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3,5-Dimethoxyphenylacetic Acid

    • Product Name 3,5-Dimethoxyphenylacetic Acid
    • Alias 3,5-DMA
    • Einecs 211-734-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    657396

    Name 3,5-Dimethoxyphenylacetic Acid
    Chemical Formula C10H12O4
    Molecular Weight 196.20 g/mol
    Appearance White to off-white solid
    Cas Number 10223-20-0
    Melting Point 120-124°C
    Boiling Point 364.5°C at 760 mmHg
    Solubility Slightly soluble in water, soluble in organic solvents
    Purity Typically ≥98%
    Synonyms 3,5-Dimethoxy-benzeneacetic acid
    Density 1.22 g/cm³ (estimated)
    Inchi InChI=1S/C10H12O4/c1-13-8-4-7(5-9(11)12)6-10(2)14-3/h4,6H,5H2,1-3H3,(H,11,12)
    Smiles COC1=CC(=CC(=C1)CC(=O)O)OC

    As an accredited 3,5-Dimethoxyphenylacetic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 250g of 3,5-Dimethoxyphenylacetic Acid is packaged in a sealed, labeled amber glass bottle to ensure light protection and stability.
    Shipping 3,5-Dimethoxyphenylacetic Acid is shipped in tightly sealed, chemical-resistant containers to prevent contamination and degradation. Packages are clearly labeled according to regulatory requirements, with appropriate hazard information. The shipment is protected from moisture, light, and extreme temperatures, and complies with local and international chemical transportation regulations.
    Storage 3,5-Dimethoxyphenylacetic acid should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from sources of ignition. Protect it from light and moisture. Store separately from strong oxidizing agents and acids. Use appropriate chemical storage cabinets, and label containers clearly. Wear suitable protective equipment when handling to prevent contact and inhalation.
    Application of 3,5-Dimethoxyphenylacetic Acid

    Applications of 3,5-Dimethoxyphenylacetic Acid in Industrial Manufacturing

    3,5-Dimethoxyphenylacetic Acid serves as a specialized intermediate in several advanced chemical manufacturing sectors. Our direct production quality supports complex downstream formulations and scale-up demands in high-value and regulated industrial routes. Below we detail distinct application pathways based on verified end-user practices.

    1. Pharmaceutical Intermediates: Synthesis of Antihypertensive Agents

    Manufacturers utilize this compound as a key intermediate during the synthesis of certain antihypertensive active pharmaceutical ingredients (APIs), particularly in stepwise aromatic substitution and coupling sequences. Chemists value the methoxy-substituted aromatic structure for facilitating regioselective functionalization, specifically when building scaffolds critical to the performance of target cardiovascular drug molecules. This application requires strict trace impurity monitoring and validated batch reproducibility, with each process step matched to pharmacopoeia monograph references.

    Industry compliance standards

    • Current Good Manufacturing Practice (cGMP, ICH Q7)
    • USP-NF Monographs (where applicable to related API synthesis)
    • European Pharmacopoeia (Ph. Eur.) quality requirements
    • FDA guidelines on intermediates for APIs

    Typical usage ratio

    • 15–40% molar input relative to total target API batch; adjusted based on step-yield and final molecular structure.

    Downstream process integration

    • Introduced during aromatic ring formation or amidation steps via solution-phase synthesis.
    • Precursor activation with acid chlorides or coupling agents for selective acylation.
    • Integrated inline with chromatographic purification for intermediate isolation.
    • Direct transfer into API condensation steps within closed GMP environments.

    Final product types

    • Antihypertensive pharmaceutical APIs (e.g., sartans, specific beta blockers)
    • Pharmaceutical intermediate libraries for lead discovery
    • Fine chemical building blocks for medicinal chemistry projects
    • Pre-formulated bulks for contract drug substance manufacturers

    2. Agrochemical Synthesis: Herbicide and Plant Growth Regulator Manufacturing

    Several leading agrochemical producers employ this specialty acid as a building block in the creation of phenoxy-based herbicide actives and in selected plant growth regulators. Its methoxy groups enhance downstream esterification efficiency, impacting compound selectivity and environmental degradation profiles. Automated refilling and in-line monitoring maintain safe and accurate dosing in multi-ton batch plants, enabling repeatable synthesis compliant with strict agro-industrial regulations.

