Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
Follow us:

2-Pyridinethiol 1-Oxide

    • Product Name 2-Pyridinethiol 1-Oxide
    • Alias Pyrithione
    • Einecs 220-836-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    768149

    Chemicalname 2-Pyridinethiol 1-oxide
    Casnumber 1121-32-0
    Molecularformula C5H5NOS
    Molecularweight 127.17
    Appearance White to off-white crystalline powder
    Meltingpoint 62-65°C
    Boilingpoint 276.2°C at 760 mmHg
    Solubility Soluble in water and ethanol
    Density 1.32 g/cm3
    Pka 5.0
    Iupacname 1-oxidopyridin-2(1H)-thione
    Synonyms Pyrithione, Pyridinethione N-oxide

    As an accredited 2-Pyridinethiol 1-Oxide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle, tightly sealed with a screw cap, labeled "2-Pyridinethiol 1-Oxide, 25g", with hazard symbols and handling instructions.
    Shipping 2-Pyridinethiol 1-Oxide is shipped in tightly sealed containers to protect from moisture and contamination. It is typically packed according to chemical safety regulations, with hazard labeling. The package must be handled with care, stored at room temperature, and kept away from incompatible substances. Shipping is in compliance with international transport guidelines.
    Storage 2-Pyridinethiol 1-oxide should be stored in a tightly sealed container, away from moisture, heat, and direct sunlight. Keep it in a cool, dry, and well-ventilated area, separate from incompatible substances like strong oxidizers and acids. Proper labeling and secondary containment are recommended to prevent accidental release or contamination. Use appropriate personal protective equipment when handling the chemical.
    Application of 2-Pyridinethiol 1-Oxide

    Applications of 2-Pyridinethiol 1-Oxide in Industrial Manufacturing

    2-Pyridinethiol 1-oxide (PTO), recognized by its strong antimicrobial and chelating abilities, finds application across several specialized downstream markets. We manufacture high-purity grades of PTO, supporting sectors that demand precise formulation standards, process reliability, and regulatory compliance. Below we provide detailed insights into actual industrial applications with clear process, dosage, standards, and finished product references.

    1. Anti-dandruff Active in Personal Care Formulations

    Leading anti-dandruff shampoos rely on 2-pyridinethiol 1-oxide zinc salt as a primary active component, combating scalp fungi and ensuring long-lasting consumer safety. Formulators add PTO during the aqueous mixing stage, maintaining clear batch documentation to fulfill global cosmetic norms. Final formulation depends on region and targeted application, balancing antimicrobial claims with scalp tolerance and product aesthetics.

    Industry compliance standards

    • EU Regulation (EC) No 1223/2009 on Cosmetic Products
    • U.S. FDA Title 21 CFR § 358.710–740 for OTC skin protectant drug products
    • China National Standard GB/T 29665 for Shampoo
    • ASEAN Cosmetic Directive Annex VI (permitted preservatives)

    Typical usage ratio

    • 0.3–1.0% w/w, adjusted for regional restrictions and targeted antidandruff efficacy levels

    Downstream process integration

    • Added to the surfactant blend post-emulsification; controlled under cooling to preserve active integrity and prevent pre-mature precipitation

    Final product types

    • Anti-dandruff shampoos (mass-market and professional lines)
    • Medicated scalp lotions
    • Conditioner treatments targeting seborrheic dermatitis

    2. Industrial Water Treatment Biocide

    PTO functions as a non-oxidizing biocide in cooling towers, closed loop water systems, and industrial process water, selected for its broad performance against a spectrum of bacterial and algal contaminants. Water treatment companies monitor active levels on-site to comply with environmental and occupational standards, making batch-to-batch adjustments based on biological load and water chemistry.

    Industry compliance standards

    • U.S. EPA Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) registration requirements
    • EN 12671:2003 for Water Conditioning Agents – Part 2: Microbiocides
    • Chinese Standard GB 3096 for Industrial Circulating Cooling Water Biocides
    • REACH Registration, Evaluation, Authorization and Restriction of Chemicals (EU, if marketed as a biocidal active)

    Typical usage ratio

    • 5–50 ppm in recirculating water, optimized by microbial challenge tests and operational cycle time

    Downstream process integration

    • Dosed directly into circulating water reservoirs or pipelines using automated dosing pumps connected to biocide control systems

    Final product types

    • Chemically stabilized water treatment biocide concentrates
    • Ready-to-use cooling tower water additives
    • Industrial process water microbial control formulations

    3. Latex and Emulsion Polymer Preservation

    Manufacturers of synthetic latex for adhesives, paints, and coatings use PTO to inhibit microbial spoilage during emulsion polymerization and subsequent storage. Selection and dosing depend on specific end-use regulations regarding in-can preservatives, and documented risk assessments supporting product shelf-life claims are mandatory for market access in regulated geographies.

