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3,5-Dichlorobenzoic Acid Methyl Ester

    • Product Name 3,5-Dichlorobenzoic Acid Methyl Ester
    • Alias Methyl 3,5-dichlorobenzoate
    • Einecs 218-876-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry sales7@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    156907

    Product Name 3,5-Dichlorobenzoic Acid Methyl Ester
    Cas Number 2362-63-2
    Molecular Formula C8H6Cl2O2
    Molecular Weight 205.04 g/mol
    Appearance White to off-white solid
    Purity Typically ≥98%
    Melting Point 78-81°C
    Boiling Point 282°C (estimated)
    Density 1.42 g/cm³ (estimated)
    Solubility Slightly soluble in water; soluble in organic solvents like ethanol, chloroform
    Smiles COC(=O)C1=CC(Cl)=CC(Cl)=C1
    Inchi InChI=1S/C8H6Cl2O2/c1-12-8(11)5-2-6(9)4-7(10)3-5/h2-4H,1H3
    Storage Temperature Store at room temperature, tightly sealed and dry
    Synonyms Methyl 3,5-dichlorobenzoate
    Hazard Statements May cause skin and eye irritation

    As an accredited 3,5-Dichlorobenzoic Acid Methyl Ester factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 25 grams of 3,5-Dichlorobenzoic Acid Methyl Ester, tightly sealed with a screw cap and labeled for laboratory use.
    Shipping 3,5-Dichlorobenzoic Acid Methyl Ester is shipped in tightly sealed containers suitable for chemicals, protected from moisture, heat, and direct sunlight. Packaging complies with international transport regulations. The substance is handled by authorized personnel and accompanied by safety documentation (SDS). Specialized labeling and shipping precautions are observed due to potential health and environmental hazards.
    Storage 3,5-Dichlorobenzoic Acid Methyl Ester should be stored in a tightly sealed container in a cool, dry, and well-ventilated area, away from direct sunlight and sources of ignition. Keep away from incompatible substances such as strong oxidizers and acids. Store at room temperature and ensure proper labeling to avoid accidental misuse or contamination.
    Application of 3,5-Dichlorobenzoic Acid Methyl Ester

    Applications of 3,5-Dichlorobenzoic Acid Methyl Ester in Industrial Manufacturing

    As a direct manufacturer with extensive expertise in the synthesis and quality assurance of 3,5-Dichlorobenzoic Acid Methyl Ester, we supply this intermediate for well-established industrial applications. On this page, we detail deployment in several critical sectors, focusing on real-world integration, regulatory adherence, dosage guidance, process alignment, and end-product specification. Each application scenario below highlights practical manufacturing perspectives based on ongoing commercial practice.

    1. Agrochemical Synthesis – Herbicide Intermediates

    This material plays a key role in synthesizing diaryl herbicides used for crop protection. Agrochemical producers rely on specific halogenated aromatic building blocks in controlled coupling reactions to generate active ingredients that deliver targeted weed control in major agricultural economies. The downstream process leverages its chlorinated structure to obtain high-purity intermediates, minimizing byproducts in the final formulation and ensuring consistency for large-scale field deployment and regulatory submissions.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • ISO 9001:2015 for chemical manufacturing process control
    • REACH (EC 1907/2006) pre-registration and substance evaluation
    • US EPA 40 CFR Part 180 raw material standards for pesticidal actives

    Typical usage ratio

    • Ranges from 10% to 18% of total reaction mass in intermediate coupling steps, adjusted according to the target herbicidal active, reaction scale, and required conversion efficiency

    Downstream process integration

    • Introduced during the initial condensation or Suzuki coupling phase with alkyl amines or boronic acids, followed by multi-step purification and crystallization to ensure impurity profiles meet agrochemical active ingredient guidelines

    Final product types

    • Herbicidal technical concentrates (e.g., diaryl chlorobenzoic herbicides)
    • Pre-emergent and post-emergent crop protection formulations
    • Ready-to-use agricultural herbicide blends

