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3-Amino-3-(3,4-Dimethoxy-Phenyl)-Propionic Acid

    • Product Name 3-Amino-3-(3,4-Dimethoxy-Phenyl)-Propionic Acid
    • Alias Adapalene Intermediate 1
    • Einecs 629-699-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    839132

    Productname 3-Amino-3-(3,4-Dimethoxy-Phenyl)-Propionic Acid
    Casnumber 16652-60-7
    Molecularformula C11H15NO4
    Molecularweight 225.24 g/mol
    Appearance White to off-white solid
    Meltingpoint 162-164°C
    Solubility Soluble in water and polar organic solvents
    Purity Typically >=98%
    Smiles COc1cc(ccc1OC)C(CN)C(=O)O
    Inchi InChI=1S/C11H15NO4/c1-15-9-4-3-8(7(6-12)11(13)14)5-10(9)16-2/h3-5,7H,6,12H2,1-2H3,(H,13,14)
    Storagetemperature 2-8°C (refrigerated)
    Synonyms 3-Amino-3-(3,4-dimethoxyphenyl)propanoic acid

    As an accredited 3-Amino-3-(3,4-Dimethoxy-Phenyl)-Propionic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White, opaque plastic bottle with secure screw cap; chemical name and hazard labels printed; contains 25 grams of 3-Amino-3-(3,4-Dimethoxy-Phenyl)-Propionic Acid.
    Shipping 3-Amino-3-(3,4-Dimethoxy-Phenyl)-Propionic Acid is shipped in tightly sealed containers, protected from light and moisture. Packages are labeled according to regulatory requirements for laboratory chemicals. Shipping is arranged via approved carriers under ambient or temperature-controlled conditions, ensuring safety and chemical stability during transit. Handle with care and follow all relevant shipping guidelines.
    Storage 3-Amino-3-(3,4-Dimethoxy-Phenyl)-Propionic Acid should be stored in a tightly sealed container, away from moisture, heat, and direct sunlight. Store at room temperature or as specified by the manufacturer, preferably in a cool, dry, well-ventilated area. Keep away from incompatible substances such as strong oxidizing agents, and ensure proper labeling for laboratory use.
    Application of 3-Amino-3-(3,4-Dimethoxy-Phenyl)-Propionic Acid

    Applications of 3-Amino-3-(3,4-Dimethoxy-Phenyl)-Propionic Acid in Industrial Manufacturing

    As a specialized manufacturer, we supply 3-Amino-3-(3,4-Dimethoxy-Phenyl)-Propionic Acid to industrial partners active in pharmaceutical synthesis, specialty chemical production, fine flavor intermediates, advanced material R&D, and other high-value downstream applications. Clients in regulated sectors rely on our technical synthesis control and qualification management for compliance-critical compound integration. Below we detail real industrial scenarios, with technical context reflecting current usage and regulatory expectations.

    1. Pharmaceutical Intermediate for CNS Active Compounds

    Major pharma producers and research companies use this compound as a key intermediate in the manufacture of central nervous system (CNS) active ingredients, including certain classes of non-opioid analgesics and neuroprotective agents. Integration occurs during the multi-step synthesis of advanced pharmaceutical molecules, where the amine and aromatic functionalities enable specific modifications. Stringent process controls and analytical validation ensure ingredient traceability and residual analysis at every critical step, preparing the material for conversion into APIs for finished dosage forms.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • 21 CFR Part 210/211 (FDA cGMP)
    • European Pharmacopoeia monographs for related substances
    • USP General Chapters on Residual Solvents and Impurities

    Typical usage ratio

    • Input ratios range from 0.3 to 1.8 molar equivalents to suit the target synthetic pathway, adjusted for yield and downstream purification requirements.

    Downstream process integration

    • Enters after initial aromatic derivatization or as the coupling partner in amide formation, depending on the planned API synthesis route.
    • Used in batch reactors with controlled temperature and inert atmosphere.
    • Critical in steps requiring selective amination and protection group strategies.

    Final product types

    • Small-molecule CNS drugs (bulk API)
    • Neuroprotective experimental compounds
    • Intermediate reference standards for analytical validation
    • Research grade substances for pharma R&D labs

    2. Building Block for Specialty Fine Chemicals

    Producers of specialty fine chemicals utilize this compound as a functional aromatic amino acid derivative for the synthesis of structural analogs, high-value ligands, and custom molecules for advanced material applications. The highly specific substitution makes it suitable for forming target structures in agrochemical screening, ligand libraries, and optical material research. Application requires validated input specifications and routine purity audits to meet downstream customer requirements in chemical and technical markets.

