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2-Methoxyfuran

    • Product Name 2-Methoxyfuran
    • Alias 2-Methoxy-2,5-dihydrofuran
    • Einecs 249-001-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    561200

    Cas Number 2545-25-1
    Molecular Formula C5H6O2
    Molecular Weight 98.10 g/mol
    Iupac Name 2-Methoxyfuran
    Appearance Colorless liquid
    Boiling Point 86-88°C
    Melting Point -84°C
    Density 1.02 g/cm3
    Flash Point 4°C (closed cup)
    Solubility In Water Slightly soluble
    Refractive Index 1.458 (20 °C)
    Synonyms 2-Furyl methyl ether

    As an accredited 2-Methoxyfuran factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 2-Methoxyfuran is supplied in a 100 mL amber glass bottle with a secure screw cap and clear hazard labeling.
    Shipping 2-Methoxyfuran is shipped in sealed, chemical-resistant containers under inert gas to prevent moisture and air contact. The packaging complies with hazardous materials regulations, labeled with appropriate hazard warnings. It is transported at controlled temperatures, avoiding heat and ignition sources. Shipping documentation includes safety and handling instructions as per regulatory guidelines.
    Storage 2-Methoxyfuran should be stored in a tightly sealed container, kept in a cool, dry, and well-ventilated area away from sources of ignition. Protect it from moisture, heat, and direct sunlight. Store separately from oxidizing agents, acids, and bases. Clearly label the storage area and ensure proper spill containment. Use explosion-proof equipment where necessary.
    Application of 2-Methoxyfuran

    Applications of 2-Methoxyfuran in Industrial Manufacturing

    2-Methoxyfuran serves specific roles across several advanced chemical manufacturing processes, leveraging its reactivity and unique structural attributes. As an experienced manufacturer, we highlight its verified application scenarios where it delivers reliable performance, meeting the technical and regulatory needs of global industrial customers.

    1. Fine Chemical Intermediates Synthesis

    Producers of fine chemical intermediates use 2-Methoxyfuran as a reactive building block in the construction of heterocyclic compounds and specialty ligands. This material integrates smoothly into multistep synthesis cascades, especially where selective furan functionalization advances complex molecular scaffolds needed for pharmaceuticals and advanced materials. Accurate measurement and controlled addition at the coupling step ensure high yield for specialized compounds destined for regulated industries.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006
    • ISO 9001:2015 Quality Management Systems
    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients (for pharma intermediates)
    • Responsible Care global charter requirements

    Typical usage ratio

    • Routinely 0.5–2.5 molar equivalents relative to the core substrate; adjustments depend on the electrophile/nucleophile ratio in the reaction scheme

    Downstream process integration

    • Charged during the coupling or cyclization step in batch or semi-continuous reactors prior to in-line purification or downstream derivatization

    Final product types

    • Pharmaceutical key intermediates
    • Agrochemical building blocks
    • Polyfunctional ligands for catalyst R&D
    • Electronic chemical intermediates

    2. Pharmaceutical API Research and Route Scouting

    Medicinal chemistry labs and pilot facilities rely on this raw material as a starting scaffold to introduce substituted furan motifs in next-generation drug candidates. Its selective reactivity helps design libraries of analogs while maintaining manageable impurity profiles. GMP-compliant facilities calibrate addition to avoid overalkylation or undesired ring opening during scale-up, with systematic in-process controls guiding purity specifications for clinical route validation.

    Industry compliance standards

    • USP-NF and Ph. Eur. raw material and impurity requirements
    • GMP Guidelines (21 CFR Parts 210/211)
    • EMA/IPEC Quality Agreement Guidance
    • FDA Q3A/Q3C for residual solvents and impurities

    Typical usage ratio

    • 0.1–1 molar equivalent per target intermediate, adjusted after route scouting based on structure-activity findings and impurity tracking

    Downstream process integration

    • Added at scaffold diversification, late-stage functionalization, or as a masked functional group for further transformation under mild conditions

    Final product types

    • Lead compound analog libraries for drug discovery
    • Process route intermediates for clinical API synthesis
    • Labeled isotope intermediates (for regulatory studies)

    3. High-Performance Polymer Precursors

    2-Methoxyfuran acts as a functional monomer or comonomer in the manufacture of specialty polymers with enhanced barrier properties and thermal stability. Polymer producers integrate it into polycondensation or copolymerization steps, allowing insertion of furan rings within polymer backbones for flexible electronics, packaging, or engineering plastics. Formulators adjust feed ratios to balance material properties and regulatory compliance for migration and trace impurities.

