Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
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3,3-Dimethylbutyric Acid

    • Product Name 3,3-Dimethylbutyric Acid
    • Alias pinacolonic acid
    • Einecs 211-989-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    463765

    Chemical Name 3,3-Dimethylbutyric Acid
    Cas Number 541-18-4
    Molecular Formula C6H12O2
    Molecular Weight 116.16 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 170-172 °C
    Melting Point -24 °C
    Density 0.895 g/cm³ at 25 °C
    Solubility In Water Slightly soluble
    Pka 4.85
    Flash Point 70 °C
    Refractive Index 1.4040 at 20 °C

    As an accredited 3,3-Dimethylbutyric Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 250g of 3,3-Dimethylbutyric Acid is packaged in a sealed amber glass bottle with a secure screw cap and hazard labeling.
    Shipping 3,3-Dimethylbutyric acid should be shipped in tightly sealed, chemical-resistant containers to prevent leaks and contamination. Package according to local and international transport regulations, clearly labeling with hazard information. Avoid extreme temperatures, direct sunlight, and incompatible substances during transit. Ensure documentation accompanies the shipment for safe handling and emergency response.
    Storage 3,3-Dimethylbutyric acid should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from incompatible substances such as oxidizers. Keep it away from heat sources and direct sunlight. Ensure proper labeling and minimize exposure to moisture. Store at room temperature and prevent contact with strong bases and acids to avoid hazardous reactions.
    Application of 3,3-Dimethylbutyric Acid

    Applications of 3,3-Dimethylbutyric Acid in Industrial Manufacturing

    As an established producer of 3,3-Dimethylbutyric Acid, we supply this key intermediate to multiple specialized industries. Here we outline its functional roles and integration methods across high-value downstream manufacturing scenarios.

    1. Pharmaceutical Synthesis of Anticonvulsant Actives

    3,3-Dimethylbutyric Acid is frequently utilized during the production of specific anticonvulsant drugs, notably as a carboxylic acid component in the coupling stage for valproic acid derivatives. Manufacturers carry out direct amidation or esterification to build the pharmacophore, with this raw material supplying both structural and metabolic attributes. Integration into pharmaceutical synthesis demands precise control of purity and traceability, requiring batch-level documentation and analytical validation from initial raw material intake through the final API crystallization process. End formulation depends on solubility, dosage form, and regulatory submission pathways, which shape the acid’s specifications and handling protocols on site.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • European Pharmacopoeia (Ph. Eur.) monographs for intermediates
    • USP–NF General Chapters for process chemicals
    • FDA 21 CFR Part 211: Current Good Manufacturing Practice for Finished Pharmaceuticals

    Typical usage ratio

    • Generally 1.0–1.25 molar equivalents per target API unit; precise ratio tailored to substrate conversion efficiency and waste minimization in pilot-scale validations.

    Downstream process integration

    • Charged into the coupling vessel typically after substrate activation and prior to final quench; quality control by in-process HPLC characterization.

    Final product types

    • Valproate-based APIs
    • Other branched chain fatty acid pharmaceuticals in neurological classes
    • Intermediate building blocks for custom-synthesized research compounds

    2. Manufacturing of Synthetic Lubricant Esters

    Branched-chain acids such as 3,3-Dimethylbutyric Acid play a defined role in the esterification processes employed by lubricant and specialty oil producers. Its structure imparts oxidative stability and pour point improvement in ester-based base stocks. This raw material introduces steric effects that slow down peroxide and radical attack, extending lubricant life. Processing requires controlled esterification, typically via acid catalysis, with downstream vacuum distillation to achieve product color and volatility specifications. Batch traceability and contaminant control are necessary due to critical end-user performance requirements in automotive and industrial lubrication.

    Industry compliance standards

    • ISO 15380: Specification for biodegradable lubricants
    • DIN 51517 for industrial oils
    • REACH Regulation (EC) No. 1907/2006 – registration for industrial base oils
    • ASTM D6078 for oxidation stability analysis

    Typical usage ratio

    • Introduced at 10–25% w/w in multi-component base stock blends, adjusted to achieve viscosity index, volatility, and cold flow targets verified by lab simulation.

