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2-Methyleneglutaronitrile

    • Product Name 2-Methyleneglutaronitrile
    • Alias 2-Methylidenepentanedinitrile
    • Einecs 'EINECS 214-263-5'
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    889494

    Cas Number 1507-26-4
    Molecular Formula C6H6N2
    Molecular Weight 106.13 g/mol
    Appearance Colorless to yellowish liquid
    Boiling Point 232-233 °C
    Melting Point -25 °C
    Density 1.02 g/cm³ at 20 °C
    Refractive Index 1.4620 at 20 °C
    Flash Point 108 °C (closed cup)
    Solubility In Water Slightly soluble

    As an accredited 2-Methyleneglutaronitrile factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 2-Methyleneglutaronitrile, 500g: Supplied in a tightly sealed amber glass bottle with hazard labeling, ensuring protection from light and contamination.
    Shipping 2-Methyleneglutaronitrile should be shipped in tightly sealed containers, protected from moisture, heat, and ignition sources. It is classified as a hazardous material and must comply with relevant regulations, including proper labeling and documentation. Transportation should be by a licensed carrier experienced in handling chemicals, ensuring safety and environmental protection during transit.
    Storage 2-Methyleneglutaronitrile should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible materials such as strong acids, bases, and oxidizers. Keep the container clearly labeled and protected from light and moisture. Use secondary containment to prevent leaks or spills, and store at ambient or recommended temperature per supplier specifications.
    Application of 2-Methyleneglutaronitrile

    Applications of 2-Methyleneglutaronitrile in Industrial Manufacturing

    2-Methyleneglutaronitrile serves as a strategic intermediate for specialty polymer and fine chemical manufacturers, supporting advanced molecular design in controlled industrial settings. We supply this material directly from our production facility, addressing the needs of established downstream process leaders with tight control of quality, specification, and traceability.

    1. Production of Specialty Polyamide Monomers

    Leading polyamide producers incorporate 2-Methyleneglutaronitrile as a chain extender or precursor in the synthesis of high-performance polyamides, especially for applications requiring custom thermal and mechanical properties. The nitrile functionality improves molecular rigidity and chemical resistance. Operators maintain closed-system processes to contain volatility and ensure consistent conversion. Polyamide manufacturers control purity thresholds and adjust ratios depending on targeted end-use functionalities such as barrier films or engineering plastics.

    Industry compliance standards

    • ISO 9001:2015 Quality Management Systems
    • REACH (EC 1907/2006) Registration for polymer raw materials
    • EU Regulation (EU) No 10/2011 for polyamide food-contact materials (when intended for food packaging grades)
    • UL Yellow Card for flame-retardant plastics (select finished grades)

    Typical usage ratio

    • 5–15 wt% as a monomer additive, adjustable based on desired polymer backbone structure and molecular weight control; higher levels used in copolymer settings for increased rigidity

    Downstream process integration

    • Metered addition at the monomer synthesis stage before polycondensation; integrated with dicarboxylic acid or diamine reactants in solvent or melt-phase processes

    Final product types

    • High-barrier polyamide packaging films
    • Glass fiber-reinforced automotive parts
    • Engineering thermoplastics for electrical insulation

    2. Synthesis of Active Pharmaceutical Ingredient (API) Intermediates

    Pharmaceutical companies rely on 2-Methyleneglutaronitrile as a critical building block in the synthesis of certain API intermediates, supporting efficient formation of heterocyclic scaffolds. Fine chemical production units ensure material traceability and validated purification at this step. Its bifunctional structure enables selective reactions, reducing side-product formation during multi-step processes. GMP-compliant facilities prioritize impurity profiling and batch record integrity due to the intermediate’s downstream regulatory impact.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice Guidelines for Active Pharmaceutical Ingredients
    • US FDA CFR Title 21 Part 210/211 for API intermediates handling
    • EU GMP Annex 8: Sampling of starting and packaging materials
    • USP–NF monograph references for related intermediates where applicable

    Typical usage ratio

    • Stoichiometric addition (1.0–1.2 equivalents) in the specific intermediate synthesis step; exact ratio determined by molecular target and yield optimization studies

