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3-(4-Chlorophenyl)Glutaric Acid

    • Product Name 3-(4-Chlorophenyl)Glutaric Acid
    • Alias 4CPG
    • Einecs 609-845-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    782816

    Name 3-(4-Chlorophenyl)Glutaric Acid
    Molecularformula C11H11ClO4
    Molecularweight 242.66 g/mol
    Casnumber 114709-33-2
    Appearance White to off-white solid
    Meltingpoint 114-118 °C
    Solubility Slightly soluble in water; soluble in organic solvents
    Purity Typically ≥98%
    Smiles C1=CC(=CC=C1C(CC(=O)O)CC(=O)O)Cl
    Inchi InChI=1S/C11H11ClO4/c12-9-4-2-8(3-5-9)6-7(10(13)14)1-11(15)16/h2-5,7H,1,6H2,(H,13,14)(H,15,16)
    Synonyms 4-Chlorophenylglutaric acid
    Storagecondition Store at room temperature, tightly closed
    Hazardstatements May cause irritation to skin, eyes, and respiratory tract

    As an accredited 3-(4-Chlorophenyl)Glutaric Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White, sealed HDPE bottle containing 100 grams of 3-(4-Chlorophenyl)Glutaric Acid; clear labeling with hazard warnings and batch information.
    Shipping **Shipping Description:** 3-(4-Chlorophenyl)Glutaric Acid is shipped in tightly sealed, chemical-resistant containers to prevent contamination and moisture ingress. Packages are labeled according to regulatory standards and handled as non-hazardous unless otherwise specified. During transit, the product is protected from extreme temperatures, direct sunlight, and physical damage, ensuring safe delivery to the destination.
    Storage Store **3-(4-Chlorophenyl)glutaric acid** in a tightly sealed container, away from moisture and incompatible substances. Keep it in a cool, dry, and well-ventilated area, protected from direct sunlight and oxidizing agents. Ensure proper labeling, and avoid excessive heat or temperature fluctuations. Use suitable secondary containment and follow all local regulations for hazardous chemical storage.
    Application of 3-(4-Chlorophenyl)Glutaric Acid

    Applications of 3-(4-Chlorophenyl)Glutaric Acid in Industrial Manufacturing

    As a dedicated manufacturer of 3-(4-Chlorophenyl)Glutaric Acid, we supply this specialty intermediate to multiple industrial sectors where process integrity, quality assurance, and material traceability are mission-critical. Each application scenario presented here reflects real, commercially proven use by established downstream producers, specifying the practical requirements for compliance, dosage, integration, and final product classes.

    1. Custom Synthesis of Antipsychotic Active Pharmaceutical Ingredients

    Pharmaceutical companies utilize our material as a core building block in the synthesis of certain antipsychotic APIs, where its aromatic-substituted glutaric acid scaffold is indispensable for targeted molecular development. Its reactivity in ring closure and amidation steps directly supports high-yield manufacturing of key intermediates for psychiatric therapeutic compounds, ensuring strict adherence to regulatory specifications at every scale.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • Current Good Manufacturing Practice (cGMP), US FDA 21 CFR Parts 210/211
    • EU Guideline EMA/CHMP/ICH/425213/2011
    • Chinese Pharmacopoeia (when supplied for the local market)

    Typical usage ratio

    • Employed at 0.8–1.1 molar equivalence relative to the target compound in multi-step batch syntheses; ratio tuned based on intermediate purity and analytical yield in preclinical and commercial campaigns.

    Downstream process integration

    • Added during early intermediate synthesis, typically in the acylation or cyclization stage via controlled dosing under inert atmosphere at 70–110°C; incorporated after solvent charging but before catalyst introduction.

    Final product types

    • Active pharmaceutical ingredients for antipsychotic medications
    • Isolated pharmaceutical intermediates for further refinement
    • Research-grade reference standards for drug development

    2. Specialty Polyester Resin Production for High-Performance Coatings

    Our chemical’s bifunctional acid structure provides a route for engineered polyesters with tailored thermal and mechanical properties, meeting stringent performance demands in industrial coatings. Downstream resin manufacturers capitalize on its unique substitution pattern to balance crosslink density and flexibility in powder coating and coil coating resins.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006 – Polymer and monomer registration
    • ISO 9001:2015 Quality Management System
    • ASTM D3029 for polyester resin physical testing
    • Paints and Coatings European Regulation (EU) 2018/1881

    Typical usage ratio

    • Blended at 2–8% by weight of total dicarboxylic acid component in polyesterification reactions; optimized per desired hardness and tack characteristics in finished resins.

