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2-Nitroimidazole

    • Product Name 2-Nitroimidazole
    • Alias Ethomicide
    • Einecs 211-235-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    779530

    Cas Number 527-73-1
    Molecular Formula C3H3N3O2
    Molecular Weight 113.08 g/mol
    Iupac Name 2-nitro-1H-imidazole
    Appearance Yellow to orange crystalline powder
    Melting Point 338 °C (decomposes)
    Solubility In Water Slightly soluble
    Synonyms 1H-Imidazole, 2-nitro-
    Density 1.54 g/cm³
    Pubchem Cid 9996
    Smiles C1=NC=NC1[N+](=O)[O-]

    As an accredited 2-Nitroimidazole factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 2-Nitroimidazole is supplied in a sealed amber glass bottle, labeled clearly, containing 25 grams of pale yellow crystalline powder.
    Shipping 2-Nitroimidazole is shipped in tightly sealed, chemical-resistant containers to prevent moisture absorption and contamination. It is handled according to hazardous material regulations, with clear labeling and proper documentation. The packaging ensures protection from light and physical damage during transit. Shipping must comply with local and international chemical safety guidelines.
    Storage 2-Nitroimidazole should be stored in a tightly sealed container in a cool, dry, and well-ventilated area, away from sources of heat, sparks, and open flames. It should be protected from moisture and direct sunlight. Store separately from incompatible substances such as strong oxidizers or reducing agents. Proper labeling and adherence to relevant chemical storage regulations are essential.
    Application of 2-Nitroimidazole

    Applications of 2-Nitroimidazole in Industrial Manufacturing

    2-Nitroimidazole serves as a pivotal intermediate in several highly regulated downstream sectors, supporting technologically advanced production lines around the world. As the original manufacturer, we precisely control each production batch to the specification needs of chemical and pharmaceutical customers. Below, we outline the primary industrial applications, compliance considerations, dosage practices, integration points, and final product types relevant to our customers’ industries.

    1. Active Pharmaceutical Ingredient (API) Synthesis for Antiprotozoal Agents

    Pharmaceutical manufacturers incorporate 2-Nitroimidazole in API synthesis for nitroimidazole-based antiprotozoal drugs, following strict regulatory protocols. Formulators rely on its predictable reactivity to construct core drug intermediates, particularly for the treatment of anaerobic infections and protozoal diseases. Each campaign must document traceability back to GMP-compliant material registers, and analytical results must meet pharmacopeia purity profiles prior to further downstream transformations such as hydrogenation or alkylation.

    Industry compliance standards

    • Current Good Manufacturing Practice (cGMP, 21 CFR Part 210/211, FDA USA)
    • ICH Q7: Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • European Pharmacopoeia (Ph. Eur.) quality monograph for intermediates
    • WHO Prequalification for finished pharmaceutical products

    Typical usage ratio

    • 0.95 – 1.10 molar equivalents relative to downstream imidazole intermediates, dose adjusted for target yield and impurity profile control

    Downstream process integration

    • Reaction input during condensation with aliphatic or aromatic aldehydes in batch reactors; often followed by in situ reduction or heterocyclic ring modification

    Final product types

    • API for metronidazole
    • API for tinidazole
    • API for ornidazole
    • API for ronidazole

    2. Radiosensitizer Building Block in Radiotherapy Adjuncts

    Manufacturers in the radiopharmaceutical and medical device industry utilize 2-Nitroimidazole as a precursor for radiosensitizing agents. Accurate process controls ensure low impurity backgrounds, critical for subsequent transformation into injectable preparations or diagnostic enhancers. Consistent particle size and moisture profile optimize conversion in downstream functionalization, supporting patient safety in clinical oncology.

    Industry compliance standards

    • ISO 13485: Medical devices – Quality management systems
    • United States Pharmacopeia (USP) monographs for injected contrast materials and research chemicals
    • FDA Drug Master File (DMF) Type II submission/tracking
    • European Medicines Agency (EMA) guidelines for radiopharmaceutical precursors

    Typical usage ratio

    • 5% – 15% by weight in chemical conversion steps depending on the radiosensitizer target molecule, adjusted during alkyl substitution or hydroxyalkylation

    Downstream process integration

    • Addition to functional group introduction reactors for production of nitroimidazole-labeled compounds; typically follows initial substrate activation

    Final product types

    • Precursor for misonidazole injectable solutions
    • Radiosensitizer adjuvant active ingredients
    • Experimental imaging contrast agents for tumor hypoxia detection
    • Custom reference standards for clinical research

    3. Intermediate in Veterinary Pharmaceutical Synthesis

    Veterinary medicine producers incorporate this raw material to synthesize nitroimidazole derivatives for animal health products. Process engineers must calibrate reaction parameters according to specific impurity and residual solvent limits set by national agencies, particularly for food-producing animal treatments. Continuous in-process testing ensures all batches meet the standards required for further GMP-conforming granulation and tableting operations.

