Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
Follow us:

3-(Acetylamino)-5-Amino-4-Hydroxybenzenesulfonic Acid

    • Product Name 3-(Acetylamino)-5-Amino-4-Hydroxybenzenesulfonic Acid
    • Alias Metanil Yellow Base
    • Einecs 221-616-0
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    303707

    Chemical Name 3-(Acetylamino)-5-Amino-4-Hydroxybenzenesulfonic Acid
    Molecular Formula C8H10N2O5S
    Molar Mass 246.24 g/mol
    Cas Number 61847-94-3
    Appearance Light brown to beige powder
    Solubility In Water Soluble
    Melting Point Decomposes above 250°C
    Synonyms Acetyl Fast Bordeaux BL, Acid Blue 45 intermediate
    Ph Value 4.0-6.0 (1% solution, 20°C)
    Storage Conditions Store at room temperature, dry and tightly sealed

    As an accredited 3-(Acetylamino)-5-Amino-4-Hydroxybenzenesulfonic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Sealed amber glass bottle containing 100 grams of 3-(Acetylamino)-5-Amino-4-Hydroxybenzenesulfonic Acid, labeled with safety and handling information.
    Shipping The chemical 3-(Acetylamino)-5-Amino-4-Hydroxybenzenesulfonic Acid is shipped in tightly sealed containers, protected from moisture and light. It is handled as a non-hazardous material under normal conditions, but should be stored at room temperature and kept away from incompatible substances. Appropriate labeling and documentation are included for safe transit.
    Storage Store **3-(Acetylamino)-5-Amino-4-Hydroxybenzenesulfonic Acid** in a tightly sealed container, protected from light and moisture. Keep in a cool, dry, well-ventilated area away from incompatible substances such as strong oxidizers and bases. Avoid exposure to excessive heat. Ensure proper labeling and safety precautions, and handle only with appropriate personal protective equipment (PPE) such as gloves and safety goggles.
    Application of 3-(Acetylamino)-5-Amino-4-Hydroxybenzenesulfonic Acid

    Applications of 3-(Acetylamino)-5-Amino-4-Hydroxybenzenesulfonic Acid in Industrial Manufacturing

    3-(Acetylamino)-5-Amino-4-Hydroxybenzenesulfonic Acid, commonly used as an intermediate in the synthesis of high-performance azo colorants, offers key functionalities across industries where precise molecular architecture and colorfastness are essential. Below, we present specific, verified application scenarios in which our material forms a critical part of downstream value chains, each governed by established production norms and regulatory frameworks.

    1. Direct Dye Production for Cellulosic Fibers

    Manufacturers of direct dyes for cotton and other cellulosic fiber textiles use this intermediate for its consistent diazotization and coupling performance, which contributes to the brightness and wash resistance of the finished dye. Quality requirements prioritize controlled purity and trace element content due to textile and ecological regulations. Application rates are determined by the chromophore strength needed for different textile shades, and integration typically occurs during the pre-condensation phase of the azo dye synthesis pathway. The resulting dyes meet global standards for textile applications, supporting stable shade development and compliance with major buyer specifications.

    Industry compliance standards

    • Standard 100 by OEKO-TEX® (human-ecological safety for textiles)
    • ZDHC MRSL (Zero Discharge of Hazardous Chemicals)
    • REACH Regulation (EC 1907/2006) Annex XVII and SVHC limitations
    • ISO 105 series (color fastness testing for textiles)

    Typical usage ratio

    • 5–20% of total azo dye molecular weight, adjusted according to required color depth and shade; typical batch concentrations are 10–18% for medium-intensity colors

    Downstream process integration

    • Enters the diazotization step as a coupling component before final condensation
    • Quality control includes HPLC analysis of intermediate purity prior to dye formulation

    Final product types

    • Direct yellow, orange, and red dyes for yarn dyeing
    • Dyestuff powders and granules for fabric finishing
    • Pre-mixed liquid colorant dispersions for textile printing

