Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing admin@sinochem-nanjing.com 3389378665@qq.com
Follow us:

2-Methylpyrazine

    • Product Name 2-Methylpyrazine
    • Alias 2-Methyl-1,4-diazine
    • Einecs 108-001-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    422126

    Cas Number 109-08-0
    Iupac Name 2-Methylpyrazine
    Molecular Formula C5H6N2
    Molecular Weight 94.12 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 139-141°C
    Melting Point -23°C
    Density 1.063 g/cm³ at 20°C
    Solubility In Water Soluble
    Odor Nutty, roasted, chocolate-like
    Flash Point 37°C (closed cup)
    Refractive Index 1.510 at 20°C

    As an accredited 2-Methylpyrazine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 250 mL amber glass bottle with a tight-seal cap, labeled "2-Methylpyrazine, 98%," featuring hazard and handling instructions.
    Shipping 2-Methylpyrazine is shipped in tightly sealed containers, protected from moisture, heat, and ignition sources. It should be labeled according to hazardous material regulations. Transport follows international and local guidelines, as it is a flammable and irritant compound. Proper ventilation and handling procedures must be in place during shipping to ensure safety.
    Storage 2-Methylpyrazine should be stored in a cool, dry, and well-ventilated area, away from sources of ignition, heat, and incompatible materials such as oxidizing agents. Keep the container tightly closed when not in use. Store in a chemical storage cabinet designed for flammable liquids. Properly label the container and ensure ground and bonding during transfers to prevent static discharge.
    Application of 2-Methylpyrazine

    Applications of 2-Methylpyrazine in Industrial Manufacturing

    2-Methylpyrazine serves as a foundational intermediate in multiple industrial sectors, supporting the synthesis and formulation of high-value, specialty downstream products. As the original chemical manufacturer, we work with global processors to ensure quality, traceability, and reliable application in end-user manufacturing. Below are the primary industrial application segments with compliance, usage, integration, and product insights.

    1. Food Flavoring Ingredient Production

    Manufacturers in the food additive sector integrate 2-methylpyrazine as a key aroma and flavor precursor in savory and roasted food concepts, especially for snack, cereal, and seasoning production. Precise dosing control is critical to achieve desired note intensity while maintaining food safety and regulatory thresholds. All additions are monitored for consistency in high-temperature processing and subsequent flavor development during baking, roasting, or extrusion.

    Industry compliance standards

    • FCC (Food Chemicals Codex) requirements for flavoring substances
    • EU Regulation (EC) No 1334/2008 on flavorings and certain food ingredients
    • GB 2760-2024 Chinese National Food Safety Standard for use of food additives
    • 21 CFR Part 172.515 (US FDA: Synthetic flavoring substances and adjuvants)

    Typical usage ratio

    • 0.1 – 10 ppm (parts per million) in final food products
    • Adjusted based on matrix fat/oil content and process loss
    • Not to exceed 2 mg/kg as per most national standards for natural-analog flavors
    • Usage documented in batch records according to GFSI schemes (e.g., BRCGS, FSSC 22000)

    Downstream process integration

    • Added during blending of flavor premixes or top-note systems
    • Thermal stability allows addition before extrusion or vacuum cooking
    • Inclusion after deodorization stages to preserve aromatic character
    • Documented in material traceability and finished batch QC sampling

    Final product types

    • Instant noodle soup bases
    • Savory snack coatings (potato chips, crackers, pretzels)
    • Cereal grain roasting flavors
    • Spice compound blends

    2. Pharmaceutical API Synthesis Intermediate

    2-Methylpyrazine acts as a core intermediate in the synthesis routes for certain antitubercular and anticancer pharmaceutical active ingredients. Chemical engineers integrate the material primarily through Friedel-Crafts or acylation sequences in multi-step synthesis. Strict compliance and in-process monitoring assure both the purity of input and the structural integrity of pharmacopeial intermediates.

