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2-Quinolinylmethanol

    • Product Name 2-Quinolinylmethanol
    • Alias quinolin-2-ylmethanol
    • Einecs 205-953-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    454612

    Iupac Name 1-(quinolin-2-yl)methanol
    Molecular Formula C10H9NO
    Molecular Weight 159.19 g/mol
    Cas Number 33435-06-8
    Appearance White to off-white solid
    Melting Point 72-75°C
    Solubility In Water Slightly soluble
    Smiles C1=CC=C2C(=C1)C=CC=N2COH
    Inchi InChI=1S/C10H9NO/c12-8-9-6-5-7-11-10(9)3-1-2-4-9/h1-7,12H,8H2
    Pubchem Cid 11239094

    As an accredited 2-Quinolinylmethanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 25g amber glass bottle labeled "2-Quinolinylmethanol," sealed with a screw cap, featuring standard safety and handling information.
    Shipping 2-Quinolinylmethanol is typically shipped in tightly sealed containers to prevent contamination and moisture absorption. It should be stored and transported in a cool, dry place, away from incompatible materials and direct sunlight. Proper labeling and documentation must comply with relevant chemical safety and transport regulations to ensure safe handling.
    Storage 2-Quinolinylmethanol should be stored in a tightly sealed container, away from direct sunlight and moisture, in a cool, dry, and well-ventilated area. Keep it separate from strong oxidizing agents and acids to prevent unwanted reactions. Properly label the container and store it at a temperature recommended by the manufacturer, typically at room temperature or below. Handle with appropriate personal protective equipment.
    Application of 2-Quinolinylmethanol

    Applications of 2-Quinolinylmethanol in Industrial Manufacturing

    As the direct manufacturer of 2-Quinolinylmethanol, we supply global partners in diversified downstream industries. This intermediate delivers unique value to chemical synthesis, development, and production for various specialized applications. Below we detail specific industrial sectors, standards, blending ratios, integration points, and resulting end products based on real customer practice and market access requirements.

    1. Pharmaceutical Intermediate for Antimalarial Agents

    Pharmaceutical companies use 2-Quinolinylmethanol as a critical intermediate during the synthesis of select antimalarial drug API formulations, especially in second- and third-generation quinoline derivatives. The compound participates in nucleophilic additions and ring transformations necessary for constructing core pharmacophores. Downstream integration focuses on the post-condensation step before final functionalization or derivatization, impacting potency and yield. Only GMP-approved facilities and validated QC procedures can handle this material at scale for regulated drug manufacturing.

    Industry compliance standards

    • ICH Q7: Good Manufacturing Practice (GMP) for Active Pharmaceutical Ingredients
    • US Pharmacopeia (USP) Monograph guidelines where applicable
    • European Pharmacopoeia General Chapters
    • FDA 21 CFR Part 210/211

    Typical usage ratio

    • 0.8–1.2 molar equivalents per target API batch; adjusted based on reaction pathway and impurity profile monitoring

    Downstream process integration

    • Introduced after substrate activation during ring closure or as the main building block in C–C coupling reactions via Grignard or Buchwald-Hartwig protocols

    Final product types

    • Medicinal APIs for antimalarial therapy (e.g., chloroquine/dihydroquinoline derivatives)
    • Related bulk pharmaceutical compounds with quinoline frameworks

    2. Agrochemical Synthesis Intermediate

    Major crop protection manufacturers incorporate this raw material in the multi-step production of new-generation quinoline-based fungicides and insecticides. Its primary use involves forming nitrogen heterocycles, which improve biological activity in final formulations. Factories must follow REACH registration and agrochemical-specific environmental controls during production, storage, and transport to minimize risks. Formulators adjust material input based on target compound specifications, reaction time, and purification efficiency.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006
    • ISO 9001:2015 Quality Management
    • OECD Guidelines on Chemical Safety in Agrochemicals

    Typical usage ratio

    • 0.5–1.4 molar equivalents relative to starting aryl halide; reactivity and conversion checked by HPLC or GC-MS

    Downstream process integration

    • Added post-initial halogenation to participate in cyclization or reductive amination during intermediate buildup for active ingredient finalization

    Final product types

    • Fungicide APIs containing quinoline motifs (e.g., triazole-quinoline hybrids)
    • Insecticide intermediates with enhanced systemic action

    3. Specialty Dye and Pigment Manufacturing

    Advanced pigment plants employ 2-Quinolinylmethanol for constructing high-performance quinoline-derived colorants, supporting demanding optical and durability properties. Its selective reactivity allows formation of fused aromatic systems to tune chromophore behavior and improve lightfastness or solvent resistance. Operators use this intermediate during the core extension phase, and end-user products target demanding coatings or electronic sectors. Quality control involves color strength validation and impurity quantification in accordance with international pigment standards.