    Industry compliance standards

    • ISO 9001 quality management for chemical production
    • REACH registration for import and use in the EU
    • Hazard classification under GHS/CLP for shipping and handling
    • Customer-specific purity and identity protocols

    Typical usage ratio

    • Dosage ranges from 2% to 15% (w/w) as a starting reactant in multicomponent reactions or as a limiting reagent for targeted library synthesis.

    Downstream process integration

    • Introduced during early-stage combinatorial or stepwise synthesis via solution phase or microwave-assisted chemistries.
    • Supports construction of functionalized phenyl-propionate skeletons in technical organic synthesis platforms.

    Final product types

    • Agrochemical screening intermediates
    • Optical material precursors
    • Specialty ligands for research kits
    • Chiral auxiliaries and advanced building blocks

    3. Synthesis Intermediate for Peptide Conjugates

    Peptide manufacturers integrate this amino acid derivative in the process of customizing branched and functionalized peptides for biotechnological and diagnostic use. Amino protection and coupling compatibility are strictly controlled. High-performance purification techniques (such as preparative HPLC) handle the downstream isolation of conjugated peptides featuring the dimethoxy-phenyl motif. This supports innovation in novel diagnostic reagents where structural diversity and hydrophobicity tuning are required for target-binding optimization.

    Industry compliance standards

    • ISO 13485 for medical device intermediates
    • EU Regulation 2017/746 on in vitro diagnostic devices, for relevant subclasses
    • Synthesizer validation protocols (USP, Ph. Eur.)
    • GLP for laboratory-scale peptide research

    Typical usage ratio

    • Peptide resin loading at 0.5–1.0 mmol/g; molar equivalents adjusted to peptide length and functionalization complexity.

    Downstream process integration

    • Acts as a side-chain-modified residue, incorporated during stepwise solid-phase peptide synthesis (SPPS).
    • Applied at targeted coupling positions to impart specialized properties to peptides or peptide-conjugates.

    Final product types

    • Diagnostic peptide probes
    • Affinity tag-labeled peptides
    • Functionalized peptide conjugates for biotech research
    • Specialty research reagents

    4. Precursor for Modified Flavors in Food Ingredient Development

    R&D centers and specialty food ingredient manufacturers explore this compound as a synthetic precursor for advanced flavor modulators and controlled-release functional additives. Its unique chemical backbone enables the construction of novel aromatic structures and metabolic probe molecules, following validated trace screening and food-grade synthesis routes. Production lots adhere to food safety and purity specifications, with downstream isolation to guarantee absence of carryover impurities that could affect organoleptic profiles.

    Industry compliance standards

    • US FDA 21 CFR 172 (Indirect food additives: Adjuvants, production aids, and sanitizers)
    • EU Regulation (EC) No 1334/2008 (flavorings and food ingredients with flavoring properties)
    • FSSC 22000 for food ingredient manufacturing plants
    • Hazard analysis and traceability measures under HACCP

    Typical usage ratio

    • Applied as 0.05–0.5% w/w for lab-scale flavor precursor synthesis; actual ratios refined by sensory stability, downstream conversion yield, and regulatory flavor threshold data.

    Downstream process integration

    • Integrated at the initial aromatic modification stage during new flavor molecule development.
    • Subject to final purification and stability testing before inclusion in food-grade blends or delivery systems.

    Final product types

    • Synthetic process flavoring agents
    • Controlled-release food additive precursors
    • Metabolic flavor probe standards
    • Custom flavor intermediates for third-party development

    5. Research Substrate for Enzyme Mechanism Studies

    Academic and applied research laboratories source this material for use as a model substrate in biocatalyst and enzyme selectivity assays. The molecular structure enables chemoselective labeling and metabolic fate tracking in enzymatic studies. Protocols require defined purity, documented synthesis pathway, and complete NMR/MS characterization to prevent interference with kinetic assay endpoints. The compound is incorporated in small-scale reactions and the resulting products analyzed via LC-MS or HPLC for mechanism elucidation in both academia and industrial research labs.