    Industry compliance standards

    • ICH Q7A GMP for Active Pharmaceutical Ingredients
    • USP/NF monograph requirements for pyrazine-based intermediates
    • EDQM guidelines for trace impurity control in API manufacturing
    • Chinese Pharmacopoeia ChP 2020 (when exporting to China)

    Typical usage ratio

    • Stoichiometric, depending on target molecule core (0.8 – 1.3 equivalents)
    • Adjusted per batch based on process yield and waste minimization protocols
    • Typical input mass: 40–120 g per mol of target API batch, variable with scale
    • Final pyrazine content subject to API impurity threshold of <0.1%

    Downstream process integration

    • Introduced in stepwise heterocyclic ring assembly
    • Reacts under closed-system jacketed vessels with in-situ HCl or acyl chloride introduction
    • Followed by crystallization and purification for the next API coupling step
    • Analytical verification using HPLC and GC-MS before progressing to final API synthesis

    Final product types

    • Second-line antitubercular agents (e.g., Pyrazinamide derivatives)
    • Experimental small-molecule oncology drugs
    • Pyrazine-based contrast agent intermediates
    • API intermediates for CNS-active compounds

    3. Agrochemical Active Ingredient Manufacturing

    Producers of crop protection agents utilize 2-methylpyrazine for pyrazine-building-block integration in pesticide, herbicide, and fungicide synthesis. The chemical typically enters the early condensation or cyclization stage and is crucial for generating specific bioactivity profiles. Industry focus includes reduction of environmental impact through traceable raw feeds and compliance with safety tolerances.

    Industry compliance standards

    • FAO/WHO specifications for plant protection agents
    • REACH Regulation (EC) No 1907/2006 on chemical registration
    • ISO 17025 for analytical validation in agrochemical synthesis
    • China ICAMA registration for agrochemical active substances

    Typical usage ratio

    • 10 – 60% molar equivalent, adjusted by end-use product type
    • Up to 110 g/L in cyclization feed tanks, depending on product yield expectations
    • Minimized through recycling of excess pyrazine in the mother liquor
    • Batch adjustments based on seasonal procurement cost fluctuations

    Downstream process integration

    • Charged in the condensation reactor with acid/alkali catalyst systems
    • Combined with other heterocyclic components for targeted activity
    • Reaction temperature monitored (typically 90–120°C) to ensure full conversion
    • Integrated pre-formulation QC testing for residual pyrazine

    Final product types

    • Pyrazine-derived insecticides
    • Herbicide intermediates for broadleaf weed control
    • Fungicidal actives in cereal protection
    • Chemical seed treatment agents

    4. Polymer Modifier and Additive Preparation

    The polymer processing industry incorporates 2-methylpyrazine for functional monomer modification and as a chain-modifying additive, particularly in specialty engineering plastics and resins. This application targets improvements in flame retardancy, anti-static properties, and modification of crystallinity. Producers follow REACH and RoHS directives strictly, maintaining trace impurity levels to prevent polymer yellowing and off-gassing during molding.

    Industry compliance standards

    • EU RoHS Directive 2011/65/EU (Restriction of Hazardous Substances)
    • REACH compliance for polymers and polymer additives
    • UL 94 plastic flammability standards
    • ISO 9001:2015 certified QC management for trace analysis

    Typical usage ratio

    • 0.3 – 2.5% by polymer mass for modifier blends
    • 1–10 g/kg in specialty resin masterbatches
    • Decreases as base polymer purity increases
    • Low-dose inclusion for electrical grade polymers to balance conductivity

    Downstream process integration

    • Direct blending at the extruder feed throats
    • Compounders add at pre-polymerization or during direct polymer melt phase
    • Monitored via DSC (Differential Scanning Calorimetry) in QC labs
    • Documentation required for end-user audit trails

    Final product types

    • Modified polyamide and polycarbonate pellets
    • Flame-retardant engineering plastics
    • Anti-static packaging sheets
    • Performance coatings for wire and cable insulation

    5. Specialty Solvent & Heterocyclic Compound Synthesis

    Chemical processors use 2-methylpyrazine as a building block in the manufacture of advanced heterocyclic compounds, including custom solvents and fine chemicals for electronics and analytical applications. These syntheses require controlled conditions for purity and critical documentation for traceability, often under ISO or cGMP guidelines. Integration occurs in facilities with capabilities for solvent distillation and purification.