    2. Pharmaceutical Intermediate for Active Substance Synthesis

    Pharmaceutical manufacturers integrate this methyl ester as a key aromatic intermediate in the synthesis routes for specific APIs, notably for anti-microbial or anti-inflammatory drugs containing dichlorinated benzoic moieties. Its well-defined substitution pattern supports high selectivity in nucleophilic substitution, ester exchange, and amide bond formation stages. This strong performance under cGMP-controlled environments contributes to high batch yield and tight reproducibility for regulated drug substance manufacturing.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP/NF and Ph. Eur. for relevant finished drug substances (as an intermediate raw material)
    • FDA 21 CFR Part 211 for process validation and traceability
    • GMP certification in production of chemical intermediates

    Typical usage ratio

    • Typically used at 12%–20% molar ratio relative to final API yield, with adjustments based on the reactor scale, impurity limits, and regulatory dossier requirements

    Downstream process integration

    • Added during early to mid-synthesis, frequently as the starting esterification substrate or as a protected group in multi-stage transformations, followed by hydrolysis, amination, or coupling with heterocycles as required by the active substance's structural motif

    Final product types

    • Dichlorobenzoic acid-derivative APIs
    • Amino acid conjugated pharmaceuticals
    • Finished pharmaceutical dosage forms (tablets, capsules) after secondary processing

    3. Specialty Polymer Modification – Advanced Coatings

    Producers of specialty polymers and functional coatings utilize methyl esters of dichlorobenzoic acid to introduce halogenated aromatic functionality, enabling targeted property changes such as UV absorption, thermal resistance, and surface energy modification. Downstream manufacturers incorporate this raw material in polymer backbone modification or side-chain functionalization campaigns, optimizing final product performance under high-frequency UV exposure or aggressive chemical environments.

    Industry compliance standards

    • ISO 9001:2015 for specialty polymer manufacturing and QC
    • RoHS Directive 2011/65/EU and amendments for halogen content
    • ASTM D5201 for chemical resistance in coatings
    • REACH (Annex XVII) for safety assessment of input chemicals

    Typical usage ratio

    • Blended at 1%–5% by weight in copolymerization or functionalization steps; dosage varies to balance UV protection and mechanical properties in the final coating matrix

    Downstream process integration

    • Fed into solution polymerization, melt blending, or post-polymerization modification processes, where it acts as a reactive site for chain extension or surface modification; followed by drying, extrusion, or film casting depending on desired product geometry

    Final product types

    • High-performance UV-stable coatings for electronics or optical components
    • Heat-resistant specialty films for industrial packaging
    • Polymer-based protective laminates for automotive and aerospace parts

    4. Fine Chemical Production – Custom Synthesis for Research Reagents

    Laboratories and custom synthesis houses demand high-purity dichlorinated methyl esters as protected precursors or scaffolds in multi-step chemical route development. In research and pilot-scale synthesis, this material supports selective functionalization, controlled deprotection, and stable storage of advanced intermediates. Its defined substitution pattern allows researchers to efficiently build complex molecular libraries, screen analogs, or produce batch quantities of specialty compounds for analytical and functional studies.

    Industry compliance standards

    • ISO 17025 for analytical laboratories
    • GLP (Good Laboratory Practice) as per OECD Principles
    • Specific institutional protocols for transparency and chemical traceability
    • Internal quality assessment procedures for research-grade material supply

    Typical usage ratio

    • Varies from 2% to 20% depending on synthesis complexity, target molecule, and scale (mg to multi-kg); precise ratio dictated by protocol optimization and analytical target

    Downstream process integration

    • Used as a coupling partner or protection group input at defined steps in route design, then subjected to sequential transformation such as Grignard reactions, ester hydrolysis, or selective aromatic substitution; intermediate is purified, stored, or immediately consumed based on workflow

    Final product types

    • Custom reagents for medicinal chemistry
    • Reference standards for method development
    • Molecular fragments for combinatorial library generation
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    More Introduction

    Introducing 3,5-Dichlorobenzoic Acid Methyl Ester: A Practical Perspective from the Manufacturer