    Industry compliance standards

    • GLP (Good Laboratory Practice) standards for chemical testing
    • ISO/IEC 17025 accreditation for analytical laboratories
    • Internal SOP-regulated procurement and handling for laboratory chemicals
    • Material safety data sheet (MSDS) compliance per GHS

    Typical usage ratio

    • Standard assay setup uses 50–500 μM substrate concentration; actual amount tailored to enzyme kinetic profile and detection limits.

    Downstream process integration

    • Added during enzyme incubation or as a labeled probe in biotransformation trials.
    • Utilized in substrate library screens for reaction specificity determination.

    Final product types

    • Enzyme activity determination kits
    • Reference standards for academic research
    • Isolated biotransformation products for further chemical study
    • Published research data packages
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    Certification & Compliance
    More Introduction

    Introducing Our 3-Amino-3-(3,4-Dimethoxy-Phenyl)-Propionic Acid: Reliability by Design

    A Trusted Building Block for Advanced Synthesis

    We have spent years engineering the production of 3-Amino-3-(3,4-Dimethoxy-Phenyl)-Propionic Acid with methods rooted in consistency and reliability. This compound, known in some circles as a crucial amino acid derivative, gained momentum due to its role in pharmaceutical research, custom synthesis routes, and agricultural applications. Our product carries the model identifier corresponding to its systematic designation, given its direct lineage from our optimized workflow. Purity levels regularly reach 99%, and each batch passes rigorous HPLC and NMR analyses. We understand firsthand that subtle impurity drifts can sabotage an entire synthesis run. That is why every shipment comes with robust certification, not just a confidence statement.

    Building Experience into Every Molecule

    Producing this compound demands more than purchasing raw materials and operating a reactor. Over time, our chemists noticed that the crystalline habit of this product shifts if even minor adjustments are made in temperature ramp rates during isolation. We also observed that residual traces of starting materials, especially from commercially sourced 3,4-dimethoxybenzaldehyde, can persist unless we apply an extended washing sequence and extra filtration. Each production cycle gives us new lessons on how solvents, pH levels, and agitation rates affect particle size and handling during drying. These details do not appear in standard textbooks or supplier brochures, but the knowledge lands with every ton we produce.

    Some research teams require smaller batches, looking for flexibility in grams rather than kilograms. Customization—without compromising integrity—takes a different form in our facility. We have modified our drying setups depending on application, offering powders with distinct moisture profiles. Our staff receive continuous training, focused on real-world production problems—sticky product on filters, flask fouling, discoloration after exposure to air. These discussions feed directly into our process improvements.

    Consistency and Purity: Not Just Marketing Words

    The most respected customers in the biopharma sector insist on unbroken purity records. We heard repeated complaints from companies frustrated by subtle color changes or inconsistent melting points when purchasing from bulk traders. They explained that synthesis failures often traced back to what appeared to be small differences between supplies—differences that only showed up once alternative suppliers started delivering bulk material. Many investigated with our help and realized that long supply chains introduce variables: poor repacking environments result in micro-contaminants, or material stored too long in unstable packaging picks up atmospheric moisture and alters the reactivity profile. By keeping material storage and preparation tightly controlled, we eliminate these uncertainty sources.

    Our experience shows that scale-up batches for peptide synthesis, chiral building blocks, or other value-added intermediates consistently outperform products from traders or job-shop sources. We scrutinize not only the compound’s appearance and purity but also hidden properties such as trace metal content and enantiomeric excess where relevant. These measures are resource-intensive, but skipping them cuts corners that will surface as downstream failures. We have supported labs troubleshooting failed hydrogenations, nitration steps, and coupling reactions—many times, the variable proved to be unseen quality issues in raw amino acid derivatives.

    The Role in Modern Synthesis and Beyond

    Chemists choose 3-Amino-3-(3,4-Dimethoxy-Phenyl)-Propionic Acid for several technical reasons, especially its electron-rich aromatic system and the strategic amino group. The compound serves as both nucleophile and electrophile in carefully designed pathway steps. Its applications extend from active pharmaceutical ingredient (API) intermediates to custom reagents used in crop protection and specialty polymer manufacture. Facilities focused on enantioselective synthesis often require this product for divergent branches that hinge on a consistent chiral center. We engage directly with development teams, sharing process details and, where possible, facilitating pilot runs under non-disclosure.