    Industry compliance standards

    • US EPA 40 CFR Part 180 (Preservatives in Adhesive/Coating Applications)
    • European Biocidal Products Regulation (BPR, Regulation (EU) No 528/2012)
    • China GB/T 9756 for Synthetic Emulsion Paints
    • ISO 9001:2015 Quality Management in Manufacturing

    Typical usage ratio

    • 0.05–0.2% based on monomer solids, referenced to microbial stability testing and compliance with allowed preservative thresholds

    Downstream process integration

    • Added to the water phase before polymerization; additional booster dosing as post-additive during drum/tank filling as validated by shelf-life studies

    Final product types

    • Vinyl acetate-based adhesives with enhanced storage stability
    • Acrylic emulsion paints and coatings
    • Styrene-butadiene latex dispersions

    4. Metalworking Fluid Preservation

    PTO is incorporated as a preservative in water-dilutable metalworking fluids to prevent microbial contamination which otherwise leads to fluid putrefaction, hazardous biofilm, and operational downtime. Downstream metalworking fluid compounds depend on harmonized standards for biocide efficacy and operator safety, with processing conditions driven by end-user requirements in automotive, aerospace, and heavy industry production lines.

    Industry compliance standards

    • ASTM E686 (Standard Test for Bacterial Resistance of Metalworking Fluids)
    • U.S. OSHA 29 CFR 1910.1200 Hazard Communication for Workplace Chemicals
    • EU CLP Regulation (EC) No 1272/2008 for classification, labelling and packaging of substances.
    • Deutsche Verband Unabhängiger Schmierstoffhändler (VSI) Quality Standards for Metalworking Fluids (Germany)

    Typical usage ratio

    • 200–1000 ppm, determined by fluid tank volume, water hardness, and routine microbial load monitoring

    Downstream process integration

    • Dosed into concentrate at blending phase or post-dilution in central fluid reservoirs; mixing enhanced using low-shear mechanical agitation

    Final product types

    • Water-miscible metalworking concentrates
    • Ready-to-use semi-synthetic and fully synthetic metalworking fluids
    • In-plant system cleaning additives

    5. Papermaking Process Slimicide

    Papermills use PTO as an anti-slime agent to protect process water loops and machine surfaces from microbial-induced fouling. Strict regulatory controls enforce trace limits in paper, with mill chemists integrating PTO based on periodic bioburden assays, operational flow volume, and final product standards, especially in food-contact and specialty paper segments.

    Industry compliance standards

    • FDA 21 CFR 176.300 (Slimicides for Paper and Paperboard in Contact with Aqueous and Fatty Foods)
    • EN 648 (European Methods for Determining Migration from Paper to Food)
    • SCAQMD Rule 1171 for emission controls in paper processing (California, US)
    • China GB 4806.8-2016 for Food Contact Paper and Board

    Typical usage ratio

    • 5–50 ppm in process water, adjusted to pulp throughput, seasonal bioburden, and final paper destination

    Downstream process integration

    • Dosed into high-consistency pulp stream or directly to white water systems; monitored through in-line microbial count sensors

    Final product types

    • Food-contact packaging paper
    • Hygiene tissue papers
    • Specialty printing boards
    Free Quote

    Competitive 2-Pyridinethiol 1-Oxide prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    2-Pyridinethiol 1-Oxide: Our Mature Specialty Offering

    From Our Lab to Your Process: A Trusted Choice

    Over the years, our team has invested expertise and practical know-how in developing the reliable production of 2-pyridinethiol 1-oxide. We manufacture this material by employing a direct synthesis method that tightly controls each step, letting us strike a balance between productivity and purity. Our unique production-line monitoring brings us batch-to-batch consistency, so users do not contend with performance gaps or unexpected results. Across the globe, formulators, chemists, and process engineers know this compound as a mainstay in research labs, pilot projects, or full-scale industrial systems.

    Physical Form, Handling, and Packaging: Built Around Real-World Needs

    Years refining batch handling and storage have shown how important clear, accurate labeling and stable packaging really are. Our material generally appears as a pale yellow to off-white crystalline powder, with a mild but characteristic odor. Particle size, bulk density, and moisture levels have proven to be decisive for different applications, so we maintain tight controls to ensure these parameters meet users’ process constraints. For those aiming for rapid dissolution, our typical sieve distribution centers material in the optimum particle size, supporting efficient blending or slurry preparation. Stability in ambient warehouse conditions helps personnel ship, store, and dispense this compound with confidence – minimizing risk for caking, agglomeration, or loss of performance during delivery and storage.

