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3,5-Dichlorobenzhydrazide

    • Product Name 3,5-Dichlorobenzhydrazide
    • Alias 3,5-Dichlorobenzoyl hydrazide
    • Einecs 223-429-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    357617

    Cas Number 635-07-8
    Molecular Formula C7H6Cl2N2
    Molecular Weight 189.04 g/mol
    Appearance White to off-white crystalline powder
    Melting Point 186-190°C
    Purity Typically >98%
    Solubility In Water Slightly soluble
    Density 1.45 g/cm³ (approximate)
    Synonyms 3,5-Dichlorobenzohydrazide
    Smiles Clc1cc(cc(Cl)c1)C(=O)NN
    Inchi InChI=1S/C7H6Cl2N2O/c8-5-1-4(7(12)11-10)2-6(9)3-5/h1-3,10H,10H2,(H,11,12)

    As an accredited 3,5-Dichlorobenzhydrazide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White, sealed plastic bottle containing 25 grams of 3,5-Dichlorobenzhydrazide, labeled with chemical name, hazard symbols, and handling instructions.
    Shipping 3,5-Dichlorobenzhydrazide should be shipped in tightly sealed containers, clearly labeled, and protected from light and moisture. The chemical must be handled as per standard hazardous material protocols, with appropriate documentation, and transported via regulated carriers, in compliance with local and international shipping regulations for chemicals.
    Storage **3,5-Dichlorobenzhydrazide** should be stored in a tightly closed, clearly labeled container in a cool, dry, well-ventilated area, away from direct sunlight, heat sources, and incompatible materials such as strong oxidizers and acids. Protect from moisture and physical damage. Follow all relevant safety protocols and local regulations for hazardous chemical storage.
    Application of 3,5-Dichlorobenzhydrazide

    Applications of 3,5-Dichlorobenzhydrazide in Industrial Manufacturing

    3,5-Dichlorobenzhydrazide is an essential intermediate in several specialty chemical manufacturing sectors. As the direct producer, we supply high-purity grades for controlled downstream applications where strict compliance, defined formulations, and reliable integration into established processes are required. The following sections detail core industrial uses, supported by real-world regulatory frameworks, process details, and finished product types.

    1. Synthesis of Agricultural Herbicide Active Ingredients

    Many agrochemical manufacturers use 3,5-dichlorobenzhydrazide to produce selective herbicide intermediates, particularly for rice and wheat protection products. This raw material enters multi-step reactions for ring formation or hydrazide coupling, enabling the creation of molecules with enhanced weed control selectivity. During scale-up, operators must comply with national and international regulations around pesticide intermediate handling and environmental impact controls.

    Industry compliance standards

    • FAO/WHO Specification for Pesticide Technical Material (FAO)
    • ISO 9001:2015 Quality Management System
    • REACH Regulation for chemical intermediates (EU)
    • Chinese GB/T 1600 Series for agrochemical production

    Typical usage ratio

    • 5%–15% by weight in multi-component synthesis, adjusted by targeted molecule structure and conversion yield requirements

    Downstream process integration

    • Dosed at the initial condensation or amidation step for active ingredient precursor formation
    • Controlled addition with continuous pH and temperature monitoring
    • Intermediate sampling for residual hydrazide quantification before downstream hydrolysis or further derivatization

    Final product types

    • Active herbicide technical powders
    • Wettable granules and liquid SC formulations for field application
    • Registered intermediate products shipped to contract formulation sites

    2. Intermediate for Pharmaceutical APIs (Active Pharmaceutical Ingredients)

    The pharmaceutical sector incorporates 3,5-dichlorobenzhydrazide for key coupling steps in the synthesis of select API molecules, including anti-infective and anti-inflammatory drug candidates. GMP facilities demand strict traceability, batch documentation, and regular analytical validation when using this hydrazide. The compound often acts as a building block in hydrazone or substituted pyrazole synthesis routes, which are prevalent in innovative and generic drug pipelines.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP-NF and Ph. Eur. relevant monographs (reference for impurities if applicable)
    • FDA 21 CFR Part 211 for finished pharmaceuticals
    • Chinese Pharmacopoeia qualitative requirements for synthetic raw materials

    Typical usage ratio

    • Varies by synthetic pathway: generally 2%–10% by molar ratio relative to the target intermediate
    • Precise dosage calculated based on limiting reagent protocols per batch record SOP

    Downstream process integration

    • Added during condensation reaction with aldehydes or ketones for API core formation
    • Integrated in semi-batch reactors equipped with nitrogen blanketing for safety
    • Residual monitoring in crude API analyzed via HPLC or GC for regulatory compliance

    Final product types

    • Bulk intermediate for pharmaceutical synthesis
    • API compounds for formulation of tablets and capsules
    • Reference standards for regulatory submissions

    3. Fine Chemical Synthesis for Specialty Dyes and Pigments

    Producers of specialty dyes and pigment dispersions utilize 3,5-dichlorobenzhydrazide as an initiator or coupling agent in the manufacture of modified azo and hydrazone chromophores. The compound’s functional structure allows for tailored molecular modifications, improving shade stability and dispersibility for textile and plastic coloration. Fine chemical manufacturers require defined raw material specification and impurity profiling for color consistency across production lots.