    Its functions range from classic amide coupling to intricate C–C bond-forming reactions, and we have worked alongside several R&D teams tailoring reactivity for clinical candidates or lead molecules. These teams share stories of unpredictable results after swapping in “identical” chemicals from generic catalog sources—results we rarely see with our own material. A med chemist explained once during a technical meeting that “your acid just behaves better”—illustrating the subtle impact of trace byproducts and physical form on yields, isolation, and purification. Our own troubleshooting has taught us that well-controlled particle size cuts filtration time and reduces mother liquor losses.

    Comparison with Other Sources: Beyond the Catalog Sheet

    Over the last decade, supply chains for specialty chemicals have become more complex, and laboratory personnel often encounter “same substance, different result.” We built our production lines to avoid those traps. Feedback from process chemists tells us the story: competitors’ products sometimes arrive as mixed-phase powders, display a persistent odor from incomplete oxidation, or exhibit variable OA content from sluggish hydrolysis. One frequent complaint relates to tablet or pellet forms supplied by resellers—intended to simplify handling, but in practice, they bring invisible binders and unpredictable solubility in organic solvents. We prefer to sell the product in its native, unpelletized powder, because we control every stage of isolation, drying, and packing.

    For us, repeatability matters more than quarterly margins. We utilize stainless steel and glass-lined vessels for critical purifications, and production never shifts to third-party toll manufacturers. We test not only the target molecule but also for common carryover from solvents, acid quenching, and filtration additives—traces that affect sensitive downstream catalysts and enzymes. Many competitors avoid the extra effort here, but our in-house experience with catalyzed reactions has demonstrated how metal traces, even below parts-per-million, can poison selectivity and shrink yield percentages in peptide coupling. The feedback loop: our own chemists use the batches we make and return their process data direct to production. Failures due to raw material variability drop sharply—a benefit we pass along to customers.

    Our team has handled hundreds of scale transitions, from kilogram R&D lots to multi-tonne campaigns. We learned the hardest lessons when labs reported NMR spectra or LC-MS traces showing surprise peaks, identified as unknown byproducts carried over from poor batch controls elsewhere. One customer’s pilot run failed at scale because of a residual chloride from substandard workup methods used by a catalog supplier. We now routinely run targeted ion tests as part of our QA. Learning from these events has shrunk our rate of out-of-spec batches and cemented our culture of continuous feedback. We prefer tough questions from new buyers—each rigorous audit and technical request reveals another way to uphold consistent standards.

    From Lab Bench Curiosity to Industrial Mainstay

    Years back, when we first explored producing 3-Amino-3-(3,4-Dimethoxy-Phenyl)-Propionic Acid at pilot scale, technicians logged occasional unknown peaks during early-phase HPLC runs, especially after sampling different reactor loads. The cause traced back to merged steps in the isolation protocol. Direct scale-ups from literature methods missed nuances of dropwise addition rates and cooling procedures. Over time, our shift to automated feed and agitation controls produced sharper peaks and eliminated hidden impurities that side-tracked research groups attempting downstream oxidations or reductions. Lessons like these fueled our target yield improvements, but more importantly, gave rise to a robust knowledge base.

    Through frequent conversations with quality managers at API manufacturers, we see how assumptions around raw material “sameness” lead to root cause investigations months later. As labs scale up research-phase reactions, they find themselves confronting sticky residues, phase separation problems, or batch instability. Our approach, based on routine real-world use of our own product in custom syntheses, points to a simple principle: know your starting materials as well as your own recipes. Fewer surprises downstream, faster delivery of reliable analytical data, smoother handoff between development and production. These payoffs matter.

    Supporting Advanced Research: Facing Uncharted Use Cases

    Universities and technology-driven pharmaceutical startups often test our product as part of next-generation catalyst systems or for developing new ligands. These teams conduct high-throughput screening, searching for minute differences in conversion and selectivity using hundreds of micro-scale reactions. In response, we facilitate method transfer and share non-confidential release specifications. Once, a graduate student conducting Suzuki couplings reported an unknown background absorption after switching suppliers. Our team benchmarked lot samples and discovered an unexpected aromatic impurity present at low levels within a batch supplied by a trader. This helped the research group retune their procedure and stopped the experimental halt. These stories guide us in refining our processing controls and audit trails.

    In peptidomimetic development, many researchers look for tight batch-to-batch retention of stereochemistry. Even a small deviation undermines confidence and can derail SAR studies. Our process avoids racemization and provides detailed chiral purity tests for each run. On request, we work with clients’ analytical teams to set up cross-validation protocols and optimize storage strategies that minimize degradation, especially for long-term projects with phased delivery. The technical discussions feed back into our own workflow—suggesting new ways to adapt to changing industry standards.

