Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
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3,4-Hexanedione

    • Product Name 3,4-Hexanedione
    • Alias diacetylacetone
    • Einecs 209-995-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    955370

    Cas Number 4437-25-4
    Molecular Formula C6H10O2
    Molecular Weight 114.14 g/mol
    Iupac Name hexane-3,4-dione
    Appearance Yellow to orange liquid
    Boiling Point 190-191 °C
    Melting Point -13 °C
    Density 0.99 g/cm³ at 25 °C
    Solubility In Water Miscible
    Flash Point 77 °C (closed cup)
    Refractive Index 1.439 (20 °C)
    Vapor Pressure 0.3 mmHg (25 °C)

    As an accredited 3,4-Hexanedione factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 100g amber glass bottle with a secure screw cap, labeled "3,4-Hexanedione," featuring hazard warnings and storage instructions.
    Shipping 3,4-Hexanedione is classified as a hazardous chemical and must be shipped in accordance with relevant regulations (such as DOT, IATA, or IMDG). It should be securely packed in airtight, chemical-resistant containers, appropriately labeled, and accompanied by a Safety Data Sheet (SDS). Shipping must ensure protection from heat, sparks, and physical damage.
    Storage 3,4-Hexanedione should be stored in a tightly closed, amber-colored container to protect it from light. Keep it in a cool, dry, well-ventilated area, away from heat sources, sparks, and incompatible materials such as oxidizers and strong acids. Storage should be in a dedicated chemical storage cabinet, and proper labeling and secondary containment are recommended to prevent accidental exposure or spills.
    Application of 3,4-Hexanedione

    Applications of 3,4-Hexanedione in Industrial Manufacturing

    As a direct manufacturer of 3,4-Hexanedione, we support specialized industries that require precise intermediate chemistry for their production workflows. The following segments reflect reliable, established applications where this compound plays a decisive role in process quality and final product integrity, reflecting real industrial practice across diversified yet focused sectors.

    1. Synthesis of Heterocyclic Pharmaceutical Intermediates

    Our 3,4-Hexanedione is extensively deployed in the synthesis of nitrogen-containing heterocycles—essential scaffolds in API (Active Pharmaceutical Ingredient) development, especially for the manufacture of pyrazine- and pyrimidine-based medication precursors. QC teams in pharmaceutical manufacturing depend on tight specifications of 3,4-Hexanedione to ensure high conversion rates and minimal impurities during cyclization steps within multipurpose reactors. Chemists integrate this diketone into reaction routes requiring C4 intermediates and achieve consistent product characteristics through standardized batch control.

    Industry compliance standards

    • ICH Q7: Good Manufacturing Practice Guidance for Active Pharmaceutical Ingredients
    • United States Pharmacopeia (USP) for intermediate controls
    • European Pharmacopoeia (Ph. Eur.) monographs for process intermediates
    • 21 CFR Part 211 (cGMP for Finished Pharmaceuticals)

    Typical usage ratio

    • Applied as a key diketone at 0.7–1.3 molar equivalents relative to nucleophile, depending on the targeted heterocycle and route yield optimization. Ratio adjusted based on reaction selectivity and solvent system.

    Downstream process integration

    • Charged in initial condensation reactions of stepwise multistage organic synthesis, usually after solvent charging and base addition; consumption tracked via in-process HPLC analytics. Remains a single-use intermediate, not recycled within batch.

    Final product types

    • Pyrazine pharmaceutical intermediates (e.g., for antitumor, anti-infective APIs)
    • Pyrimidine derivatives for antiviral and CNS medication building blocks
    • Key intermediates for vitamin B6 analogues
    • Bulk non-sterile pharmaceutical intermediates for contract manufacturing

    2. Agrochemical Intermediate Manufacturing

    The diketone structure of our product supports the agrochemical industry, where synthesis of specific herbicide and fungicide actives requires robust, scalable intermediate steps. Our customers, typically agricultural chemical plants, value strict process regularity in the supply of 3,4-Hexanedione to ensure reactivity in the condensation processes that form critical rings and linkers for pesticide molecules. Consistent material characteristics simplify downstream purification and reproducibility in pilot and production runs.

    Industry compliance standards

    • FAO/WHO: Specifications and evaluations for agricultural chemicals
    • ISO 9001:2015 (Quality Management Systems for chemical synthesis)
    • EPA (US Environmental Protection Agency) regulations for chemical intermediates
    • Chemical Facility Anti-Terrorism Standards (CFATS, US Department of Homeland Security), where applicable

    Typical usage ratio

    • Generally added at 1.0 equivalent to the core aromatic or sulfur component during initial cyclization or condensation, with some processes utilizing 5–12% w/w in pre-mix. Adjustments based on crop protection molecule complexity or production scale.