    Downstream process integration

    • Reacted directly with polyol alcohols in presence of acid catalyst; product ester fraction separated by vacuum distillation during final purification.

    Final product types

    • High-performance synthetic esters for gear oils
    • Hydraulic fluids
    • Compressor lubricants
    • Specialty transformer and circulating oils

    3. Flavor and Fragrance Ester Intermediate

    Within the flavor and fragrance sector, 3,3-Dimethylbutyric Acid is valued for its branched structure, facilitating synthesis of distinctive esters via Fischer or enzymatic esterification. Such esters serve as profile-building blocks for fruity, buttery, and nutty aromatic notes. Compliance requires adherence to global food additive rules, full verification of allergen absence, and low-level impurity thresholds. Precision in acid-to-alcohol ratio and process temperature is critical, with the finished flavor ingredients often introduced at ppm levels in beverage, confectionery, and bakery applications. Production documentation must comply with customer-specific HACCP and identity preservation protocols.

    Industry compliance standards

    • FCC (Food Chemicals Codex) purity requirements
    • 21 CFR 172.515: FEMA GRAS flavoring substances
    • EU Regulation (EC) No 1334/2008 on flavorings
    • ISO 22000 Food Safety Management Systems

    Typical usage ratio

    • Reactant ratio of 1:1.05 to alcohol (typically ethanol or isobutanol), yielding final esters dosed at 50–300 ppm in finished food flavor formulations.

    Downstream process integration

    • Combined with alcohols in batch reactors under catalyst control; ester product refined by successive extractions and microfiltration.

    Final product types

    • Artificial fruit flavoring esters
    • Fragrance ingredients for fine perfumes
    • Beverage and confectionery flavor additives
    • Baked goods flavor compounds

    4. Advanced Polymer Additive Manufacturing

    Producers of certain functional polyamides, polyesters, and acrylate copolymers employ 3,3-Dimethylbutyric Acid as a chain-branching or end-capping monomer. The steric hindrance from dimethyl substitution provides specific control over melt viscosity and glass transition of the final polymer, supporting tailored processing windows and improved film toughness. Additive dosing reflects target polymer physical characteristics and customer extrusion equipment; real-time viscosity measurements guide ratio optimization in scale-up. All production follows strict polymer-specific good manufacturing practice, with all-batch lot testing to exclude unknown oligomers or processing catalyst residues. Documentation traces raw acid use through the polymerization reaction and pelletization stages.

    Industry compliance standards

    • ISO 9001 for quality management in polymer production
    • EU Regulation (EC) No. 10/2011 for plastic food contact materials
    • ASTM D638 and D882 for mechanical testing of plastics
    • REACH (EC) No 1907/2006: Polymer registration

    Typical usage ratio

    • Incorporated at 3–7% by weight based on final polymer mass; adjustment confirmed by pilot melt flow and impact resistance validation.

    Downstream process integration

    • Metered into the reactor at monomer addition stage or as an end-capping reagent in final condensation/polymerization; residual acid removed during devolatilization.

    Final product types

    • High-toughness polyamide composites
    • Heat-stable polyester films for electronics
    • Acrylic co-polymers for adhesives
    • Packaging films with controlled barrier properties
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    Certification & Compliance
    More Introduction

    Introducing 3,3-Dimethylbutyric Acid: A Behind-the-Scenes Look from Our Manufacturing Floor

    In chemical manufacturing, quality arises from more than the right recipe. Real value comes from experience, technical discipline, and respect for the process at every stage. At our plant, we approach 3,3-dimethylbutyric acid production not as a transaction, but as a craft. We watch how each batch develops, listen to feedback from practical applications, and lean on years of trial, measurement, and adjustment. This hands-on approach shapes everything about our product, from the purity of each lot to the consistency customers have come to expect from us.