    Industry compliance standards

    • ISO 787-24: General Methods of Test for Pigments and Extenders
    • EN 71-3: Safety of Toys – Migration of Certain Elements for pigment products in toys
    • RoHS Directive (2011/65/EU) where used in electronic components

    Typical usage ratio

    • 5–15% by weight relative to other aromatic units in reaction mixture; final percentage set by target hue and depth

    Downstream process integration

    • Fed during condensation or coupling reactions in pigment backbone formation or during halogenation/methylation finishing steps

    Final product types

    • Solvent-soluble dyes for plastics and coatings
    • High-color-strength pigments for inks, plastics, and electronic displays

    4. Ligand Component in Organometallic Catalysts

    Catalyst manufacturers process this substance as a functional ligand precursor for assembling chelating systems in organometallic catalyst design, which sees use in fine chemical and polymerization industries. The precise structure derived from the quinoline backbone enhances selectivity and thermal stability in subsequent catalytic reactions. QC teams verify purity and integrity through NMR and LC-MS prior to application in complexation or catalyst screening steps. Integration with proprietary ligand frameworks requires trace impurity control for maximum catalyst performance in downstream operations.

    Industry compliance standards

    • ISO 17034: General Requirements for the Competence of Reference Material Producers
    • CFR Title 40—Protection of Environment (for process emissions in catalyst plants)
    • Responsible Care Management Systems (RCMS®) for chemical catalyst production

    Typical usage ratio

    • 0.2–0.5 equivalents per transition metal center in ligand synthesis; adjusted for desired chelation geometry

    Downstream process integration

    • Serves in ligand installation via amination or alkylation steps, then complexed with precious/base metals in final catalyst formulation

    Final product types

    • Homogeneous or heterogeneous catalysts for fine chemical synthesis
    • Catalyst systems in modern polymerization units
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    Certification & Compliance
    More Introduction

    2-Quinolinylmethanol: A Closer Look from the Manufacturer's Perspective

    Understanding 2-Quinolinylmethanol in Everyday Practice

    Stepping into the lab with a fresh batch of 2-Quinolinylmethanol marks the beginning of a process that draws on years of technical know-how and a genuine commitment to quality. Over time, working directly on production lines and in quality control, it becomes clear that details make or break the outcome. The compound itself isn’t just a line in a product catalog—each step of synthesis, purification, and packaging shapes how it performs for chemists and downstream industries. It opens the door for reliable results where minute variations can tip the balance.

    Introducing 2-Quinolinylmethanol means working with a compound defined by its quinoline core, where a methanol group attaches at the 2-position. This structural choice brings together the aromatic stability of quinoline with the reactivity of a benzylic alcohol. In our plant, outputs such as this product reflect hours spent tuning reaction conditions, handling reagents, and supervising drying protocols. There’s always a level of pride that comes with delivering a substance that not only matches but exceeds the purity most synthetic routes demand.

    Product Model and Specifications in Real-World Terms

    This particular batch—identified by the 2-Quinolinylmethanol descriptor—translates to a compound with a molecular formula of C10H9NO and a molecular weight close to 159.19 g/mol. Chemistry at industrial scale brings out hidden variables: the consistency of crystallization, the freedom from by-products, the ease of handling, and the ability to withstand storage without degradation. Typically, our team prepares this compound as a white or off-white crystalline solid, maintaining moisture content at a minimum, since even trace water can upset downstream transformations or analytical work.

    In each lot, we confirm identity and quality through spectral checks—NMR, HPLC, and mass spectrometry analyses turn theoretical purity into documented fact. Having hands on the process, you learn what purity above 98% actually means on the bench: sharp melting points, predictable solubility, and zero headaches for researchers that receive the final product. Specification sheets in our files list these analytical values, sure, but the real test comes from customer feedback and repeat use. Any outlier in melting point or color demands a root-cause investigation and, if needed, a remanufacture—trust forms through details, not just certificates.

    Connecting Lab-scale Chemistry and Industrial Demand

    Conversations with colleagues and partners guide decisions on scale and usage. 2-Quinolinylmethanol keeps showing up in research settings and pilot plants as a critical building block. Academics and formulation scientists often detail how they use it as a key intermediate, customizing its structure for pharmaceutical research, agrochemical innovations, and advanced material synthesis. We hear stories where its chemical backbone gives the edge—strong enough for oxidation reactions; reactive enough for coupling and substitution protocols; stable enough to ship worldwide in standard packaging without worrying about rapid degradation or incompatibility.

    Each time a customer details an issue—maybe a batch doesn’t dissolve quickly in the usual solvent, or an unexpected peak appears during analysis—it traces directly to how attention or neglect shaped that batch. Over the years, improvements took root: switching to higher purity solvents, controlling atmosphere during crystallization, or redesigning filtration setups. Success doesn’t come from luck—it emerges from countless adjustments, logging anomalies, and continuous skill-building in both equipment handling and chemical intuition.