    Downstream process integration

    • Introduced after solvent charging and pH adjustment, functioning as a monomer building block in one-pot or multi-stage syntheses. Monitoring by GC or LC-MS ensures full utilization, and any residual diketone removed via aqueous workup in downstream separators.

    Final product types

    • Precursors for selective herbicides (e.g., triazolinone-type compounds)
    • Fungicide actives (e.g., strobilurin analogues)
    • Intermediate forms for insect growth regulators
    • Technical grade intermediates for crop protection formulations

    3. High-Performance Dyes and Pigment Synthesis

    Our diketone raw material enters the fine chemical value chain as a core reagent in synthesizing specialty dyes and pigments for inks, coatings, and imaging industries. Producers rely on the electron-deficient template 3,4-Hexanedione provides during the construction of extended conjugated systems—giving rise to high-purity, heat-stable pigments necessary for demanding coloration applications. The compound's reactivity profile supports multi-step condensation and oxidative coupling chemistry on both laboratory and industrial scales, ensuring chromophore stability and batch-to-batch reproducibility.

    Industry compliance standards

    • ETAD (Ecological and Toxicological Association of Dyes and Organic Pigments Manufacturers) guidelines
    • ISO 9001:2015 (Quality Controls in chemical colorant production)
    • OEKO-TEX® Standard 100 test protocols if destined for textile contact
    • ECHA and REACH compliance for pigment registration and labeling

    Typical usage ratio

    • Dosage in the range of 0.5–1.5 molar equivalents to aromatic diamines, depending on pigment structure and yield requirements. Usage fine-tuned during pilot-scale optimization to manage color purity and reaction completeness.

    Downstream process integration

    • Supplied directly into the dye kettle or reaction vessel after substrate dissolution, followed by stepwise temperature ramping and controlled condensation. Residual diketone and byproducts separated via recrystallization or chromatographic purification.

    Final product types

    • Aniline-derived dyes for industrial inkjet formulations
    • Benzoquinoxaline-based pigments for plastic masterbatch
    • Color filter materials for LCD and OLED panel applications
    • Photoactive dyes for specialty coatings and UV curing systems

    4. Fragrance and Flavor Intermediate Synthesis

    Within the flavors and fragrance sector, 3,4-Hexanedione serves as a tailored synthetic intermediate for the construction of musk and macrocyclic lactone molecules, which provide enduring scent profiles to high-end fragrances, soaps, and flavor enhancers. Regulatory frameworks demand complete documentation and rigorous traceability, and our material meets food-grade and cosmetic precursor purity levels where required. Application engineers and flavorists consistently achieve greater control over olfactory properties by using well-characterized diketone batches at precise points in their molecular assembly.

    Industry compliance standards

    • IFRA (International Fragrance Association) Code of Practice compliance
    • US FDA 21 CFR 172.515 (Flavoring Substances for food-grade routes)
    • EU Regulation (EC) No 1334/2008 for flavoring substances
    • ISO 9001:2015 (GMP for fragrance and flavor chemicals)

    Typical usage ratio

    • Typically 0.6–1.2 moles relative to cyclization partners; adjusted for molecule ring size, catalytic system, and olfactory intensity targets. Specific molarity calculated during technical formulation and process scale-up.

    Downstream process integration

    • Blended into the cyclization or macrolactonization stage following initial catalyst loading, usually under controlled temperature and pH conditions. Remnant diketone eliminated during subsequent distillation or extraction steps to ensure purity of the volatiles.

    Final product types

    • Macrocyclic musk precursors (e.g., muscone analogues)
    • Lactone-based flavor compounds for beverage and confectionery aromas
    • Soap and detergent fragrance blenders
    • Ingredients for custom perfumery accords and high-value food flavors
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    Certification & Compliance
    More Introduction

    3,4-Hexanedione: Manufactured with Precision, Built on Experience

    Our Commitment to Quality Chemicals

    Day in and day out, we produce specialty chemicals that end up in labs and factories worldwide. Each batch of 3,4-Hexanedione reflects not just our technical know-how, but a hands-on dedication to safety, consistency, and function. Many years in chemical manufacturing have shaped how we handle every liter moving through a reactor. In our facility, process reliability matters as much as purity. We’ve grown to understand that chemists expect more than just a reagent. They look for a dependable partner, someone who knows what it means to protect raw materials against moisture, who checks the clarity of each drum, and who monitors every analytical curve coming off the GC or NMR. Our approach draws from decades on the production floor, refining practical details that keep operations smooth.

    What Sets 3,4-Hexanedione Apart?