    What Makes 3,3-Dimethylbutyric Acid Stand Out

    The molecule itself — a branched carboxylic acid — might look simple on paper. But it pulls surprising weight in multiple industries. Our own experience with 3,3-dimethylbutyric acid suggests its true value lies in fidelity and adaptability; it plays a foundational role in fine chemical synthesis, agrochemical intermediates, fragrances, and pharmaceutical research. We've seen requests from crop protection companies seeking a specific impurity profile, perfume houses after a robust, nuanced base note, and labs pushing the boundaries of drug precursor chemistry. We supply all of them, but the requirements rarely match. That’s where our process control makes a difference. We don’t follow a script — we cultivate expertise batch by batch, because no two production runs look exactly the same once you're deep in the details.

    Our facility produces 3,3-dimethylbutyric acid in a pure, colorless form — with minimal water, control of organic impurities, and strict adherence to agreed-upon ranges for melting point and acidity. Our batches surpass 99 percent purity as tested by gas chromatography. We maintain water content below 0.2 percent by Karl-Fischer titration. By regularly calibrating our instruments and employing experienced operators, we can guarantee consistent acid value and melting range. These details may sound routine but achieving them is complex. Factors such as temperature uniformity, choice of catalyst, rate of neutralization, and handling of crude fractions impact the final content. Some customers require material with residual solvents kept below 0.01 percent; we tune our vacuum stripping and drying accordingly. It’s the small technical choices that create a distinct difference—each change matters down the line, both for regulatory compliance and processing yield on the customer’s side.

    Practical Applications and Demands We’ve Witnessed

    Customers rarely buy 3,3-dimethylbutyric acid just for storage. Most of our output travels straight to active R&D or high-volume production lines. In the fragrance industry, perfumers reach for this acid as a raw material when crafting certain esters, prized for their fruity, robust undertones. The pharma sector leans on its structural backbone when building more complex molecules, using its branching to tune biological activity. Agrochemical companies value its stability during synthesis and its tolerance to a range of reaction conditions. We’ve learned that application methods drive requirements. Some partners prefer smaller, high-purity microbatches for early-stage research, while others, especially those operating multi-ton reactors, depend on drum quantities with matching certificates of analysis for every lot. Our logistics team responds with everything from custom-packaged borosilicate bottles for small jobs to lined steel drums for industrial customers.

    Differences Compared to Similar Carboxylic Acids

    3,3-dimethylbutyric acid stands apart from straighter-chain and less-branched analogs in several concrete ways. Isobutyric acid, for instance, lacks the same steric hindrance, so it often reacts faster with certain coupling agents but loses out on thermal and storage stability. Pivalic acid shares similar branching, but the two-carbon difference influences not only reactivity but also downstream physical properties. This can pivot the whole project when aiming for a specific intermediate or solvent system. We’ve solved bottlenecks for clients whose processes demand this particular balance of volatility and reactivity — situations where a swap to a more common acid results in lower yields or unstable formulations. Our feedback loop with formulation chemists goes back years. They’ve let us know that substituting even a comparable carboxylic acid sometimes triggers issues, from unexpected byproducts to batch failures, because the branching in 3,3-dimethylbutyric acid delivers a unique combination of hydrophobicity and boiling point. Over time, these nuanced properties become critical for anyone fine-tuning molecule performance or optimizing plant throughput.

    Process-Driven Quality Without Unnecessary Complexity

    Scaling up from laboratory synthesis to commercial production means no two operations look quite alike. Back when we first started working with this product, small deviations in crystallization or purification left residual odor, or color. We've since invested in vertical wiped-film evaporators and modernized our filtration protocols, not for the sake of making process charts look impressive, but because the impact shows up directly on the customer end. An odd sulfurous note or a faint tint in a drum can completely undermine an entire perfume formulation or lead to rejected batches in pharma. Our operators live and breathe this reality. Each set of hands involved in our workflow understands what’s at stake. This connection keeps our approach straightforward — eliminate unnecessary steps, intervene only where experience shows it's needed, and always prioritize reproducibility. Our plant engineers routinely review key parameters like reflux ratio, column packing efficiency, and drying conditions. This consistency translates to lower risk for our business partners.