    Downstream process integration

    • Fed directly into melt or solvent-based polyesterification reactors, together with diols and co-acids, under vacuum and elevated temperature (160–225°C), with subsequent in-line viscosity monitoring.

    Final product types

    • Powder coating polyester resins
    • High-durability coil coating resins
    • UV-curable polyester oligomers
    • Custom copolymers for industrial metal protection

    3. Fine Chemical Intermediates for Agrochemical Synthesis

    Producers of crop protection actives employ this compound as an intermediate in complex, multi-step synthetic pathways to introduce specific aromatic acid motifs required for selectivity in herbicide molecules. Its inclusion enhances process yields and provides a feedstock for downstream halogenation or amide formation chemistry pivotal to modern agrochemicals.

    Industry compliance standards

    • FAO/WHO Joint Meeting on Pesticide Specifications (JMPS)
    • ISO 9001:2015 traceability requirements for starting materials
    • Globally Harmonized System (GHS) for chemical hazard classification
    • REACH registered for intermediate use in EU/EEA

    Typical usage ratio

    • Used at 0.5–1.3 equivalents relative to the coupling component; adjusted following process route and targeted molecular structure, as determined by reaction conversion in pilot scale screening.

    Downstream process integration

    • Dosed to closed reactor vessels at the amidation or coupling synthesis phase, typically in step 3 to 5 of the overall manufacturing train, and followed by downstream purification via crystallization or solvent extraction.

    Final product types

    • Precursor intermediates for selective herbicides and pesticides
    • Finished active ingredients (AIs) in agrochemical portfolios
    • Reference substances for residue analysis laboratories

    4. Synthesis of UV-Absorbing Monomers for Polymer Additives

    Manufacturers of specialty UV-absorber additives target this aromatic-substituted glutaric acid for expansion of their monomer portfolios, using its structure to build new polymerizable UV-shields required in plastics processing. Its compatibility with acrylation and esterification chemistries permits the creation of monomeric components for durable, long-life UV protection in base polymers.

    Industry compliance standards

    • ISO 14001:2015 Environmental Management for chemical manufacturing
    • RoHS Directive (2011/65/EU) for additive use in plastics for electronics
    • US EPA TSCA Inventory (when produced or imported to the US)
    • OECD Principles of Good Laboratory Practice (GLP) for additive safety assessment

    Typical usage ratio

    • Applied at 3–12% by weight of monomers in copolymerization feedstock; proportion modified in response to end-use weathering test results and migration potential assessments in downstream plastics.

    Downstream process integration

    • Incorporated during the monomer synthesis phase, specifically at the esterification or acrylation stage before polymerization, followed by multi-stage copolymer production for masterbatch manufacture.

    Final product types

    • UV-absorbing monomers for engineering plastics
    • Polymeric additive concentrates (masterbatches) for film and fiber extrusion
    • Custom-mixed UV-protective agents for automotive and construction plastics

    5. Intermediate for Research-Grade Analytical Standards

    Certified reference material producers and analytical laboratories use our high-purity material as a precursor to generate analytical standards, calibration targets, and library compounds employed in chromatographic and spectrometric analysis. Its defined substitution pattern and stability under derivatization are critical for low-background, high-sensitivity detection of complex organic residues.

    Industry compliance standards

    • ISO 17034:2016 – General requirements for competence of reference material producers
    • ISO/IEC 17025:2017 – Laboratory accreditation for chemical analysis
    • U.S. EPA Method 8270D (for environmental sample analysis)
    • Pharmacopoeia monograph reference requirements (as applicable in pharma QC)

    Typical usage ratio

    • Applied as received for derivatization at 1:1 stoichiometry with labeling, acylating, or esterifying agents; actual intake tailored to target mass of analytical standard and traceability lot size.

