Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
Follow us:

3-(4-Carboxyphenyl)Propionic Acid

    • Product Name 3-(4-Carboxyphenyl)Propionic Acid
    • Alias hydrocinnamic acid
    • Einecs 213-636-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    878687

    Productname 3-(4-Carboxyphenyl)Propionic Acid
    Casnumber 2215-69-4
    Molecularformula C10H10O4
    Molecularweight 194.18 g/mol
    Appearance White to off-white powder
    Meltingpoint 200-204 °C
    Solubility Soluble in DMSO, sparingly soluble in water
    Purity Typically ≥98%
    Storagetemperature 2-8°C
    Smiles OC(=O)C1=CC=C(C=C1)CCC(=O)O
    Synonyms 4-(3-Carboxypropyl)benzoic acid
    Pka 4.4 (Carboxyl group, approximate)
    Ecnumber 218-684-4

    As an accredited 3-(4-Carboxyphenyl)Propionic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing White, sealed plastic bottle containing 100 grams of 3-(4-Carboxyphenyl)propionic acid, labeled with product details and safety information.
    Shipping 3-(4-Carboxyphenyl)propionic acid is shipped securely in sealed, chemical-resistant containers, clearly labeled with hazard and handling information. Packaging complies with regulations for the transport of laboratory chemicals. During transit, the material is protected from moisture, direct sunlight, and extreme temperatures to maintain stability and ensure safe delivery.
    Storage 3-(4-Carboxyphenyl)propionic acid should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from incompatible substances such as strong oxidizers. Protect from moisture and direct sunlight. Store at room temperature (15–25°C). Ensure appropriate labeling and keep it away from sources of ignition. Follow all relevant safety and chemical hygiene protocols.
    Application of 3-(4-Carboxyphenyl)Propionic Acid

    Applications of 3-(4-Carboxyphenyl)Propionic Acid in Industrial Manufacturing

    Our large-scale production and quality assurance of 3-(4-Carboxyphenyl)propionic acid supports specialized industrial manufacturers in several strictly defined downstream sectors. Below, we outline key application scenarios where this material is directly integrated into advanced processes, each with specific regulatory, formulation, and production requirements.

    1. Synthesis of Non-Steroidal Anti-Inflammatory Drug (NSAID) Intermediates

    Pharmaceutical active ingredient manufacturers use 3-(4-Carboxyphenyl)propionic acid as a core intermediate in the multistep synthesis of advanced non-steroidal anti-inflammatory drugs. This compound provides the arylpropionic acid backbone necessary for targeted molecular modification, meeting specific chiral purity and impurity control demands set by global regulatory agencies. Carefully controlled insertion during the condensation and cyclization stages enables precise yield management and batch reproducibility for API production plants.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients)
    • Current USP and EP monographs for NSAID APIs
    • 21 CFR Parts 210 & 211 – US FDA cGMP for finished pharmaceuticals
    • EU GMP Annex 1–3 for intermediates and finished dosage forms

    Typical usage ratio

    • 0.6–2.3 molar equivalents relative to the target NSAID core, with ratio adjusted according to substrate reactivity and desired impurity profile

    Downstream process integration

    • Charged during early-stage condensation before ring closure, followed by purification and in-process chromatographic checks

    Final product types

    • Enantiomerically pure NSAID APIs (e.g., naproxen, flurbiprofen derivatives)
    • Bulk pharmaceutical intermediates for further synthesis

    2. Advanced Aromatic Polyester Monomers for Specialty Polymers

    Chemical manufacturers producing high-performance polyesters employ this aromatic carboxylic acid derivative as a custom chain-extending monomer. It confers targeted rigidity and functional group density in specialty polymers for high-temperature and engineering plastic applications. Its integration into melt polymerization lines requires precise control for molecular weight distribution and branching characteristics, allowing downstream customers to tailor product performance to demanding end uses such as automotive, electronics, and medical device housing parts.

    Industry compliance standards

    • ISO 9001:2015 Quality Management for manufacturing traceability
    • REACH Regulation EC1907/2006 for polymer precursors
    • RoHS Directive (2011/65/EU) for electronics-related polymer uses
    • FDA 21 CFR 177.1590 for select food contact polymer applications

    Typical usage ratio

    • 5–18% w/w of total dicarboxylic acid input, tailored based on targeted Tg, crystallinity, and mechanical specifications

    Downstream process integration

    • Fed directly to esterification or transesterification reactors, followed by polycondensation and granulation

    Final product types

    • Heat-stable polyester engineering resin pellets
    • Polyester copolymer sheets and injection moldable resins

    3. Functional Dyes and Fluorophore Precursors

    In fine chemical synthesis for specialty colorants, 3-(4-Carboxyphenyl)propionic acid serves as a pivotal aromatic spacer in the assembly of advanced fluorescent dyes and pigment molecules. Its structural features allow convenient coupling with amine or alcohol-functionalized fluorophores via amide or ester linkages, delivering modified absorption/emission properties required for biological staining, sensor markers, and industrial ink formulations. Manufacturers must monitor impurity carryover and ensure that every lot is fit for high-sensitivity application.

