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2-Propylaniline

    • Product Name 2-Propylaniline
    • Alias 2-Propylphenylamine
    • Einecs 202-721-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    429360

    Cas Number 643-28-7
    Molecular Formula C9H13N
    Molar Mass 135.21 g/mol
    Iupac Name 2-Propylaniline
    Appearance Colorless to pale yellow liquid
    Boiling Point 225-227 °C
    Melting Point -15 °C
    Density 0.948 g/cm³
    Refractive Index 1.553
    Solubility In Water Slightly soluble
    Flash Point 94 °C
    Pubchem Cid 21725

    As an accredited 2-Propylaniline factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle labeled “2-Propylaniline, 100 mL”; features hazard symbols, chemical formula, batch number, and tightly sealed cap.
    Shipping 2-Propylaniline is shipped in tightly sealed containers, protected from light, moisture, and incompatible substances. It must be handled following all safety procedures, including proper labeling and documentation. Transportation complies with local, national, and international regulations for hazardous chemicals to prevent leaks, spills, and exposure during transit.
    Storage 2-Propylaniline should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from sources of ignition, heat, and incompatible materials such as oxidizing agents, acids, and bases. Protect from light and moisture. Proper chemical labeling and secondary containment are recommended to prevent leaks and ensure safe handling. Always follow relevant safety guidelines.
    Application of 2-Propylaniline

    Applications of 2-Propylaniline in Industrial Manufacturing

    As a specialist manufacturer of 2-Propylaniline, we ensure dedicated compliance, quality control, and technical service for industrial customers. Below, we provide an in-depth overview of practical applications across key downstream industries, focusing on real-world compliance criteria, proportioning guidelines, integration points within the manufacturing chain, and the final product classes produced by our customers.

    1. Synthesis of Agrochemical Intermediates

    2-Propylaniline acts as a core building block in manufacturing selective herbicide and fungicide intermediates, where its alkylated aniline structure enables targeted modifications on aromatic rings under catalytic amination or acylation conditions. Agrochemical formulators incorporate it for chain extension or amide linkage, tuning the biological profile of actives while controlling by-product formation. Engineers must balance its addition with yield and selectivity requirements, and continually adapt to evolving pesticide regulations in export markets.

    Industry compliance standards

    • EPA 40 CFR Part 180 (Tolerance regulations for pesticide residues)
    • REACH (EC) No 1907/2006 (Chemical safety requirements for intermediates)
    • ISO 9001:2015 (Quality management in chemical synthesis)
    • China National Safety Production Code for Hazardous Chemicals (GB 30000 series)

    Typical usage ratio

    • Typically 8-15% w/w of total reactant mass, adjusted based on molar ratios needed for intermediate yield. Excess usage minimized to prevent side-product contamination.

    Downstream process integration

    • Charged to batch or continuous stirred tank reactors during aromatic ring modification; added post-nitration for coupling or amidation steps; reaction temperatures and times tuned according to target intermediate specification.

    Final product types

    • Herbicide intermediates (e.g., propionic acid derivatives, amide-linked pre-cursors)
    • Fungicide synthesis blocks
    • Final pesticide formulations (after further downstream processing)

    2. Dye and Pigment Manufacturing

    Dye formulators employ 2-Propylaniline as a key amine source in diazo coupling, granting specialized shades and fastness properties to direct and disperse dye classes. Its propyl substituent moderates oxidative stability and dyes' solubility profile, impacting textile, paper, and plastics applications by driving reproducible color yields and batch consistency. QC managers continually monitor residual amine levels amid regulatory updates on aromatic amine safety.

    Industry compliance standards

    • OEKO-TEX® Standard 100 (Textile safety, aromatic amine restrictions)
    • EN 71-3 (Safety of toys – migration of certain elements, for pigment use)
    • REACH Annex XVII (Restrictions on azo dyes releasing certain amines)
    • ISO 105-C06 (Colorfastness standards for textiles)

    Typical usage ratio

    • Ranges from 2-7% of total dye or pigment mass, set by target color shade and molecular structure. Fine adjustment by spectrophotometric analysis during lab scale-up.