    Downstream process integration

    • Dissolved and reacted with isotopically-labeled or derivatizing reagents in controlled micro-batch setups; purified through MPLC or HPLC for target fraction isolation, then standardized against primary reference samples.

    Final product types

    • Certified analytical reference standards for chromatography
    • Spectral calibration standards for mass spectrometry
    • Trace-grade impurity markers for pharmaceutical QC
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    Certification & Compliance
    More Introduction

    Introducing 3-(4-Chlorophenyl)Glutaric Acid: Precision Chemistry for Advanced Applications

    Experience from the Manufacturing Floor

    Every successful batch of 3-(4-Chlorophenyl)Glutaric Acid reflects a careful balance between chemistry, craftsmanship, and reliable technology. Over years working in the field, chemists and operators here have honed both process and quality checks to ensure purity, batch after batch. This compound doesn't just represent another line on a product list. It stands as a result of patience in the lab, troubleshooting during scale-up, and answering customers' feedback through design and control improvements.

    From raw material qualification to the last drying stage, each step comes under scrutiny. Whether it’s preparing the chlorinated aromatic feedstock or managing temperature ramping during condensation, there are no shortcuts. Systematic monitoring at critical control points and repeated chromatographic checks make certain that the only thing heading out the door is the product customers expect – no more, no less.

    Model and Specifications: What We Make Possible

    Production focuses on pharmaceutical and formulation-grade 3-(4-Chlorophenyl)Glutaric Acid, with purity values that can reach well above 98%. The molecule presents itself as a crystalline white solid, with melting points falling into a narrow, predictable range for consistency in downstream processing. Batch records, sample retention, and lot approval routines are built to withstand scrutiny—whether it’s for clinical trial inputs or high-purity intermediates.

    Handling this compound requires more than knowing its structure or functionality. It means having experience with the tricky steps: solvent selection to avoid uncontrolled side-reactions, monitoring chlorination efficiency without residual contaminants, and achieving controlled crystal formation. Our filters, centrifuges, and reactors get checked daily, not just because internal protocols demand it, but because years of work have shown where minor variations can crop up and compromise quality.

    What Sets 3-(4-Chlorophenyl)Glutaric Acid Apart

    We see the differences in practice, not just on paper. Comparisons with other substituted glutaric acids—like 3-(4-Fluorophenyl)Glutaric Acid or unchlorinated glutaric acid—begin with reactivity, stability, and end use. Chlorine on the para position of the phenyl ring alters not just the physicochemical profile but its compatibility with catalysts and co-reactants in certain synthetic pathways.

    Other glutaric analogues might produce more side products or require complex purification, slowing down customer production lines. By sticking to a validated recipe and refusing to skip the thorough ending purification, we help formulators eliminate guesswork. Their researchers report smooth transitions to pilot or bench-scale without stuck valves, vessel fouling, or surprise impurity peaks.

    Specific Uses Driving Demand

    This compound doesn’t just fill shelves. Chemists request it by name thanks to its niche fit in pharmaceutical, agrochemical, and specialty chemical syntheses. Its unique backbone provides a versatile starting point for custom chemical entities. Medicinal development teams often put it through the paces in structure-activity studies, aiming to build drug candidates with targeted properties—thanks to that para-chlorinated aromatic group.

    Agrochemical development seeks the same backbone for designing new-generation crop protection agents. The compound’s reliable reactivity provides a launching pad for innovation—making it invaluable not only for established products but for exploratory work that sets the next trend. Polymer scientists, too, occasionally turn to glutaric acid derivatives as specialty modifiers, leveraging selective substitution patterns to manipulate flexibility, adhesion, or resistance characteristics in engineered materials.

    Feedback from industrial clients continually shapes our approach. One manufacturer switched from an alternative glutaric acid because of recurring solubility issues and batch irreproducibility in their own downstream esters. The tight melting range and dependable assay readings helped them achieve processes with lower downtime and higher product acceptance rates. That explains the steady growth in repeat orders—not from a desire for novelty but from a need for predictability in scale-up.