    Understanding the Product from the Factory Floor

    3,5-Dichlorobenzoic Acid Methyl Ester doesn’t just appear on a specification sheet — it comes from real-world experience earned over years of chemical manufacturing. Operators here know that each batch of methyl 3,5-dichlorobenzoate must deliver consistency, high purity, and reliability every time. Demand for this compound has grown, particularly in agricultural and pharmaceutical sectors, not only due to its chemical characteristics but because it delivers predictable reactivity batch after batch. In our experience, the smallest changes in raw material quality or process control can impact the outcome, so we don’t take shortcuts. You won’t find unexplained variances in melting point or purity — we’ve learned how to maintain tight controls, from weighing to reactor charge, to drying and final QC.

    Reliable Performance Built on Real-World Application

    Every time we supply methyl 3,5-dichlorobenzoate, it’s not just about meeting a document spec; it’s about work that fits into established industrial processes without surprises. Synthesis of active ingredients – for example, in crop protection products – can’t afford unplanned delays or yield loss because of inconsistent intermediates. Over the years, we’ve worked with technical managers who report that side reactions or by-product formation can arise from residual moisture, high acidity, or unreacted starting acids. That’s why actual moisture testing, clear color evaluation, and GC purity checks are mainstays in our workflow. Sometimes a chemist will ask about filtration or solubility in downstream reactions — our operational data on how this ester handles under different conditions often guides process improvement at customer sites.

    Model and Specifications Grounded in Day-to-Day Production

    Inside our plant, we catalog batches by product model and lot for traceability, but the real specification story goes deeper. For methyl 3,5-dichlorobenzoate, purity often aims above 99%. Solid at ambient, off-white to faintly yellow, it gives a reliable GC signature, with melting points clustering in the 42–46°C range. Any outlier gets held back for reprocessing or deeper review. Impurities, especially from chlorinated by-products, are closely tracked below 0.5%. Water content gets checked with Karl Fischer titration, and we consistently hit less than 0.3%. Customers who need custom particle size, lower moisture, or tailored packaging find us ready to talk through actual constraints — these are not menu options, but results of hands-on production planning and equipment optimization.

    What Sets Our Ester Apart in a Crowded Market

    Competitors sometimes supply methyl esters where trace organic acids, or inconsistent crystallization, can disrupt scale-up reactions. Some use older process routes that introduce unnecessary heavy metal residues or halogen compounds, which complicate EHS protocols in downstream usage. Over years, we refined our reaction pathways to minimize not only batch time but also the impurity load, giving a more straightforward purification step. Customers often notice how our material gives predictable results in next-stage reactions like nucleophilic substitution or amidation, which straightens the path to the target compound. A plant manager once observed that older batches from other vendors took longer to dry or released unexpected volatiles during evaporation — that feedback drove us to tighten our reflux and distillation steps, improving not only the measured purity but also user experience in real labs.

    Usage in Practical Terms: Views from Partners and Downstream Users

    To people outside manufacturing, methyl 3,5-dichlorobenzoate usually appears as a data line — a precursor or intermediate. In practice, users mostly deploy this compound for synthesizing pharmaceutical building blocks, herbicides, and certain specialty plastics. In large-scale reactions, the reproducibility of this intermediate directly impacts not only yield but clean-up costs. Purification after a coupling or hydrolysis step becomes simpler with high-purity methyl esters; fewer side products are generated, making chromatography or crystallization less trouble. We’ve seen some research labs use our material in structure–activity relationship studies, reporting minimal background interference in spectroscopic analysis.

    End users also report solvent compatibility as a key differentiator. Unlike some substitutes, methyl 3,5-dichlorobenzoate dissolves smoothly in common organic solvents, and rarely forms persistent emulsions when washed. This makes inline extraction or filtration steps less time-consuming. As our partners scale up, the ability to load material without lengthy pre-treatment preserves both man-hours and solvent budgets. Our support teams keep in touch with regular users, collecting firsthand reports about uncommon impurities or performance quirks, and we bring those notes directly back to R&D meetings on batch next steps.

