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2-Methyl-4-Nitrophenol

    • Product Name 2-Methyl-4-Nitrophenol
    • Alias p-Nitro-o-Cresol
    • Einecs 221-836-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    719841

    Cas Number 88-75-5
    Molecular Formula C7H7NO3
    Molecular Weight 153.14 g/mol
    Appearance Yellow crystalline powder
    Melting Point 97-99 °C
    Boiling Point 357 °C at 760 mmHg
    Solubility In Water Slightly soluble
    Density 1.34 g/cm³
    Purity Typically ≥98%
    Refractive Index 1.632
    Flash Point 159.4 °C
    Synonyms 2-Methyl-4-nitro-phenol, 4-Nitro-o-cresol

    As an accredited 2-Methyl-4-Nitrophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle, 100 grams, sealed cap. Label: "2-Methyl-4-Nitrophenol," CAS, hazards, supplier logo, and handling instructions.
    Shipping **Shipping Description for 2-Methyl-4-Nitrophenol:** 2-Methyl-4-Nitrophenol should be shipped in tightly sealed containers, clearly labeled, and protected from light and moisture. Handle as a hazardous chemical; use appropriate secondary containment, avoiding excessive heat and physical shock. Comply with local, national, and international regulations regarding the transport of toxic and environmentally hazardous substances.
    Storage 2-Methyl-4-Nitrophenol should be stored in a cool, dry, and well-ventilated area, away from sources of ignition, heat, and direct sunlight. Keep the container tightly closed and clearly labeled. Isolate from incompatible materials such as strong oxidizing agents and acids. Use chemical-resistant containers, and ensure all storage complies with local regulations for hazardous chemicals.
    Application of 2-Methyl-4-Nitrophenol

    Applications of 2-Methyl-4-Nitrophenol in Industrial Manufacturing

    2-Methyl-4-Nitrophenol serves as a specialized intermediate across several chemical manufacturing sectors. As a raw material producer, we support high-purity requirements and process integration for major industrial transformations. Below we outline four distinct downstream applications along with detailed regulatory, formulation, processing, and final product information for each sector.

    1. Agrochemical Synthesis: Selective Herbicide Intermediates

    Major agrochemical companies employ 2-Methyl-4-Nitrophenol in the synthesis of selective phenolic herbicides. This material enters as a key aromatic precursor during multi-stage processes to produce active molecules such as fluroxypyr and related pyridyloxy acid herbicides. Manufacturers must control both feedstock purity and reaction conditions to avoid the formation of undesired byproducts impacting herbicidal activity and registration standards.

    Industry compliance standards

    • FAO/WHO Specification for Plant Protection Products
    • OECD Good Laboratory Practice (GLP) for pesticide development
    • EU Regulation (EC) No 1107/2009 for Plant Protection Products
    • US EPA 40 CFR Part 158 data requirements

    Typical usage ratio

    • Up to 1.0–1.2 molar equivalents per mole of target herbicidal acid, with adjustment based on stoichiometric yield and batch process scale

    Downstream process integration

    • Introduced in the aromatic nitration and etherification steps of pyridyloxy acid synthesis
    • Subject to hydrogenation and coupling reaction pathways
    • In-process quality controls for residual nitro content and aromatic substitution
    • Coordination with downstream crystallization and formulation stages

    Final product types

    • Fluroxypyr active ingredient
    • Formulated herbicide EC, SC, or WP
    • Pre-mix combination products for cereal and broadleaf weed management
    • Custom synthesis intermediates for R&D pipeline

    2. Pharmaceutical Intermediate: Analgesic and Antipyretic APIs

    2-Methyl-4-Nitrophenol acts as an advanced intermediate in the synthesis pathway of specific antipyretic and analgesic pharmaceuticals. Its nitrated phenolic moiety supports further reduction and condensation reactions critical to assembling complex heterocyclic drug structures. The pharmaceutical sector demands low impurity profiles and strict analytical controls to meet pharmacopeia specifications for downstream API production.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients
    • US Pharmacopeia (USP) monographs for related APIs
    • European Pharmacopoeia (Ph. Eur.) for purity and residual limits
    • 21 CFR Part 210/211 GMP for finished drugs