    Industry compliance standards

    • ISO 9001:2015 certified fine chemical manufacturing
    • High-purity solvent standards (ASTM D1078 for distillation range checkpoints)
    • SOCMA ChemStewards® stewardship program requirements
    • Responsible Care® management systems for specialty intermediates

    Typical usage ratio

    • Varies from 15 – 70% of total reactant mass, depending on the synthetic route
    • High-purity grades for electronics: <30 ppm water content stipulated
    • Enters as either primary reactant or as a functional group donor
    • Batch-specific adjustment based on downstream process yield analysis

    Downstream process integration

    • Fed into glass-lined or stainless reactors with specific condensing agents
    • Distilled post-reaction to maximize product isolation and product yield
    • Purification includes azeotropic drying and solid-phase extraction for analytical grades
    • Lab sampling and GC/LC-MS documentation accompany every batch shipment

    Final product types

    • Specialty aprotic solvents for electronics cleaning
    • Analytical standards for chromatography
    • Heterocyclic building blocks for advanced material synthesis
    • Intermediates for custom organic laboratory reagents
    Free Quote

    Competitive 2-Methylpyrazine prices that fit your budget—flexible terms and customized quotes for every order.

    For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.

    We will respond to you as soon as possible.

    Tel: +8615371019725

    Email: admin@sinochem-nanjing.com

    Get Free Quote of Sinochem Nanjing Corporation

    Flexible payment, competitive price, premium service - Inquire now!

    Certification & Compliance
    More Introduction

    2-Methylpyrazine: Expertise from the Manufacturing Floor

    An Introduction Drawn from Hands-On Manufacturing

    Years shaping pure 2-Methylpyrazine have taught us what reliable quality truly means for buyers and downstream users. In our production halls, this aromatic compound’s story begins with the raw chemistry—precise reaction controls and high-purity feedstocks make all the difference in yield and clarity. Its chemical structure, C5H6N2, marks it as a simple methylated pyrazine, but its applications and sensory impact run much deeper than the formula suggests.

    Molecular Properties: Distinction through Purity and Consistency

    Every batch of 2-Methylpyrazine we produce meets rigorous standards, with GC assay readings consistently clocking above 99.5%. Pale yellow to colorless in appearance, it comes across the line clean and free-flowing. Its boiling point, in the lower 130s Celsius, lines up with what experienced customers look for in a volatile flavor intermediate. Residual moisture and ash content receive special attention—if you have ever stepped into a flavors lab and watched the impact of a few stray impurities on the finished note, you know why.

    Uses Shaped by Real Experience

    Demand for 2-Methylpyrazine draws heavily from flavor and fragrance houses, where it imparts roasted, nutty, cocoa-like tones even at trace concentration. Most of the people who call us for regular shipments run labs concerned about flavor authenticity in food, beverages, and tobacco. Having worked closely with flavorists, we know nothing slows down new product launches like off-notes or inconsistent supply. We maintain clear material traceability and full QA/QC documentation to avoid surprises at the application stage, since real-world experience has shown that small lapses can quickly translate to lost batches and costly trouble-shooting. For those using it in pharmaceutical synthesis or agrochemical intermediates, batch-to-batch uniformity keeps processes efficient and avoids revalidation headaches.

    What Sets Our 2-Methylpyrazine Apart

    Our manufacturing teams insist on uninterrupted process control, from reaction time and temperature to purification and final packaging. There is nowhere to cut corners when it comes to removing residual solvents or controlling headspace oxygen, because storage stability depends on these steps. Some competitors supply material that tests fine right after packing but drifts in color or titer after transport. We’ve learned to minimize these issues through inert-gas blanketing and using HDPE containers that avoid unwanted leaching or permeability. These are details manufacturers notice, often only after discovering why a new source turned sour. Our logistics team ships with short turnaround times to reduce warehouse holds, a practice that comes from direct customer feedback about previous instability with oxidized batches.

    Why Quality Here Matters More Than a Certificate

    Any lab can print a certificate of analysis, but too many buyers have found that certificates alone don't tell the whole story. We invite site visits, periodic audits, and open discussions about cleaning regimens, storage tank conditions, and in-process control—not just the final product specifications. Experience shows that supply hiccups don't always start with the big issues; sometimes, it’s a cleaning cycle cut short on a transfer line. So we run our QC samples on each drum, not just on bulk tanks, especially before loads headed overseas. Users working in food or tobacco rely on this diligence, since regulatory and sensory hurdles can put pressure on every new launch.