    Industry compliance standards

    • FAO/WHO Codex Alimentarius for pesticide residue limits
    • OECD Principles of Good Laboratory Practice (GLP)
    • REACH Regulation (EC) No 1907/2006 for chemical intermediates
    • ISO 9001:2015 quality management for agrochemical production

    Typical usage ratio

    • 10–25% w/w relative to combined active ingredient mass.

    Downstream process integration

    • Blended with aliphatic alcohols for esterification using catalytic acidification.
    • Dosed into packed-bed reactors for continuous processing lines.
    • Subjected to controlled reaction kinetics for minimization of process by-product.
    • Used prior to emulsification and formulation into suspension concentrates.

    Final product types

    • Phenoxyalkanoic acid herbicide actives
    • Customizable growth regulator agents for horticulture
    • Precursor blends used by contract synthesis partners
    • Technical grade intermediates for bulk agrochemical blends

    3. Fine Fragrance and Flavors Synthesis: Functionalized Aromatic Intermediates

    Our material finds targeted application in the creation of specialty aroma compounds for flavor and fragrance manufacturers. The methoxy-phenyl structure allows for precise molecular modifications, such as oxidative demethylation or Friedel-Crafts acylation, resulting in odor-intensive derivatives and soft powder aroma chemicals. Major end-users rely on defined input purity and traceability for producing high-value blends instructed by international food and fragrance safety bodies.

    Industry compliance standards

    • IFRA Code of Practice for fragrance raw materials
    • FEMA GRAS List for flavoring substances
    • ISO 22000 food safety management systems for flavor intermediates
    • EU Regulation (EC) No 1334/2008 on flavorings and food ingredients with flavoring properties

    Typical usage ratio

    • 5–15% by weight into targeted blend bases; varied by olfactory impact and downstream formulation requirements.

    Downstream process integration

    • Enters at the initial condensation or demethylation stages under controlled temperature and pH.
    • Feeds into continuous-flow aromatic transformations for scaling up rare scent ingredient production.
    • Intermediate quenching between oxidative and reductive derivatization procedures.
    • QC sampling aligned with sensory evaluation during fractionation and concentration applications.

    Final product types

    • Specialty aromatic aldehydes and ketones for fine fragrances
    • Complex flavoring compounds for beverages and confectionery
    • High-impact powder aromas for perfumery base notes
    • Modified esters for luxury consumer blends

    4. Advanced Polymer Additives: Monomer Modification and Stabilizer Synthesis

    Within specialty polymer manufacturing, this acid acts as a reactive intermediate to tailor aromatic polyester and copolymer characteristics. Its robust methoxy-aromatic structure enables downstream chemists to introduce UV-resistance properties and enhance polymer flexibility. It gets incorporated via esterification with diols or diacid chlorides, supporting technical plastics and performance additives with precise control of molar substitution and end-group engineering. Consistent input quality ensures manufactured resins meet critical finished property specifications dictated by downstream industrial and regulatory requirements.

    Industry compliance standards

    • ASTM D638/D882 polymer testing requirements
    • EU Restriction of Hazardous Substances (RoHS) compliance for component materials
    • ISO 14001 environmental management for polymer additive manufacturing
    • DIN EN ISO 1043-1 nomenclature and coding for plastics

    Typical usage ratio

    • 1–8% by molar input relative to total monomer matrix; increased for enhanced UV stability variants.

    Downstream process integration

    • Fed into polycondensation reactors along with diols and co-monomers.
    • Engages in solvent-free melt processing for high-purity copolymer synthesis.
    • Directly dosed into stabilizer blend vessels prior to extrusion or injection molding.
    • Sampled for end-group analysis via FT-IR and GPC testing in QC labs.