    Downstream process integration

    • Introduced to azo coupling reactors after diazotization of aromatic amines; dosed in multi-step syntheses for complex colorants; strict timing and temperature control to prevent over-coupling and off-shade formation.

    Final product types

    • Direct and disperse dyes for textiles
    • Printing inks for industrial marking
    • Polymer-compatible color pigments
    • Specialty automotive coatings

    3. Pharmaceutical Active Pharmaceutical Ingredient (API) Synthesis

    Within pharmaceutical fine chemical synthesis, 2-Propylaniline serves as an intermediate for constructing certain non-steroidal anti-inflammatory drugs (NSAIDs) and API molecules that require specific alkylated aniline scaffolds. Its precise reactivity profile enables amide and urea linkage formation under GMP-compliant conditions, with process engineers tightly regulating input ratios to ensure API batch traceability, impurity control, and global pharmacopoeia alignment.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice for Active Pharmaceutical Ingredients)
    • USP <795>, <797> (United States Pharmacopeia standards for compounding, APIs)
    • EDQM CEP (Certification of Suitability to the Monographs of the European Pharmacopoeia)
    • WHO TRS 986 Annex 2 (Good manufacturing practices)

    Typical usage ratio

    • Varies from 0.5-3 molar equivalents relative to other building blocks, adjusted per route efficiency and waste minimization; validated in pilot runs with QC screening during scale transfer.

    Downstream process integration

    • Added post-halogenation to coupling or condensation reactors; purification stages isolate reaction intermediates for final API assembly; integration with in-line analytics to monitor process quality.

    Final product types

    • Certain NSAIDs with propyl-amide motifs
    • Specialized pharmaceutical intermediates
    • Research chemicals for medicinal chemistry programs

    4. Rubber Antioxidant Additive Production

    Manufacturers of synthetic rubber compounds incorporate 2-Propylaniline as a precursor in the synthesis of antioxidant additives, where its alkyl substituent supports stabilization of polymer chains during high-temperature vulcanization and storage. Compounders optimize its dosing to extend product shelf life while maintaining stringent batch uniformity, with formulation reporting dictated by regulatory frameworks in rubber processing.

    Industry compliance standards

    • ISO 9001:2015 (General quality management for rubber chemicals)
    • ASTM D4676 (Rubber compounding materials—classification and analytical methods)
    • EU Regulation (EC) No 1223/2009 (Restriction of hazardous substances in consumer products for rubber goods)
    • UNE-EN 1420 (Rubber and plastics hoses and tubing)

    Typical usage ratio

    • Typically dosed at 0.3–1.2 phr (parts per hundred rubber), with adjustments based on antioxidant efficiency testing under accelerated aging protocols.

    Downstream process integration

    • Reacted with other rubber chemicals in pre-mixing stages; incorporated in compounding lines prior to final blending and curing; monitored via in-process QC for dispersion and additive uniformity.

    Final product types

    • Rubber antioxidant additive concentrates
    • Conveyor belt and tire rubber compounds
    • Industrial elastomer seals and gaskets

    5. Specialty Chemical Synthesis for Corrosion Inhibitors

    Engineers in the oilfield and water treatment sectors apply 2-Propylaniline during the preparation of amine-based corrosion inhibitors. Its structural features provide enhanced film-forming properties when formulated with phosphate or sulfonate synergists, allowing protection of pipelines and industrial vessels. Strict adherence to environmental and safety frameworks governs its use, requiring process optimization to balance protective efficiency and residual toxicity.