    Industry compliance standards

    • VICH GL21: Good Manufacturing Practice for Active Pharmaceutical Ingredients for Veterinary Medicinal Products
    • China Veterinary Pharmacopoeia (CVP)
    • EU Regulation (EC) No 470/2009 on residue limits of pharmacologically active substances
    • OECD Series on Principles of Good Laboratory Practice

    Typical usage ratio

    • 0.85 – 1.05 molar equivalents in the formation of veterinary nitroimidazole intermediates; adjusted for conversion efficiency and impurity thresholds

    Downstream process integration

    • Initial reactant charged into stepwise synthesis of ornidazole or ipronidazole; integrated before catalytic reduction and acetylation

    Final product types

    • Veterinary metronidazole API
    • Ornidazole veterinary oral dosage forms
    • Ipronidazole for poultry and livestock
    • Premix powders for water solubilization

    4. Intermediate for Agricultural Fungicide & Pesticide Active Synthesis

    Chemical manufacturers use this specialty intermediate in the synthesis of nitroimidazole-based crop protection agents. Regulatory inspections necessitate full analytical validation of trace nitrosamine and solvent residues within all outgoing shipments. Accurate weighing, feeding, and in-line mixing systems maintain tight control of stoichiometric ratios and enable scale-up to commercial batch runs for highly regulated export markets.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • China National Standards for Pesticide Residues (GB 2763)
    • ISO 9001:2015 Certified Quality Management System (for agrochemical manufacturing)
    • REACH Regulation (EC) No 1907/2006 for chemical registration in the European Economic Area

    Typical usage ratio

    • 2 – 4% by weight in formulated synthesis routes, with ratio variability depending on the targeted pesticide efficacy spectrum and co-formulant/reactant ratios

    Downstream process integration

    • Charged into precursor synthesis vessels for fungicide or pesticide backbone construction; follows solvent stripping and pH adjustment for downstream formulation

    Final product types

    • Nitroimidazole-based agricultural fungicide technicals
    • Intermediates for broad-spectrum pesticide actives
    • Stock solutions for further formulation
    • Export-grade bulk pesticide intermediates
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    Certification & Compliance
    More Introduction

    2-Nitroimidazole: Direct from the Source

    Every batch of 2-Nitroimidazole that leaves our plant goes through the same hands-on process that we’ve trusted for years. As a chemical manufacturer with decades of experience, we see firsthand how 2-Nitroimidazole supports both scientific advancement and dependable industrial processes. We control production from the first step – no outsourcing, no unknowns. This approach means chemists and engineers won’t have to worry about quality drifting off-spec or supply running dry.

    Years of Refinement Create Reliability

    In our years of making 2-Nitroimidazole, we’ve worked with research labs, pharmaceutical makers, and specialty industrial clients. Each has their own goals, but they come to us because they don’t want to lose time tracking down inconsistencies or rerunning experiments. Our synthesis and purification routes avoid recurring issues we’ve seen customers face when they source material from blending houses or outside brokers. The model we offer, with a purity of at least 99%, reflects our firm focus on clarity and traceability in the production line.

    We keep focus on minimizing residual solvents and related impurities, knowing these can compromise results—especially for those working on sensitive pharmaceutical intermediates, radiolabeled compounds for PET imaging, or as component parts in anti-infective research. It’s not just a matter of “meeting spec.” In the lab and the plant, contaminants create hours of troubleshooting, false positives, or even safety hazards. Every time we optimize our reactor parameters or invest in more advanced filtration equipment, we think about how much time our customers will save further down the line.

    2-Nitroimidazole: Function and Purpose in the Real World

    We talk to formulation scientists who rely on 2-Nitroimidazole as a radiosensitizer or as raw material for exploring the chemistry of new pharmaceuticals. Other customers use it to develop diagnostic agents that help doctors identify tumors under PET scans. These applications place a high demand on material purity, not just because regulators ask for it, but because unexpected variances directly sabotage test results. Our lab techs track every variable, from the grade of starting material to the final drying step, so end users can move forward with confidence.

    In chemical synthesis, 2-Nitroimidazole adds a highly electron-withdrawing nitro group to the imidazole backbone, giving it unique reactivity. This opens up reactions that would otherwise be slow or impossible, especially in nitro-reducing environments where selective functionalization means everything. Too many times, we’ve watched others “get by” with low-grade precursors, only to run into series after series of failed yields, unidentified side products, or—worst of all—failed preclinical studies. Our shelves never include such compromise. We batch-test everything and publish impurity profiles alongside each shipment, so no one’s left guessing.

