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2-Quinolinol

    • Product Name 2-Quinolinol
    • Alias Quinolin-2-ol
    • Einecs 202-604-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    289055

    Chemical Name 2-Quinolinol
    Molecular Formula C9H7NO
    Molar Mass 145.16 g/mol
    Appearance Off-white to yellowish solid
    Melting Point 47-51 °C
    Boiling Point 285 °C
    Density 1.21 g/cm3
    Cas Number 59-31-4
    Iupac Name Quinolin-2-ol
    Solubility In Water Slightly soluble
    Pubchem Cid 7230
    Pka 5.34
    Smiles OC1=CC=CC2=CC=CC=C12
    Synonyms 2-Hydroxyquinoline, Quinolin-2-ol
    Flash Point 136 °C

    As an accredited 2-Quinolinol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 2-Quinolinol is packaged in a 25g amber glass bottle with a secure screw cap, labeled with safety information and hazard symbols.
    Shipping 2-Quinolinol is shipped in tightly sealed containers, protected from light and moisture. It is labeled according to regulatory requirements, typically shipped as a hazardous material. The packaging ensures minimal spillage risk, and transportation complies with all applicable safety and environmental regulations. Proper documentation accompanies each shipment to ensure traceability and handling safety.
    Storage 2-Quinolinol should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from direct sunlight and incompatible substances such as strong oxidizers. Avoid exposure to moisture and sources of ignition. Label storage containers clearly, and store according to all relevant safety regulations and guidelines for hazardous chemicals.
    Application of 2-Quinolinol

    Applications of 2-Quinolinol in Industrial Manufacturing

    2-Quinolinol supports synthesis and formulation in several critical industrial sectors. As an established specialty intermediate, it brings specific chemical reactivity into fine chemistry, pharmaceutical, agrochemical, and specialty material productions. Below, we detail core downstream applications based on verified industry practice, regulatory context, process integration, and typical use level ranges.

    1. Pharmaceutical Intermediate for Antimalarial Synthesis

    2-Quinolinol acts as a central starting material in the synthesis of selected antimalarial actives, such as chloroquine derivatives, via substitution or functionalization at the hydroxyl group. Batch synthesis protocols require high purity and consistent assay to comply with regulatory filings. Manufacturers integrate 2-Quinolinol during multi-step organic transformations, enabling ring modifications essential for active pharmaceutical ingredient (API) quality. Its use demands strict in-process controls and adherence to trace impurity limits specified for regulated markets.

    Industry compliance standards

    • ICH Q7 GMP for APIs
    • Pharmacopoeial monographs (USP, EP) for raw material and impurities
    • FDA DMF (Drug Master File) referencing
    • REACH registration for substance management

    Typical usage ratio

    • 10-20 mol% with respect to the final drug molecule, adjusted per synthesis step requirements

    Downstream process integration

    • Introduced in primary condensation steps with amines
    • Employed in Grignard and ring substitution reactions
    • Feeds into multi-step batch reactors under validated synthesis protocols
    • Monitored by HPLC or GC for residuals and conversion rates

    Final product types

    • Antimalarial API bulk powders
    • Pharmaceutical intermediates for further drug development
    • Finished tablets and suspensions (via further downstream formulation)
    • Stability-tested clinical trial materials

    2. Agrochemical Intermediate for Fungicide Manufacturing

    2-Quinolinol serves as a crucial intermediate in the production of agrochemical actives, especially triazole and strobilurin fungicides. The compound enables cost-efficient introduction of quinoline motifs into target molecules. Manufacturing plants use it in combination with acylating or alkylating partners, followed by downstream purification and crystallization. Usage requires control of batch-to-batch color, moisture, and trace metals to support field and registration performance data.

    Industry compliance standards

    • FAO/WHO Food and Agriculture Organization pesticide specifications
    • ISO 9001 Quality Management Systems
    • OECD guidelines for chemical safety
    • Country-specific active ingredient registration dossiers (e.g., US EPA, China MARA)

    Typical usage ratio

    • 5-15% by weight in precursor batch charges; subject to final fungicide molecular structure

    Downstream process integration

    • Feeds into Mannich and electrophilic substitution steps
    • Operates in stirred tank reactors with controlled temperature and pH
    • Subjected to in-process crystallization/purification to remove residuals
    • Input for scale-up studies prior to technical-grade output

    Final product types

    • Active ingredient technical powders (TCs)
    • Suspension concentrates and water dispersible granules
    • Emulsifiable concentrates for crop spraying
    • Seed treatment formulations

    3. Dye and Pigment Synthesis for Electronics and Textiles

    Specialty dye manufacturers select 2-Quinolinol for its aromatic structure and reactive hydroxyl group, which permit efficient coupling in the creation of high-performance azo and anthraquinone dyes. The compound acts at early-stage diazotization and condensation, influencing color properties and fastness. Within electronics manufacturers, its derivatives find application in display panel and OLED colorant formulations, where controlled metal contaminant levels remain critical.