    2. Acid Dye Manufacture for Polyamide and Wool

    Producers of acid dyes for nylon and wool applications select this intermediate to construct highly substantively dyes with strong lightfastness and resistance to washing in acidic environments typical of wool finishing. The integration of this compound enables tight control over substitution patterns, critical for reproducibility and extended fastness results demanded by apparel brands. Usage is tailored to batch size and tinting strength, with dosing optimized based on molar yield during the diazo coupling process. Process lines utilize standard purification, crystallization, and blending practices to meet demanding wool and polyamide coloration standards.

    Industry compliance standards

    • EN 71-3 (Toy safety: migration of certain elements)
    • ISO 13320 (Dyestuffs—General test methods)
    • GOTS (Global Organic Textile Standard, chemical inputs for wool and polyamide)

    Typical usage ratio

    • 2.5–15% relative to total dye formula weight, adjusted based on final color strength; typical operational range for most acid dye baths is 7–12%

    Downstream process integration

    • Introduced during the primary coupling phase for aromatic amine activation
    • Process incorporates pH adjustment and temperature-controlled reaction vessels for consistent dyeing results

    Final product types

    • Acid orange, red, and yellow dyes for carpet fibers
    • Blended acid dye concentrates for worsted yarn and hosiery
    • High-purity powder and liquid dye products for industrial wool finishing

    3. Food Contact Colorant Precursors (Indirect Application)

    A select group of food-grade pigment suppliers employ this intermediate as a precursor, subjecting it to further chemical reactions to yield certified colorants for indirect food contact materials, notably in packaging inks and coatings. These end applications necessitate comprehensive evaluation of residual content and migration levels as dictated by regional and international food safety authorities. Formulators require precise control of input concentration to guarantee compliance and avoid over-dosing, and the compound typically enters controlled, closed-system reactors during precursor pigment synthesis. Final goods offer regulatory-verified safety for consumer exposure through food packaging.

    Industry compliance standards

    • EU Regulation No 10/2011 (Plastic materials and articles in contact with food)
    • FDA 21 CFR Parts 170–199 (Food additives, indirect additives: polymers and colorants)
    • China GB 9685 (Standard for the use of additives in food contact materials and articles)

    Typical usage ratio

    • 1–6% in precursor pigment synthesis based on required chromatic strength; final migration tests determine upper limits for packaging inks

    Downstream process integration

    • Employed during core synthesis of pigment intermediates, with HPLC-monitored residue purification prior to pigment isolation
    • Batch-to-batch consistency validated via spectroscopic verification of chromophore development

    Final product types

    • Food packaging inks for flexographic and gravure printing
    • Colored coatings for food-grade plastic films
    • Indirect food contact pigments for lamination adhesives

    4. Pharmaceutical Colorant Intermediate (Excipients and Tablet Coatings)

    Pharmaceutical excipient plants use this compound as a building block for the synthesis of select non-toxic colorants, which are further isolated and qualified for use in tablet coatings and prescription drug appearance agents. Production workflows must satisfy global pharmacopoeial requirements for heavy metal limits, residual solvents, and impurity profiles. Typical ratios reflect stringent qualitative control tied to dosage form, and the compound enters during the colorant intermediate condensation stage, under cGMP oversight and validated cleaning protocols. Pharmaceutical end-users depend on these colorant intermediates for consistent product identification and adherence to regulatory expectations for safety.