    Downstream process integration

    • Fed into high-performance batch reactors during the construction of heterocyclic or dinitrile intermediates; material enters prior to cyclization, amidation, or nitrile reduction steps

    Final product types

    • Pyridine-based API intermediates
    • Specialty amine and amide intermediates for patented drugs
    • Building blocks for CNS and cardiovascular therapeutics

    3. Precursor for Industrial Crosslinking Agents

    Coatings, adhesive, and elastomer manufacturers use this nitrile compound as a precursor for synthesizing advanced crosslinking agents. Its unsaturated structure introduces controlled crosslinked domains, improving thermal stability, chemical resistance, and dimensional control in formulated systems. Facilities adapt the ratio of this intermediate in resin and oligomer synthesis stages according to final end-use durability requirements.

    Industry compliance standards

    • ISO 14001:2015 for Environmental Management in chemical synthesis
    • ASTM D3960: Standard Practice for Determining Volatile Organic Compound (VOC) Content of Paints and Coatings
    • REACH Annex XVII for hazardous substance restrictions
    • UL GREENGUARD Gold certification pathway for indoor air applications

    Typical usage ratio

    • 3–10 wt% in crosslinker formulations; adjusted for network density and viscosity targets within acrylic and epoxy matrix resins

    Downstream process integration

    • Introduced at the oligomerization or prepolymer synthesis phase; reacts under controlled conditions with acrylate or isocyanate-functional intermediates to generate crosslink-active agents

    Final product types

    • High-performance industrial coatings
    • Multi-part epoxy adhesives
    • Specialty thermoset elastomers for gaskets and seals

    4. Manufacturing of Agrochemical Synthesis Intermediates

    Producers of advanced crop protection agents utilize 2-Methyleneglutaronitrile in the construction of dinitrile and heterocyclic intermediates critical for selective herbicide and fungicide molecules. Quality assurance protocols emphasize low residual solvent content and precise batch control for downstream reaction efficiency. Integration typically occurs in the early-stage assembly of the target molecule’s core scaffold, impacting the bioactivity spectrum and environmental stability of the final agrochemical formulation.

    Industry compliance standards

    • OECD Principles of Good Laboratory Practice (GLP) for agrochemical development
    • FAO/WHO Joint Meeting on Pesticide Specifications (JMPS) requirements
    • ISO 9001:2015 for production traceability
    • REACH Annex II for extended safety data sheet (eSDS) provisions

    Typical usage ratio

    • 5–12 wt% in intermediate generation step; ratio adjusted according to molecular design and yield maximization in bulk batch or semi-batch reactors

    Downstream process integration

    • Fed into early-stage condensation or cycloaddition reactions, forming the reactive dinitrile or heterocyclic nucleus; followed by functional group modifications requisite for target selectivity

    Final product types

    • Active ingredient intermediates for triazine herbicides
    • Pyridine-based fungicide precursors
    • Building blocks for insecticide R&D candidates

    5. Fine Chemical Synthesis for Specialty Additives

    Manufacturers of specialty chemical additives employ this intermediate in the tailored production of modifiers for lubricants, fuel additives, and plasticizers. Its reactivity and bifunctional groups support fine-tuned molecular transformation, ultimately improving performance features such as oxidation resistance and migration control in resultant additives. Process chemists track conversion rates closely to minimize by-products and meet client-specific purity benchmarks.

    Industry compliance standards

    • ISO 9001:2015 Certification for documented manufacturing processes
    • Compliance with TSCA Inventory (US) for specialty additives
    • REACH Registration and CLP Regulation (EC) No 1272/2008 labelling
    • SAE J312 Standards for engine oil additives (where used in automotive lubricants)

    Typical usage ratio

    • 2–8 mol% as a reactive intermediate, depending on additive molecular design and targeted functionality; increased ratios for viscosity modifier applications

    Downstream process integration

    • Engaged during core synthesis steps as a reactive intermediate, followed by purification and further derivatization to achieve the target additive’s performance specifications

    Final product types

    • Antioxidant additives for industrial lubricants
    • Custom plasticizer esters for flexible PVC
    • Fuel performance enhancers for low-emission technologies
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    Certification & Compliance
    More Introduction

    2-Methyleneglutaronitrile: Proven Performance from a Dedicated Chemical Manufacturer

    Experience Behind Every Drum

    Working in chemical synthesis doesn’t leave room for runarounds or half-answers. Over years of producing high-purity organic nitriles for both established firms and R&D labs, we’ve learned the importance of reliability and consistency in substances like 2-Methyleneglutaronitrile (2-MGN). Every batch carries the same care for reproducibility that we would expect ourselves, knowing how one deviation can snowball through a production line.

