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2-Methyl-3-Nitroaniline

    • Product Name 2-Methyl-3-Nitroaniline
    • Alias 2-Methyl-3-nitrobenzenamine
    • Einecs 221-899-8
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    766885

    Cas Number 578-61-0
    Molecular Formula C7H8N2O2
    Molecular Weight 152.15
    Iupac Name 2-methyl-3-nitroaniline
    Appearance Yellow to orange solid
    Melting Point 73-76°C
    Solubility In Water Slightly soluble
    Smiles Cc1cccc(N)c1[N+](=O)[O-]
    Synonyms 2-Amino-6-nitrotoluene
    Pubchem Cid 68029

    As an accredited 2-Methyl-3-Nitroaniline factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle, tamper-evident cap, chemical-resistant label; contains 25 grams of 2-Methyl-3-Nitroaniline. Hazard and safety information included.
    Shipping 2-Methyl-3-Nitroaniline should be shipped in tightly sealed containers, clearly labeled, and protected from physical damage. It must be transported by trained personnel according to local, national, and international regulations for hazardous chemicals, specifically for toxic and potentially combustible substances. Avoid exposure to extreme temperatures, ignition sources, and incompatible materials during transit.
    Storage 2-Methyl-3-nitroaniline should be stored in a cool, dry, and well-ventilated area, away from sources of ignition, strong oxidizing agents, and direct sunlight. Keep the container tightly closed and properly labeled. Store in a chemical-resistant, compatible container. Use secondary containment to prevent spills. Ensure appropriate safety signage and limit access to trained personnel. Avoid physical damage and moisture exposure.
    Application of 2-Methyl-3-Nitroaniline

    Applications of 2-Methyl-3-Nitroaniline in Industrial Manufacturing

    As a dedicated manufacturer of 2-Methyl-3-Nitroaniline, we support downstream producers in multiple specialized sectors with application-focused expertise. Below, we detail real-world industrial scenarios in which this raw material plays a critical role, referencing standards, usage ratios, processing details, and typical end products.

    1. High-Performance Dye and Pigment Intermediate

    This compound serves as a key intermediate in the synthesis of certain azo and anthraquinone dyes required for technical textiles, automotive coatings, and specialty inks. Formulators select it for its electron-donating methyl group and nitro functionality, which contribute to high purity colorant properties and improved batch consistency in downstream azo coupling and reduction steps. Industrial processors integrate it directly during diazotization and subsequent coupling, maintaining stringent documentation and traceability from raw input to finished pigment dispersion.

    Industry compliance standards

    • OEKO-TEX® Standard 100 (for textile colorants)
    • REACH (EC) No 1907/2006 chemical registration and safety assessment
    • ISO 9001:2015 Quality Management in pigment production
    • GHS hazard and labeling compliance for colorant intermediates

    Typical usage ratio

    • Usually 3–8% of total pigment intermediate batch weight, adjusted according to target chromophore intensity and application (higher levels in technical textile dyes, lower in industrial inks)

    Downstream process integration

    • Charged at the primary aromatic amine preparation or diazotization stage; reactions conducted under controlled temperature and pH to ensure complete conversion to the desired colorant precursor

    Final product types

    • Reactive dyes for cellulose and wool textiles
    • Azo pigments for paints and printing inks
    • Colorants for plastic masterbatches
    • Surface coatings used in automotive and industrial equipment

    2. Active Pharmaceutical Ingredient (API) Synthesis Intermediate

    Pharmaceutical manufacturers include this material as a controlled intermediate in the synthesis of select heterocyclic APIs, particularly where methyl and nitro-substitution enhances reactivity for subsequent cyclization or reduction steps. Batch records must document identity and purity to meet regulatory verifications, and plant operators minimize cross-contamination by using closed-system charging in GMP-validated suites.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • 21 CFR Part 211 (USA)
    • European Pharmacopoeia (Ph. Eur.) monographs for intermediates
    • China GMP for Pharmaceutical Products

    Typical usage ratio

    • 1.5–6% of total wet reaction mass in heterocycle-forming processes, adjusted based on substrate and desired ring system

    Downstream process integration

    • Loaded during aromatic nitration or amidation step in multi-stage reactor trains; input tracked via batch-specific control systems and in-process chromatography

    Final product types

    • Synthetic intermediates for anti-infectives and antimicrobial APIs
    • Specialty fine chemicals for contract pharmaceutical manufacturers
    • Building blocks for research-scale medicinal chemistry
    • Intermediates for veterinary drug production