    Industry compliance standards

    • EN 71-3 for migration of certain elements in dye applications
    • ISO 18314-1 for color measurement and quality control in pigments
    • REACH Registration for aryl acid dye intermediates
    • Quality system requirements per ISO 14001 for environmental impact of dye manufacturing

    Typical usage ratio

    • 0.2–1.2 molar equivalents based on chromophore backbone length and functionalization demands; excess may be used to drive reactions to completion in low-yield routes

    Downstream process integration

    • Used in aromatic substitution or amidation steps, followed by purification and spectral confirmation

    Final product types

    • Water-soluble fluorescent dyes for analytical kits
    • High-stability colorants and pigments for inks and coatings

    4. Tailored Surface Modifiers for Biomedical Device Coatings

    Surface treatment specialists integrate this carboxyphenylpropionic acid as a linker or functionalizing agent during the manufacture of anti-fouling and bioactive coatings for medical devices. The material's bifunctional structure is activated through carbodiimide chemistry to covalently bond active groups to polyurethane, silicone, or metal surfaces. Production environments require careful control over reagent exposure times and byproduct removal to guarantee biocompatibility, meeting the strictest clinical standards and traceability requirements.

    Industry compliance standards

    • ISO 10993-1 Biocompatibility evaluation for medical device materials
    • ISO 13485:2016 Medical device quality management
    • FDA 21 CFR 820 (USA) for medical device manufacturing controls
    • USP Class VI biological reactivity tests

    Typical usage ratio

    • 0.05–0.4% wt/wt surface treatment composition, with precise dosage based on surface area and required coating thickness

    Downstream process integration

    • Applied in surface activation step, followed by rinse and secondary curing or bonding

    Final product types

    • PTCA-functionalized stents and catheters
    • Bioactive hydrogels for prosthetic devices

    5. Targeted Functional Building Block for Agrochemical Active Synthesis

    Producers of advanced crop protection compounds utilize 3-(4-Carboxyphenyl)propionic acid as an intermediate in the multi-stage synthesis of specific selective herbicides and growth regulator active ingredients. The compound is employed for introducing defined aromatic-propionic motifs into the active structure to influence systemicity and binding characteristics. Stringent QC and traceability are essential at each process step to ensure compliance with both human safety and environmental protection regulations before end-use formulations are prepared and globally distributed.

    Industry compliance standards

    • FAO/WHO JMPR specifications for pesticide active ingredient quality
    • OECD Guideline 107 for partition coefficient determination
    • ISO 17025-accredited laboratory analysis for purity
    • REACH Annex II requirements for chemical safety assessment

    Typical usage ratio

    • 0.9–1.4 molar equivalents per active moiety depending on the intended formulation and target pest spectrum

    Downstream process integration

    • Integrated during nucleophilic aromatic substitution, followed by downstream oxidation and methylation cascades

    Final product types

    • Selective systemic herbicides with arylpropionate backbone
    • Growth regulator actives for specialty horticulture
    Free Quote

    Competitive 3-(4-Carboxyphenyl)Propionic Acid prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    Introducing 3-(4-Carboxyphenyl)Propionic Acid: Experience from Our Factory Floor

    Our Journey with 3-(4-Carboxyphenyl)Propionic Acid

    Daily work at the intersection of organic chemistry and practical application brings a different relationship with the products we produce. 3-(4-Carboxyphenyl)Propionic Acid has a firm place on our line. Years spent in production allow us to see firsthand how its particular structure—benzene ring para-substituted to carboxylic acid with a three-carbon propionic acid chain—creates a molecule ready for diverse synthesis tasks. No exaggerations: real value shows in how customers and technicians put it to use, and how consistently it performs. Its CAS number clears up ambiguity, but our care and practice make the difference.

    From Raw Materials to a Reliable Intermediate

    Every batch of 3-(4-Carboxyphenyl)Propionic Acid starts with closely monitored sourcing of quality raw chemicals. There is little room for compromise. We weigh, react, and purify the ingredients in stepwise fashion, watching for color, odor, and freeze-point shifts as production progresses. The solid product emerging from crystallization flows well in the hand—fine, white, and with a clean, distinctive profile. Analytical checks in our QC lab back up what experienced eyes already catch: high assay, low water, and predictable melting points. These aren’t dry details—they reflect real-world stability and processing behavior.