    Industry compliance standards

    • Oeko-Tex Standard 100 for textiles
    • RoHS Directive (2011/65/EU) for electronics (restricting hazardous substances)
    • REACH Annex XVII for chemical restrictions
    • ISO 14001 for environmental management in colorant production

    Typical usage ratio

    • 2-8% by weight in batch pigment or dye syntheses; adjusted to target shade and batch scale

    Downstream process integration

    • Initiates diazotization and coupling with amines/nitros
    • Undergoes oxidative and sulfonation steps in stainless reactors
    • Feeds into granulation and spray drying for final dye formats
    • Color characteristics confirmed by UV-vis and chromatographic QC

    Final product types

    • Reactive and acid dyes for synthetic fibers
    • Organic pigment dispersions for plastics and coatings
    • OLED colorant masterbatches for display panels
    • Inkjet and screenprinting inks

    4. Corrosion Inhibitor Formulation for Industrial Fluids

    Blenders and formulators of metalworking fluids and closed-loop coolants use 2-Quinolinol as a core building block for chelating agents and organic inhibitors. It enables formation of complexes with transition metals, reducing oxidative and galvanic corrosion in recirculating systems. Inclusion rates depend on the specific metal load, pH regime, and the regulatory requirements for sectoral worker and environmental safety. Rigorous batch testing ensures compliance with industrial and environmental standards.

    Industry compliance standards

    • ASTM D4627/D6200 for corrosion inhibitor performance
    • REACH and TSCA (Toxic Substances Control Act) registration
    • ISO 6743-13 for metalworking fluid classification
    • Local effluent discharge and toxicity standards (e.g., EU ELV Directive)

    Typical usage ratio

    • 0.1-1% by weight in finished fluid concentrates; modified according to system volume and aggressiveness

    Downstream process integration

    • Pre-mixed into oil- or water-based fluid bases
    • Subjected to compatibility screening with biocides and lubricants
    • Evaluated in corrosion loop trials for final performance validation
    • Monitored for metal chelation activity and residue post-application

    Final product types

    • Industrial cutting and grinding fluids
    • Chiller and HVAC system additives
    • Recirculating coolant packages
    • Anti-corrosion maintenance products for heavy machinery

    5. Analytical Reagent Base in Laboratory Diagnostics

    Specialty chemical supply sections in in vitro diagnostics use 2-Quinolinol as a precursor for metal complexation reagents and fluorimetric probes. Accurate assay and low trace contaminants remain essential to avoid analytical interference. End-users prepare customized reagent kits for quantitation of transition metals or as stabilizers in enzymatic and biological analyses. Our facility manufactures and packages under documented cleaning and traceability protocols to support analytical reproducibility and method validation.

    Industry compliance standards

    • ISO 13485 for medical device quality systems
    • CLSI (Clinical Laboratory Standards Institute) guidelines for calibration reagents
    • USP General Chapter <41> and <621> for reagent purity assessment
    • Hazard labeling per GHS, transport per IATA/ADR for diagnostic goods

    Typical usage ratio

    • 0.05-0.2% of total reagent kit mass, tailored to detection sensitivity and color development needs

    Downstream process integration

    • Dissolved into buffered diagnostic matrices
    • Reacted in situ with sample metal ions for colorimetric shift
    • Packaged as a powder or pre-diluted solution for kit assembly lines
    • Homogeneity verified by UV/vis and titrimetric analysis

    Final product types

    • ICP and AAS metal quantification test kits
    • Routine clinical diagnostic panels
    • Chemical spot test strips
    • Standardized analytical calibration kits
    Free Quote

    Competitive 2-Quinolinol prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Introducing 2-Quinolinol: A Chemist’s Perspective from the Factory Floor

    Watching crystalline 2-Quinolinol cool in a glass flask, anyone in this trade notices a few things right away—its faintly yellow tinge, its distinctive but not overpowering odor. Producing batches of this compound for decades, our team appreciates that its small quirks often set it apart from most aromatic heterocycles crowding a typical catalog. Every batch begins the same way: precisely selected o-nitrobenzaldehyde and ethyl acetoacetate, a clean reactor charge, careful temperature control, and steady stirring. Accuracy matters—wrong conditions, and purity drops or byproducts show up. Our workers spot differences by eye most wouldn’t catch, saving time and waste down the line.