    With 3,4-Hexanedione, applications rarely sit still. Over the years, we have shipped this material in quantities both small and large, each time working closely with users who demand strict batch consistency. In flavors and fragrances, our product finds its way into essential research for new aromatic molecules. Customers in specialty syntheses use it for constructing complex heterocycles, often highlighting feedback on our reliability with batch-to-batch behavior. Academic researchers value traceability, and our lot histories supply them with the confidence needed to publish and patent results.

    Handling 3,4-Hexanedione, we’ve seen it take on diverse roles. In pharmaceutical research, chemists search for key intermediates with a sharp focus on impurity control. We tune our purification and containment practices accordingly, giving special attention to minimizing byproducts and water content. Our plant engineers revisit each tank clean-out schedule frequently, making sure only fresh, clean product goes into every drum. We rarely encounter failures, but if an odd result crops up, our technical team quickly investigates, a practice developed through years facing the surprises that come with live chemistry at scale.

    Specifications, Built on Real-Life Constraints

    We never settle for abstract figures on a spec sheet. Each specification arose from real-world trials, customer feedback, and the lessons learned from plant floor mishaps. Our 3,4-Hexanedione regularly tracks above 98% purity, verified by both GC and titration checks. Customers with strict requirements for moisture or trace metal levels trust us to keep those impurities in check, often because they’ve tested our product themselves. Solvent residues, trace color bodies, and storage conditions—all these reflect choices we’ve learned are relevant from ongoing industry conversations.

    Volume flexibility also grew from direct experience. In early days, orders came in by the kilogram; today, we support both drum-scale and full tanker loads. Such adaptability allows us to keep pace with major contract manufacturers and small specialty shops alike, which often appreciate fast turnaround and uncomplicated logistics.

    Purity Standards Anchored to Practical Outcomes

    If a batch tests outside the target purity, we don’t just adjust paperwork. We follow up with corrective actions—sometimes holding the line, delaying shipment, or in rare cases, reprocessing a run at our own cost. That’s the standard we’ve worked hard to sustain. Many customers, after switching from alternative sources, point to our transparency in providing real chromatograms and impurity profiles. They know that when they call, they’ll speak to folks who’ve watched those reactors cycle through, not to a sales desk working off unfamiliar notes.

    Our plant team also knows from experience that 3,4-Hexanedione prefers airtight packaging, especially at higher ambient humidity. We routinely triple-check each container seal before it leaves because we’ve learned how sensitive diones can be to moisture ingress. Storing it under nitrogen has become second nature. Minor adjustments like these, based on practical issues faced by our customers, have driven process refinements that most spec sheets never mention.

    Comparing with Other Diones and Intermediates

    Markets showcase a variety of diketones, but not all behave alike in synthesis or storage. For instance, 2,5-hexanedione or pentane-2,4-dione (commonly called acetylacetone) feature prominently in catalogs, yet our long-standing customers often report very specific reactivity differences when switching between isomers. In scale-up scenarios, subtle behavior in condensation reactions or the formation of byproducts can make a world of difference. Our experience has taught us that predictability, not theoretical reactivity, tends to win over chemists under tight deadlines.

    During customer trials, 3,4-Hexanedione repeatedly delivers reproducible results in key transformation steps—for example, in Paal–Knorr synthesis routes. Unlike lower-mass diketones, this product offers enhanced selectivity for building six-membered rings. End-users working in pharma pathfinding have remarked on reduced color body formation during downstream processing, which can simplify post-reaction purification. We hear often from pilot-scale teams that switch to our dione to overcome issues related to unanticipated byproduct flavor notes or stubborn solvent residues.

    Practical Aspects of Handling and Use

    Experience in batch production has shown that diligent foregrounding of safety and storage pays off. 3,4-Hexanedione emits a distinct odor, so ventilation should always stay a priority. In our own handling routines, we limit storage at room temperature and recommend transferring quickly into inert-atmosphere containers after opening. On-site, our operators suit up with gloves and goggles daily, not just for show, but to prevent skin or respiratory irritation that can arise with higher volatility.

    Lab managers from partner companies tell us they appreciate thorough upfront discussions of these pragmatic details. Small accidents cause downtime, and learning from the mistakes of the past informs every recommendation we offer. In remote regions or with infrequent hazmat access, we suggest auxiliary packaging to prevent accidental release, drawing on lessons from our global shipments. From the drum loading dock to the R&D bench, 3,4-Hexanedione rewards careful observation and disciplined handling.

    Supporting Innovation Across Applications

    Research groups exploring novel synthetic routes often call on us at early project stages. We’ve been pulled into discussions about alternative condensation partners, green chemistry alternatives, and scaling ideas that don’t always follow textbook patterns. In custom projects, our plant chemists share feedback drawn from extensive runs, diving into how slight changes in temperature or stirring speed shift conversion rates. This open exchange of experience helps shorten timelines for new product development, a fact our repeat customers cite as a reason to stick with direct manufacturers like us over resellers.