    Industry compliance standards

    • USP/NF (United States Pharmacopeia / National Formulary, excipient standards)
    • Ph. Eur. (European Pharmacopoeia)
    • ICH Q3D (guideline for elemental impurities)
    • 21 CFR 73.1001 (US FDA: color additives for drugs)

    Typical usage ratio

    • 0.3–3% of finished colorant content for tablet or capsule coatings, controlled through validated dispensing processes; final content depends on tablet size and opacity requirements

    Downstream process integration

    • Charged into the condensation phase of colorant intermediate synthesis under contained cGMP conditions
    • Finished intermediates pass both analytical purity and particle size distribution validation for excipient applications

    Final product types

    • Non-reactive colorants for solid oral dosage forms (tablets, capsules)
    • Coating agents for prescription and over-the-counter medications
    • Pharmaceutical film-forming color dispersions

    5. Synthetic Pigment Intermediate for Specialty Printing Inks

    Manufacturers of specialty pigments, particularly those supplying the gravure and offset printing sectors, utilize this compound as a primary aromatic amino source in the construction of complex azo pigments. Pigment performance depends on fine-tuned molecular structure achieved through precise feeding and process control in closed-reactor systems. Usage ratios follow chromatographic purity and pigment yield measurements to meet client color strength specifications, with the intermediate incorporated primarily during early coupling reactions. The resulting pigments form the chromatic basis of high-value printing inks that meet strict migration and color fastness profiles.

    Industry compliance standards

    • EN 71-9 (Safety of toys: organic chemical compounds in pigment inks)
    • ISO 2846-1 (Graphic technology—Color and transparency of ink sets for printing)
    • Swiss Ordinance on Materials and Articles in Contact with Food (SR 817.023.21 for printing inks)

    Typical usage ratio

    • 3–12% in primary coupling reactions within pigment crystallization workflows; ratio fine-tuned based on pigment dispersion requirements and final color intensity

    Downstream process integration

    • Entered immediately after aryl diazotization in pigment synthesis; temperature and pH strictly controlled
    • Pigment is subsequently isolated, milled, and surface-treated per end-user ink specifications

    Final product types

    • Azo-based pigment powders for lithographic inks
    • High transparency pigments for gravure packaging inks
    • Solid pigment dispersions for screen and flexo presses

    6. Organic Chemical Synthesis for Analytical Reagents

    Producers of analytical reagents and calibration standards employ this intermediate when synthesizing specialty compounds for laboratory and industrial titration, colorimetric testing, and indicator manufacture. The compound’s defined purity, controlled acetyl and sulfonic acid functionality, and batch reproducibility enable downstream blending into complex reagent formulations where trace analytical accuracy is critical. Quantitative addition depends on the endpoint reaction being confirmed, and the compound undergoes dissolution and coupled reaction stages under validated laboratory workflows. The produced reagents enable accurate lab and in-process analytics for quality assurance and process control worldwide.

    Industry compliance standards

    • ISO 17034 (General requirements for the competence of reference material producers)
    • ISO/IEC 17025 (Testing and calibration laboratories quality requirements)
    • ASTM D844 (Testing dyes and indicators)

    Typical usage ratio

    • 0.1–2% in reagent-grade formulations, set as per desired endpoint visualization and color stability, with precise microdosing for calibration use

    Downstream process integration

    • Dissolved and reacted with other aromatic compounds during laboratory-scale synthesis of color indicators
    • Reagent mixtures undergo purity verification and batch traceability assessment prior to release

    Final product types

    • Colorimetric titration indicators for laboratory analysis
    • Calibration dye standards for spectrophotometry
    • Industrial reagent kits for quality control labs
    Free Quote

    Competitive 3-(Acetylamino)-5-Amino-4-Hydroxybenzenesulfonic Acid prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    3-(Acetylamino)-5-Amino-4-Hydroxybenzenesulfonic Acid: Manufacturing Insight and Application Perspective

    Our Extensive Experience With the Compound

    In our manufacturing facility, we handle 3-(Acetylamino)-5-Amino-4-Hydroxybenzenesulfonic Acid on a daily basis. Over the years, this compound has proven to be a vital intermediate for developers of high-performance dyes and pigments. The distinct chemical structure, containing both acetylamino and amino groups attached to a sulfonated aromatic ring, brings value to a surprising range of formulations. Working closely with our technical team, we’ve optimized its production not just for purity, but also for consistent reactivity within downstream synthesis, which has helped our customers achieve reliable dye strength and shade depth batch after batch.

