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2'-Nitrobenzanilide

    • Product Name 2'-Nitrobenzanilide
    • Alias 2-nitro-N-phenylbenzamide
    • Einecs 217-863-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    406462

    Cas Number 86-29-3
    Molecular Formula C13H10N2O3
    Molecular Weight 242.23 g/mol
    Iupac Name 2-nitro-N-phenylbenzamide
    Appearance Yellow crystalline powder
    Melting Point 181-184 °C
    Solubility In Water Insoluble
    Density 1.36 g/cm³
    Synonyms 2-Nitrobenzanilide, o-Nitrobenzanilide
    Smiles C1=CC=C(C=C1)NC(=O)C2=CC=CC=C2[N+](=O)[O-]
    Inchi InChI=1S/C13H10N2O3/c16-13(11-6-2-3-9-12(11)15(17)18)14-10-7-4-1-5-8-10/h1-9H,(H,14,16)
    Pubchem Cid 70460

    As an accredited 2'-Nitrobenzanilide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 2'-Nitrobenzanilide is packaged in a 25g amber glass bottle with a tightly sealed cap and proper hazard labeling.
    Shipping 2'-Nitrobenzanilide is shipped in tightly sealed containers to prevent moisture and contamination. It should be packed according to local, national, and international regulations for chemicals, typically using cushioned secondary packaging. Ensure labeling with hazard information and ship with the appropriate documentation. Store and transport in cool, dry conditions, away from incompatible materials.
    Storage Store 2'-Nitrobenzanilide in a tightly sealed container, in a cool, dry, and well-ventilated area away from sources of ignition and incompatible substances such as strong oxidizing agents. Keep it away from direct sunlight and moisture. Label the container clearly, and ensure access is restricted to trained personnel. Follow all relevant safety guidelines and local regulations for storage.
    Application of 2'-Nitrobenzanilide

    Applications of 2'-Nitrobenzanilide in Industrial Manufacturing

    2'-Nitrobenzanilide is a functional aromatic amide intermediate widely adopted in specialty chemical synthesis for distinct industrial sectors. Its chemical stability, selective reactivity, and compatibility with multistep synthesis enable its value in regulated downstream manufacturing workflows.

    1. Agricultural Chemical Synthesis

    Major agrochemical formulators integrate 2'-Nitrobenzanilide as a precursor in the multi-step production of selective herbicides and growth regulators. This compound supports the construction of specific active ingredient cores via acylation and reduction sequences. Manufacturers control process variables closely, ensuring consistent purity that matches strict government registration dossiers for finished crop protection agents.

    Industry compliance standards

    • China GB/T 5009.204 (Pesticide residue determination)
    • US EPA 40 CFR Part 180 (Tolerances and exemptions for pesticide chemicals in food)
    • REACH Annex XVII (EU restrictions on certain hazardous substances)
    • FAO/WHO JMPR technical monographs

    Typical usage ratio

    • Ranges from 5% to 15% in reaction mass, depending on desired chain length and targeted final molecule complexity. Ratios adjust based on downstream reduction or coupling yields.

    Downstream process integration

    • Introduced in the condensation or acylation stage of agrochemical synthesis, proceeding to hydrogenation and purification steps. Incorporated before formulation of actives into technical and granular products.

    Final product types

    • Selective pre-emergence herbicide technical concentrates
    • Plant growth regulator intermediates
    • Crop protection active substance bulk intermediates
    • Bulk pesticide actives for registered major brands

    2. Dyestuff and Pigment Intermediate Manufacturing

    Global pigment and dyes producers deploy 2'-Nitrobenzanilide as a key intermediate during azo and anthraquinone dye synthesis. Its nitro-functional benzamide framework participates in coupling processes, generating nano-scale dyes and pigments with tailored light-fastness and color intensity. End-users require traceable batch-to-batch identity and color consistency for regulated textile and polymer applications across export markets.

    Industry compliance standards

    • EN 71-3 (Migration of certain elements for toy safety)
    • OEKO-TEX Standard 100 (Textile chemical restrictions)
    • EU REACH SVHC candidate list (Substances of Very High Concern)
    • ISO 105-A03 (Textile color fastness testing)

    Typical usage ratio

    • From 2% up to 10% by mass in batch dye synthesis, based on chromophore structure requirements and specific shade depth targeting.