    2-Methyleneglutaronitrile: What Sets It Apart

    2-Methyleneglutaronitrile has drawn increasing attention within the specialty chemical community. Its five-carbon backbone, double bond at the 2-position, and terminal dinitrile groups create a unique molecular structure that brings valuable reactivity—not offered by the far more common glutaronitrile or adiponitrile. This product stands out in applications demanding a controlled methylene function next to the nitrile: a subtle feature that opens up specific polymerization, crosslinking, or intermediate possibilities, which is critical for customers working on engineered plastics and fine chemicals.

    Specifications Matter—And They’re Earned in Practice

    Volume manufacturers don’t have the luxury of “close enough.” We guarantee a minimum purity level with every shipment, which isn’t just a claim on paper but the outcome of procedures refined over years of continuous production. Our analytical team battles trace impurities, including possible hydrolysis products and unexpected double-bond isomers. Each batch submits to precise GC and NMR scanners for composition clarity, so the product arrives as expected, supporting demanding applications like monomer synthesis, specialty resin production, and even some pesticide active ingredient manufacture.

    We offer our standard model at industrial scale, suitable for thousands of tonnes per annum output. Physical properties get tightly monitored. Boiling point, density range, and moisture content all fall within published ranges, but we don’t rely on book values alone. We operate in both large and small lots to serve both full-volume converters and agile R&D clients who need a kilo to test a formulation before scaling up.

    Real-World Uses: More Than a Building Block

    Project managers and plant chemists bring up 2-Methyleneglutaronitrile not just for its dual nitrile groups but also for the uniquely reactive methylene bridge. In practice, this enables precise crosslinking and branch formation in specialty polymer applications, and that specificity can’t be matched by glutaronitrile, succinonitrile, or adiponitrile, which lack the same methylene reactivity. Companies targeting high-end engineering plastics often report notable property improvements when using 2-MGN-derived monomers; better impact resistance, distinctive flexibility, and increased thermal tolerance stem from the backbone modifications this molecule supports.

    For intermediates, 2-Methyleneglutaronitrile’s structure enables tailored modifications in custom synthesis—something seasoned development chemists appreciate. Its reactivity stands out in the creation of heterocyclic compounds, which find their way into advanced coatings, agricultural chemistries, and pharmaceutical pipelines. In every case, reliability and transparency from the producer matter at least as much as molecular performance. Those who have wrestled with unreliable sourcing or sub-spec materials know the headaches: jams in column chromatography, off-color batches, and erratic yields.

    Quality Drives Innovation: Consistency Is Not a Buzzword Here

    We have run production tracks where downstream outcomes change dramatically due to variations in incoming 2-Methyleneglutaronitrile. Minutes spent double-checking reactions, wasting time on failed purifications, or chasing root causes daily—these are frustrations our customers avoid. With tight control over water content and double-bond purity, reactivity stays constant. No operator wants to start an overnight reaction, only to find that a hidden contaminant causes byproducts nobody can filter away. Our on-site testing lab identifies these risks before customers ever load the reactor.

    Feedback from the Field

    Large resin manufacturers have repeatedly shared data showing higher yield rates after switching to our grade of 2-Methyleneglutaronitrile. Feedback from independent coating developers highlights the clean reactivity profile, which saves both solvent and time in their pilot batches. Even in more niche applications—advanced adhesives, for example—the precision offered by the methylene group at the 2-position leads to stronger, longer-lasting bonds at workable cure temperatures. The product’s behavior under cationic and radical initiation supports a wider formulation window, which suits both high-throughput lines and experimental research alike.