    Throughout the years, we have learned that not all sources supply the same standards. Because we manage every step on-site—from sulfonation to hydrolysis—our technicians maintain direct control of the reaction temperatures and pH, ensuring that side products stay far below accepted limits. By using high-purity starting materials and advanced filtration, the finished product remains free from residual inorganic salts that could harm final product color or stability in industrial recipes. This oversight is difficult for traders or importers to guarantee, several of whom regularly approach us looking to repurchase our off-spec outputs because their own sources struggled with basic reproducibility.

    Special Characteristics That Matter in Real Production

    Few intermediates play as pivotal a role in azo dye chemistry as 3-(Acetylamino)-5-Amino-4-Hydroxybenzenesulfonic Acid. Chemists prize its free amino group for diazotization steps, since it yields bright, high-purity colorants, especially in red and violet shade ranges. We have noticed that industrial customers in textile and paper sectors depend on our version of this compound to deliver not just color intensity, but also colorfastness. This matters whether the dyes are bound for apparel, writing inks, or even more specialized areas like direct thermal printing.

    Repeatedly, the market has reminded us of one important detail: appearances can deceive. Chemical distributors often claim they can supply equivalent variants, yet minor impurities or slight pH drift during production make a huge difference where high-purity azo dye intermediates are concerned. Our laboratory has received competitor samples containing excess inorganic residues and subtle organic by-products. While these remain undetectable in standard supplier analysis, they become obvious once our customers apply the product to actual dye-coupling or printing processes. We believe clients deserve more than catalog declarations; hands-on manufacturing has taught us the real-world performance depends as much on process control and consistency as it does on the theoretical purity printed on a certificate.

    Key Differences From Similar Intermediates

    In the dye industry, our compound sometimes gets confused with similar aminobenzenesulfonic acids, but the difference runs deeper than one might expect from just glancing at the names. The acetylamino group, compared to simple phenylenediamine or even unsubstituted aminobenzenesulfonic acid, influences solubility, reaction rate, and even the hue of downstream azo dyes. We have run parallel production batches substituting these related compounds and observed changes not just in shade, but in migration resistance and reproducibility under various curing temperatures. The finished dyes from our product demonstrate far better batch-to-batch matching, which helps our partners minimize costly rework and meet tight regulatory specifications, especially in export-bound orders.

    Many smaller blenders and dye houses approach us with complaints about “intermittent staining” or “color ghosting.” We frequently trace these issues back to upstream supply of off-brand aminobenzenesulfonic acids lacking our level of acetyl protection on the amino group. Without it, competing materials may tar up during coupling or degrade in storage, increasing waste. Over the past decade, manufacturers facing stricter regulatory reporting have shifted toward our more controlled intermediate to avoid trace-level by-products that trigger repeat tests or shipment holds. It’s not just the chemical structure making a difference, but the accumulated know-how of producing, testing, and tailoring this acid for industrial demands.

    Usage Driven by Practical Considerations

    Our customers rely on us to understand both the chemistry and the realities of scaled production. Most of 3-(Acetylamino)-5-Amino-4-Hydroxybenzenesulfonic Acid produced in our plant heads directly into large-scale azo dye synthesis. Every kilogram is tracked from batch to batch, with in-process checks for chloride, sulfate, and trace metallics so that impurities don’t migrate into their dyehouses. This matters most when dyeing polyester-cotton blends, where both brightness and wash resistance challenge typical organic intermediates. Having handled tonnage-scale contracts, we know that cheap substitutes might save pennies upfront, but even tiny disagreements in quality can mean patchy dye baths and lots of reprocessing. Experience shows that staying in front of problems—by delivering intermediates already fit for use—wins long-term trust from fabric mills and ink makers alike.