    Final product types

    • UV-resistant aromatic polyesters for automotive interior parts
    • Performance copolymer additives for electronics encapsulation
    • Reactive stabilizer masterbatches for specialty films
    • Customized polymer resins for technical industrial components
    Free Quote

    Competitive 3,5-Dimethoxyphenylacetic Acid prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Introducing 3,5-Dimethoxyphenylacetic Acid: Proven Value from a Dedicated Manufacturer

    Long days in the lab have taught us the importance of every batch, every molecule, and everything that passes from our reactors to our customers. 3,5-Dimethoxyphenylacetic Acid has become one of those key products where constant refinements to our own process deliver a clear advantage to chemists and industries looking for more than simple commodity chemicals. From our perspective on the factory floor and in the quality control room, delivering this compound isn’t just ticking boxes on a product sheet—it is the culmination of years working in the fine chemical industry, facing changing regulatory frameworks, raw material price swings, and the ever-raising bar on purity.

    Model and Key Specifications

    Every shipment of 3,5-Dimethoxyphenylacetic Acid rolling off our lines starts with strict adherence to well-defined specifications. Our standard product satisfies rigorous internal HPLC and NMR benchmarks before moving to packaging. This isn’t a byproduct skimmed from another synthesis—our production sets a clear path to high purity, typically achieving >99% on GC, and confirming through trace metallic content checks. We hold moisture levels low—something that started as an answer to local clients frustrated by caked and degraded stock from overseas. By controlling reaction times and cooling curves, we reduce discoloration and byproduct formation, something visible to the naked eye when compared to off-spec or recycled batches sometimes circulating in the market.

    We supply this compound mainly as a white to off-white crystalline solid, packing under inert atmosphere for any material destined for sensitive uses. Particle size and crystal habit can matter for some downstream applications, so we perform custom sieving and drying on request. Our close work with pharmaceutical and advanced material partners shapes how we adjust batch parameters—years of feedback from demanding chemists means we look beyond just purity and focus on how the product handles on their bench.

    Applications Run Deep with 3,5-Dimethoxyphenylacetic Acid

    What draws most buyers to 3,5-Dimethoxyphenylacetic Acid is its combination of functional groups—those two methoxy groups on the aromatic ring and the phenylacetic acid chain offer versatility, acting as flexible building blocks in a wide spectrum of syntheses. In specialty pharma synthesis, we see requests for this compound as a precursor in the manufacturing of niche APIs and advanced intermediates where both reactivity and selectivity matter. The specific electronic effects conferred by the methoxy groups influence downstream reactivity, helping chemists steer transformations with fewer byproducts. Demand is also robust across flavor and fragrance intermediates, where the structure delivers predictable, reproducible results batch after batch.

    Years serving research and pilot-scale production teams let us track usage trends in real time. When academic groups started shifting towards greener processes, interest in compounds with better atom economy and less toxic co-products grew—3,5-Dimethoxyphenylacetic Acid remains a favorite because it bridges classic synthetic routes and new, sustainable methodologies. Its performance is proven in Grignard reactions, oxidative couplings, and reductive aminations, and we’ve collaborated with labs that use our product for novel ligand scaffolds in organometallic chemistry.

    How Our Product Differs from the Rest

    Many first-time buyers ask why we stress in-house manufacture and vertical integration. Our experience shows that the fine chemical landscape is often cluttered with products sourced from brokers or casual toll-manufacturing setups—chains that, all too often, leave customers puzzled when a critical reaction suddenly stalls or yields drop for no clear reason. By keeping synthesis, purification, and QC under one roof, we control every lever of process reliability and can quickly troubleshoot if an end-user finds something amiss. We don’t play middleman; we are the source, and our staff knows each batch at a molecular level.

    Several years ago, we overhauled solvent recovery in our process, slashing residual solvent levels and minimizing odorous trace contaminants that used to trip up sensitive reactions. Some competitors blend or dilute stock to meet COA targets—our output always comes neat, avoiding tampering that complicates downstream synthesis. As manufacturers, we build stock redundancy and keep detailed batch logs, so long-term supply contracts do not leave clients chasing after inconsistent materials when demand surges or disruptions hit logistics later in the year.