    For Those Who Need Consistency Every Time

    What makes our 2-Nitroimidazole stand out isn’t just the numbers printed on the label. It’s feedback from formulators who need precision each time they process a kilogram, and researchers who hit the same analytical marks across multiple runs. We’ve produced for both kilo-lab and full production scale, tuning our crystallization so the material flows well, without excess fine powder or sticky agglomerates that clog process lines. Our attention to particle size and flow properties saves headaches both in automated reactors and manual handling.

    There’s no “one size fits all” for fine chemicals, but certain flags tell you when you’re working with material made by people who understand your situation. Customers bring us questions about long-term stability, bulk storage, and how 2-Nitroimidazole handles exposure to moisture and air. We walk through storage protocols, suggest best-practice humidity controls, and provide real feedback from earlier batches aged under realistic warehouse conditions. The data comes from our own stability chambers, not borrowed literature or vendor statements.

    Differences Matter: How Our 2-Nitroimidazole Compares

    Not every 2-Nitroimidazole on the marketplace meets our benchmarks. Years ago, some tried sourcing intermediates from cut-price resellers, only to return with tales of batch-to-batch inconsistency. We’ve analyzed plenty of “off-the-shelf” lots coming from multiple sources. They routinely show elevated chlorinated byproducts, higher moisture content, or presence of poorly separated isomers. When these impurities slip through, it’s researchers who pay with lost time; purification follows, and that means extra cost and schedule overruns.

    We made it a point to use precise temperature profiles during nitro group introduction to suppress side reactions. It means a slightly slower process, but removing post-synthesis headaches makes that extra time worth it. By running our own final analytical tests with HPLC and GC-MS, we ensure the product meets not only general standards, but our own, refined to avoid surprises even in high-sensitivity applications. Much of the feedback we get is about consistency: same spectra, same melting point, every order.

    Application-Driven Choices

    Customers working on PET imaging tracers look for extremely low baseline radioactivity and a tight impurity profile. Early on, we collaborated with a clinical research group that needed 2-Nitroimidazole for new diagnostics. One of their biggest headaches was unexplained peaks in high-resolution mass spec—artifacts caused by inconsistent side-product control. We modified our purification steps to squash those variables, monitored trace metals and handled packaging in nitrogen-flushed bottles. The result is a lab-proven product trusted right through to clinical batches.

    In active pharmaceutical ingredient synthesis, 2-Nitroimidazole often acts as an intermediate. Here, even small impurities can affect downstream catalytic hydrogenations or create stop-points during scale-up. We design each campaign to minimize these burdens—our full process includes double recrystallization and solvent-trace analytics, not just basic sifting. Where generic material may carry over minor unknowns (sometimes revealed only after weeks of further chemistry), our regular customers run those steps with the assurance that every lot will behave the same way.

    The Manufacturing Interface: People, Equipment, and Process

    Our manufacturing plant isn’t just an assembly line. Operators, QC managers, and engineers work together, anticipating bottlenecks and spotting subtle shifts in purity or yield before they turn into headaches for others. By processing 2-Nitroimidazole end-to-end under one roof, we keep oversight locked down. Small issues don’t balloon into major problems. We track every variable, from temperature ramp rates to final packaging, and document any slight change. When someone calls us about a process or formulation, they speak directly with someone who ran—or tested—the batch.

    No lab or manufacturing process stays static. We continually improve routes to reduce byproducts, recover solvents effectively, and minimize waste. Even though environmental rules only set minimum targets, we run cleanups and checks beyond what regulations demand. Why? Teams in our sector learn quickly: any shortcut at the early stage becomes a headache further down the chain, whether that’s a slow filter cake or a fouled reactor step. Our experience creating and shipping 2-Nitroimidazole over the years builds a kind of trust you can measure.

    Specifications Crafted From Practical Experience

    Our material typically comes with a minimum 99% assay—verified not by just a quick IR scan, but by multiple analytical runs that back up every shipment. We list all known residuals, keep water content below 0.5%, and include certificates showing actual environmental exposure levels. Bulk packaging uses liners and nitrogen blankets to keep out unwanted air and moisture. These details show up not as marketing points, but as results: fewer rejected batches downstream, easier blending in reactors, and less need for re-qualification.

    Customers often ask about solubility and handling. We found that our 2-Nitroimidazole dissolves cleanly in polar aprotic solvents and performs robustly in both batch and continuous reactors. Unlike material blended elsewhere that sometimes cakes, ours pours and stirs reliably. Technicians using it for radiolabeling or medical diagnostic precursors benefit from its stability, with minimal degradation after weeks on the shelf (when kept in the right conditions with sealed packaging).