    Comparisons with Other Pyrazines and Imitation Risks

    Many industrial users compare 2-Methylpyrazine with structurally similar compounds, such as methylated pyrazines with isomers at other positions, or with ethylpyrazines that offer nuances in flavor or reactivity. The methyl group at the 2-position brings a distinct, round warmth—less piercing than its 3-substituted cousin, and clearly different from 2,3-dimethylpyrazine’s intense roasted note. Customers have learned to spot supply sources that blend lower-cost byproducts or off-cut material to present a superficially compliant aroma. If a batch brings a sharp or musty undertone, chances are high there’s more than just the targeted isomer in the drum. We don’t cut lots or blend residues; everything leaves the line after passing through a set of analytical and organoleptic checks.

    Production Challenges and Real-World Solutions

    Pyrazine chemistry rewards patience and penalizes shortcuts. At scale, exothermic steps during methylation create risks for unwanted polymerization, so our reactors are jacketed for precise thermal control. One missed hotspot, and you get colored tars instead of the bright, pure product customers want. Thorough degassing and staged crystallization help ensure clarity and recognizable aroma strength in every outgoing drum. We continue to invest in catalyst recovery and solvent recycling, not because it looks good on paper, but because we have lived through the real headaches that arise from supply disruptions or charge contamination. More than a decade ago, we lost batches to a faulty distillation column gasket, so we now perform line checks by default before every production run.

    Food Safety, Regulatory, and Traceability Focus

    Direct experience tells us that traceability and compliance put real constraints on production. For food-adjacent and food-grade supply, every solvent and auxiliary is food-contact-rated, from reaction to drums. Allergen declarations, migration tests, and REACH data sets are kept live and ready for review. We maintain HACCP plans not as marketing, but as a living part of the workflow—because only consistent scrutiny stands up to the questions regulatory auditors ask. For customers producing ingredients for export to North America, Europe, or Japan, our in-house compliance team tracks changes and works through new requirements in advance, sending updated documentation at the batch and container level. Real experience has shown that advance notice and joint audits head off paperwork bottlenecks months down the line.

    Handling, Packaging, and End-User Experience

    We know from years of feedback that packaging makes a big difference once materials reach a busy mixing, blending, or application facility. We moved early from metal barrels to heavy-walled food-grade plastics, eliminating flavor taint, ensuring lighter lifting, and cutting spillage from bung corrosion. Each drum comes with easily scannable labeling and lot coding; unloaders can check the material on the spot before it enters a facility. These details matter on the plant floor and have come directly from stories told by customers who had lived through confusing drum swaps or labeling errors before switching to us.

    Safety as Practiced, Not Just Published

    2-Methylpyrazine belongs to a low-to-moderate risk group in chemical processing, but nothing in our shop happens without PPE, air handling, and training. We have handled single-drum to bulk-tanker scale-offs, always controlling emissions and storing away from oxidizers and acid-sensitive materials. Storage in cool, dry, well-ventilated buildings, with spill trays staged and inspected, helps mitigate the real spill risks that infrequent users and smaller crews sometimes overlook. Our crews run through fire and vapor release drills, prompted not by regulations alone, but by a close call with a barrel shift in shipping years ago that nearly led to a hazardous material response.

    From Student Benches to Factory Lines: Supporting R&D and Innovation

    R&D teams often approach us seeking trial lots or scaled-down packaging, especially when testing new formulations. Instead of standard bulk drums, we have adjusted to include smaller, tamper-evident canisters, since the true value sparks when users can dose accurately and reseal the remainder. This practice began with a university lab group struggling to keep their test stock from spoiling—after visiting and learning their needs, we reworked our filling line to run pilot- and lab-scale volumes. These new practices flow upward, showing established customers what extra service looks like.

    The Realities of Market Shifts and Supply Pressures

    We have weathered raw material price spikes, transport bottlenecks, and currency swings—no manufacturer escapes market cycles. Years back, a sharp rise in feedstock cost squeezed smaller factories out of the race; only forward contracts and early bulk purchases allowed steady shipments to carry through. We share honest forecasts with downstream buyers and help them build inventory plans that cushion against seasonal fluctuations. In periods of global freight slowdowns, we lean on regional supply chains and use local partnerships to act faster than the wider global market, so those depending on us avoid some of the harsher shortages or quality stumbles seen elsewhere.