    3. Agricultural Chemical Synthesis (Herbicide and Fungicide Intermediates)

    This raw material acts as a precursor for synthesizing select nitrogen-containing heterocyclic compounds applied in modern agrochemicals. Its controlled reactivity under hydrogenation and cyclization creates high-yield intermediates for post-emergence herbicide and fungicide formulations. QC and technical teams ensure each batch is free from chlorinated or sulfur impurities that would compromise downstream field performance or regulatory audits.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • European Chemicals Agency (ECHA) Plant Protection Products Regulation (EC) No 1107/2009
    • ISO 17025 Laboratory Accreditation for pesticide manufacturing labs
    • Environmental Protection Agency (EPA) registration in the United States

    Typical usage ratio

    • 2–7% of total reaction mass depending on herbicide or fungicide selectivity, with dose calculated based on required substitution pattern and downstream process yield

    Downstream process integration

    • Added at the heterocycle construction stage or reduction stage in closed reactors with nitrogen blanketing; product transfer monitored to prevent exposure and environmental release

    Final product types

    • Key intermediates for post-emergence herbicides
    • Pre-cursors for systemic fungicides in cereal crop protection
    • Raw materials for custom agrochemical blends
    • Building blocks for growth regulator formulations

    4. Electronic Chemicals and High-Purity Material Applications

    The compound is specified as an intermediate in the synthesis of high-performance polymers and molecular dopants for advanced electronic components, such as OLEDs and specialty circuitry resins. Purity and trace metal levels directly impact dielectrics and color stability in downstream processes; therefore, the raw material’s lot control, pre-filtration, and analytical documentation are strictly enforced from incoming goods to final downstream blending.

    Industry compliance standards

    • IEC 60747-1 for semiconductor devices (chemical purity for electronic grade materials)
    • IPC-4101B for base materials in printed circuit manufacturing
    • RoHS Directive 2011/65/EU for hazardous substance limits
    • Cleanroom ISO 14644-1 for material handling

    Typical usage ratio

    • 0.2–3% in the polymer matrix, determined by specific required conductivity and optical properties of end electroluminescent materials

    Downstream process integration

    • Introduced at the pre-polymerization step, often dissolved or dispersed in high-purity solvents and filtered before copolymerization or formulation into oligomeric resins

    Final product types

    • High-purity dopants for OLED displays
    • Conductive polymers for microelectronics
    • Specialty adhesives for flexible circuit boards
    • Color filter materials for precision optoelectronics

    5. Specialty Chemical Synthesis for Analytical Reagents

    Research and analytical reagent producers employ this compound in the creation of fine chemicals and standardized test agents demanded in forensic, environmental, and biochemical analytical labs. The selective functional groups introduced serve as reference standards or detection agents, with every batch accompanied by lot-specific CoA and detailed impurity profiling to comply with trace analysis protocols.

    Industry compliance standards

    • ISO 17034 General Requirements for the Competence of Reference Material Producers
    • EN ISO/IEC 17025 for calibration and testing laboratories
    • US Pharmacopeia (USP) standards for analytical reagents
    • Hazard labelling per GHS for laboratory chemicals

    Typical usage ratio

    • Direct usage as a reference material or 0.1–2% in custom reagent formulations, depending on analytical detection limits and method validation needs

    Downstream process integration

    • Blended in final reagent or detection kit compounding under nitrogen or inert atmosphere to prevent chemical degradation; strict batch splitting for QA/QC sample reserves

    Final product types

    • Certified reference standards for chromatographic analysis
    • Colorimetric detection agents in environmental test kits
    • Fine chemical solutions for pharmaceutical and forensic laboratories
    • Analytical grade reagents for research institutes
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    Certification & Compliance
    More Introduction

    2-Methyl-3-Nitroaniline: What Sets Our Product Apart

    Our Experience with Manufacturing 2-Methyl-3-Nitroaniline

    Producing 2-Methyl-3-Nitroaniline over the years has taught us that attention to detail at every step brings real results for the end user. Here, quality means more than numbers on a certificate. For us, it comes down to how precisely we control the reaction conditions, how carefully we select our raw materials, and how strictly each batch matches the intended chemical profile.

    Chemical Profile and Key Properties

    2-Methyl-3-Nitroaniline (often referenced in labs and production lines as 2M3NA) carries the CAS registration familiar to chemists in the dye and pigment industry. Each molecule features a methyl group and a nitro group connected to an aniline ring. The difference this structure brings — compared to other methyl-nitroaniline isomers — lies in how it reacts in further synthesis, especially for coupling and diazotization procedures. Chemists prefer it when they need selectivity in downstream chemistry, without introducing unnecessary side-products.

    Our experience shows that strict control of moisture, temperature, and pH yields not just better purity but also reduces unwanted tars and polymeric byproducts. Chemically, you can expect a pale yellow to orange crystalline powder, with melting points and spectroscopic signatures that consistently fit the standards demanded by formulators. For those running quality control or scaling up for commercial dyes, every batch runs through gas chromatography and, if required, HPLC to confirm not only the assay but also the absence of troublesome trace contaminants.