    Industry compliance standards

    • OEKO-TEX® Eco Passport for textile chemicals
    • ISO 9001 certification for fine chemical manufacturing
    • EU REACH SVHC compliance for dye intermediates
    • ZDHC guidelines for hazardous discharge control

    Typical usage ratio

    • 1%–8% by mass in dye synthesis reactions, adjusted based on target molecule and color strength specification

    Downstream process integration

    • Blended at the coupling step in azo dye synthesis, immediately after diazotization
    • Reaction progress adjusted via inline colorimeter and pH control
    • Followed by purification, filtration, and drying operations

    Final product types

    • Granular or powder dyes for textile processing
    • Pigment concentrates for plastics compounding
    • Water-based dispersions for digital and textile printing

    4. Hydrazide Derivatives for Polymer Chemical Modification

    Polymer manufacturers employ 3,5-dichlorobenzhydrazide as a chain-terminating or cross-linking agent, enabling the synthesis of specialty polyimides, hydrazone-crosslinked elastomers, and performance coatings. The compound introduces specific functional end-groups to polymer backbones, enhancing thermal resistance, mechanical strength, or chemical durability as required by application standards. Producers closely monitor dosing to meet target molecular weights and cross-link density.

    Industry compliance standards

    • ISO 11357 for polymer characterization via DSC
    • ISO 9001 quality assurance for specialty polymer production
    • Chinese National Standard GB/T 33372 for chemical agent use in plastics
    • RoHS compliance for electronic and electrical polymer compounds

    Typical usage ratio

    • Typically 0.2%–2% by total monomer weight, tailored based on desired chain length and functionalization rate

    Downstream process integration

    • Metered directly into polymerization reactors during prepolymer or final-stage modification steps
    • Chemical integration monitored via FTIR or titration of residual functional groups
    • Post-reaction extraction and devolatilization to remove residual hydrazide

    Final product types

    • High-performance polyimide films
    • Flexible hydrazone-cured elastomers
    • Functional resins for heat- and chemical-resistant coatings
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    Certification & Compliance
    More Introduction

    Introducing 3,5-Dichlorobenzhydrazide: A Look Inside Our Production Line

    Walking the production floors and pouring over batches, quality teams and process operators get plenty of hands-on experience with every drum of 3,5-Dichlorobenzhydrazide we manufacture. The process, from raw material receipt to product certification, reflects the skill and care involved. Chemists here know every step builds on the last—every blend, reaction, and rinse keeps us close to the material and its story.

    What Makes 3,5-Dichlorobenzhydrazide Practical in Everyday Chemical Work?

    As a manufacturer, it's clear which steps create the most critical difference in performance. Each batch of 3,5-Dichlorobenzhydrazide brings feedback from our technical team. They see its function in a wide array of final products—sometimes as an intermediate, sometimes as a supporting agent, sometimes serving as the primary ingredient in a multi-step synthetic pathway.

    Consistent quality matters, of course, but downstream partners talk a lot about particle control, easy handling, and stability. We pay attention at every scale-up phase to ensure we deliver powders that move cleanly during transfer and dissolve predictably during application. Our own line operators know how much time can be lost if clumping or sudden moisture uptake appears. With 3,5-Dichlorobenzhydrazide, users appreciate its clean, reliable appearance and behavior, tied directly to constant plant improvements—filter upgrades, air-handling corrections, not just compliance for compliance’s sake, but to make the job smoother for those who handle the product each day.

    Specifications Through the Manufacturer's Lens

    We don’t treat the numbers on the spec sheet as paperwork. Each listed parameter—melting point, assay purity, residual solvent content—connects straight to someone’s task on the line. Operators adjust reaction temperatures and agitation settings after reviewing each synthesis log. Analysts at the QC bench confirm specification windows batch by batch, drawing on years of cumulative experience reading chromatography peaks and spectra. Only the lots that check out by these standards earn release to our warehousing team, who document every outgoing drum with its batch identity.