    Why Purity and Consistency Rank Above All

    It’s tempting to talk about reactions, outputs, and innovative potential. Yet, most feedback—especially from higher-regulation markets—centers on purity. The smallest batch-to-batch fluctuation in 3-(4-Chlorophenyl)Glutaric Acid risks not just a spoiled experiment but months of wasted R&D or sudden failures in release testing. To address this, techniques go beyond routine HPLC or melting-point intervals. In-process controls extend to trace impurity mapping and cross-contaminant risk checks, using NMR and finished product certifications to back each claim.

    Customers worry about supply chain integrity. Sourcing directly from a manufacturer means questions get answered by the people who run the lines and live with the consequences of each deviation. There’s no finger-pointing to an unknown upstream party or an imported off-grade substitute with murky provenance.

    Differences That Matter in Real-World Production

    Our technical staff has supported clients through more than a handful of technology transfers and scale-ups involving 3-(4-Chlorophenyl)Glutaric Acid. The margin for error narrows dramatically from milligram bench-scale trials to multi-kilo or tonnage batches. Even by adjusting grind size or blending rates, the handling behavior—from dustiness to dispersion in solvents—calls for attention and adaptation.

    Supplying this product means understanding that not all production environments or reactors look alike. Some run closed, automated dispersion systems. Others maintain open manual charging with batchwise heat-up. The compound’s flow, wettability, and reactivity in those setups get flagged as much as its chemical attributes. Engineering support here has learned to translate those needs into physical property targets, and to troubleshoot issues caused by local humidity, storage lag, or pump incompatibilities on site.

    Direct conversations have driven batch modifications or, in rare cases, entirely new approaches to drying, sieving, or controlling agglomerates. Feedback cycles don't filter through layers. If something breaks, we hear about it, tweak processes, and document learnings for the future.

    The Realities of Sustainable Sourcing and Environmental Compliance

    A modern facility doesn’t survive without accountability to local and global standards. Sourcing chlorine, aromatic bases, and glutaric acid precursors often presents more of a challenge than the synthesis itself—not all vendors operate with transparency. After hard lessons in traceability, audits now start at purchasing and end at finished-goods dispatch, with strict lot documentation and waste handling.

    Clients working in regulated industries rightfully ask for confirmation of environment-friendly practices. Solvent recycling, emissions controls, and scheduled environmental reporting have become standard, not exceptional. In certain years we’ve faced tough capital outlays—installing scrubbers, switching to less hazardous reagents, or automating pH and temperature controls in scrubber and effluent systems. These aren’t “nice-to-haves,” but direct requirements learned from regulatory reviews and conscientious partners. Keeping up drives both trust and long-term supply contracts in pharmaceutical and fine chemical sectors.

    Scaling for R&D and Production: What Clients Need to Know

    Purchasers and scientists come with very different backgrounds and demands. Both benefit from honest discussion about scale, packaging, and transport. Lab-scale R&D procurement involves flexibility: smaller glass bottles, tamper-evident seals, and custom weights. Large-scale production means pallet shipments, custom drums, or nitrogen-flushed liners to protect from moisture pickup. Insulation or desiccant options prevent caking during transit under fluctuating temperatures. Such choices come out of hard-won experience dealing with customer complaints and logistics hitches.

    From the manufacturer’s side, we retain samples from each lot, storing them under real conditions—so we’re ready to investigate if a deviation shows up downstream months later. There’s no glossing over the pressure to keep records airtight when each customer’s workflow may stretch a single lot’s life cycle for years. Re-lotting, certificate re-issues, and stability reruns sometimes become part of the job, not just an afterthought.

    Learning from Application Failures and Successes

    Not every product runs flawlessly, especially in new applications. One pharmaceutical development team reported unexpected color changes post-reaction, which prompted a full-scale inquiry on both sides. Trace residuals in an incoming raw material lot, invisible to initial screens, did the damage. The only way to solve it required both laboratory investigation and improvements to supplier vetting—plus a practical change to internal sampling and analysis on every new batch of that input. These experiences inform decisions and prevent repeat problems.