    Why Reliable Supply Chains Matter: Stories from the Field

    Supply should never be an afterthought. We know that missed delivery or unexpected lot failures can upend production schedules downstream, especially in peak agriculture season or in tight pharma development windows. Planning and logistics take as much effort as the actual chemistry. Unpredictable events — shipping slowdowns, raw material delays, temperature excursions during transport — all threaten quality. Direct feedback from our logistics partners led us to invest in better moisture-barrier packaging for methyl 3,5-dichlorobenzoate. In warm, humid months we now line drums internally to prevent caking or softening in transit. Distributors have told us how even short-term exposure to ambient conditions led to visible quality loss with other suppliers’ goods. We take such reports seriously, running field simulations and adjusting packaging protocols.

    We also learned early on not to overpromise during raw material crunches. Consistent inventory and transparent lead times matter more than quick sales. Our team built strong relationships with upstream chlorination and esterification partners, which helps us keep supply steady even during volatile quarters. More than once, a customer called us for emergency supply after spot deals with trading houses fizzled. Our own records show we filled every confirmed order on time during past production surges, even when local demand from domestic pharma factories rose sharply. That reliability brings many long-term partners back to us year after year.

    Comparison with Related Esters and Substitutes: What Experience Shows

    In chemical synthesis work, not all esters perform the same. We’ve handled batches of related benzoic acid esters — for example, methyl 2,4-dichlorobenzoate or ethyl 3,5-dichlorobenzoate — and each brings its own quirks. In our reactors, methyl 3,5-dichlorobenzoate gives a cleaner distillation profile. By contrast, 2,4- or 2,6-dichloro variants tend to foam, leading to more frequent product loss unless handled with slow ramping and extra agitation. Ethyl esters, while similar, dissolve less readily in certain nonpolar solvents, and generally require higher temperatures for efficient downstream hydrolysis or transesterification.

    Feedback from formulation chemists has highlighted that methyl 3,5-dichlorobenzoate’s consistent structure makes it less prone to unwanted rearrangements in high-temperature steps. Comparisons of by-product profiles show fewer unwanted bridged compounds or colored tars, especially in high-throughput synthesis. Some buyers initially tried to replace methyl esters with less expensive analogs but found that end yields dipped by several percentage points after accounting for more intensive purification. Cost-savings on paper rarely outweigh cleanup costs and lost time on the plant floor. Over the last decade, nearly every long-term customer we’ve had has come back to the 3,5-dichloro methyl ester for projects where reliability matters most.

    Quality Minded from Start to Finish: How We Manage Process and Analytical Control

    Success in chemical manufacturing doesn’t stem from slogans — it comes from decades of learning what can go wrong, and how to prevent it. Methyl 3,5-dichlorobenzoate’s quality depends on proactive process management, not just last-minute checks. During scale-up, it’s easy for subtle issues — slight over-chlorination, trace acid carryover, incomplete methylation — to introduce off-flavors or color. Each plant operator here follows a real-world checklist: clear solution in initial charge, stable exotherm control, timed separation, and staged temperature ramps. Along the way, we sample each phase, tracking impurities at every step.

    Quality control teams use calibrated equipment for both wet and instrumental analysis. FTIR and GC-MS each week confirm proper substitution patterns; we never rely on just one tool. We store reference material for every lot, making it possible to investigate any complaints or claims years later. A client once shared a problem with delayed reaction kinetics; we tracked down a trace impurity missed by competitors’ suppliers — since then, we introduced more frequent in-process sampling, which all but eliminated the risk. We don’t keep that learning to ourselves — we tell our clients exactly what we found and how we fixed it, so everyone improves.

    Packaging, Handling, and the Real Cost of Carelessness

    Packaging isn’t just a vessel. Over the years, we’ve seen what goes wrong with the wrong drum lining or seal. Methyl 3,5-dichlorobenzoate will absorb moisture from air during open transfer, which changes not only color but performance in coupling steps. Early on, we faced higher complaint rates from customers who saw slight caking in pails shipped long-distance. That drove us to introduce sealed liner bags, which now ensure each batch arrives in free-flowing form. Distribution centers and partner warehouses now report near-zero complaints related to packaging-induced quality loss.