    We also field application questions: how to best dissolve, how to dose, whether to expect interferences with certain reducing agents. Our in-house technical department documents answers drawn from actual practice, not textbook speculation. For instance, we’ve had to tweak dissolution temperatures for fragrance makers who encountered cloudiness using certain alcohol bases. Our advice, grounded in trial and error and day-to-day troubleshooting, helped solve issues others might miss. These details, sometimes overlooked in datasheets, are where true manufacturing support lives.

    Storage and Handling from the Manufacturer’s Perspective

    We view storage and handling recommendations as an extension of our reliability. Each lot is shipped based on real-time environmental conditions—hot weather, humidity, and transit times all factor into our procedures. For example, in damp regions, we take extra care to limit exposure time during drum transfers and keep desiccant stock on-hand for immediate packing. We’ve found HDPE drums and lined steel vessels both hold up against the acid’s low volatility and avoid any pick-up of metallic ions that would taint downstream syntheses. We don’t just recommend standard room temperature storage; we test samples pulled after months to check for shelf life. Batches show negligible breakdown or acidification even after long storage in sealed containers, which matters to clients who keep inventory for extended periods. Predictable results flow from predictable storage practices—and these are formed through manufacturer discipline, not generic advice.

    Supply Assurance and Flexibility in a Volatile World

    Modern supply chains never stop moving. Unscheduled demand spikes happen, regulatory changes appear seemingly overnight, and global logistics rarely go easy on packaging. Years of hands-on experience have taught us that direct customer relationships and a bit of manufacturing flexibility go a long way. We keep buffer stock of both raw materials and finished product. Our in-house laboratory tests every outgoing batch, so if a customer suddenly needs documentation for a regulatory update, our quality control team already has the data. This readiness lets us avoid delays when others in the market are still waiting on certificates or missing intermediary analysis. We've weathered cyclones, port closures, and customs holdups by keeping a contactable, empowered team in-house who follow every step from kettle to customer. Sitting close to the production line instead of working through tiers of middlemen lets us keep our promises. Our partners never have to guess if they're dealing with a trader or someone guessing at origins — our doors are open, our process is transparent, and our word means something.

    Regulatory, Safety, and Traceability Commitments

    Safety is non-negotiable, and so is regulatory diligence. Our technical files for 3,3-dimethylbutyric acid cover not only local environmental rules, but those governing international shipments. Any declaration — whether concerning REACH compliance, full traceability of origin, or impurity profile for pharma application — gets documented and cross-checked by our certifications team. Each lot produced in our plant can be traced back through production logs, raw material procurement, and operator sign-off. We follow relevant national and international classifications, not to fill out forms but because regulatory short-cuts do not serve anyone. Our safety recommendations are rooted in how we handle the product ourselves: everyone who works with concentrated acids on our floor gets real training and protective equipment. We never cut corners on packaging or transport, and we supply full documentation on request. Direct transparency is what separates a committed manufacturer from a distributor passing along a label. This level of traceability has saved headaches for our pharma partners undergoing inspections, and it remains a point of pride for our facility management. We invest in upgrading our systems, even when regulations lag behind the risks — an approach learned from seeing up close what can go wrong if safety or compliance gets treated as a paperwork chore, not an operating principle.

    Challenges We Face — and Overcome — in the Course of Manufacturing

    Industrial chemistry rarely grants smooth sailing. We face real pressures: market volatility for starting materials, shifting buyer requirements, and day-to-day uncertainties in logistics. As a manufacturer, our answer to each challenge lies in preparation and a healthy skepticism about shortcuts. We source feedstock only from vetted suppliers and keep direct oversight during incoming raw material testing. Technical issues arise, such as fouling of reactor internals by residues or slight shifts in melting point ranges after a hot summer shipment. Years of logged experience allow us to adapt, correct course quickly, and keep the integrity of each lot intact. Our engineering team doesn't make changes in pursuit of marginal cost savings alone — throughput matters, but long-term customer relationships grow out of batch-to-batch integrity, not headline prices. The chemical industry runs on trust. Customers remember the day their materials don’t arrive or don't perform as promised. We respond to that reality by never overselling and always keeping an open line about both capacity and potential bottlenecks. Recent years have underscored the need for backup planning, from raw materials to redundant electrical supply for critical reactors. Our refusal to sacrifice quality for volume sets us apart in a market where round-the-clock trading can sometimes overshadow diligence at the source.