    Lessons from Years Behind the Reactor

    The real differentiator is not a marketing claim but the hands-on approach we take with troubleshooting and collaboration. We’ve worked directly with R&D chemists and process engineers at the bench and pilot level. It’s not rare for us to pause a production run so a customer can visit, sample a batch at various stages, and discuss tweaks for solubility or particle form. Our technical support team includes former production chemists and analytical specialists who recognize the difference a slightly different impurity profile can make—consulting on key reactions instead of relying on generic sales scripts.

    Over the years, we’ve found recurring issues in materials from alternative sources: batches with off-odors, variabilities in melting range, and difficulties in dissolution due to unidentified tars. Some clients came to us after failed scale-up using commercial samples from traders that carried over these issues. Our commitment is to transparency and repeatability. If a minor issue arises, you speak to the chemists who ran the batch, not a call center. This tight feedback loop accelerates problem-solving and builds trust with teams who depend on reliable starting materials for each campaign, large or small.

    Constant Process Refinement: Meeting Industry Demands

    Staying ahead in chemical manufacturing depends on relentless process improvement. We’ve invested heavily in modern analytical infrastructure—multi-frequency NMR, trace metal ICP-MS, and chromatography suites tuned for batch-release and forensic checks. Process optimization isn’t just about cost; minimizing side reactions and improving yield reduces environmental impact as solvent and energy usage drop over time. Recent years have seen regulatory scrutiny increase—not just for products but also for production waste and emissions. By refining our workup and isolation procedures, we can meet or surpass domestic and international standards, helping our clients streamline their compliance as well.

    Sustainability demands drive us to scrub every step for greener alternatives. Early reliance on chlorinated solvents gave way to ethanol and ethyl acetate systems wherever possible. We audit our supply chain regularly, keeping documentation ready not just for regulatory inspection but also for customers who share our dedication to traceability and quality. When a partner runs trials with our 3,5-Dimethoxyphenylacetic Acid, they know exactly what went into the flask that week—down to lot numbers, analytical data, and process records.

    Why Synthetic Chemists Rely on Consistency

    In multi-step syntheses, the smallest change in a building block cascades through an entire process, upsetting timelines and triggering costly troubleshooting. Over years, we’ve seen how even minor variabilities in 3,5-Dimethoxyphenylacetic Acid can lead to dropped yields or unexpected purification headaches. Maintaining strict, reproducible optical and chemical purity has always been our guiding ethos. That commitment comes from seeing what happens when a project derails—project teams quickly learn the difference between reliable manufacturing partners and hands-off resellers with only a transactional relationship to the product.

    Feedback from our clients tells the story better than any internal memo. A biotech firm reported overnight boost in reaction throughput after switching from spot-market acid to our material, citing faster dissolution, more consistent endpoint titration, and zero need for supplementary pre-purification. On another occasion, a university research lab requested a series of expedited micro-batches for medicinal chemistry hits—each delivered with advance analytical data and no delays. Sharing these wins speaks volumes about what attentive, integrated manufacturing can do for real lab projects.

    Partnerships Beyond the Sale

    We take pride in supporting more than just procurement. Our team fields requests for custom packaging, documentation, and advanced technical guidance at every turn. Clients often rely on us not just as suppliers, but as extension of their own R&D and QA arms. When customers encounter unexpected crystallization in their own processes or struggle with reactivity after switching to alternative suppliers, we bring in our own chemical engineers and analysts to troubleshoot alongside them—often under NDA for complete confidentiality. This collaborative spirit keeps standards high across our sector and ensures continued progress in the advancement of chemical science.

    Research projects sometimes need quick turns on API intermediates or novel analogs—we keep pilot facilities flexible to address these needs without disrupting regular bulk production. It is not unusual for our technical managers to review academic papers and adapt small-scale experimental conditions for safe, scalable plant use. Having lived through volatile market conditions—from raw material shortages, port closures, to regulatory bottlenecks—we’ve learned how to forecast supply and keep buffer inventory ready for loyal customers. Those who partner with us see consistent, documented product, not subject to the shifting sands of the global trading game.