    On the manufacturing floor, safe and efficient handling matters. We train loading crews on avoiding contamination during filling. We encourage downstream users to avoid storing open drums under humid conditions, especially during rainy seasons. From our end, every batch leaves the plant with an exterior lot number and inner liner pre-labeled for fast identification. In many cases, we help customers by sharing handling protocols that align with their unique plant layouts and climate challenges. It’s not about mandates; it’s about sharing what we learned by solving the same issues ourselves.

    Working with Our Customers for Continuous Progress

    At the end of the day, manufacturing isn’t just about moving product. Our most valuable insights come from eye-level feedback — the chemists facing yield drops, the procurement manager balancing cost against quality risk, the operations leader tracking downtime. We turn those stories into action: holding regular review meetings with R&D, adjusting batch size targets, and testing alternative purification agents as feedback comes up. It’s never a one-way street. When a major customer struggled with a chromatography blockage caused by unusual by-products, we ran their process at pilot scale using our batch, then tweaked drying conditions based on firsthand findings. That experience not only solved a problem for them but led to a standard process change for everyone.

    Some prospective users ask us what sets our approach apart. We point to the headcount and hours dedicated to watching, sampling, and learning — not just computer-generated batch records, but real people in the plant room ready to highlight a subtle shift or suggest a corrective tweak. It’s an everyday process, not a one-off project. That attention to detail — in both manufacturing and customer support — is the foundation for every batch we release, every partner we keep, and the reputation our methyl 3,5-dichlorobenzoate has earned in tough, competitive sectors.

    Environmental Considerations and Responsible Manufacturing Practices

    Our field has changed. Expectations now include not just technical quality, but also environmental responsibility. Through years of plant operation, we’ve learned where the real environmental impact lies: solvent waste, wash water contaminants, and fugitive emissions. Traditional batch chlorination introduced high salt outflows and off-gasses. Continuous improvement led us to install closed-system handling for chlorinated intermediates, recycling condensers, and better brine neutralization tanks.

    Many of our partners expect products free from persistent organic pollutants or uncontrolled halogenated residues. We run periodic audits against not only our local standards but those of key client countries — the same samples used for batch release are rechecked quarterly for compliance. The investment in these checks didn’t happen overnight, but over time, regulators and end users see that practical care drives not only performance but long-term sustainability.

    Risk Management: Insights from the Frontlines

    Managing risk in chemical manufacturing is not just a regulatory burden — it’s a survival skill. From the first batch of methyl 3,5-dichlorobenzoate, plant managers understood that even routine operations can go off track. We maintain constant review cycles, with each shift logging real-time data across reactors, distillation columns, and drying zones. Early detection of anomalies — steam pressure, unexpected condenser fouling, rising color levels in filtrate — prompts immediate response, not a scheduled meeting days later.

    We work directly with customers when issues arise. If a lot ever falls outside agreed targets, we run joint studies, compare batch data, and sometimes rerun small-scale syntheses using customer-specific protocols. This avoids finger-pointing and speeds up root-cause analysis. Tough lessons — like past incidents of runaway reactions in hot summer months — now inform not only our plant protocols but also the seasonal planning advisories we share with long-term users.

    Looking Ahead: Evolving with Industry Needs

    Our years making methyl 3,5-dichlorobenzoate have taught us that change is constant. Process improvements, regulatory updates, and customer priorities all shift over time. Last year, input cost volatility pressed us to rethink solvent recovery. Before that, new limits on residual solvents from global authorities led to fresh investments in analysis and purification. We’re aware that tomorrow’s synthesis techniques or market trends could shape the needs for purer intermediates, faster deliveries, or even stricter traceability.

    This isn’t something we face alone — we rely on two-way communication with customers, regulators, and even direct competitors. Industry roundtables and trade association feedback loops inform where we head next. Behind each drum of methyl 3,5-dichlorobenzoate we deliver, there is a team that treats every issue and every improvement as personal. That attitude, and the willingness to share lessons learned, keeps both product and company moving forward in lockstep with those who use our chemistry to drive innovation.