    We take pride in offering consistent batch quality, minimal impurities, and reliable physical properties. Our standards mean that whether clients use it for pharmaceutical intermediates, specialty polymers, or research projects, their results stay consistent from start to finish.

    Product Model and Specifications Shaped by Experience

    We produce 3-(4-Carboxyphenyl)Propionic Acid in both standard and customizable models. Most demand falls to our high-purity grade, typically exceeding 99 percent by HPLC. Granulation and particle size can be dialed in by request: most users working in lab synthesis or pilot extrusion prefer a fine powder, while full-scale chemical reactors may benefit from a slightly coarser cut to improve handling and reduce dust. Moisture content always receives special attention, as water traces can complicate downstream coupling or esterification. Every lot ships with an analytical report, though many long-term customers know the number by heart from their own QC runs.

    Stable packaging reduces caking and cross-contamination. Our team double bags bulk product and uses light-proof drums. Clumping or yellowing tends to disappear with a careful airtight seal, an improvement we adopted after feedback from early partners years ago. It’s the kind of lesson only real plant experience brings.

    What Sets This Chemical Apart?

    Plenty of aromatic propionic acids fill catalog pages, but the balance of carboxyl placement and chain length in 3-(4-Carboxyphenyl)Propionic Acid makes it a sharp tool for both classical and modern synthesis. The para orientation ensures manageable reactivity: substituents at this position tend to yield predictable coupling results, whether you are attaching protective groups, forging amide links, or building novel bioactive motifs. Ortho and meta isomers, by contrast, introduce sterics and unpredictable substitution patterns.

    Over the years, customers repeat a point: the balance between reactivity and selectivity offered by this product fits modern organic synthesis, especially when making intermediate blocks for drug discovery. We have customers in pharmaceutical research who value the compound’s ability to remain stable under both acidic and basic conditions, opening avenues for both solution-phase and solid-phase synthesis.

    Comparing to standard benzoic acids or shorter-chain analogs, the extra carbon atoms in 3-(4-Carboxyphenyl)Propionic Acid’s side chain offer real practical advantages for further functional group transformations. A longer side chain means more options—amidation, coupling with peptide fragments, or building block roles for advanced monomers. Our technical team often supports projects requiring regioselective transformations, and the structure of this compound delivers consistent, high-yield results.

    Applications Informed by Real-World Practice

    Every week, emails arrive describing new projects: novel drug candidates, developments in advanced adhesives, specialized corrosion inhibitors, or research on peptidomimetics. 3-(4-Carboxyphenyl)Propionic Acid enters these workflows as more than just another line in a lab notebook—its profile means scientists and manufacturers get reliable, actionable results.

    Pharmaceutical chemists use it to build saturated carboxylic acid derivatives, a key step in many non-steroidal anti-inflammatory agents, antibacterial drugs, and CNS-active molecules. The presence of both an aryl and an aliphatic group, each carboxyl unit spaced with a propionic linker, allows fine adjustment of electronic and lipophilic characteristics—tools medicinal chemists continually seek to optimize.

    Polymer scientists blend this compound into specialty materials. The para-carboxyl group offers predictably strong hydrogen bonding, leading to structural elements in co-polymers, hydrogels, or supporting frameworks for molecular recognition. The acid’s unique aromatic-aliphatic structure can be harnessed for electronic materials, where electron delocalization and side-chain flexibility play a major role.

    Hydrolytic stability and moderate solubility in polar organic solvents make it a favorite for surface-modifying agents. Some clients tell us they adapt it to prepare monomeric units for controlled-release carriers or functional coatings. Real utility comes from knowing years down the line whether a specialty compound will react the same way under normal atmospheric conditions and storage; our experience tells us 3-(4-Carboxyphenyl)Propionic Acid provides this reassurance.

    Pragmatic Challenges—and Our Paths Forward

    Chemical production remains a trade as much as a science. Any operator knows there’s always some tension between purity, cost, yield, and ease of handling. Taking feedback from the field, we have improved drying technology, adopted inert gas flushing for storage, and invested in automated visual inspections—small but significant changes that preserve the barely visible quality edges.

    Finding the right pH in the crystallization and filtration process turns out more important than many would guess. Too high, and you risk trace salts. Too low, and product can oil out or form sticky residues. Our operators developed a hands-on, iterative method for pH adjustment, drawn from years of tuning the process—no textbook can replace this kind of accumulated knowledge.