    Why 2-Methyleneglutaronitrile Instead of the Alternatives?

    A question from clients frequently comes up: why specify 2-Methyleneglutaronitrile over simpler dinitriles or more common molecules? The answer lies with structure-activity relationships. Adiponitrile contains two more methylene units, but lacks the reactive unsaturation; this limits its cross-linking ability and versatility in specialty syntheses. Glutaronitrile, so often used as a base chemical, has its place, but falls short where targeted modification is required. 2-MGN’s conjugated methylene group opens synthetic routes and generates physical properties that neither glutaronitrile nor adiponitrile can provide. In several well-published research and patent filings, its role isn’t just as another building block—it’s the difference-maker behind novel performance in polymers and heterocyclic rings.

    Safe Handling: Protecting Workers and Output

    Production sites operate most smoothly when raw material risks are known. 2-Methyleneglutaronitrile isn’t a household name, and it demands respect in containment and handling. We’ve built practices that recognize its volatility and toxicological characteristics, with full process enclosure, exhaust management, and user-level controls. Instructions go beyond minimum paperwork, because keeping the material in specification is as important as keeping team members protected. Any deviation, whether from storage temperature spikes or cross-contamination, can degrade product quality as quickly as it affects safety.

    Supply Chain Control Means Lower Downtime

    With experience in direct manufacturing, we can say changes in supplier behavior telegraph downstream fast. Shortages, long delays, or corner-cutting to squeeze additional volume often backfire, causing costly plant stoppages. We maintain control over each step: starting materials, in-process purification, and finished goods storage, reducing the drama that haunts contract buyers. Inventory levels track against customer schedules, not market speculation. For end-users, this means less line idling and fewer last-minute reformulations—a lesson learned during sudden global logistics problems in recent years.

    Supporting New Product Development

    Labs developing emerging coatings, adhesives, and resin chemistries use 2-Methyleneglutaronitrile as a foundation for performance breakthroughs. We work directly with formulating chemists who share early feedback and request quick model shifts—smaller lots or pilot-scale runs. Advanced polymer engineers return for support as they tweak initiator systems, reaction conditions, or post-treatment protocols. We see iterative improvements firsthand, where a small adjustment in 2-MGN feedstock quality can raise sticker shock during a trial—but deliver tenfold returns down the line in stability, clarity, or resistance testing. The product’s sharp reactivity enables new molecular architectures, many of which become tomorrow’s market leaders.

    Environmental and Regulatory Responsibility

    Regulatory demands evolve, especially regarding organic intermediates. We’ve experienced an uptick in customer questions about traceability, registration, and residual contaminant levels. Our compliance team draws on firsthand experience working through REACH, TSCA, and other global chemical compliance systems. Reporting and documentation require more than passing audits. Our onboarding process covers every relevant detail for environmental and occupational health impact—upstream and downstream. Quality control includes not just batch certifications but routine checks against regulatory triggers for environmental release, which supports customer submissions and responsible handling throughout the supply chain.

    Ongoing Process Improvement

    Continuous improvement isn’t a slogan inside the control room. Operators run shifts that track real-world yield improvement by fine-tuning catalyst inputs, solvent recovery systems, and waste minimization practices. We invest in maintenance, automation, and small pattern changes that may seem invisible from the outside, but show up as higher-purity product, fewer out-of-spec drums, and less process waste. Failures get logged, root causes sought, and solutions implemented—not papered over. This approach pays off as customers report greater batch-to-batch consistency in reactivity and appearance.

    Comparing 2-Methyleneglutaronitrile to Other Common Nitriles

    Comparisons help clarify why formulators turn to 2-Methyleneglutaronitrile despite its specialty status. Adiponitrile, for example, appears in simple nylon synthesis, where bulk pricing and volume dominate, but can’t support the tailored physical characteristics our end-users require. Glutaronitrile and succinonitrile have utility in solvents and plastic intermediates, with established positions in commodity manufacture, but neither offers the reactive handle needed to customize branching or rigidity in higher-value materials. The methylene group in 2-MGN anchors multiple synthetic pathways: it enables cyclization, crosslinking, and site-specific substitution. The difference translates into better performing plastics, coatings with sharper property profiles, and active intermediates with fewer side reactions.