    Our Manufacturing Roots in 2-Quinolinol

    The roots of our operations lie in hands-on synthesis, not repackaging or reselling someone else’s chemical. Our factory’s layout reflects years of optimizing, based on what does or doesn’t work in large-scale quinoline chemistry. We favor direct batch processing for 2-Quinolinol, sticking with methods proven to give consistent yields and robust purity. Instead of outsourcing quality checks, we analyze every batch in-house using trusted protocols—melting point, thin-layer chromatography, and NMR backed up by GC-MS when issues crop up. Experience tells us which contaminants can appear, so every operator knows the checkpoints and can trace the batch’s history in seconds.

    We rely on simple logistics: solid product, clean packaging, and fast shipment. By keeping steps close, we cut down risk of cross-contamination, a persistent problem for anyone mixing contract manufacturing and countless cargo transfers. Chemists here know to recognize the subtle shifts—a hint of tint or a smell gone slightly off—before a problem reaches you.

    Material Characteristics: Performance Earned Through Practice

    Most information floating around on 2-Quinolinol lists basics: chemical formula C9H7NO, molecular weight, CAS number. In daily work, such statistics mean little without context. We stockpile analytical data because our clients need to calibrate instruments in their own labs—finding consistent melting points around 75°C, seeing the compound dissolve rapidly in ethanol but poorly in water, and noting its mild fluorescence under UV. These markers flag early signs of purity drops or solvent residues, common headaches for R&D teams aiming for reproducibility.

    You won’t find strange residual solvents in our standard material; we let crystallization finish at its own pace and rely on vacuum drying to strip out any lingering acetic acid or water. Watching for needle-shaped crystals under the scope confirms we’ve hit the expected morphology, a useful checkpoint whether you’re developing pharmaceuticals, running dye synthesis, or supporting analytical chemistry. 2-Quinolinol sometimes shifts color with exposure—a reminder to keep seals tight and avoid sunlight, wisdom passed down from our oldest plant operators.

    Usage: Bridging Lab Theory and Industrial Reality

    Ask around the shop floor and you’ll hear stories of 2-Quinolinol moving from academic labs to applied processes over the years. Its structure—hydroxyl at position 2 of the quinoline ring—gives it a unique set of reactivities. Some clients rely on it as an intermediate when building complex pharmaceuticals, using its lone electron pair to anchor metallic catalysts or to add selectivity in condensation reactions. Its moderate reactivity avoids unwanted side reactions, something no one wants when margins are thin or regulatory audits loom. Paint and pigment producers appreciate how the compound’s aromatic core anchors chromophores, building color depth that endures weather and light.

    We’ve supported researchers trialing 2-Quinolinol in sensor development, leveraging its fluorescence and affinity for certain ions. Their feedback shapes our batch control steps—quenching, filtering, and final mill. The compound’s versatility keeps demand steady, whether in standard organic labs, agrochemical synthesis, or custom API production. Researchers need freedom to push reactions in new directions, so we commit to a dependable, high-purity feedstock. Cutting corners here undermines every downstream step, so we stick to what works and keep records for traceability.

    Comparing 2-Quinolinol to Related Compounds: The Subtle Distinctions

    Industry veterans swap notes about differences between 2-Quinolinol and its siblings. Somewhere in most supply chains, 4-quinolinol or 8-hydroxyquinoline show up as alternatives. Inexperienced analysts might view them as interchangeable, but the exact substitution changes everything—reactivity, solubility, environmental profile. 2-Quinolinol sports a hydroxyl group at a location particularly useful for certain condensation reactions, an advantage for pharmacologists tailoring synthetic routes. Small shifts in substitution orient molecular interactions differently, leading to clear differences in solubility and spectral properties.

    Comparing with 8-hydroxyquinoline, for example, 2-Quinolinol brings more selectivity in chelation processes and lends itself to preparation of unique ligands for coordination chemistry. Pharmaceutical chemists often highlight that 2-Quinolinol’s aminating reactions allow more precise assembly of complex structures. Traditionally, we’ve fielded questions about why one works better than another—it comes down to where you want electron density, or which ring position tolerates modification in a given process. In our hands, reliable separation and purification prevents cross-contamination that would otherwise blur the lines between these compounds.

    Few distributors can trace a single kilogram back to its reactor, but as manufacturers, we can—every container labeled, every lot tracked, no guesswork involved. This control gives process engineers confidence when swapping between related compounds or scaling from pilot to full production. Environmental specialists request our 2-Quinolinol for its manageable storage and transport requirements, once the right seals and packaging are chosen. Bulk handlers report the absence of fine dust and static buildup, a point that rarely makes sales pitch decks but matters when workflow suffers from minor spills or product loss.