    Specifications and Quality Control

    On every batch release, our internal lab runs characterization for purity, active content, and residual solvents. Typically, our purity level exceeds 98.5% by HPLC, with total volatiles and heavy metals monitored to single-digit ppm levels. Most partners in high-value formulations, such as those in pharmaceutical intermediates or specialty polymer additives, demand this assurance. Years serving these stringent segments has led us to invest in automated sampling, high-resolution chromatography, and in-house reference standards. Products that fail our critical impurity profiles do not leave our doors, shielding customers from process drift or unexpected reactivity.

    Why 2-Pyridinethiol 1-Oxide Stands Out

    Some applications need more than ordinary additives or basic intermediates. 2-pyridinethiol 1-oxide has a proven track record when it comes to situations where reactivity and chelation both matter. For example, in water treatment and personal care preservation, end-users rely on its ability to inhibit microbiological activity at low dosage rates. Its sulfur-nitrogen structure binds tightly to transition metals. That unique binding power lets it play a double role in some formulations: disrupting microbial metabolism and at the same time, sequestering trace metal ions that catalyze oxidation or discoloration. In our experience, this dual-function marks a real difference compared to one-function preservatives or chelators.

    Many customers bring us difficult questions about process optimization. Batch users in emulsion polymerization often try alternatives, such as benzisothiazolinones or standard thiol-based stabilizers. We see those fade in performance when pH swings or heavy-metal contamination come into play. 2-pyridinethiol 1-oxide displays strong resistance to hydrolysis at neutral and mildly basic pH, and it maintains efficacy even with elevated iron or copper content. This chemical resilience means less troubleshooting at the plant and fewer recalls in product quality audits.

    Applications: Real Feedback, Not Just Brochure Claims

    Personal care formulators come to us after running extensive challenge tests on their own production lines. They tell us about the real-world pressure to pass preservative efficacy tests while avoiding controversial halogenated ingredients. In the shampoo and conditioner space, 2-pyridinethiol 1-oxide has emerged as a strong choice when sulfate-based surfactants are present, since it resists degradation and preserves shelf-life even in warm, humid supply chains.

    Engineers at water treatment facilities have reported that this product keeps microbial fouling in cooling towers in check, despite fluctuating water hardness or trace contaminants. Traditional biocides can lose punch when organic loads change, but the chelating part of our compound gives it a distinct edge: it disables metal-ion catalyzed breakdown of the active molecule, extending service life where process water recirculates for weeks.

    Paint and coatings producers often struggle with in-can preservation, especially in zero-VOC or waterborne technologies. 2-pyridinethiol 1-oxide performs well at low inclusion rates and does not impart unwanted color shifts, making it easier for laboratories to hit batch stability targets while staying below allergen or irritant thresholds. We listen to customer feedback on pigment compatibility and film integrity, using those insights to narrow our specification window, so each drum arriving at their plant supports consistent, reproducible blends.

    Over the last decade, we have worked directly with specialty plasticizers and lubricant additive manufacturers. Many complain about unwanted sulfurous odors or yellowing brought on by conventional thio-based antioxidants. Our version of 2-pyridinethiol 1-oxide offers a low-odor alternative, with formulation flexibility for those pursuing OEM or regulatory compliance. Its oxidative stability, even in high-temperature systems, opens up uses in cable insulations, greases, and polymer finishes where shelf-life and resistance to discoloration matter.

    Comparisons: Why We Focused on 2-Pyridinethiol 1-Oxide Over Alternatives

    In the chemical product world, even subtle functional differences matter. We see it in side-by-side comparisons with sodium pyrithione, benzisothiazolone, isothiazolinones, and classic disulfide inhibitors. Sodium pyrithione has value in some antimicrobial settings, but our clients find that its higher solubility also brings leaching and instability in polymer matrices exposed to humidity. Isothiazolinones often run into skin sensitization issues, and regulatory compliance has gotten stricter each year. Our product’s molecular composition carries both the chelating pyridine ring and the reactivity of a thione sulfur, without the volatility or allergenic profile found in some competitors.

    Many competitors’ products carry higher levels of inorganic or organic contaminants, either by design or by process by-products. Our direct synthetic route, refined through customer feedback, delivers a low-residue product with a neutral odor and fewer co-extractives. If batch consistency and ease of downstream analytical monitoring mean fewer process headaches for your technical or QC team, our product makes a practical case for itself versus less controlled alternatives.

    Meeting Regulatory and Environmental Demands

    Global compliance expectations keep rising. Our approach builds compliance into production from the beginning, rather than bolting it on at the end. Each lot is made and tested to meet the major requirements for heavy metals, active content, and microbiological purity needed in high-standard markets. We do not use banned preservatives or hazardous processing aids, so there is one less headache during third-party audits.