    Typical usage ratio

    • 0.8 to 1.1 equivalents per target molecule, adjusted according to yield optimization and impurity minimization studies

    Downstream process integration

    • Reductive transformation to aminophenol intermediates
    • Condensation with carboxylic acids or heterocyclic reagents for final API synthesis
    • Inline HPLC and GC analysis for residual nitro and organic impurities
    • Integrated waste management for nitrated co-products

    Final product types

    • Pharmaceutical-grade aminophenol intermediates
    • Antipyretic API such as acetaminophen derivatives
    • Combined analgesic tablet formulations
    • API supply for OTC and prescription medicines

    3. Dye and Pigment Manufacturing: Metal Complex Dye Production

    The dye and pigment segment utilizes 2-Methyl-4-Nitrophenol in the formation of special azo and metal complex dyes. The compound’s phenolic structure provides essential resonance stabilization and coloration properties for dyes targeted at leather, textile, and specialty ink applications. Manufacturers focus on achieving precise hue characteristics, fastness properties, and compliant discharge of process effluents.

    Industry compliance standards

    • ZDHC MRSL (Zero Discharge of Hazardous Chemicals Manufacturing Restricted Substances List)
    • ISO 9001:2015 Quality Management Systems for pigment manufacture
    • OEKO-TEX Standard 100 for textile dyes
    • REACH Annex XVII for azo dye hazardous substance control

    Typical usage ratio

    • Typically 0.5–1.0 molar equivalents relative to diazonium component, with precise ratio adjusted for color intensity and depth

    Downstream process integration

    • Coupling with diazonium salts during azo dye formation
    • Application of chelation with transition metals for metal complex dyes
    • Color matching and filtration for end-use specifications
    • Effluent treatment for nitroaromatic process streams

    Final product types

    • Leather and textile dyes with enhanced fastness
    • Specialty inorganic pigments for plastics
    • Mixed-metal complex dyes for printing applications
    • Color additives for industrial coatings

    4. Chemical Research & Fine Chemicals: Aromatic Nitration Studies

    Advanced laboratories and fine chemical producers include 2-Methyl-4-Nitrophenol in aromatic nitration research and high-value reference compound synthesis. Its well-defined structure and labeling suitability make it a valuable substrate for reaction mechanism studies, trace analytical standards, and tailored molecular building blocks. Consistent batch reproducibility and traceability support regulated contract synthesis and academic research environments.

    Industry compliance standards

    • ISO 17025 accreditation for testing and calibration laboratories
    • GLP compliance for regulatory submissions and controlled studies
    • Responsible Care Management System certification in fine chemical production
    • Specific project-based analytical protocols for purity

    Typical usage ratio

    • Quantities determined by synthetic route design; generally, 0.1–5.0 grams per research batch, scaled up to 10–100 grams for reference grade or pilot-scale applications

    Downstream process integration

    • Employed as a starting material for selective substitution or reduction
    • Serves as a matrix for mechanistic labeling in spectroscopic studies
    • Integrated with chromatography and mass spectroscopy workflows
    • Batch documentation and sample tracking for regulatory audits

    Final product types

    • Reference standards for analytical laboratories
    • Custom-synthesized fine chemicals and intermediates
    • Labeled isotopic markers for mechanistic studies
    • Specialty compounds for contract research
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    Certification & Compliance
    More Introduction

    2-Methyl-4-Nitrophenol: Direct from Our Manufacturing Process

    We understand the significance of transparency in chemical manufacturing. Years of experience on the production floor have shaped our approach toward compounds like 2-Methyl-4-Nitrophenol—a specialty intermediate whose versatility remains crucial for durable applications. The compound, distinguished by a pale-yellow crystalline appearance and an unmistakable sharp scent, has been developed and refined through repeated efforts to improve consistency and reliability in each batch that leaves our facility.