    A Manufacturer’s View on Why Consistency Creates Value

    Every container bearing our name represents work we can stand behind. In the fine chemicals trade, too many products change hands before delivery — losing clarity about how they came to be, or what actually went into them. Our approach is different. With 3,3-dimethylbutyric acid, as with all our products, we focus on what happens in the plant — vigilant monitoring, targeted interventions only where needed, and ongoing attention to feedback from users in industry and academia alike. Our experience leads us to believe that every claim we make must be defendable with records, samples, and real batch data. Otherwise, the value we promise is just a gamble. This product, while maybe a small cog in a much bigger process for many of our customers, carries implications far beyond our factory gates — for safety, quality, regulatory standing, and even long-term supplier reputation. We live with those consequences, taking responsibility for every lot. That is what binds us, as practical manufacturers, to the industries that rely on us for critical raw materials.

    Direct Answers to Common Questions Drawn from Our Plant Experience

    Can we accommodate varying purity requirements? Absolutely. We supply standard lots above 99 percent purity and can increase purification for those needing even tighter specifications for sensitive applications. Is product availability subject to seasonal delays? We counteract much of that unpredictability with regular inventory controls and backup supply streams, although sudden, extreme weather or shipping gridlocks can interfere. Do we take customer feedback seriously? Every suggestion or recurring concern prompts a joint review by technical, quality, and operations so that we address the root, not just the symptom. Does our technical team share best practices for downstream use? We publish practical guidance based on how we run our own lines, and adjust as we learn from new use cases. Our knowledge accumulates from day-to-day troubleshooting, not just specification sheets.

    For those grappling with odd formulation or processing outcomes, our role goes well beyond shipment — we share results from varied dissolution trials, blending protocols, reactivity issues, and even packaging adaptations for long-term stability. New customers sometimes find unexpected shifts in performance after switching suppliers; our hands-on support aims to prevent those headaches. We often advise on storage under local humidity, compatibility with preferred solvents, or residues during downstream synthesis. It’s these on-the-ground efforts that set the standard for manufacturer responsiveness, much more than any third-party guarantees or labels ever could.

    The Human Side of Precision Chemical Manufacturing

    Machines alone don’t produce quality materials; people do. From the operators who monitor each reflux stage, to the technicians running routine Karl-Fischer titrations, and the logistics crew prepping shipments for safe transport, we nurture a culture that values feedback, diligence, and shared responsibility. We hold weekly plant meetings focused on not just numbers but what went right and what went wrong. Each discussion translates into better batches, faster troubleshooting, and real-world improvements in the material we send out. Our leadership team listens to feedback from everyone involved — from seasoned chemists to new hires learning the ropes — so we can keep refining our approach. This environment not only reduces errors but produces a more resilient manufacturing pipeline, turning knowledge into product value, year after year.

    Final Thoughts from the Manufacturing Floor

    3,3-dimethylbutyric acid is more than a line in a catalog; it reflects the standards, technical discipline, and adaptability that only manufacturers close to the process can bring. We keep our systems calibrated, train our team with the latest knowledge, and prioritize consistency and transparency. The difference between generic supply and true value lies in the details: purity rooted in careful process control, documentation backed by traceable data, and customer relationships founded on facts and real problem solving. Our commitment to 3,3-dimethylbutyric acid production comes from years at the reactor, hours spent refining practices, and a belief that real quality is never accidental — it’s built one careful batch at a time.