    True-to-Spec Supply: Lessons Learned Across Years

    Fast growth brings its own challenges. We’ve scaled up from kilo-lab glassware into full plant campaigns by gradually increasing batch size, adjusting reflux, and automating unit operations. Each jump brings the risk of carrying over trace process impurities, which surface during final analysis or—worse—at a customer’s plant. Our team has worked through unforeseen results, from variable color bodies popping up in large drums to subtle shifts in GC retention. Every time a plant trial called for urgent root-cause tracking, we learned the value of identifying and eliminating sources of inconsistency. Today’s production lines benefit from those stories—helpful not because they showcase perfection, but because they show how continuous feedback and teamwork deliver real improvements.

    Partnering With Users: Collaborative Problem-Solving

    Our relationships with clients go beyond sales. We have been called in for troubleshooting when a batch fails unexpectedly or a downstream application creates an anomaly. Sometimes customers need three-lot comparison samples delivered in days, not weeks, to identify whether a new property comes from the base chemical or from a change in catalyst. Experienced eyes recognize the difference a subtle purity increase brings, saving whole workdays in rework and retest. Chemists in the field often return with ideas for process changes that cascade all the way back to starting material drumming. Sharing knowledge, testing alternative purification routes, or scheduling short-order customizations for stretch projects—these actions all come from a hands-on approach as a manufacturer, not a middleman.

    Supporting R&D: What Product Developers Get From Manufacturer Insight

    New ideas often arrive from bench scientists looking for that extra reactivity or selectivity missing in existing dinitriles. Out of many conversations, we’ve learned the practical importance of consistency: the repeatable reactivity of 2-Methyleneglutaronitrile allows confident scaling from gram-scale flask to multi-ton reactor. Early-stage research groups explore structure–activity relationships using our low-size lots; the lessons discovered there feed upgrades to the quality control regime. The line-level feedback loop closes the gap between pilot work and commercial success. Our familiarity with downstream challenges gives a real-world advantage to clients—knowing how changes upstream can help or hinder a bigger rollout.

    Operational Resilience: Weathering Market Jumps

    Raw material prices fluctuate, and logistics headaches never disappear. Having direct control over raw sources, process management, and scheduling protects our customers from the roller coaster that can hit buyers relying on outside aggregators. During global events that have upended transportation and regulatory environments, we have kept shipments moving and quality standards high. Our logistics team works as an extension of the production crew, communicating supply chain challenges and updating customers honestly. Downtime at our facility means downtime for you—so production planning, inventory management, and emergency protocols stay tight. Those who lived through unexpected shortages in recent years know how this vigilance impacts their own business security.

    Looking Forward: Challenges and Solutions in 2-Methyleneglutaronitrile Production

    No product exists in a vacuum. Environmental standards, emission controls, and new safety findings push development forward. Energy efficiency and solvent recovery are at the center of process updates on our site; each improvement supports lower carbon footprints and healthier operating environments. Closed-loop production systems shrink waste output and maximize usable yield. Consistent product at lower environmental cost is not just an aspiration—it’s the day-to-day work of chemical manufacturing. As regulatory frameworks grow stricter, the combination of experience and steady refinement of procedures helps manufacturers like us stay ahead, securing both compliance and operational reliability.

    Summary: Product With a Track Record, Manufactured With Integrity

    Chemical manufacturing rewards those who pay attention to detail, think ahead, and stay honest in communications. 2-Methyleneglutaronitrile, with its critical role in specialty polymers, coatings, adhesives, and advanced synthetic intermediates, represents both an opportunity for innovation and a test of manufacturing diligence. Over many cycles of production, feedback, troubleshooting, and improvement, we’ve built a product that delivers not just on specification sheets, but in the labs and plants that depend on it. Our experience and responsiveness allow users to pursue new applications without worrying about the headaches that come from unreliable sourcing or inconsistent quality. The quiet confidence earned in process lines, not in boardrooms or conference booths—this is what defines genuine producer-driven chemical supply.