    Usage Scenarios from Practical Experience

    Our most frequent clients operate in medicinal chemistry, where the 2-quinolinyl group acts as a launching pad for further modifications. In synthesis, researchers often utilize the primary alcohol group to introduce new side chains, form ethers or esters, or generate reactive intermediates. The quinoline structure, robust under standard reaction conditions, stands up to a range of transformations—electrophilic substitution, cross-coupling, or oxidation to aldehydes and acids.

    Colleagues in materials science point to the value of this compound in accessing heterocyclic building blocks. Sometimes, post-synthetic modification relies on the alcohol’s direct chemical accessibility; other times, its electronic properties support the stabilization of intermediates in catalyst development. The point here isn’t just academic. Handling thousands of grams in controlled vessels, we’ve seen how storage stability, ease of weighing, and compatibility with standard solvents makes life easier for users chasing tight deadlines and precision yields.

    Regulators and QA teams always stress safety and documentation. Years of audits and client reviews have shown that thorough labeling, reliable packaging, and clear documentation matter as much as chemical characteristics. Buyers—especially in regulated markets—demand evidence that batch records, impurity profiles, and storage conditions line up with best practices. The skill of preparation isn’t enough; full traceability sets the best apart from the rest.

    How 2-Quinolinylmethanol Stands Out Among Related Products

    Within our portfolio, each quinoline-derived compound brings its own challenges and advantages. For instance, 2-Quinolinylmethanol contains a single alcohol group at the 2-position, while other derivatives might carry halogens, nitro groups, or second functional units. The single alcohol function allows targeted reactivity, which synthetic chemists prefer for both modular construction and minimal side products.

    Comparing this with multi-functionalized quinolines, 2-Quinolinylmethanol presents a more controlled, direct route for subsequent derivatization. Its physical properties—especially solubility and melting range—avoid the headaches linked to some heterocyclic analogues, which can oil out or resist crystallization entirely. In our experience, those handling it daily favor its manageable dusting, predictable storage stability, and safe handling profile, provided basic laboratory precautions are observed.

    While some products bear halogen or nitro substituents which complicate storage and disposal, we have found that the alcohol group provides versatility without the red tape associated with more hazardous moieties. Downstream partners often remark that fewer restrictions streamline process design, shipment, and eventual waste treatment.

    Discussions with long-term clients in pharmaceuticals and custom synthesis reveal that specificity counts. The route to their desired active ingredient or intermediate often starts with 2-Quinolinylmethanol due to its single, highly reactive handle on a stable aromatic platform. In contrast, analogues with more delicate or less predictable substituents require extra work-up steps that bog down schedules and introduce unnecessary risk.

    Quality, Consistency, and Continuous Improvement

    Every production cycle gives insight into consistency. In our facility, staff training and routine checks serve as the backbone for repeatable results. Over decades, sight and smell during synthesis often catch anomalies just as quickly as instruments. Feedback loops between the floor and QA lab produce learning opportunities: a slight yellow tint, a hint of off-odor, or an inconsistent yield all push a process review.

    We’ve invested in analytical tools, but the human element—chemists with a nose for trouble—remains essential. Many improvements in drying, filtering, and packaging stem from technicians who report details that formulas and algorithms can miss. Coupling this with rigorous documentation provides the traceability modern clients and regulators demand.

    Documented Performance and Application Success

    Publications and patent filings almost always mention the source and purity of their starting materials. Our track record includes feedback from customers running multi-step syntheses where deviations even in trace impurities proved disastrous. In such cases, strong partnerships emerge from staying close to results—responding to concerns, troubleshooting issues, and making batch replacements without delay.

    Environmental teams inside and outside the plant pay special attention to waste minimization and solvent choices. We’ve adapted over time, choosing recyclable solvent systems and upgrading containment measures to prevent loss or contamination. Many institutions scrutinize supply chains for adherence to environmental standards; we treat this as a core operating value—minimizing emissions, monitoring effluent, and certifying each process step.

    Increasingly, production managers from pharmaceuticals and fine chemicals praise the reliability of sourcing a product that can go straight from bottle to reaction flask without additional pre-treatment or concern over impurity carryover. The product’s manageable reactivity, predictable physical form, and trustworthy analytical profile let teams plan resource allocation and workflow with fewer surprises.

    Challenges and Solutions in Manufacturing and Supply

    Supply chains have grown more complex. Raw material availability, transportation restrictions, and regulatory expectations tighten every year. Maintaining consistent access to quality starting materials—without passing off increases in cost or complexity to end users—drives our sourcing strategies. Direct relationships with raw-material suppliers and redundancy in storage keep production lines moving when unexpected delays hit.