    Downstream process integration

    • Dosed at the coupling or condensation stage for azo dye or pigment formation. Purified by filtration and crystallization before blending for finished pigment dispersions and dye formulations.

    Final product types

    • Azo and anthraquinone dye intermediates
    • High-performance organic pigment concentrates
    • Colorants for plastic masterbatches
    • Textile dyestuff for synthetic fiber processing

    3. Pharmaceutical Intermediate Synthesis

    In active pharmaceutical ingredient (API) and advanced intermediate production, regulated manufacturers utilize 2'-Nitrobenzanilide to construct key heterocyclic ring systems. This material supports route development for APIs by functioning as an amide substrate in both nucleophilic substitution and reduction steps. Regulatory teams track impurity profiles and ensure traceability for every API batch released to cGMP standards.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice for APIs)
    • China Pharmacopoeia (2020 Edition)
    • 21 CFR Part 211 (US FDA cGMP for finished pharmaceuticals)
    • EU GMP Volume 4 (Pharmaceutical manufacturing guidelines)

    Typical usage ratio

    • Commonly 3% to 8% as a stoichiometric or excess reagent depending on synthetic step, process scale, and desired selectivity.

    Downstream process integration

    • Introduced during early-stage amide bond formation or nitro-reduction reactions. Purified intermediates progress to final coupling, crystallization, and formulation steps under cGMP environments.

    Final product types

    • Antibiotic advanced building blocks
    • Heterocyclic API intermediates
    • Clinical trial grade candidate intermediates
    • GMP pharmaceutical intermediates for contract manufacturing

    4. Polymer Additive Components

    Manufacturers in the polymer sector integrate 2'-Nitrobenzanilide as a functional additive precursor or modifier, supporting the design of specialty polymer chain extenders or crosslinkers. Its molecular structure contributes to thermal resistance and specific performance traits in engineered resin matrices. Quality assessment covers impact on molecular weight distribution and compliance with relevant downstream application standards.

    Industry compliance standards

    • UL 94 (Standard for Safety of Flammability of Plastic Materials)
    • FDA 21 CFR 177.1520 (Indirect Food Additives: Polymers)
    • RoHS Directive 2011/65/EU (Restriction of hazardous substances)
    • ISO 11357 (DSC analysis for polymers)

    Typical usage ratio

    • Normally 0.2–2% in polymer masterbatches, adjusted according to required performance and compatibility with target resin types.

    Downstream process integration

    • Blended into pre-polymer mixtures during compounding, before extrusion or polymerization. Acts as a reactive modifier or performance additive during thermal processing.

    Final product types

    • Specialty engineering plastic granules
    • Performance thermoplastic elastomers (TPEs)
    • High-heat resistant resin compounds
    • OEM-grade custom polymer masterbatch

    5. Fine Chemical Custom Synthesis

    Dedicated fine chemical contract manufacturers employ 2'-Nitrobenzanilide for customer-specific synthesis of high-value specialty molecules used in electronic chemicals and high-performance coatings. Specifications center on controlled purity, tailored particle size, and minimal cross-contamination. Downstream processes require full traceability and batch-specific documentation to fulfill end-user audit and quality demands.

    Industry compliance standards

    • ISO 9001:2015 (Quality Management Systems)
    • ISO 14001:2015 (Environmental Management Systems)
    • GHS classification (Globally Harmonized System for hazardous labeling)
    • Customer-specific QC and analytical protocols

    Typical usage ratio

    • Customized for each contract, typically 1–10%, dependent on synthesis protocol and targeted molecular complexity.

    Downstream process integration

    • Used as a locked step intermediate—introduced by order at designated reaction stages, followed by sequential purification and conversion to client-defined molecules.