    Typically, a batch coming off our reactors matches the identification of 3,5-Dichlorobenzhydrazide by melting point, with analytical purity exceeding 98%. Moisture control gets close scrutiny—damp material isn’t just a nuisance, it risks spoilage in longer-term storage. We built extra drying checkpoints into our process. Even in hot, humid months, inventory that sits a few days always gets another round of moisture testing before packing. These checks aren’t listed on customer-facing specs, but they drive real-world confidence.

    The Challenges of Consistency in Real-World Manufacturing

    Natural variability in raw input supplies, especially chlorinated benzenes, asks for ongoing vigilance. Teams log every shift and deviation in process control documentation, providing a trail if troubleshooting occurs months later. It’s not only about a single number: sometimes a subtle color shift or faint odor tells an observant team member something went awry early in the batch.

    Our labs trace contaminants to potential bottlenecks—sometimes a residual metal from an upstream reactor cleaning, sometimes an unwanted byproduct from unstable temperature in run-up. Each lesson turns into revised SOPs, reviewed with operators and engineers. We share these findings with customers interested in process reliability. Their technical liaisons recognize how trace impurities or batch variability can impact their formulations. Hearing from commercial partners who test our 3,5-Dichlorobenzhydrazide in their own bench trials, they want the batch-to-batch difference as low as possible, aiming for near-invisible variability in the final step of a larger chemical process. It’s a daily point of pride, not just a marketing tick-box.

    Why Users Pick Our Material Over “Generic” Options

    There’s a difference between producing a laboratory reference sample and filling metric tons per month at industrial scale. We know the variables in reactors, drying ovens, and packing rooms don’t always behave. So over years of operation, we tweaked our process not simply to match standards, but to make sure each load feels familiar to hands accustomed to batch work. In the plant’s early days, we saw lots of feedback about uneven granule sizing and off-odors. Process improvements didn’t just address those specific complaints. The fix led to less equipment fouling and easier washing in downstream steps, meaning less downtime and better on-stream time for our clients.

    Several users tell us they switched from competitors because they saw less dust in their workshops during handling. One paint additive maker in particular noted how the improved flow helped maintain yield across their kneader without sticking and clumping. On the analytical side, regulatory filings rely on clean impurity profiles. Cross-examinations at their R&D site confirm that material from our lines delivers fewer outlier peaks, which saves on repeated testing and documentation back-and-forth. In short, it’s the invisible aspects of daily handling—ease in scooping, pouring, dissolving, and blending—that make or break repeat purchasing for practitioners.

    Specifications and Practical Handling for Formulators

    Choosing by purity alone often fails to account for product life-cycle or shop floor headaches. Chemists in the field, especially those behind scale-up projects, report time lost to issues like caking, segregation in storage tanks, or inconsistent solubilization. So in our ongoing R&D, every decision about particle form, drying time, drum liner material, and closure method gets field-tested internally before full product release. Warehouse teams track shifts in shipping temperatures, logging feedback when material passes through humid coastal air.

    One time, an entire container load got stuck in customs during a heat wave. Months later, a downstream plant manager told us the drums still poured nicely, with no crust or residue left inside. We shared those logistics findings with the internal process engineering team to lock in even tighter controls on moisture checkpoints and anti-static packing. No spec sheet replacement makes up for everyday usability, and that’s the goal seen in our filling area day after day.

    Role as a Chemical Intermediate and Beyond

    3,5-Dichlorobenzhydrazide stands out most in specialty synthesis, especially as a tightly controlled building block for downstream benzoic acid derivatives, crop protection compounds, and certain pharmaceutical intermediates. Customers with highly specific end-use approvals count on traceability through every lot. This means consistent assay and impurity profiles—trace levels of chlorinated by-products, for instance, prompt immediate batch retests or line washings on our end. Technical teams from downstream plants tour our facilities to verify process controls and spot how we handle cross-contamination and changeovers.

    Some batches feed directly into dye production chains, others into fine chemical syntheses. Each field application brings its own handling requirements, so we work directly with these teams to verify suitability. Process adjustments, whether as simple as switching drum sizes or adding extra drying, address practical concerns voiced from hands-on field chemists, not just regulatory boxes.

    The Batch Perspective: Logging, Auditing, and Learning

    Every batch shipped comes with detailed trace documentation. On our end, the latest iterations of plant management software give operators a minute-by-minute window into reactor temperature, pH, and agitation. We see exactly which operator ran which shift, which maintenance team checked a pump, how long filtration or drying lasted in each campaign. These digital records get matched with classic logbooks and material testing reports. The result: a living history of 3,5-Dichlorobenzhydrazide, tightly bound to the people who produced it.