    How 2-Methyl-3-Nitroaniline Finds Its Place in the Industry

    Most of our 2M3NA finds purpose in the synthesis of azo and anthraquinone dye intermediates. Research labs order the product for small-scale reactions, but we see large industrial operations as the mainstay—where the consistency of our material keeps each tank batch predictable, reducing waste and scrap pigment. Differences in performance may seem subtle, but switching sources mid-production can throw off the shade and solubility profile of complex dyes.

    If you work in organic synthesis, you have probably encountered situations where slight impurities in starting materials disrupt your process. We put a lot of effort into managing reaction exotherms and post-reaction washing steps so our product remains free from unreacted acid, halide residues, or heavy metals typically present from non-integrated manufacturing setups. This makes a difference for mid- and downstream transformations, whether you make pigments, rubber chemicals, or pharmaceutical intermediates.

    How Our Manufacturing Sets the Standard

    Our facility relies on stainless steel reactors designed to handle the energetic nitration steps without temperature swings. Raw aniline passes through pre-purification before nitration, so we don’t fight byproduct formation later. Each stage—nitration, methylation, and isolation—runs under continuous monitoring. This keeps color, reactivity, and flow properties within expectations, a significant benefit for formulators who need tight controls on their input reagents.

    We load finished product only after rigorous solvent removal, passing crystalline batches through vacuum ovens to limit moisture. Optical and chemical purity isn’t just about numbers; the true test comes from customer feedback. We track customer results over years—dye yields, batch consistency, clarity—so we can refine our parameters and anticipate what end users actually care about.

    Specifications that Matter in Everyday Operations

    Across industries, purchasing managers and lab techs pay close attention to melt point, purity by HPLC or GC, trace metals, and solvent residue levels. Typical specifications include a melting range closely matching literature values, with purity reaching above 98 percent by normalized area integration. Trace iron, chlorides, and organic solvents are kept low, minimized by a combination of thorough washing and atmospheric controls during production and storage.

    Particle size plays a role for those charging 2-Methyl-3-Nitroaniline straight to reactors or using automated feeders. From our side, we screen each batch, passing material through standardized sieving protocols so flow, handling, and dispersion stay reliable, even in bulk, giving paint and coating manufacturers less dust, clumping, or loss during charging. End users commonly report improved handling compared to some older, unoptimized batches on the market.

    Safety and Handling Awareness Built from the Shop Floor

    Some raw materials, handled carelessly, lead to long-term headaches—either through dust nuisance, trace fumes, or unstable storage. We run a closed charging system at every stage, with dust capture and fume abatement to keep things tidy and low-risk for both the workforce and the end product. Regular training sessions ensure our team remains familiar with the unique reactivity of nitroaniline derivatives, minimizing exposure and keeping quality consistent. Shipments go out only after we check, every time, that containers remain sealed and uncontaminated.

    What Sets 2-Methyl-3-Nitroaniline Apart from Similar Compounds

    Comparisons come up most between 2M3NA and its isomeric relatives, especially 4-Methyl-3-Nitroaniline or 2-Methyl-4-Nitroaniline. Their impact downstream rarely matches in synthesis applications. The methyl and nitro groups in the 2,3-positions give a unique activation pattern in electrophilic aromatic substitution, leading to dyes and pigments with shades or fastness you don’t get from other isomers. Chemists working in pharmaceutical or pigment intermediates have reported clean reactions, better conversion rates, and less frequent filtration problems when they switch from less pure, poorly controlled versions or alternative isomers.

    Competitor samples, sourced from smaller plants or brokers, sometimes come with higher tars or batch-to-batch drift. This disrupts in-plant blending and can force process tweaks at a late stage. We’ve tackled these challenges through continuous improvement: shifting from batchwise to semicontinuous operation, tighter filtration, and strict in-process analytic controls, so our product runs cleaner across different orders, year after year.

    Application: A Day in the Life with 2-Methyl-3-Nitroaniline

    Dye manufacturers using our 2-Methyl-3-Nitroaniline see improved predictability when making reactive dyes. In beta-naphthol coupling, the resulting azo compounds show higher color strength, with more consistent fastness. In pigment synthesis, purity translates into easier purification steps and sharper chromaticity. You can tell the difference in the filter cake — less sludge, fewer fines, and a smoother filtration profile.

    Pharmaceutical intermediate makers report better reactivity when introducing the nitroaniline fragment onto a core scaffold. Less batch-to-batch drift means regulatory filings go more smoothly, since the impurity profile remains within filed limits, reducing the need for requalification and keeping production timelines on track.

    Continuous Improvement and Customer Collaboration

    We don’t run manufacturing in isolation. Our team collaborates with pigment, dye, and pharmaceutical makers, reviewing not just specification sheets, but also customer process data and feedback on individual batch results. Many times, changes in downstream process conditions—solvent choice, pH, or temperature—lead to customer inquiries about input quality. By sharing technical observations and real process histories, we work through tweaks in purification steps or discuss tighter controls on certain contaminants that influence the user’s product quality.