    Every time a production variable shifts—a vendor changes solvent quality, an equipment upgrade tweaks crystallization—technicians run comparison batches, monitor analytical readouts, and collaborate with downstream users before finalizing changes. Years in this role cement the value of incremental learning; troubleshooting one challenge lays the groundwork for avoiding the next.

    Safety considerations remain paramount. Pure 2-Quinolinylmethanol handled in large lots demands well-ventilated work areas, chemical-resistant gloves, and personal protective equipment. Storing in tightly sealed, light-protected containers, we reduce risk of oxidation and contamination. Internal guidelines, built from both regulation and hard-earned experience, direct how personnel work with every kilogram produced. An incident is never just a statistic—it’s a chance to refine protocols, strengthen training, and protect every team member on site.

    Building Trust and Meeting Industry Needs

    Looking across years of product shipments, ongoing support, and routine audits, it is clear that reliability in delivery anchors client relationships. Buyers who start with small research quantities often return as production scales up, relying on that same consistency for kilograms or metric tons. This continuity grows out of both technical attention and honest communication—for example, flagging storage tips or potential handling quirks in advance.

    Emerging industries and niche applications keep changing what customers expect. We’ve worked directly with clients adapting 2-Quinolinylmethanol for new catalyst systems, energy applications, and bioactive molecule synthesis. Each application brings a set of critical needs—the right physical form, contamination-free processing, a flexible packaging size. We work with those teams directly, modifying batch sizes, adjusting drying setups, or tuning particle size for improved dispersibility.

    Success depends on showing value beyond a chemical formula. We invest in regular training, cross-department knowledge sharing, and reviewing field results—even minor user complaints guide improvements for future lots. Setting high standards for purity, stability, and regulatory documentation reflects a belief in delivering more than just inventory.

    Industry Outlook for 2-Quinolinylmethanol

    Markets evolve as discovery chemistry speeds up and regulatory landscapes shift. Over time, the drive for safer, more effective intermediates pushes innovation both in product design and production technique. Previously, a handful of researchers represented main buyers; now, inquiries come from biotech, advanced materials, and electronics.

    In house, adapting to changing demands means both updating procedures and anticipating shifts from new research. We monitor literature, engage in technical conferences, and support collaborative validation with users scaling up from lab to pilot plant. Feedback flows both ways—identified impurities or scale-up failures on the customer side often produce improvements on the manufacturing floor.

    Quality regulatory compliance never takes a back seat. Familiar auditors expect traceable, reliable documentation—batch records, validated production methods, and well-organized certificates of analysis arrive with every shipment. Transparency builds credibility, reassuring researchers and procurement officers they are making a safe, predictable choice with minimal regulatory complications.

    A broader appreciation for sustainable operations shapes how we run. From water recycling to minimizing emissions, each year brings a new round of reviews and improvements. Clients find value not just in technical data but in open communication about eco-friendly practices, waste reduction, and responsible sourcing. The value of producing 2-Quinolinylmethanol extends into a commitment to both chemical excellence and environmental stewardship.

    Continuous Learning and Customer Partnership

    Every day on the production floor and in quality assurance, opportunities for learning surface. That ranges from updating analytical methods to tackling more ambitious purification goals or rethinking packaging options for easier, safer transport. Long-term customers appreciate responsiveness—questions get real answers, not copy-paste disclaimers. These dialogues help us address handling quirks, optimize reaction yields on the client side, and troubleshoot obstacles in unfamiliar chemistries.

    Investments in talent, from experienced process chemists to sharp-eyed technicians, give us an edge. Each year, new hires bring fresh perspectives and challenge established routines. In doing so, operations sharpen, risks decrease, and reliability grows. By keeping lines of communication open, we partner with users from the R&D stage through commercial-scale production—learning from each other and raising standards along the way.

    A practical example: some partners voiced trouble getting clean phase separations due to tiny impurities. We reexamined the process, tightened specifications, and implemented added QA checkpoints. This sort of collaboration, where knowledge passes both directions, defines real partnership at every scale of production.

    Moving Forward with Insight and Integrity

    As a manufacturer, pride comes from knowing each drum or bottle of 2-Quinolinylmethanol has a story—hundreds of hours behind every clean NMR or spotless mass spec report. We take feedback seriously and keep striving for even higher standards of purity, performance, and environmental safety. The ongoing evolution in how 2-Quinolinylmethanol serves the scientific and industrial world reflects both client innovation and the rigorous, boots-on-the-ground work that starts here in manufacturing.

    Going forward, we adopt new chemistries, refine methods, and foster open lines of communication. Each challenge—scaling up a process, investigating batch-to-batch variation, or responding to a unique request—pushes us to grow. These collective efforts not only deliver on the practical needs of users but also reinforce the trust earned batch by batch. 2-Quinolinylmethanol, for us, signifies more than a product on the shelf; it represents a commitment to science, industry, and responsible chemical stewardship.