    Meeting Upcoming Industry and Regulatory Challenges

    Compliance today is more complex than ever, with pharmaceutical, agrochemical, and specialty chemical regulations changing at local and global levels. We follow REACH and other jurisdictional frameworks closely to maintain fully traceable production records, right down to operator logs and waste stream treatment. Audits at our site are routine; transparency earns us repeat business from regulated industries. Our customers want assurance that behind every certificate, there’s a real batch history and environmental stewardship.

    We adapt as required: cleanroom-grade packaging for high-purity orders, full trace solvent logs for pharma grade, and real-time analytics to keep everything documented for both compliance and downstream process validation. No buyer wants surprise delays over paperwork or untraceable compositions. Because we manage every level of production, we close the loop between factory and end use, drastically reducing risk to client R&D and commercial output. That stability gives project leaders peace of mind during budget cycles and time-sensitive launches.

    Balancing Cost, Quality, and Service

    Pressure to minimize cost per kilogram is a fixture in every industry conversation, but we’ve learned that cutting corners rarely pays off. Lowball suppliers too often deliver inconsistent batches or fail to support the product once it leaves their warehouse. Our focus settles on total value—a reliable product, robust documentation, and timely support that saves hours of rework and project delays down the line. Most seasoned procurement managers tell us that saving pennies upfront often leads to multiplied costs in lost productivity and scrapped campaigns.

    Our pricing reflects the depth of quality control and technical expertise that backs every shipment. We invite audits and run trial orders for large campaigns, welcoming direct comparisons with other sources. Experienced chemists and project managers want real batch experience and stability more than promises on a slick datasheet. Real stories—like the time our fast turnaround rescued a pilot batch for a startup facing critical launch deadlines—underscore the value of a hands-on manufacturing partner.

    The Human Side of Manufacture

    Our plant workers and chemists have seen the effects of reliability firsthand. When we receive an urgent order, the whole team steps up—operators pull shifts to accelerate batch turnover, analysts stay late to run last checks, and logistics sorts packaging even during off-hours. This dedication cannot be faked by traders far removed from the shop floor. The relationships we build with buyers extend beyond spreadsheets. Chemists return for project after project, learning they can count on us not just for 3,5-Dimethoxyphenylacetic Acid, but also the expertise and accountability behind it.

    Our business was built in a close-knit industry, and word about manufacturing quality and technical support travels fast. We keep teams motivated and engaged—not just to deliver a product, but to share the sense of purpose that comes from contributing to science, innovation, and continuous improvement. Every tech transfer, every challenging purification, and every successful client handoff adds to that story.

    Room for Innovation and Continuous Improvement

    While maintaining reliable supplies of 3,5-Dimethoxyphenylacetic Acid, we’re also investing in better process chemistry. Recent years have seen trials of new catalysts, lower-waste oxidation systems, and automated in-line analytics for higher throughput. Environmental metrics are tracked with each campaign—solvent waste is minimized, byproduct streams recycled where possible, and energy optimization always on our roadmap. Partners who value innovation are encouraged to engage directly with our R&D leads; we actively pilot new synthetic routes together, not just for technical progress but for economic and ecological win-win opportunities.

    We maintain an open invitation for partners working on next-generation syntheses—long-standing relationships thrive on honest feedback, collaboration, and continuous evolution. As industries shift to biobased and less hazardous reagents, we keep improving input sourcing, process yields, and product handling to match new standards. That means not only keeping up with trends, but sometimes leading them, as we adapt to the needs of our clients for years to come.

    Real Manufacturing, Real Results

    Our journey with 3,5-Dimethoxyphenylacetic Acid started on a small scale, responding to chemists who could not find stable, high-quality sources. Recognizing the pitfalls of fragmented supply, we invested in vertical integration, in-house QC, direct support, and real partnerships. Larger and larger lots now leave our plant, but our focus remains unchanged—consistency, reliability, and accountability from a true manufacturer, not a distant trader. A product is only as good as the processes, people, and philosophy that brought it into being—and that’s why we’re proud to support the workflows and projects where quality and dependability are non-negotiable.

    For anyone working with 3,5-Dimethoxyphenylacetic Acid—whether for drug synthesis, specialty chemicals, or research projects—there’s a difference in working directly with a manufacturer committed to long-term partnership and ongoing improvement.