    Hands-On Feedback: Real Users, Real Results

    We get stories from the field almost every week. Academic researchers caught abnormal TLC bands traced back to an off-market sample—then switched to our material and solved the repeatability issue. Pilot plants scaling up hydrogenation steps discovered some sources led to sluggish kinetics or fouled catalysts, but when they used our 2-Nitroimidazole, the reaction ran clean. In one case, a biotech team needed kilogram quantities on short notice and found our logistics and in-house stock kept their project on track, without long lead times or questionable intermediates.

    These stories shape how we make updates. Our R&D team hears directly from users—from those running high-throughput library screens to those doing regulatory filings for Phase I trials. We adjust particle size when a pharmaceuticals team demonstrates that a change helps with reactor washing, or tweak drying cycles based on stability data. It isn’t always glamorous, but this depth keeps our product tuned for those who rely on it.

    Mitigating Risks, Building Solutions

    Contaminants and unknowns cost more than just money. Manufacturers facing unexplained batch failures tie up equipment and lose man-hours. By offering trusted supply with comprehensive documentation, we address these risks at the front end. Our decades of data on storage, shelf-life, and trace impurity formation help downstream formulators avoid running into surprises later on. Since we’ve maintained the same core production group, we keep institutional memory—instructions that make a difference get handed down, not lost in the churn.

    Supply interruptions cause chaos. Both small and large operations depend on timely deliveries, but spot shortages and customs ties can delay projects for weeks. Because we don’t route through multiple intermediaries, our lead times stay short. Our site safety standards and compliance record also minimize the chance of last-minute delays from surprise inspections or rejections. This matters for time-sensitive sectors—like life sciences or diagnostic kit providers—who need to hit milestones every quarter.

    Differences From Other Materials on the Market

    Some outlets buy up commodity batches, rebottle, and sell into the market. These materials may appear cheaper but hide risks: unverified impurity profiles, unlabeled solvents, or poor documentation. We’ve seen these lots undergo re-testing at user sites, only to require extensive re-purification or get outright discarded. With our own chemical pathway, we control purity from the ground up. Our competitors’ lots often don’t meet the stability or reactivity targets high-purity sectors rely on.

    We never substitute starting materials or take shortcuts to raise yield at the cost of purity. Our process includes repeated analytical verification, keeping us in tune with the real needs of R&D and production. For quality-critical work—whether building a new tracer for early cancer detection or manufacturing complex APIs—these details make all the difference.

    How Our Team Transfers Value to the End User

    We answer technical questions directly, whether about a unique application, a new formulation method, or unexpected difficulties during process scale-up. Our chemists offer not just documentation but real-life troubleshooting tips, sharing experience built from years in the trenches. This keeps researchers moving forward, rather than stuck investigating unexplained failures. We encourage collaboration, often working with users on custom batch sizes or developing new analytical controls to address project-specific needs.

    Responsible supply chains build supply-side resilience. Our facility carries out audits and pulls samples for every production run, not just those headed to “premium” buyers. Environmental responsibility flows into our chemical management—recovered solvents get recycled, and every step is reviewed for possible improvements. Many who source from us say these practices reassure them when research groups or quality-control auditors scrutinize their incoming supply.

    Why Direct Manufacturing Translates to Better Outcomes

    Making 2-Nitroimidazole ourselves means we understand its quirks. We can adjust everything from solvent gradient to bin material, and we document improvements with every campaign. In a world increasingly crowded with resellers and generic brokers, those needing confidence and traceability come straight to us. There’s no substitute for hands-on knowledge of the synthesis, purification, and quality assurance behind every shipment.

    Our facility was built around the idea that transparency—both in actual process steps and in communicating them—helps everyone involved work smarter and safer. We continue to prioritize long-term partnerships, not just one-off sales. These priorities are reflected in our approach to making and shipping 2-Nitroimidazole: tightly controlled processes, open communication, and zero tolerance for shortcuts.

    Looking Ahead: Supporting Innovation and Reliability

    As the needs of the chemical industry evolve, we’re investing in new methods for greener synthesis, even cleaner impurity profiles, and expanded lot tracking. We’re constantly in touch with industry trends, regulatory shifts, and the pragmatic realities that research and production environments face every day. Rather than adapting only when forced, we test new routes and tech proactively, making sure our supply remains future-proof, not just adequate.

    Supporting the innovators, the careful formulators, and the deadline-driven manufacturers matters to us. Our 2-Nitroimidazole has been used in projects spanning from routine synthesis to cutting-edge diagnostics. Throughout, our hands-on approach saves buyers countless man-hours by delivering right-fit material every time. There’s pride in knowing we’re not just another name on a datasheet, but a genuine partner in every sense—offering materials that meet the realities you experience, not just the specs printed on a certificate.