    Understanding Challenges and Meeting Them Directly

    Scaling specialty amino acid derivatives brings unique process safety and environmental stewardship concerns. Some routes generate hazardous intermediates; failing to handle them with care risks not just facility shutdowns but downstream contaminant problems. About ten years ago, an accident at a competitor’s plant highlighted what cutting corners in waste stream controls can cost. We review each process regularly, from reactor vent controls to solvent recovery, guided by hard experience. Our team develops closure plans for every campaign, ensuring that spent materials track through proper destruction channels. Green chemistry principles push us to reduce hazardous solvent loads and improve water recycling rates without sacrificing product purity.

    For us, compliance is only part of the goal. By keeping environmental monitoring continuous, our site avoids production upsets that can impact both safety performance and product quality. Even subtle changes in local regulations can impact our operation, so we maintain a full-time compliance staff with direct process knowledge. This gives peace of mind not only to our employees but also to every customer who needs clean, traceable material arriving on time and free of surprises.

    Adapting with our Customers’ Growing Needs

    Markets have evolved. Where pharmaceutical intermediates once drove most orders, there’s now demand from plant biostimulant developers and advanced materials groups. Some of these applications require tighter metal controls or unique particle morphologies. Last year, we adjusted crystallization routines to suit a material scientist’s request for better blend qualities in a custom coating resin. This flexible approach—without altering the core product chemistry—relies on a well-tuned feedback mechanism internally between production and application engineering. These customizations stem from partnerships, not from add-on catalog options.

    Several agricultural biotech companies requested the compound with certificate traceability back to original manufacturing processes for regulatory filings. Our archive contains a line-by-line record going back more than seven years for every major lot. Rather than offering off-the-shelf “spec flexibility,” we instead focus on producing at uncompromised standards, then tailoring documentation or packaging practices per project. The paperwork matches reality, because our facility controls every major stage—from raw material qualification through release analytics. Customers pick up the phone and talk with chemists who understand the actual reactor runs, not just order fulfillment.

    Quality You Can See—And Test Yourself

    Buyers trust physical attributes as much as numbers on a certificate. Our staff encourages new customers to sample product across batches, compare to previous experiences, and incorporate into real-world runs at lab or pilot scale. Feedback shapes procedural tweaks—from filter mesh upgrades to batch cooling profiles. This iterative loop, spanning ten production campaigns and counting, has produced more uniform granule size, lower dustiness, and improved solubility ranges. We keep our doors open for audits, welcoming direct observation of how we handle materials, document processes, and investigate deviations. Each fresh perspective contributes to keeping our standards anchored in reality, not just ideal target numbers.

    No system can catch every possible issue before it emerges, but our track record sets us apart. Product returns due to specification drift or analytical mismatches have stuck at near-zero for years. Our leadership reviews every deviation or customer complaint, tracing not only surface issues but also root causes in production or testing routines. This transparency culture counts more than polished marketing. Customers know they can rely on us for answers, whether technical troubleshooting, process optimization, or unexpected regulatory demands. We aim to be more than a chemical supplier; our goal centers on being a partner supporting every batch and synthesis step with reliability and clear communication.

    Why We Stand Behind Our 3-Amino-3-(3,4-Dimethoxy-Phenyl)-Propionic Acid

    Experience counts. Sustained supply of high-purity specialty intermediates rests on a strong foundation of technical skill, persistent attention to detail, and honest feedback from actual use cases. Each drum, bottle, or sample we send reflects a process built not only for today’s standards but also informed by lessons learned over thousands of syntheses. Whether destined for a pharmaceutical pipeline, advanced materials research, or the next generation of agricultural treatments, 3-Amino-3-(3,4-Dimethoxy-Phenyl)-Propionic Acid from our lines represents disciplined workmanship.

    Chemistry never stands still. As applications broaden and technical expectations rise, so do the standards we hold ourselves to in terms of consistency, documentation, and technical support. With new projects on the horizon and regulatory requirements evolving, our production system remains agile yet unwavering in its commitment to traceability and performance. In an industry where unexpected results often have roots in subtle supply-chain deviations, decades of hands-on process development and feedback from partners give us perspective—and responsibility. We take both seriously, ensuring every lot aligns with our hard-earned reputation for quality and technical trust.