    What Sets 2-Methyl-4-Nitrophenol Apart?

    Our process starts with highly controlled nitration of the methylphenol backbone. This attention at the earliest stages drives purity above 99.5% on a consistent basis. We regularly monitor melting point and ensure its sharp onset—indicative of controlled crystallinity and absence of byproducts that interfere downstream. High-performance liquid chromatography serves as a daily checkpoint in our facility; the clarity in chromatograms translates to cleaner reactions for our customers. Technicians do not cut corners with filtration: we run each lot through multiple passes and perform trace residue checks under UV to spot outliers before packaging begins. Years of experience have taught us which minor impurities prove problematic for applications that demand reactivity or stringent color control. By removing these at source, we minimize surprises for users.

    Our own research confirms that trace heavy metals, often a legacy of less-precise methods, linger in other market offerings. Such contaminants undermine catalyst life or dye performance for our industrial clients. Through targeted purification steps, our plant keeps heavy metal content below detectable limits. Routine spectrophotometry results bear this out, month after month.

    Focusing on Real-World Applications

    Every chemical plant faces pressure to supply more than just an item from a catalog. We track how 2-Methyl-4-Nitrophenol is actually used by our customers. This feedback drives our batch size and packaging decisions. For example, larger volumes keep polymer plants running cost-effectively, while smaller, sealed containers protect reactivity for specialty pharmaceutical labs. We do not sell one-size-fits-all units. Instead, we match granular delivery with customer processes, based on years of hearing where pain points appear along the line.

    In agricultural chemistry, our customers use 2-Methyl-4-Nitrophenol as a critical intermediate during synthetic steps. The nitro and methyl positioning offers selectivity rare in ortho- or para-nitrophenol isomers. Formulators have told us that the distinct profile of our product guarantees higher yield transformation into targeted active molecules. We’ve toured client production sites to see firsthand where fine-grade crystals ease solubility and reaction setup, cutting down unexpected halts or false positives in purity checks.

    Dye manufacturers demand high chromatic consistency. Our purification methods support this by removing trace aromatic tars that cause batch coloration shifts. Labs working with pigment synthesis recognize the difference right away. In our own application testing, ink samples exposed to direct sunlight retain brightness for longer when our material forms the core intermediate, compared to more generic grades sold as bulk import. The link between sourcing and product performance stands out clearly once you’ve seen production downstream at our scale.

    Pesticide research benefits from the reactivity-to-purity ratio in each lot. Unlike broader-grade materials, our uniform handling and transport avoid micro-contamination. Analytical feedback from partners highlights a reduction in unknown signals in spectral scans during formulation, thanks to our emphasis on source traceability.

    Experience Drives Improvements

    Decades of feedback from industrial buyers and lab specialists have influenced not just our production details, but also the way we document each lot. Testing reports accompany outgoing shipments, but we don’t rely on generic certifications. Instead of just stating “meets specifications,” our team records the granulometry, color index, and even specific UV-Vis cutoff—a detail picked up by customers as soon as they scale up.

    In technical support calls, synthesis teams often ask about solvent compatibility, especially for challenging steps in agrochemical and dye synthesis. Because our technicians run pilot reactions using end-user methods, we’re able to supply not just product, but practical advice based on real data, not marketing materials. We use the same material we sell in our own test benches to confirm reliability. If a solvent interaction produces unexpected byproducts, we adjust the workflow, not just the sales sheet. This feedback goes right back into process adjustment.