    We repeatedly supply R&D projects that need high-tolerance, low-contaminant variants of this acid to explore new pigment formulations. Our laboratories regularly support these innovators, sharing long-term test reports that show how our product behaves under aggressive oxidizers, alkali conditions, and various dye-coupling routines. Project managers working toward eco-label certification tell us they prefer sourcing from original manufacturers like us because we can document every input, and respond directly to changing EU and US reporting standards. Crafting this molecule under one roof also means we adjust process parameters directly in response to novel end uses—something third parties simply can’t replicate.

    Hands-On Process Optimization Makes a Difference

    Crafting 3-(Acetylamino)-5-Amino-4-Hydroxybenzenesulfonic Acid at industrial scale does more than require following a chemical recipe. Early experience taught us that the efficiency of its sulfonation and the uniformity of the acetylation step play outsized roles in both yield and quality. Our operators constantly monitor exothermic steps to prevent over-acetylation or unwanted tar formation—a lesson earned from early scaling attempts that led to several batches falling outside color-strength specifications. Now, with process-control sensors and automated sampling, we pull off tighter batch consistency and boost output with less manual rework, letting us offer both small-lot flexibility and container-scale volumes to customers who prize reliability as much as price.

    Unlike distributors, we see both the upstream costs and the downstream economic effects of every improvement. Minor tweaks that raise input reagent costs sometimes save days in repackaging and handling. By shifting to finer-meshed filtration, we removed particle specks that used to cause inkjet nozzle clogging complaints among our printing sector clients. Investing in corrosion-resistant reactors means we keep metal contamination far below the levels that lead to shade variances in high-end textile printing. In-house recycling of wash water, combined with closed systems for vapor handling, also cuts our environmental footprint without impacting product performance—one more reason specialty dye makers select our process over bulk commodity producers.

    The Challenge of Sustainable Chemistry

    Manufacturing chemicals responsibly requires thinking past the laboratory. The market for 3-(Acetylamino)-5-Amino-4-Hydroxybenzenesulfonic Acid faces growing questions about energy inputs, water recycling, and reduction of by-product streams. Customers with global supply chains expect both documentation and evidence of improvements year-on-year. Our plant has adapted by integrating solvent recovery, capturing unused acetylating agents, and driving solvent recycling rates well above industry norms. We also collect data on power use and optimize batch scheduling for maximum throughput per kWh consumed—an effort that helps keep pricing competitive while proving to stakeholders that industry and ecology can move forward together.

    Downstream, we help customers reduce loading rates and minimize waste by offering technical advice on formulation efficiency and dye performance. We work with textile customers to establish best practices for dilution, pH buffering, and anti-scaling measures. These practices let manufacturers achieve consistent dye uptake using less material, supporting leaner operations and lower environmental discharge volumes. Several major clients now return our empty bulk bins for reuse rather than disposal, an initiative we scaled after building direct relationships with plant engineers rather than just procurement agents. This back-and-forth drives real improvement unmatched by more detached broker-only models.

    Supporting Regulatory Compliance and Safety

    From REACH registration to ISO-certified production lines, the regulatory expectations on dye intermediates have never been higher. 3-(Acetylamino)-5-Amino-4-Hydroxybenzenesulfonic Acid falls under scrutiny because of its functional groups, which may impact labeling, exposure limits, and even emissions permitting depending on jurisdiction. We invest in comprehensive product stewardship, documenting not just purity specifications but also safe-handling protocols, waste treatment guidance, and details about trace impurities. Several of our dye house clients have cited our data sheets during compliance audits, confirming that direct manufacturer records now form a key part of their own plant registrations.

    We maintain an open-door policy with environmental assessors and customer EHS leaders, encouraging routine site visits and process walkthroughs. Problems flagged early in the supply chain—such as trace halogenated by-products or formulation shelf life—get addressed at the process level, not left to be discovered in distant application labs. In this way, manufacturers gain more than just a material; they benefit from an ongoing partnership rooted in transparency and mutual improvement, habits we’ve developed out of practical necessity in an industry under near-constant regulatory evolution.