    Industry compliance standards

    • API RP 932-B (Corrosion inhibitor standards in refinery units)
    • OECD Guidelines for Testing of Chemicals (Environmental safety, biodegradability)
    • REACH (Annex XIII—PBT and vPvB assessment)
    • ASTM G170 (Evaluation of corrosion inhibitors)

    Typical usage ratio

    • Generally incorporated at 1.5–4% of the total formulation by weight, optimized according to field trial feedback and in-lab corrosion performance testing.

    Downstream process integration

    • Added to blending vessels during final stage of inhibitor concentrate production; mixed with solvent and surfactant packages before packaging; performance benchmarked in simulated or real operational systems.

    Final product types

    • Oilfield and refinery corrosion inhibitor liquids
    • Industrial circulating water treatment chemicals
    • Pipeline preservation fluids
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    Certification & Compliance
    More Introduction

    Meet 2-Propylaniline: Firsthand Insights from a Chemical Production Floor

    What Differentiates 2-Propylaniline from Other Anilines?

    Everyday work in the chemical plant teaches us more about the unique behavior of specialized aromatic amines. 2-Propylaniline, known in the lab as o-Propylaniline, stands out because of its distinct structure: a propyl group sits on the ortho position of the benzene ring next to the amino group. Even this simple shift away from the parent aniline imparts us with different reactivity, boiling points, and handling considerations out in the field.

    We see practical differences right from the start—during synthesis, purification, and packaging. 2-Propylaniline offers attributes that other aniline derivatives, like the para or meta isomers, simply can’t match. The ortho substitution not only influences the way it handles under different reaction conditions but also determines how well it integrates into downstream chemistries. Mixing it with other raw materials or feeding it into a reactor, we can predict with greater certainty how the molecule responds, which becomes crucial for fine chemical manufacturing or producing intermediates for dyes and agrochemicals.

    Working with 2-Propylaniline: Specifications and Standards

    We manufacture 2-Propylaniline to strict standards, guided by decades of bench-scale experiments and practical plant engineering. From the batch reactors to the packing line, every step receives monitoring for impurities, trace moisture, and color. Consistent color is not simply a point of pride; it signals control over degradation and byproducts, influencing performance downstream. Regular GC and HPLC checks back up our findings and let us promise a reliably pure product.

    With a boiling point much higher than aniline but lower than bulkier derivatives, we accommodate its needs by adapting condenser systems, distillation columns, and storage tanks. It’s not enough to hit the right assay targets. The integrity of each shipment reflects filtration, stabilization, and handling techniques built from real-world trial and error—not just numbers on a certificate. Over the years, the residue tests, trace amine screening, and stabilization tricks have become second nature.

    Practical Uses: Seeing Demand Grow Across Sectors

    It’s easy to talk about fine chemical manufacturing, but seeing the diversity of end users pulling 2-Propylaniline from inventory shows its versatility. In our experience, this molecule has gained traction with several segments. Crop protection chemistries regularly employ it as a starting material for selective herbicides due to how its ring placement alters activity. In pharmaceutical synthesis, the ortho-propyl moiety introduces steric hindrance, creating the right environment for making certain APIs, particularly those relying on regioselective substitutions.

    One major paint producer once confronted us with a technical challenge involving pigment intermediates. 2-Propylaniline allowed them to enhance chromatic properties that conventional mono-alkyl anilines couldn’t reach. Their feedstock performance noticeably improved upon shifting to our material, reducing side reactions and allowing greater dye purity without overhauling their existing set-up.

    Cosmetic additive suppliers press us for consistent quality, particularly low levels of meta- and para- isomers, which can alter fragrance or color outcomes. Electronics and specialty materials researchers look at our 2-Propylaniline for specialty polymerization reactions, where the ortho-propyl plays a key role in achieving desired film-forming properties. All of these fields place strong value in our commitment to batch-to-batch reproducibility, which traces all the way back to sourcing of primary benzene and process solvents.