    Consistency means delivering not just the number on a certificate of analysis but the same “look and feel” year after year. Every time the plant upgrades a reactor or tweaks the solvent system, we test not just purity but also downstream reactivity—applications testing in real-world conditions. Customers remind us: a material that meets specs on paper but surprises in scale-up costs time and money. That’s where running our own in-house molecule synthesis, right alongside the production line, pays back—it tells us ahead of time whether a batch will stand up in application.

    Ethics and Traceability in Sourcing and Production

    Global chemical supply chains run long and can grow fragile without careful management. We trace each input back to its origin. Our workforce knows which lot of raw material goes into which batch, and we keep digital and paper records to support every shipment. If there’s ever a question of contaminated or off-spec raw materials, we can review every step, and apply lessons learned to the next run.

    Clients increasingly ask about sustainability and regulatory compliance—accreditations only tell one side of the story. Our directors walk the plant at odd hours, checking on waste management, emissions, and recycling. Water saving initiatives, secondary solvent recovery, and strict inventory rotation lessen both cost and environmental load. Our aim stays fixed on long-term relationships, meaning we plan batches to minimize left-over inventory and encourage batch processing sizes that suit customer needs rather than just our own convenience.

    Supporting Innovation with Predictable Performance

    Some of the best stories come from the collaborative work that follows the sale. Inquiries roll in at odd hours, suggesting new synthetic routes or applications for 3-(4-Carboxyphenyl)Propionic Acid we never anticipated when the line first went live. Suggestions for adjustment—improved particle morphology, tighter impurity thresholds, packaging tweaks for especially sensitive chromatographic work—drive our development team. Each successful suggestion improves the offering not just for one client, but for all downstream users as well.

    Chemical manufacturing never stands still. We welcome feedback from both seasoned process chemists and researchers at the early proof-of-concept stage. Each well-run synthesis, each controlled reaction in the hands of our customers, represents an extension of all our daily work in the factory.

    Looking Back and Ahead: Lessons from the Floor

    The mark of a good specialty chemical isn’t just high assay or a familiar catalog number; it’s how many repeat customers you find using the same lot year after year, for applications you sometimes never anticipated. 3-(4-Carboxyphenyl)Propionic Acid wins loyalty not just because of its structural features but because our production habits, record-keeping, and product stewardship keep every shipment true to form.

    We owe our steady progress to the hands-on work of skilled operators, analytical chemists, and technical staff who live with the molecule every day. Their familiarity with the physical properties shows in every batch, from the clarity of crystals to the ease of shipment. Steady demand for this compound proves its utility in both research laboratories and large-scale production settings. We continue to improve based on real-time feedback from every step of our production, and our commitment remains clear: provide an honest, reliable product that chemists can rely on across applications and industries.

    Product Differences Rooted in Practice

    Choice of a carboxylic acid for intermediate or final use depends on both chemical structure and supplier reliability. We’ve observed substitutions swinging between similar acids—benzoics, substituted propionics, or even shorter-chain derivatives—each with different strengths and trade-offs. Some fit better with rapid alkylation, others prove temperamental in couplings, and still others add complexity with too many reactive groups.

    3-(4-Carboxyphenyl)Propionic Acid stands out in our production not only by chemical compatibility but also by long-term stability in diverse storage conditions. Customers who once switched acids for availability reasons nearly always come back for our version due to repeatable results and less fouling or byproduct formation in reactors. The para-relationship between carboxyl and side chain allows for precise reaction planning when compared to meta- or ortho- isomers, which often demand extra purification steps or yield unpredictable side products.

    Other manufacturers may focus tightly on minimum cost at maximum scale. Our method remains to balance efficiency with a careful eye on critical-to-quality traits shaped by real-world feedback. We earmark batches for specific application demands, rather than streaming everything into a general pool. This method proves especially valuable when experimental chemists request lot histories or support for scaling a reaction from milligram trials to kilo-scale supply.

    Your Projects, Our Experience

    Experience counts most for chemical manufacturers. Through thousands of working hours, hundreds of customer conversations, and constant observation on the plant floor, we have shaped our production of 3-(4-Carboxyphenyl)Propionic Acid to suit real needs. Every gram reflects our blend of technical rigor and lived experience—putting reliability, safety, and careful improvement above all else.

    The way we measure progress is simple—a phone call or email from a user, describing a clean reaction, a successful scale-up, or a request for just a bit more of the same lot means the world to our operators and managers. Every bottle or drum shipped contains more than a compound; it represents the honest labor and careful judgment that define real chemical manufacturing.