    For those in flavor and fragrance R&D, 3,4-Hexanedione offers unique carbon skeletons for generating rare olfactory notes. Over years, our customer base has brought us dozens of feedback loops—tweaks to purity profiles that subtly alter downstream sensory testing. By investing in dialogue rather than one-way delivery, we adapt quickly to shifting demands, providing modified lots or scaled pilot samples to support high-priority experiments.

    In academia, where grant deadlines mean everything, we understand that project flow cannot wait for a missing batch or ambiguous impurity spike. Many labs have shared stories of disappointment with unreliable sources. We take requests for custom documentation seriously—delivering supporting certificates, spectra, or even plant visit options without extra bureaucratic delays.

    Environmental Stewardship and Regulatory Compliance

    Environmental responsibility drives more than our waste treatment strategies. Decades of regulatory change have taught us to build sustainability into process design, not bolt it on later. From solvent recycling to energy efficient distillation, each new plant upgrade emerges from real measurement and experience, not abstract targets. We keep robust records to track every stage of manufacture, responding swiftly during audits or in the unlikely event of product tracebacks.

    On the regulatory side, our compliance group operates hand-in-hand with process engineers and line workers. Each documentation update reflects real modifications—no copied labels or outdated safety sheets. Regulatory shifts, such as new European documentation standards, have pushed us to create batch-level transparency so downstream users face fewer surprises during downstream reporting. Training new staff or retraining veterans on changes is a critical, ongoing part of our culture.

    Continuous Improvement Through Customer Experience

    Most improvements we have made grew from honest exchanges with those who stand on the receiving end of a drum. In the early days, a few too many partially sealed shipments forced us to revamp closure testing. Reports of color changes at higher temperatures led us to invest in temperature-controlled storage and logistics. Discovering trace solvent left over from reaction workups triggered upgrades in our purification loops and improvements to monitoring standards.

    Regular plant reviews with our long-term clients generate a steady flow of actionable feedback. These talks often result in process tweaks that everyone down the supply chain can feel. Our technical people speak the same language as our customers’ chemists because we’ve all spent time working with live reactions, not just interpreting data at a desk. We invite plant visits not to show off, but to give partners firsthand evidence of how tightly their requirements are woven into each manufacturing shift.

    Differences in Experience: Manufacturer vs. Third Party

    Years operating reactors and listening to customer stories highlight the gap between real manufacturer knowledge and desk-bound trading organizations. Direct sources know how upstream material grades influence downstream reactivity, how seasonal changes impact storage, and how packing mistakes are caught before they cause headaches. Unlike resellers, we don’t scramble for product after an order lands; we monitor supply chains continuously, always aiming to stay ahead of backorders and raw material bottlenecks.

    The depth of our records, from GC traces to cleaning logs and equipment calibration reports, helps clients trust every incoming shipment. Our doors stay open to audits, tours, or technical queries—connections built on years of delivering not just what’s requested, but on anticipating the next hurdle. Customers know they can pick up a phone and reach someone familiar with both their past projects and the gritty realities of plant operations.

    Delivering on Real Needs, Batch After Batch

    Our team measures success in more than just volumes shipped. Each shipment of 3,4-Hexanedione leaves only after crossing a final checklist: visual clarity, strong seal, full documentation, and traceable analytical data. This isn’t window dressing—it comes from years of catching problems before they cross our threshold, sparing customers delays or production overruns. Service at this level emerges directly from the roots of hands-on manufacturing.

    Over time, we’ve developed ways to anticipate recurring customer challenges: supporting urgent shipments with flexible logistics, requalifying lots to handle modified process routes, and fielding technical questions rapidly. Our experience tells us that innovation in chemical supply stems not just from process chemistry but from ongoing attention to what end users live with every day.

    3,4-Hexanedione: The Value of Manufacturing Experience

    Whether you manage a busy scale-up facility or lead a research group with rapidly shifting priorities, suppliers who understand the realities of plant chemistry make a tangible difference. Our approach, shaped by years inside actual manufacturing environments, puts reliability, traceability, and responsiveness above empty marketing. Each batch of 3,4-Hexanedione reflects not only technical rigor but the subtle lessons built up by direct, long-term experience. We invest in our team, infrastructure, and customer relationships because we know these form the real foundation for chemicals that deliver on promise and possibility.

    Choosing a manufacturer for 3,4-Hexanedione means choosing a partner with both the lab and field expertise to help you overcome obstacles and accelerate results. Our lines remain open not just for orders, but for any technical questions, process feedback, or site visits. After decades in this business, we’ve learned that trust, honesty, and practical skill set us—and our customers—up for lasting success.