who order a year’s stock at once; storage issues stay minimal, thanks to measured atmospheric and light shielding in our warehouse.

    No Substitute for Consistent Standards

    Most users have experienced the frustration of a poorly-performing lot or a supplier mixing in material that just feels “off.” We don’t cut corners on the reactivity window or let batches drift outside stated purity. Our QC lab runs NMR, GC, and UV-Vis checks on each output, catching the presence of biphenyl or benzoic acid carryovers before packing a drum. A batch that develops color or crystallizes forcibly is never sent out, no matter the backlog or demand signals from the procurement side.

    Years of contract feedback made it clear: spec lines only matter if you can repeat them at three shifts a day. We welcome site audits, blind sample retests, and external regulatory reviews, and our raw data goes into secure, time-stamped logs. Pharmaceutical auditors have consistently cleared our records, and our lot sampling gets extra scrutiny after each equipment overhaul.

    Compared with off-brand material or generic relabeling, our product offers reaction foremen and synthetic chemists a level of predictability. We track each drum back to source batch, solvent system, and in-plant temperature logs. Issues like off-flavor in fine fragrance work tie back to contaminant traces that we eliminated from our pipeline years ago. We still re-verify each time a new compliance standard comes out, or a customer requests an atypical grade—stability, not just paperwork, guarantees clean project scale-ups.

    Feedback-Informed Improvements

    We used to field calls about filtration challenges and slow dissolution rates. Some batches from years ago showed up as milky solutions during chromatography set-ups or offered strange end-point behavior. By putting their feedback straight into our training modules and process manuals, we phased out a series of old bottlenecks. Our shift managers know not to force product through marginal dryers or rush the final crystallization—the priority remains on batch integrity. Regular tooling updates let us restrict heavy-metal content, and schedule solvent swaps that react favorably with the acid’s backbone.

    This approach also means we’ve fine-tuned our documentation and material declarations. Every incoming order triggers a review of prior performance notes—no surprises, no mismatched spec lines. When customers outline the downstream catalysts or specialty glassware they run, we adjust our post-processing to avoid residue buildup and material waste. It’s common for our team to field site-specific requests, running short lots with tailored drying cycles or size adjustments that mesh with unique dosing or dispersion protocols.

    Making a Difference in Reaction Design

    Most bench chemists want to save steps in synthesis, especially when time and solvent recycle rates push up costs. 3-Benzoylpropionic Acid enters the mix where coupling, cyclization, or selective substitutions drive value. The reactivity profile lets pharmaceutical teams develop entities where both propionic and benzoyl groups serve a role, acting either as spacers or active pharmacophores.

    Over the past decade, we’ve watched this acid become a favorite where efficiency matters. Drug discovery teams favor it while mapping out SAR relationships, especially in scaffolds billowing with aromatic possibilities. Its clean conversion across various hydrogenation or reductive amination sequences limits background impurities, which is critical trust where extractions often run on tight limits.

    Research settings on the materials side trust the residue profile. In advanced coatings or specialty plasticizers, the carboxylic group promotes further design, while the benzoyl segment lends thermal and chemical resistance. End markets appreciate project success, not technical jargon—they want clean glassware, minimal fouling, and no surprises at scale.

    Practical Handling and Storage Insights

    Nobody benefits from a batch that deteriorates by the time it reaches its new home. Our experience told us that even a slight bump in humidity or exposure to strong light can impact flow characteristics and final assay. We invested in triple-sealed, low-permeability packing. Inventory rotations never exceed three months at our warehouse, and each outgoing drum leaves with shipment logs. Temperature excursions get flagged; if a truck breaks down, we delay accepting or dispatching a shipment until full product testing confirms no shift has occurred.

    Simple measures keep the material clean—dedicated lines on the milling and filling sides, and hard-walled segregation for acid and amine stocks. Every batch picked for shipment receives a detailed COA, showing test dates and instrument models, so downstream QA teams see what went right. We train all staff to spot subtle color changes or textural irregularities, and anything that raises flags sends the lot for full retest. No shipment moves until all verification boxes get ticked.

    Frequently Asked Questions from the Field

    Many users have asked why our 3-Benzoylpropionic Acid outscores basic listings on reaction suitability or filtration. Over years of troubleshooting and site visits, customers reported issues—off-ratios, odd solubility, unexpected reactivity. Working hands-on, we found that trace solvent residues or isomeric imbalances triggered these headaches. Today’s process filters and analytic runs check each of these, so the product behaves predictably across different research protocols.

    Some developers want to know how our material reacts in large-scale reactors or continuous lines. Batch uniformity, steady particle sizing, and low moisture deliver smoother handling. Investigators in new catalyst research worry about unwanted side reactions; our efforts eliminate esters and aldehydes that would trigger side-products. Each lab or plant has unique hurdles, but the feedback loop with our clients helps us improve the fundamentals.

    From Batch to Bench: Why Attention to Detail Matters

    Trust develops over time. Teams come back to us because we invest in staying ahead of predictable problems—focusing on purity, handling, and storage so that their technical teams can think forward, not troubleshoot backward. We don’t use shortcuts or stock surplus material that needs to be “moved”; each order receives fresh production, and audit trails ensure lot-to-lot connection. If a reaction batch fails upstream, we take it seriously.

    3-Benzoylpropionic Acid stands as a good example of chemistry’s impact on real-world productivity. Small changes—how dry the crystals feel, how a product dissolves, or how many steps a team can skip—accumulate into a better day at the bench and cleaner scale-up runs downstream. Our drive to tailor and re-assess each manufacturing stage means buyers don’t get stuck with generic powder from a faceless source; they get material that supports efficiency, clarity, and lasting partnership.

    Working with Us: Solutions, Not Just Supplies

    Providing 3-Benzoylpropionic Acid in line with customer needs is more than posting numbers or filenames. Regular service improvements—from polishing filtration units, to cycling dryers, to upgrading our analytic pipelines—come from customer requests and real-world snags. If a project team faces a new synthetic challenge, we welcome site visits, teleconferences, and even short-term custom prep runs. While some producers stick only with standard models, we’re willing to collaborate—modifying batch sizes, particle handling, or purity windows to support niche project work.

    We document every improvement and share our learnings with trusted clients, so plant and lab personnel understand each drum’s origin and quality. Our commitment continues through the full product life cycle, reducing downtime and risk for researchers, engineers, and technical managers. It’s a collaborative approach, built on honest feedback and mutual progress, delivering 3-Benzoylpropionic Acid as more than just another chemical. Our relationships matter as much as our material—change and growth start with attention to detail, whether at kilo scale or the next big breakthrough.