    Final product types

    • Photoinitiator advanced intermediates
    • Specialty monomers for electronics
    • High-durability coating intermediates
    • Reference standards and analytical grade chemicals
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    Certification & Compliance
    More Introduction

    2'-Nitrobenzanilide: A Manufacturer’s Perspective

    Understanding 2'-Nitrobenzanilide: Our Experience and Approach

    In chemical synthesis, reliability often depends on subtle differences in how raw materials behave across production environments. 2'-Nitrobenzanilide stands out in this regard due to its stable performance in several downstream processes, which we have observed and validated across many years of manufacturing. With the molecular formula C13H10N2O3 and a molecular weight of 242.23 g/mol, it offers consistent characteristics crucial for applications demanding both purity and stability. In our production facility, we focus intensely on tight process control because deviations, even slight, impact not only crystallinity but the yield and quality of end products.

    From our long-term engagement with dye and pigment makers, we see 2'-Nitrobenzanilide most valued in processes where purity and color stability have direct effects on cost control and downstream adjustments. Many of our partners rely on our technical feedback to optimize their recipes, only finalizing their process once the interplay with our material has been confirmed at pilot scale. Rather than assume a one-size-fits-all use, we work closely in tracking how real-world process variables, such as temperature differentials during dissolution and re-crystallization, vary according to batch differences. This sort of technical loop, supported by regular lab feedback, helps flag any risk of contaminants or unexpected by-products early.

    Our people inspect each batch, from raw nitration stages through purification, because inconsistent feedstock or rushed filtration often leaves behind micro-level impurities. These can promote side reactions during azo dye coupling or affect dispersion in finished products like organic pigments. Regular sampling and GC/HPLC analysis form our bread-and-butter routine, and we track trace residuals with a sharp focus. Many years ago, we learned that a shortcut at the purification step—sometimes used elsewhere to cut costs—invites complaints down the supply chain. So, each lot from us reflects this cumulative experience: technical discipline over mere adherence to minimal spec.

    How Manufacturing Choices Affect Final Outcomes

    As a manufacturer, we encounter different expectations from users in dye, pharmaceutical intermediate, and agricultural research laboratories. Some partners look for optimized flow characteristics, especially when feeding 2'-Nitrobenzanilide into continuous reactors or automated lines. In our plant, we fine-tune drying cycles and particle size to control for unwanted agglomeration—a particular concern for high-speed blending and precision weighing. It’s tempting to overlook such production details, but decades of feedback from research and pilot lines have taught us the costs of ignoring them.

    Precision matters, especially if downstream reactions involve diazotization or coupling steps where dissolved impurities or off-colors rob efficiency from dye formation. Our approach keeps water content to a minimum and controls for ionic residues, especially sodium or sulfate ions, introduced from earlier process steps. We chase these sources hard because they compromise reproducibility, and ever-tightening customer standards don’t forgive oversights the way they did a generation ago. We set our own internal benchmarks beyond those found in general monographs.

    Through hands-on collaboration, we’ve benchmarked our 2'-Nitrobenzanilide against equivalent materials from international suppliers, running parallel trials to compare performance in both lab and pilot scale. Feedback often points to two things: improved shade consistency in pigments, and less unplanned line stoppage due to clumping or unexpected solubility behaviors. These outcomes don’t arise by accident; controlling for these variables means applying extra care from raw material selection, through process development, right to dispatch.

    Differences that Show Up in Real-World Applications

    One well-observed difference between our 2'-Nitrobenzanilide and some other offerings is the level of batch-to-batch reproducibility. Partners across Europe and Asia have tried swapping sources only to report interruptions in their formulation or unexpected performance drops in the field. Some competitors aim to meet baseline purity—often quoted as >99%—but our lab teams scrutinize minority peaks and residues not always detailed on standard COAs. We actively record and trend data on key isomeric impurities, especially related to incomplete nitration or aniline by-products, because these outliers have outsize effects on complex reactions.

    We’ve learned that what matters over the long term is not just whether a batch passes today's specifications, but how predictably it behaves in the customer’s recipe month after month. That’s where our in-house process refinements come into play. By holding to the same sequence of washings, recrystallizations, and controlled cooling, we produce lots that deliver the same kinetic and solubility profiles every time. Some international buyers have relayed back to us that switching to an alternative supply often led to more off-shades in textiles or unstable dispersions in organic coatings. The lesson stays with us: incremental improvements at the source translate to cost and time savings for the end user.