    Why Transparency and Customer Dialogue Matter

    The most valuable improvements in our 2-Methylpyrazine production have come from two-way discussion with customers, not just process optimization inside our gates. We treat every complaint or product-return request as training for future batches. Over the years, we created new analytic standards—like extra microtrace impurity screens or expansion of sensory evaluation panels—by responding to customer QA teams who found note variations or performance drifts that lab numbers alone might have missed. Our technical liaisons work directly with application chemists at customer sites when troubleshooting is needed. We don’t believe in sealing up proprietary methods so tightly that a user can’t see what might affect their final blend or ingredient line.

    Spotting and Combating Counterfeit and Sub-Grade Supply

    Having been asked to identify “fake” or tampered samples more than once, we stay vigilant in monitoring trademark infringements and repacked product entering the gray market. Astute buyers have brought in competitive samples that varied widely from true 2-Methylpyrazine profiles—sometimes diluted with higher-boiling solvents or off-grade pyrazines that introduce unwanted odor or performance issues. We've developed and refined our analytic and authentication measures so users can authenticate genuine supply quickly, protecting both our business and theirs from costly surprises.

    Lessons Learned from Decades of Practice

    Some of our best improvements have come from mistakes made and subsequently addressed over years of continuous production. From resolving a feed tank miscalibration during storm-induced blackouts, to riding out a regulatory investigation sparked by an unlabeled allergen claim, we’ve accumulated direct knowledge of the practicalities at every production and supply step. This hard-won expertise informs both the structure of our processes and our communication style: grounded, practical, and equally open about both strengths and the limits of what a pure chemical can deliver.

    Environmental Impact and Responsible Manufacturing

    The industry standard lacks specific guidance for climate-sensitive production of pyrazines, so we took it upon ourselves to implement solvent recovery, renewable utility sourcing, and optimized waste management. We balance solvent life cycle with environmental risk; outdated methods that trade energy savings for potential contamination don’t fit in modern operations. Those investing in green chemistry demand full process transparency, especially as downstream markets for organic and natural flavors gain traction. By auditing our output streams, we quantify residual load, export volume, and recovery efficiency—then share this data with long-term customers when they audit us for compliance with their own sustainability goals.

    Potential Improvements and What Still Needs Work

    2-Methylpyrazine has a well-established place in flavor, fragrance, and specialty chemistry, but efficiency and quality improvements continue to present new challenges. We push for tighter process analytics, more robust contaminant removal, and faster logistics tied directly to order cycles. Customers in high-value food and beverage rely on this understanding for smoother launches, but there remain gulfs to cross in harmonizing regulations among global markets. Product labeling, additive lists, and quality testing still change at different rates, making ongoing dialogue and joint adaptation a regular part of our operations. As new technologies appear—continuous reactors, digital QC platforms, sealed sampling systems—we adopt and test in parallel, but never at the expense of material traceability or batch retention.

    Customer Support Beyond the Sale

    Some industry players finish the sale and move on, but years of real experience confirm that after-sales support is where reputations are built—or lost. Our customer support includes guidance for storage practices, technical use advice, and repeat sampling driven by user feedback. Many of our strongest business relationships started with a troubleshooting call, not an automated order. Sometimes that support means rapid batch replacement in the wake of a shipping miscue, or collaborative troubleshooting when a customer’s process hits a snag. We aim to build the same trust and technical backbone we would expect ourselves, had the roles been reversed.

    Future Applications and Industry Development

    Market interest in 2-Methylpyrazine continues to reach beyond traditional flavoring—emerging uses show up in smart packaging, where sensor technologies harness its volatility; others look to its structural backbone in the search for new pharmaceutical intermediates and synthetic building blocks. These applications raise new quality requirements, so we engage with R&D departments to co-develop new grades or adjust specifications where it makes sense. We treat every novel application as an opportunity to learn, adapt, and grow, helping shape an industry that remains at the cutting edge of both chemistry and practical manufacturing expertise.

    Why We Keep a Practical Perspective

    Manufacturing 2-Methylpyrazine goes far beyond technical recipes or rote specifications. It draws on the collective lessons our teams have gathered, the challenges we’ve survived, and the partnerships we have built along the way. Every bottle, drum, and container shows the sum total of those lessons, and we stand by this material with the practical knowledge only direct manufacturing can provide.