    For clients using 2-Methyl-4-Nitrophenol in scale-up scenarios, the thermal stability profile matters more than appearance. Since we constantly analyze DSC and TGA data, we understand where a lot might develop instability at elevated temperatures typical in large reactors. If necessary, we’ll hold back a shipment and reprocess rather than let a borderline batch into the field. Long-term relationships come from such decisions, even if it puts a squeeze on short-term margins. We track outlier incidents in a monthly review to avoid systemic production drift.

    Why Specifications Matter in the Real World

    Product brochures can make any intermediate seem interchangeable. In practice, we’re well aware of the nuisance caused by uncontrolled impurities during hydrogenation, nitration, or coupling reactions. Customers tell us that inconsistent feedstock slows R&D, causes spotty batch failures, or damages specialized reactor linings. The nitro group and methyl placement on our compound have proven, through our repeated bench testing, to provide a sweet spot of reactivity not found in either 2-methylphenol or in 4-nitrophenol alone. Choosing a clean, reliable source saves hours of troubleshooting and cuts unnecessary expenditure on purification downstream.

    Real production lines don’t pause for academic definitions. We see firsthand how upsets—even when involving parts-per-million contamination—can throw off high-throughput synthesis. Over the years, we have realized that customers working in pharma intermediates value a consistent melting point almost as much as HPLC purity—since it signals batch uniformity critical for patent filings or regulatory submissions. Our QA team takes this responsibility seriously. Every time an anomaly pops up in a test, it means a deep-dive into recent procurement of raw stock and review of process logs, not just a re-analysis. The follow-up doesn’t wait for someone to complain.

    Shipping conditions often go unmentioned in technical descriptions. Yet, in regions with wide temperature swings, careful packaging and temperature data-logging during transit reduce risks of clumping or degradation. We developed an internal protocol for packaging 2-Methyl-4-Nitrophenol after discovering that humidity spikes during ocean transit led to slight surface oxidation in early years. Since then, air-tight containers lined with moisture-absorbing material form our standard. If end users signal a sensitivity upstream (for instance, in pharma or electronics sectors), we match our shipment schedule to avoid the high-risk months and optimize for fast customs clearance at destination ports.

    Feedback-Driven Refinements

    Supply contracts often begin with tight technical negotiations. Over the years, direct conversations with production chemists and plant managers taught us that not every spec on a data sheet is equally important. Some worry about residual toluene; others focus on trace amines. Our process adapts to these real-world requests. For a major pigments manufacturer, a year-long collaborative project with us led to an improved final drying step that cut down residual solvent markers below industry norms. The client’s technical team received side-by-side color measurement charts from us before any final scale adoption. For a crop protection partner, we tweaked our oxidation kinetics profile, slowing the endpoint to prevent formation of minor aromatic aldehyde contaminants.

    End users rarely want a dry recitation of catalog numbers or shelf life guesses. They want assurances the material they receive this month will match what they purchased the year before, down to minute properties that influence their final application yield. Our batch sampling protocols stretch beyond industry minimums, especially before large scheduled shipments. Random selection and analytic cross-checking against long-term batch library samples keep our production from drifting. This extra step cuts down on troubleshooting field complaints, which often trace back to minor lot-to-lot shifts in competitor’s supply routes.

    Comparison with Similar Products and Market Options

    Comparisons to other phenolic compounds help clarify what makes 2-Methyl-4-Nitrophenol unique. Chemically, it offers a balance of hydrophobicity from the methyl group and electron-withdrawing character from the nitro substituent. Unlike 4-nitrophenol, it produces derivatives with lower water solubility and higher binding selectivity in coupling reactions. This trait matters in specialty intermediates for OLED and dye chemistry, where solvent compatibility can make or break final properties.

    From our plant floor experience, ortho isomers display significant volatility differences, affecting storage stability and practicality for shipment over long distances. Past batches of alternative isomers—sometimes requested by researchers wanting a comparison—have shown unexpected loss to evaporation or discoloration by the time products reach the customer. Such problems do not appear with our 2-Methyl-4-Nitrophenol, provided manufacturers adhere to our established storage guidelines.