    Trusted Handling: Safety and Production Challenges Learned Over Time

    Prolonged work with aromatic amines shows that chemistry doesn’t follow textbooks precisely. 2-Propylaniline, though more manageable than some counterparts, supplies unique handling stories from the plant. Early on, operators found that ordinary seals on pumping systems didn’t handle its tendency to soften gaskets as well as we thought. We re-engineered fittings with upgraded elastomers, reducing downtime and eliminating leaks.

    Temperature swings during purification meant periodic instability and loss by evaporation, especially during the summer. It took practical changes to chiller settings and tank insulation protocols to tame the volatility. As small impurities build up unnoticed during multistep syntheses, we adjusted internal quality standards. Beyond regulatory compliance, our in-house goal is now two to three times tighter on impurity thresholds than what’s strictly required, based on downstream feedback—not because a spreadsheet says so, but because failed reactions at clients’ plants hurt both their yield and our credibility.

    Odor management stands as a real, ongoing concern. Aniline derivatives carry a distinct scent profile, and ortho-propyl imparts a slightly less aggressive aroma compared to methylated variants. Still, our teams wear full respirator protection and have invested heavily in local ventilation upgrades in packing areas. Neighbors have commented on the improvement in air quality around the plant in recent years. These aren’t faceless upgrades—they come from real conversations, midnight maintenance callouts, and the lessons we’ve picked up from living alongside our equipment.

    Sustainability Practices Developed for Modern Plants

    Many of the big production shifts in the last few years relate to sustainability. Instead of simply designing for process efficiency, we look at solvent recovery, waste minimization, and closed-loop systems as everyday facts of factory life. For 2-Propylaniline, the solvent selection process moves beyond reaction efficiency; the downstream recoverability of solvent becomes just as important. The earlier practice of dumping spent streams now feels dated. Today’s plant operators balance raw material efficiency with environmental responsibility, aided by real-time monitoring systems and a culture that encourages speaking up about risks or oversights.

    We switched to using in-line analyzers that flag out-of-spec material as close to real time as possible, which reduces waste by keeping bad batches from building up unnoticed. Residue collection methods improved after a sharp-eyed technician discovered subtle changes in color during tank cleaning, which reflected polymeric buildup that would have quietly cut into product purity. Weekly reviews of waste flows and solvent losses aren’t bureaucratic—they become sources of pride when teams point out reductions they’ve achieved compared to last season.

    Some of our continuous improvement projects target water consumption, as aromatic amine production can easily require dozens of wash cycles for even small product lines. Process engineers found success switching to counter-current washes and implementing re-use streams for non-critical cleaning. These changes let us shrink our water bill, but more importantly they lessen our overall environmental impact—a topic that everyone from staff to visitors asks about. It’s a process that grows, not a single event.

    Used drums and containers once cluttered our yard; now, return and recycling programs with partners ensure that packaging waste leaves the factory with a new purpose. That attention to logistics stands as much a part of our business as the reactions inside the plant.

    Customer Relations and Feedback Shaping Our Practice

    Every batch of 2-Propylaniline we send feels like more than a transaction; each shipment begins a dialogue with customers. Large-scale buyers with their own quality control programs regularly share analytical results and application data, sometimes revealing performance trends that only appear after field use. Our technical support teams use this information to tweak feedstock grades or modify drying and filtration steps. This ongoing feedback loop forms the backbone of product improvement.

    For smaller customers, open channels let us adapt packaging—moving from bulk tankers to drums or IBCs as needed—and offer storage guidance suited to their local climates. Many clients work in regions with high humidity, spurring us to rethink desiccant usage and develop tailored drying procedures for certain lots. These recommendations grow from noticing how moisture shifts impact final-use results—a far cry from broad, impersonal advice.

    Occasionally, delivery routes revealed subtle issues with product stability in hotter regions. Years ago, shipments arrived with faint color changes from extended terminal storage under the sun. In response, we brought in UV-resistant drum coatings and adopted climate-controlled warehousing at major transit points. These fixes came directly from the lived experiences of users and our drivers, turning potential problems into strengths.