    Some new users ask us about differences between 2'-Nitrobenzanilide and similar compounds such as 4'-Nitrobenzanilide or 2-Nitroacetanilide. At the molecular level, isomeric placement of the nitro group dictates not only reactivity but also melting range, solubility, and colorants’ interaction during diazo coupling. We have run side-by-side experiments in our own pilot units: under identical reaction conditions, solubility curves and crystallization rates vary noticeably. 2'-Nitrobenzanilide, due to its structure, provides better control in pigment formations where the position of substitution influences color yield and fastness. Users who attempt to interchange similar compounds often circle back to the original due to these controlled differences.

    Our Challenges and Commitment to Consistent Output

    Production at scale introduces challenges that aren’t always visible in bench trials. Our operations team tracks changes in raw material lots—the quality of starting aniline and nitro compounds sharply affects yield and overall safety. We have direct experience with unanticipated variations in reaction exotherm profiles when switching feedstocks, which has taught us to continuously monitor and refine temperature controls. Our QC department doesn’t rely on a single-point test; we incorporate real-time in-process monitoring and retain control samples from every batch for retrospective checks.

    Over time, we have observed that process drift can sneak into routine operations. Slight changes in atmospheric humidity or aging of filtration equipment put a subtle, yet measurable, effect on the final characteristics of 2'-Nitrobenzanilide. We rotate our process teams across different shifts and enable frequent cross-checks, because repeated human oversight helps catch trends early before they develop into quality issues. Our best improvements often spring not from technology upgrades, but from regular debriefings where experienced staff share first-hand observations on how a process tweak re-shaped output or improved purity.

    Our people carry many decades of combined expertise, and we draw on this regularly through face-to-face troubleshooting sessions at line-side. Over the years, consistent product emerges from careful adaptation, not blind automation. In one case, we found an obscure contaminant that eluded routine detection until hands-on troubleshooting revealed a rare process side reaction, which we then corrected with a new post-crystallization wash cycle. We share such case lessons internally, keeping our process documentation updated and transparent for auditing and improvement.

    Supporting Innovation and Meeting Evolving Expectations

    Users in R&D settings and established industries keep raising their expectations for reproducibility, traceability, and environmental impact. We invest in ways to minimize our footprint through efficient waste recovery and closed-loop solvent handling in the 2'-Nitrobenzanilide line. Our internal benchmarks set solvent loss and emissions well below local regulatory requirements; this discipline pays back in consistent operational costs and fewer batch interruptions. We have cut reprocessing numbers by more than half over the last five years, freeing up both capacity and quality bandwidth. This improvement stems from granular tracking—batch by batch—enabling us to forecast and prevent downtime.

    Engagement at the technical frontier, with ongoing dialogue between manufacturing and end-users, has driven us to improve application support. Many clients want guidance integrating 2'-Nitrobenzanilide into new synthetic sequences or pigment systems. We offer our laboratory’s insight freely, helping to troubleshoot solubility snags or secondary color formation in new dye blends. Often, small adjustments in how the material is handled at charge-in lead to smoother operations; we relay operational know-how freely because waste from mishandling costs all parties. Providing technical backup builds a relationship of trust, rooted in both transparency and mutual investment in successful outcomes.

    Why We Focus on Product Traceability

    Increasingly, supply partners demand transparent, auditable data on product origins and process control. We maintain detailed batch records, tracking inputs from receipt through every processing step and down to finished lot packaging. Digital traceability systems allow us to pinpoint exactly where an issue originated if a downstream quality issue ever arises. Regulators and multinational buyers alike appreciate this rigor, and it shields them—and us—from product recalls or disruptions. Our production chain holds accountability at every level, supported by both automation and front-line operator sign-off. We see this as the foundation for long-term partnerships, especially as the industry moves toward smarter compliance and deeper material insight.

    It’s not uncommon for us to field traceability requests linked to specific final goods, sometimes months after original shipment. Our documentation framework provides the continuity required to verify each material transfer, seal integrity, and shipping interval. When clients push for deeper sustainability or origin verification, we adapt and supply supporting technical evidence on request, including impurity profiles and process certificates. We keep digital and physical retention samples for every production run—this means quick verification if anyone in the value chain needs assurance. Our investment in thorough record-keeping shines in these moments; clients rarely need to wait for a response.