    One example: customers asked about occasional pink tints in their final product. Working together, we traced this back to trace nitrosamine formation due to extended residence time in the nitration step. By tuning time and agitation speeds, monitoring online every shift, we reduced these formation risks without sacrificing yield, lowering complaint rates and bringing consistency batch after batch.

    Packaging, Storage, and Logistical Reliability

    2M3NA needs careful packaging in airtight, light-resistant containers. Moisture changes not only the handling but also the suitability in final applications. We use triple-layer bags for most shipments, loading them into sturdy drums to prevent breakage and minimize exposure. Warehouse monitoring involves hygrometers and periodic retesting, both for bulk and packed goods. Users rarely find caked material due to high humidity or crumbly product from temperature swings.

    Having own warehousing near major ports cuts down on lead times and spoilage risks, giving buyers flexibility in planning. Scheduled deliveries, matched to production cycles, take stress off our customers’ planning teams, whether they operate single-reactor pilot plants or 100-cubic-meter continuous lines.

    Environmental and Worker Health Responsibility

    Producing nitroaniline derivatives comes with environmental obligations. We maintain waste treatment units on-site, preventing nitroaromatic residues or process water from entering public drains. Ongoing monitoring draws from years of local regulatory engagement and direct relationships with environmental testing labs. Operators check effluent at set intervals, and we invest in process automation to minimize manual handling—the result is lower personal exposure and better long-term worker health.

    Dust controls and regular equipment maintenance reduce chances of exposure incidents. New hires undergo chemical safety training before entering production areas. Health checks and process upgrades—like better enclosures and more responsive process controls—improve both output and safety metrics over time.

    Beyond Chemicals: Supporting User Innovation

    Plenty of users develop custom processes requiring not just high-purity starting material but a strong technical partner. Some bring us new applications, like filtration aids for specialty processes or advanced colorants for the next generation of flexible plastics. We run side-by-side tests, open lab notebooks, and compare batch results so partners get better answers rather than a generic ‘meets spec’ reply. This collaboration highlights practical challenges: reaction bottlenecks, clumping in feeders, or subtle impurity issues that rarely show up in basic COA numbers but affect the actual run rates and yield.

    Our technical team welcomes trial orders or process reviews, drawing from decades on the shop floor and in lab fume hoods. From sharing data on impurity removal to brainstorming new sample prep protocols for upcoming regulatory filings, we see our work as more than just unit operations and shipping forms—it’s about helping innovators avoid pitfalls from overlooked variables in chemical processing.

    Quality in Action: Batch Records and Real-World Results

    Each batch comes backed by production records. We’ve caught out-of-trend results before they reach customers, thanks to real-time monitoring and in-process retesting. Over the years, adopting digital traceability reduced errors, and cumulative customer complaints dropped by more than half. Fewer process incidents, improved waste handling, and consistent product qualities add up over time—customers report reductions in downtime, fewer production stops due to unexpected inputs, and better long-term run rates.

    Internal audits cross-check every batch against historical data so deviations get handled before shipping. Batch to batch difference shows up under close statistical analysis, and ongoing improvement means customers don’t see unexplained failures or shade shifts from one order to the next. Over the years, feedback loops between our manufacturing and customer technical teams push us toward tighter controls and more reliable processes.

    Looking Ahead: Adapting for a Changing Industry

    Our work never stands still. Changes in environmental regulations or market needs push us to improve emissions control and reduce waste. Customers in regions with stricter rules expect more than a COSHH or SDS—they want lifecycle information, green-chemistry alternatives, and advice on dealing with trace contaminants. We run regular technology reviews, keeping abreast of new purification methods, alternative raw material sources, and process intensification routes.

    We engage directly with those working to design more sustainable dyes, lower-impact pigment processes, or switch to less hazardous solvents. This ongoing feedback helps us test new processes, reduce off-gassing, or tweak raw material sourcing—so end users not only satisfy regulatory requirements but also improve their own product value.

    What Our Future Customers Can Expect

    As manufacturers, we back every order of 2-Methyl-3-Nitroaniline with a decades-deep foundation of chemical know-how, reliable process controls, and real performance data from the world’s laboratories and factories. Our team brings chemistry out of the textbook and into the shop floor, helping customers achieve new results, trouble-shoot unexpected failures, and push their products forward in a competitive, evolving marketplace.

    With constant focus on quality, safety, and honest collaboration, our 2-Methyl-3-Nitroaniline has grown from a standard raw material to a foundation for dyes, pigments, pharmaceuticals, and specialty chemicals worldwide. Each success story feeds our drive to make better chemicals and foster real results for those shaping the future of chemical synthesis and industrial innovation.