    In dialogue with partners in the EU, North America, and key Asian economies, we keep ahead of new developments in chemical registrations and safety paperwork. Many application markets now require full life-cycle knowledge—not just a certificate that a product passed a test once. We provide ongoing updates if any change in our input supply chain or process could affect downstream compliance or risk management.

    Sustainability and Continuous Improvement

    Each season brings new challenges as environmental and occupational safety expectations change. We revisit our solvent systems, waste recycling, and emissions capturing for each key product, aiming to shrink our environmental impact. Where possible, we recover heat and solvent streams, investing profits from our mature product lines like 2-pyridinethiol 1-oxide to drive upgrades in our reactors and purification trains.

    Our sourcing team has built real partnerships with upstream suppliers, often working on contract terms that reward quality and transparency instead of short-term price drops. This kind of relationship means we avoid involuntary contamination from upstream mismanagement. We engage our customers in open discussions on greener alternatives, and this collaboration has let us pilot test lower-impact waste treatments for wash liquors and process mother liquors. Over the past five years, steps like these have cut our reference batch fossil fuel usage by double digits while keeping consistent quality.

    Technical Hurdles We Have Faced and How We Solved Them

    Scalable drying and grinding are not simple steps. Some earlier attempts at drying led to local overheating, forming crusted or oxidized residues that limited solubility and discolored finished products. More precise temperature zoning and modularized dryer control, combined with a revised granulation protocol, prevented hotspots and kept oxygen ingress under control. Each operator on our line gets hands-on training, so that lessons from past mistakes translate into fewer rejections and less waste.

    Achieving reliable stacking and pallet stability in shipping used to challenge us. Several trials with thicker bags, moisture-barrier liners, and even reformulation of antistatic coatings led to a robust packaging system that prevents compaction during long shipments. These improvements did not come from consultants or academic studies, but from our shippers, plant operators, and logistics team sharing practical field failures and solutions until we locked in a system that worked.

    Research Support and Custom Solutions

    We understand that most users need contextual support, not just a COA and an invoice. Our applications specialists support trials at partner labs, helping adapt dosage, dispersion techniques, or batch order-of-addition based on upstream and downstream chemistry. Early adopters in the coatings sector showed that dispersing agents or neutralizers needed tweaking to unleash the full antimicrobial potential. Rather than hand over a standard protocol, we partner through on-site visits, technical briefings, or conference calls, narrowing down variables until your team nails the process.

    Customers developing new products often require assistance in qualifying our 2-pyridinethiol 1-oxide with their existing regulatory dossiers or risk assessments. Our R&D team shares full impurity profiles and detailed process flow information under NDA, giving assurance for risk managers and regulatory officers tasked with reviewing new vendors. For specialty application seekers, we have supported requests for ultra-fine powder grades, technical blends with stabilizers, and custom packaging to suit pilot-scale development through to commercial roll-out.

    Why Our Experience Matters to You

    Years spent producing, packaging, and shipping 2-pyridinethiol 1-oxide have taught us many lessons. Reputable manufacturers do not just synthesize a molecule and move it down the road. Customers expect predictability, technical dialogue, transparent safety data, and honest answers about what this product can and cannot do. Hundreds of batches, thousands of tons shipped, and feedback from application chemists to industrial engineers reinforce our approach: reliability, safety, and partnership matter every bit as much as cost-per-kilo.

    Serving a range of application markets has driven us to keep refining our processes. Where one sector needs maximum microbiological purity, another values batch-to-batch physical stability, and a third scrutinizes packaging integrity for export supply chains. We improve not because standards force us, but because our own direct feedback loops—customer claims, internal reject analyses, and root-cause investigations—push us toward higher reliability.

    Direct Support: Fewer Middlemen, Better Outcomes

    We stand behind every drum and every kilogram that leaves our gates. If a formulation does not perform, if a shipment gets held up, or if downstream auditing turns up questions about trace metals or cross-contaminants, our technical and commercial teams respond directly. You talk to the people who know the process—not a call center. This approach has built trust with clients who depend on predictable, quick answers, whether qualifying new lots or troubleshooting in real time.

    Looking Forward

    As a manufacturer with a long track record, we see where the next decade is heading. New regulations emerging in antimicrobial usage and hazardous substances across Europe and North America demand ever-cleaner products with transparent origins. Our continued investment in plant and people keeps us ahead of the curve, letting us deliver a seasoned, trustworthy specialty ingredient that performs reliably. 2-pyridinethiol 1-oxide today holds an established position in challenging fields—not because of corporate brochures or catchy marketing, but through years of practical, real-world performance supported by open, honest engagement between process chemists and users.