    Reliability Comes from Repetition, Not Marketing

    Most of our customers return each year because they need 2-Quinolinol that works the same way every batch. Their reactors depend on batch-to-batch consistency—no surprise phase separations, no unidentified impurities creeping up on chromatograms months later. We earn loyalty by keeping our process stable. Our managers recall how early, poorly controlled syntheses spoiled entire campaigns, setting back research and production. Lessons were learned, processes adjusted, and now schedules move through the plant with fewer delays.

    We don’t just hand over paperwork and certificates; our staff answers technical questions with experience, not generic script. Need documentation to support regulatory filings? We know which reports inspectors tend to ask for. Trouble with residue left after crystallization? Our chemists walk through the protocol step by step, swapping ideas drawn from similar challenges solved in-house. This day-to-day technical dialogue keeps our quality above cut-rate competitors, aligning expectations before product ever crosses your door.

    Why Purity and Traceability Drive Success

    Traceability runs through our factory culture—each shipment can be traced back to its exact synthesis batch, complete with analytical logs and personnel who handled it. Over the years, clients flagged issues caused by inconsistent sources elsewhere. Their syntheses ran into trouble when low-level impurities accumulated, causing yield drops or new, unexpected peaks on LC-MS spectra. As direct manufacturers, we spot these patterns upward through our records, enacting process changes when anything seems off. Spot purity checks, side-by-side NMR comparisons of new and archived lots, and stability studies under different storage conditions help us guard against surprises.

    Some customers focus on heavy metal limits, especially with pharmaceutical or electronic-grade applications. We adopt protocols to keep trace metal levels as low as possible—dedicated reactors, stringent wash routines, and batch chromatography where needed. This approach costs more up front, but slashes downtime for users caught off-guard by regulatory audits or failed analyses. Our traceability program gives our partners confidence to launch pilot projects, knowing no batch will introduce an unknown variable.

    Feedback-Driven Improvement, Not Shortcuts

    We recognize the only way to refine our product is through honest feedback. Instead of hiding behind a sales team, our technical staff takes calls to gather real-world data from R&D labs, production sites, and even industrial chemists troubleshooting a new downstream process. Many improvements to our 2-Quinolinol process came from these practical exchanges—micronized grades for those blending into powder coatings, custom packaging for long sea shipments, and batch test samples to validate in high-throughput screening.

    One example sticks in memory: a customer’s scale-up campaign ran into batch filtration slowdowns. Their team sent samples and notes, our chemists ran parallel bench trials, and together we identified a culprit in our drying curve—tiny process tweaks cut drying times and led to a finer, more pourable final product. Stories like these flow through our factory floor, driving continuous improvement. Fixing a single flaw ripples up the chain, saving real money and time for end-users.

    Environmental and Regulatory Assurance

    Thanks to strict internal protocols, we comply with environmental and regulatory expectations. Our manufacturing complies with REACH requirements, and every outgoing shipment carries current documentation. By adapting solvent recovery and waste treatment strategies over the years, we trimmed disposal volumes and improved air quality inside and around our plant. We fill feedback loops between our EHS team and floor operators—if something feels wrong, someone flags it long before it escalates.

    As standards change and customer needs evolve, we stay ahead by double-checking both the product’s fate in the environment and workplace safety. We set up air monitoring for volatile product traces, keep emergency stock of containment supplies, and run regular evacuation drills. These steps come from lived experience, not textbook guidelines or theoretical “best practices.”

    Long-Term Value: Serving Chemistry, Not Just Selling Chemicals

    Our perspective as a direct producer runs deep—reliability, not surface polish, keeps your process online. 2-Quinolinol remains a workhorse for many sectors, so we respect the hidden work that goes into every kilogram we produce. By keeping core synthesis steps close and control tight, we safeguard each batch’s utility. Collaborating with our users, listening to the demands of tough chemistries, and adjusting routines where needed—these are methods learned from repeated cycles of trial and error, not shortcuts or template plans.

    While technological developments bring change, dependability comes from getting the foundation right. Over the years, new applications for 2-Quinolinol have split off from traditional roles, whether in advanced catalysis, electronic materials research, or smart agriculture. As new regulations emerge and analytical requirements shift, we stand ready to adapt and improve, bringing the experience and insight gathered from long-term manufacturing, straight from the shop floor to your lab or plant.

    We welcome connections with fellow chemists, process engineers, and researchers looking to solve technical challenges—not as a faceless supplier, but as a partner who knows the trade inside out. Understanding and fulfilling the needs around 2-Quinolinol comes not from a distant office or abstract description, but from factory hands and years of shared problem-solving. That’s how we keep raising standards, one batch at a time.