    On more than one occasion, direct involvement with downstream process engineers led to breakthrough joint development projects, using 2-Propylaniline as a scaffold for exploring new catalyst systems or testing innovative dye molecules. Such projects go beyond expectation and routinely lead to finer control or unexpected business opportunities.

    Regulatory and Compliance Realities

    Navigating regulatory frameworks takes more than memorizing guidelines. Long work with 2-Propylaniline means limited tolerance for shortcuts. Each shipment undergoes checklists built from years of compliance work: from labeling with accurate hazard statements to supplying complete certificates that reflect real batch data, nothing gets rubber-stamped. Audits from industry and government partners often focus on amine production due to historical safety incidents elsewhere in the sector.

    Over time, we’ve learned to see regulatory inspections as opportunities rather than hurdles. Upgrades driven by evolving safety codes—enhanced containment around reactor systems, improved eyewash and emergency shower access, more robust record-keeping protocols—stem from both demand and our own lessons learned. Operators know that failing to meet chemical safety standards doesn’t just draw a fine; it threatens both our license to operate and our relationship with the people whose products depend on our material. Transparent documentation, strict adherence to protocols, and a willingness to invite even tougher internal audits keep us ahead of basic compliance.

    Why 2-Propylaniline Remains Central in Changing Markets

    With each new regulation and wave of technical innovation, product portfolios shift. Unlike generic commodity chemicals where margins push toward the lowest cost, 2-Propylaniline’s appeal ties directly to its molecular quirks—a balance of reactivity, solubility, and steric effects that cannot be matched by simpler or more substituted analogs. For established and emerging applications alike, its specific ring structure keeps it relevant: whether creating new pigment intermediates, specialty polymer additives, or pharmaceutical scaffolds, the demand holds firm.

    Researchers in newer application fields, including materials science and specialty surfactants, reach out frequently for insights on how the reactivity profile of 2-Propylaniline helps them push the boundaries of their own work. Our teams supply not only the product but the practical knowledge that accumulates after years in the plant—what contaminants to watch for, reaction parameters that lessen unwanted byproducts, or storage tips if their lab setups haven’t yet scaled to true industrial volumes. This hands-on experience, more than any spec sheet, fosters trust and long-term collaboration.

    Lessons Learned on Product Diversity and Customization

    No manufacturing run follows a perfect script. Customer expectations and application needs continue to expand, often requiring new grades or forms of 2-Propylaniline. Some request lower moisture or specific color limits for sensitive syntheses, while others look for custom packaging or stabilization protocols for longer journeys. We respond by customizing filtration and drying processes and by adjusting transport conditions. Each of these innovations emerges from direct customer dialogue, plant-floor troubleshooting, and an evolving sense of what our customers genuinely need—rather than what marketing trends say.

    Batch traceability and analytical reporting now go far deeper than they once did. Conversations with users revealed that detection of tiny levels of side products could spell the difference between a pass and an expensive rejection. In response, we invested in advanced chromatographic methods and implemented batch-specific certificates, detailing all critical analytical results. This detailed documentation builds confidence beyond generic compliance, supporting product launches and enabling users to pass their own regulatory hurdles more smoothly.

    Future Outlook

    Ongoing research and industry trends suggest that 2-Propylaniline’s place in specialty chemical industries will strengthen. Producers and formulators appreciate its balance of activity and processability. As demand shifts toward more sustainable and traceable supply chains, our focus on continuous improvement and close feedback with end users puts us in a solid position. Our history of technical fixes, process adaptability, and practical customer guidance demonstrates why the product remains more than just a molecule—it reflects years of accumulated manufacturing wisdom, safety choices, and genuine respect for the users and communities that depend on us.

    Every drum of 2-Propylaniline leaving our plant encapsulates hundreds of small, sometimes invisible improvements—some born out of necessity, others spurred by a customer’s question, all rooted in a tradition of thoughtful, hands-on manufacturing. That spirit shapes our future as much as any emerging technology or regulatory change ever will.