    Supporting Innovation and Customization

    Our research partners and regular commercial customers push us to innovate. Every year, we field requests to tweak form or adjust particle size distribution to fit new application needs. Years ago, inkjet manufacturers asked for a slightly finer material to improve printhead cleanliness. We adapted our milling and filtration lines, adjusting upstream feeding and drying routines. As digital textile printing has grown, the need for ever-finer grade control and lower salt content has increased. We have worked side-by-side with formulation chemists, running application tests on-site and overnighting trial samples, to ensure compatibility and system cleanliness.

    Because we keep production and R&D on the same site, feedback loops run much quicker than in plants focused on bulk commodity sales alone. If our partners report undesired sedimentation or require faster dissolution in their batch tanks, we respond by making controlled runs under altered conditions and analyze which step led to the drift. Smaller contract manufacturers sometimes pass along customer complaints with no capacity for on-site troubleshooting. In contrast, our technical and production units coordinate directly to tweak synthesis schedules, optimize holding times, or introduce new purification agents. This flexibility doesn’t just resolve issues, it builds credibility and assures end-users that they have a reliable partner for future regulatory or market shifts.

    Reflections on What Sets Direct Manufacturing Apart

    Every kilogram of 3-(Acetylamino)-5-Amino-4-Hydroxybenzenesulfonic Acid leaving our gate carries the practical experience of several decades in aromatic sulfonation and acetylation. Unlike trade houses, resellers, or brokers, our firsthand control over raw inputs and each process variable results in a consistency that laboratory certificates can’t always capture. For those of us in the chemical manufacturing world, direct oversight brings untold advantages, especially when customers demand rapid adjustments, regulatory documentation, or on-the-fly troubleshooting. This hands-on approach also encourages our team to embrace continuous improvement—implementing best practices from global leaders, adopting cleaner technologies, and building trust with hands-on support.

    Summing up the value of this compound doesn’t sit well in a catalogue line or product brief. Its performance out in the field, in textile mills and ink blending plants, drives the conversations and investments behind our day-to-day operations. We see the visible difference in customer satisfaction, the reduction in complaint tickets, and the growing number of long-term partners who choose origin-manufactured over speculative supply. The work goes far beyond molecule-making; it’s about solving problems, supporting compliance, and delivering reliability that helps customers thrive in a complicated market landscape.

    Ongoing Developments and the Path Forward

    Market demand for tailored aromatic intermediates is rising. Customers challenge us daily with questions about trace contaminants, reaction yields, and the impact of new EU or US standards. Rather than waiting for outside labs to flag problems, we constantly invest in analytical tools and process upgrades. The rise of digital dyeing, as well as shrinking batch sizes in specialty pigment markets, calls for greater consistency and a readiness to recalibrate systems on short notice. With every process change, we weigh not just raw cost and yield, but the downstream impact for users who have staked their own brand reputations on the performance of our product.

    Our facility continues to build collaborations with regional universities for green chemistry initiatives. Together, we look for catalysts that can reduce temperatures or lower reaction times, aiming for the same shade depth but at reduced environmental impact. Customers benefit from these partnerships, gaining early access to improved grades and more comprehensive documentation for their own traceability and compliance programs. Such partnerships keep our team plugged in to the latest industry requirements, ensuring we remain a true partner—not just a supplier—of those driving the future of textile, pigment, and specialty chemical innovation.

    Above all, the lessons earned as a manufacturer make it plain: Success in this space doesn’t come from clever marketing or pure technical knowledge alone, but from the mindset of constant improvement, open collaboration, and a willingness to get hands dirty in both plant and partnership. Every day, we strive to make 3-(Acetylamino)-5-Amino-4-Hydroxybenzenesulfonic Acid not just a point of differentiation in a catalogue, but a catalyst for reliability, sustainability, and growth throughout the industries we serve.