    Experimentation and Continuous Process Refinement

    Manufacturing 2'-Nitrobenzanilide at commercial scale never stays static. Each change in input costs, regulatory expectations, or emerging application need triggers continuous review and process tuning. Over time, we have upgraded both hardware and workflow: from multi-stage filtration to tighter, automated controls in crystallization, and ongoing testing in particle size and flow properties. Small cycle upgrades lend stability throughout the chain, adding to both product value and predictability in industrial use. Our R&D staff tests not just for base chemical purity, but for downstream properties such as dispersibility or reactivity rates—directly feeding this intelligence back into process change.

    Process improvements emerge from concrete results, not simply intent or abstract planning. One adjustment, a decade ago, resulted from a pigment manufacturer’s complaint about trace off-hues during scaling. We re-mapped the final cooling curve, then reduced a problematic impurity by over 60%—a change reflected in improved customer outcomes documented independently. Such triggers keep our production team vigilant, with a sense that direct application feedback has as much value as laboratory analytics. Grounding change in direct observation—rather than theoretical metrics—keeps our operation relevant, practical, and tuned for future application needs.

    Field Use Cases and Observed Outcomes

    Across our customer base, the majority deploy 2'-Nitrobenzanilide in the development of azo dyes, organic pigments, and several cases in pharmaceutical intermediates. Field performance often exposes system weaknesses that bench chemistry cannot predict; we stay in active touch with customers to map these realities back into our process. One user in the plastics industry found improved color fastness in high-temperature thermoplastic applications, linking superior results to consistently narrow melting point range and low residual moieties in our supply. Others have reported downstream efficiencies—a smoother filter-press cycle, fewer wash cycles, or cleaner color in textiles. These results grow from details in our routine, not by accident.

    Partners in research settings look for synergy with novel reagents and ask for deeper support on compatibility checks or alternative processing conditions. Our willingness to trial new purification runs, adapt drying conditions, or sample alternative solvents for dissolving and re-crystallizing gives them the flexibility to innovate with confidence. Practical knowledge accrued through diverse field applications—ranging from pigment pastes, color dispersions, and fine chemical intermediates—feeds into our data and informs our process improvement cycles. Every reported efficiency or bottleneck becomes a target for future incremental change.

    Direct Feedback as the Backbone of Improvement

    The most valuable learning comes from solving problems on the ground, side by side with users facing unexpected variables. Whether batches run too slow in production, or dye yields drop below projections, our technical people work together with partners to review and troubleshoot. We value transparent reporting of off-spec results, as it anchors both customer loyalty and our own improvement. Each serious complaint prompts a root-cause review, often tracked to subtle equipment drift or raw material variability. Fixing these at source, rather than deflecting blame, defines how we operate—and our customers tend to respect, not penalize, this openness.

    We carry forward every lesson from these experiences. Years ago, a small shift in solvent residual caused a series of downstream handling issues in a client's process; we not only traced and corrected the cause, but added an in-line solvent sensor to preempt recurrence. This detail-driven cycle, sustained by deep technical, process, and field insight, shapes the difference between commodity-grade supply and reliable, trusted manufacturing. Our commitment doesn’t end at the loading dock or invoice issue; it lives in the detail, in the ongoing feedback loop we maintain with anyone using our 2'-Nitrobenzanilide.

    Moving Forward, Grounded in Experience

    Our relationship with the industry, honed over years of incremental gain and technical problem solving, means that buyers of 2'-Nitrobenzanilide buy more than a checklist of chemical properties. They engage with a manufacturer offering hands-on, practical understanding, technical support, and hard-earned lessons distilled into measurable product improvements. Global standards evolve, formulations change, and regulatory complexity grows, but the core value of rigorous in-house production with transparent data and direct lines of technical dialogue holds steady. 2'-Nitrobenzanilide’s contributions across a range of application areas—pigments, dyes, and specialty intermediates—continue to underscore the payoff that practical experience and process refinement bring, every time it enters a new production environment.