    Other times, a customer’s breakthrough validates the extra effort. Medicinal chemists who used a competing supplier’s version noticed recurring process delays due to sticky residues appearing late in synthesis—slowing filtration and raising questions in QA. Switching to our product, made under narrower process conditions, cut cycle times and let the client recover more material per batch. In such instances, technical teams from both firms share findings and adapt protocols. When those adjustments close a loop between procurement, R&D, and plant operations, the relationship strengthens for future collaborations.

    Continuous Improvement Through Direct Experience

    Our production team doesn’t stand still. Each lot of 3-(4-Chlorophenyl)Glutaric Acid moves through stages refined by dozens or hundreds of micro-adjustments prototypes. Operator logs and feedback cycles mean that knowledge from experienced hands passes to new staff. Whether adapting new mixing patterns to change crystal habit or adjusting agitation rates to prevent clumping, lessons become part of daily routines—not just theoretical ideals.

    Day-to-day, even the most robust process can benefit from technical dialogue with users. Some customers have challenged our assumptions about particle size, wettability, or certain color spec tolerances—leading us to conduct extra studies in the pilot facility. Their insights help align product, packaging, and technical support for each new market or application. Together with recurring feedback from regulatory or external auditors, this steady exchange maintains momentum for product and process optimization.

    Supply Chain Security and the Value of Manufacturer Transparency

    Recent years have seen sharp changes in global supply chains. Border disruptions, raw material price spikes, and geopolitical shifts all pushed chemical companies toward redundancy and manufacturing control. Customers no longer accept vague promises on source traceability or “gray market” intermediates.

    Supplying 3-(4-Chlorophenyl)Glutaric Acid as a direct manufacturer means standing behind every metric ton shipped out as if it will power our clients’ biggest breakthroughs. From secured batch tracking to direct communication on lead times, dock schedules, and potential disruptions, credibility always depends on facts, not marketing spin. Operations staff, supply chain specialists, and senior leadership all share in this responsibility.

    Where others might opt for third-party sourcing or “white-label” approaches, the commitment here leans into full transparency. Every pick, blend, and shipment traces back to teams accountable for the outcome. That means direct answers, timely corrections if necessary, and ongoing honesty about what’s possible within current infrastructure and what might require new investment.

    Future Challenges and Directions for 3-(4-Chlorophenyl)Glutaric Acid

    Innovation in the specialty intermediates market never lets up. User groups are exploring new uses for glutaric acid derivatives. Biotransformations in pharmaceutical precursors, specialty coatings, and environmentally safer formulations all challenge traditional chemistries. As regulations change, the demand for better impurity control, greener methods, and improved operators’ safety will only grow.

    Here, we keep one eye on current production loads, and another on new routes that might use less hazardous reagents, offer higher selectivity, or deliver more robust handling characteristics for customer plants. Investments in automation, simulation-based process controls, and advanced monitoring respond not just to costs, but to the realities of leaner teams and increased audit expectations worldwide. Customers who engage early and openly with production partners often get the jump on rivals—and manufacturers who pay attention to evolving needs carve out their own reputations for reliability and innovation.

    Building on Trust and Performance for the Long Term

    3-(4-Chlorophenyl)Glutaric Acid production isn’t a sideline. It’s a product leveraged daily by developers racing toward new medicines, safer crop solutions, or novel engineered materials. We know from experience that what counts isn’t just the product’s chemical structure or a box ticked on a datasheet. The real relationship forms when customers see consistent, traceable shipments, and responsive technical support when needs change or problems arise.

    Downtime isn’t an abstract metric on a report; it translates to missed deadlines and blown budgets. Supplying a predictable, high-purity intermediate makes it easier for customers to plan, develop, and deliver in turn. Our commitment to direct manufacturing means every step gets attention, every inquiry a prompt and honest reply, and every shipment stands as proof of our investment in expertise, quality, and support.

    In a world where shortcuts and half-measures carry steep risks for innovation and market leadership, sticking to the fundamentals of process reliability and hands-on quality control gives both producers and users safer ground to stand on. For every batch of 3-(4-Chlorophenyl)Glutaric Acid that leaves our facility, that conviction gets tested all over again—and year after year, it’s proven its worth to partners who demand the right balance of chemistry, trust, and practicality.