    Annual audits, both internal and from select customers, pull samples from archived lots for re-testing. Discrepancies prompt real investigations, not just desk-bound explanations. Involving multiple teams—from plant floor to laboratory—strengthens our resolve to address any single issue holistically. More than once, a stray impurity spike revealed a valve cleaning schedule was overdue, or a raw material drum had been mislabeled by a supplier. These real stories keep complacency at bay and drive ongoing improvement.

    Environmental and Safety Considerations Through Manufacturer’s Eyes

    Our on-site teams see every step of the process, including waste management and emissions control. Chlorinated compounds in particular require vigilant air and wastewater monitoring. Operators run process valves and filtration systems, alert to the dangers posed by vent leaks or incomplete trapping of exhaust streams. At the same time, production planners weigh the waste load sent to on-site treatment vs. what can be minimized in upstream raw material purification. These concerns shape daily decisions more powerfully than remote compliance checklists. Safe handling isn’t just about regulatory risk; it comes from seeing colleagues in the plant every day and respecting those on the next shift.

    We built community feedback into our hazard management meetings. Line operators, not consultants, explain best practices for avoiding slip hazards, inhalation risks, and electrical shorts. We recognized early on that even minor improvements in drum design or handling railings reduce day-to-day injury risk. Lessons from experience shape SOP updates far more durably than abstract bullet points.

    Comparing to Other Benzhydrazide Variants

    Not all benzhydrazides work the same way. The 3,5-dichloro substitution brings a distinct balance of chemical reactivity and resistance to certain decomposition pathways. In contrast, versions with only one chlorine—or substitutions at different positions—often show less controlled reactivity in the purpose-built processes run by our partners.

    Feedback from the field points out how single-chlorinated alternatives lack the same resistance to oxidative or thermal stress—issues that crop up in high-throughput or long-simmering batch reactors. Plant technicians working with our product report smooth stepwise conversion in their multi-stage syntheses and fewer fouling incidents during work-up. Customers with older processes sometimes try out less expensive grades with non-specific substitution, but eventually return to the consistent quality of our material for runs that can’t afford rework or scrap.

    Supporting Technical Partners and Problem-Solving

    One of the practical strengths of direct manufacturing is staying close to end users. Our technical support staff often receive feedback straight from labs running scale-up tests, not just commercial procurement teams. Example issues include noticing changes in precipitation timing or incomplete color development in dye synthesis. Rather than generic answers, our chemists review production data, offer process adjustments, or provide freshly sampled material for side-by-side comparison.

    Hard-won relationships with repeat users drive our decision to keep extra analytical support open. Even long after a sale, requests for historical batch data or reference samples get answered by staff who know the day-to-day details: which campaign the lot came from, how raw material stocks shifted, or even which shift filled the final drum. Direct manufacturing keeps us positioned to help solve problems, not just ship product.

    Looking Ahead: Adaptation, Product Development, and Responsible Manufacturing

    Changing regulations, shifts in raw supply, and emerging end-user demands keep things dynamic on the manufacturing floor. We’ve rebuilt certain process lines in direct response to user feedback—improved dust mitigation in filling bays, new packaging strategies for partners facing extra humidity, and investments in automated moisture checks for every outgoing lot.

    Investing in new equipment—a more energy-efficient dryer, for instance—reflects both a cost-saving mindset and a commitment to environmental responsibility. Our team reviews each new regulatory guideline and internal environmental metric as practical steps, not hurdles. We collaborate directly with customers piloting new end uses or requiring even finer purity, offering not just samples but direct feedback from operators, process engineers, and laboratory staff.

    Seeing every batch, logging every drum, and hearing every report from the field keeps our focus grounded: production is a process of learning, iteration, and partnership, not just volume and output. We realize 3,5-Dichlorobenzhydrazide’s story isn’t static; its applications, packaging, and purification adapt as real customer demands and regulatory requirements evolve.

    Conclusion: Experience Shapes Every Drum Produced

    Digging into daily production, technical teams learn firsthand that producing high-quality 3,5-Dichlorobenzhydrazide repeats the reward—and burden—of delivering on professional trust. Colleagues at every level know which raw material fits, which testing method finds outliers, how a drum should feel when sealed up for shipment. This material goes out not as a faceless commodity, but as the result of process knowledge, team coordination, and attention to the real needs of the chemists, engineers, and operators who make practical use of every batch. Treating each lot as part of a larger partnership keeps us improving, grounded, and committed to making every shipment as dependable as the one before.