    On the other hand, cheaper grades of para-substituted nitrophenols crowd the market, but consistently fail on purity or batch color index. We’ve observed competitor lots depositing brownish tar on glassware or leaving UV-Vis spectral tails unsuited for demanding synthesis. Such differences grow sharper under microscope analysis in our in-house labs. High-purity users—pharmaceutical, pigment, and intermediate compound manufacturers—repeatedly return once they realize the process advantages of super-clean, stable supply from a specialized manufacturer.

    Ongoing Quality Assurance and Traceability

    Traceability forms a cornerstone of our operations. Every batch of 2-Methyl-4-Nitrophenol can be traced back to specific precursor stocks, rechecked for consistency, and reviewed through archived chromatogram records. Direct involvement of our quality assurance teams means fewer gaps in documentation. Inspectors check not only for conventional metrics, like purity and moisture but cross-reference against archived customer feedback on each grade.

    Routine audits—internal and third-party—provide a second safeguard. On-site visitors often remark on our data tracking for incoming raw materials and outgoing product signatures. We go beyond minimum compliance not because of regulation, but because direct relationships with customers build long-term reliability. Repeat purchasers often cite the practicality of our lot documentation during their own quality audits, which keeps regulatory surprises to a minimum. Years of shared data support rapid troubleshooting if a client process ever throws a curveball.

    The Impact of Hands-On Support

    Our experience shows that prompt, concrete technical support makes the biggest difference during customer transitions or unexpected regulatory hurdles. Whether it’s scaling up a pilot to a full synthesis, troubleshooting a process upset, or adapting to new regional standards, our team works with real-time plant data to fine-tune advice. Any anomalies flagged during a scale-up trial—discoloration, altered melting point, trace gas emission—prompt a direct review of all preceding deliveries and process histories. Our on-site team does not rely on textbook answers, but instead searches for root causes based on physical investigation of reactors, solvents, and environmental factors.

    We continuously refine our supply chain and logistics based on tangible customer outcomes. Our staff track complaints and minor incidents, then compile root cause reports for continuous improvement. Over time, this approach slashes correction lead times and improves customer satisfaction ratings. We view these efforts not as add-ons, but as core elements of our business ethos, reflecting a recognition that chemical users—regardless of size—face real risks with every process adjustment or sourcing decision.

    Approach to Sustainability and Safety

    Handling compounds with active nitro and methyl groups requires discipline throughout the production cycle. We developed in-house safety protocols to restrict pathway contamination and reduce the risk of accidental arylation or nitro reduction during storage. Staff participate in regular hazard training, and plant operators run closeout safety reviews for every production shift. Spills and emissions come under constant scrutiny, with detection systems logging abnormal readings before they threaten overall batch integrity.

    Our sustainability efforts stem from the simple realization that cleaner manufacturing means fewer downstream liabilities for both us and our customers. We recover solvents carefully, recycle process water, and dispose of waste under tightly monitored conditions. Every incoming raw material is tracked for origin and compliance, discouraging shortcuts and lowering the risk of regulatory nonconformance.

    Industry Commitment

    2-Methyl-4-Nitrophenol’s utility hinges on predictable behavior in every step from synthesis to packaging to delivery. Our decades in the industry reinforce how much rides on the skill and diligence of people who oversee its production. We do not shy away from reformulating or retooling if it means removing a source of downstream nuisance for our partners. Our role does not end at dispatch; we collaborate on application trials, reformulation projects, and emergency troubleshooting. Clients who rely on stable intermediates in high-stakes industries—colorants, crop science, pharmaceuticals—know to expect more than just a shipment from us.

    Our reputation rests on standing behind every batch, not just in the numbers, but in ongoing support and continuous improvement. By listening to customer stories and always seeking technical feedback, we refine not just product but the whole ecosystem around it, delivering results that can be measured in real application yields, cleaner processes, and fewer headaches on the production line.