    Industry compliance standards

    • EU Regulation No 10/2011 for food contact materials
    • ISO 14001:2015 for production environmental management
    • ASTM D638, D790 polymer mechanical property standards
    • RoHS Directive 2011/65/EU (for electronics)

    Typical usage ratio

    • For copolymerization, 1–8 wt% of total monomer feed; adjusted upward for higher furan incorporation or down to meet migration limits

    Downstream process integration

    • Metered into monomer feed during continuous polycondensation, with real-time viscosity and conversion monitoring; followed by devolatilization and extrusion

    Final product types

    • Furan-based barrier films for food packaging
    • Polyimide blends for flexible circuits
    • Engineering thermoplastics for automotive and electronics

    4. Agrochemical Active Ingredient Synthesis

    Agricultural chemistry manufacturers utilize this compound in the targeted construction of furan-containing herbicide and fungicide actives. Its selective ring system enables the creation of bioactive motifs resistant to rapid degradation, supporting improved product persistence in crop protection. Producers fine-tune addition timing and ratio based on downstream functionalization requirements and compliance with residue and impurity restrictions globally.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • ISO 17025 for chemical testing and analytical validation
    • US EPA Pesticide Registration (FIFRA regulations)
    • EU Regulation (EC) No 1107/2009 on Plant Protection Products

    Typical usage ratio

    • Varies from 0.2–1.5 molar equivalents, guided by the specific target structure and downstream substitution efficiency

    Downstream process integration

    • Introduced before or during ring closure or selective oxidation steps, followed by purification and formulation into technical concentrate

    Final product types

    • Furan-based herbicide actives
    • Systemic fungicide technical products
    • Precursor compounds for insect growth regulators

    5. Electronic Chemical Manufacturing

    Materials suppliers for the semiconductor and organic electronics sectors leverage the compound for constructing advanced organic semiconductors and conductive polymers. Its reactivity supports the efficient synthesis of complex molecular wires and charge transport materials with high purity. Strict control over feed ratio and in-line analytical confirmation maintains required electrical performance and consistent batch reproducibility for downstream device integration.

    Industry compliance standards

    • SEMI C94 Standard for Electronic Grade Chemicals
    • IEC 61249-2-21 (for polymer materials in electronics)
    • ISO/TS 80004-8:2013 (Nanotechnology terminology, for molecular electronics)
    • RoHS Directive 2011/65/EU

    Typical usage ratio

    • 0.3–1.0 molar equivalents per coupling intermediate; adjusted to polymer chain length and required electronic properties

    Downstream process integration

    • Introduced during precursor synthesis, oligomerization/coupling, or end-group functionalization; followed by chromatographic purification and device-ready formulation

    Final product types

    • Organic field-effect transistor (OFET) materials
    • OLED intermediate chemicals
    • Conductive polymers for printed electronics
    • Molecular wire building blocks
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    Certification & Compliance
    More Introduction

    Understanding the Value of 2-Methoxyfuran: From the Manufacturer’s Standpoint

    A Direct Take from the Production Floor

    Producing fine chemicals like 2-Methoxyfuran, we gain a practical feel for what matters in real-world labs and plants. In our workshops, precision isn’t a checkbox—it's a habit reinforced across every shift. Our 2-Methoxyfuran, model MFX-050, passes through every stage of synthesis under careful observation from operators who have seen solvents, intermediates, and specialty chemicals come and go. This hands-on experience steers our choices of raw material, controls our reaction parameters, and sets a firm foundation for performance you can trust.

    Product Details: Specifications That Matter on the Job

    Each batch of 2-Methoxyfuran hits a purity of at least 98%, with residual moisture below 0.2%. Our teams collect retention samples for every lot and map each drum to its originating vessel. Specific gravity consistently falls between 0.970 and 0.980 at 20°C. The color remains water-white, free of haze, with no strange undertones. Only hydrocarbon-free stock comes in contact with the sample to keep out off-odors and surprise peroxide content. Most of our customers order this grade as a colorless, low-viscosity liquid, because the lower freezing point, below -50°C, ensures uninterrupted delivery and application, even across seasonal shifts.

    We scale production using a closed glass-lined reactor system and nitrogen inerting for safety. Inline probes continuously check for water, and our final fill line doesn’t start until Karl Fischer results pass the test—no moisture, no surprises downfield. Tanks run pressure-tested, all packaging is clean, and every outgoing drum holds a tamper-evident seal. Repeat customers often tell us this attention to detail saves headaches, especially when running moisture-sensitive reactions or building up library compounds under tight screening schedules.

    2-Methoxyfuran in Real Industry Use

    On the customer side, the teams working with our 2-Methoxyfuran mostly seek its value in organic synthesis. During extended conversations with process chemists and project managers, the talk quickly moves from wish lists to what works in the flask. Researchers in pharmaceutical, agrochemical, and material science labs have called on 2-Methoxyfuran to introduce methoxy or furan groups into complex cores. Few other intermediates offer the same mix of electron-rich structure and stability while remaining easy to manipulate in a multi-step pathway.

    Its use as a masked 4-carbon synthon, for instance, gives synthetic chemists a shortcut when stitching together heterocyclic scaffolds. We've seen medicinal projects switch to 2-Methoxyfuran when earlier attempts with standard furans or methylated furans hit limits, either due to over-reactivity or selectivity issues. The specific reactivity profile of the methoxy furan ring allows for predictable transformations under conditions that might decompose plain furan or less-protected derivatives. This means more useful intermediates and a lower risk of failed batches during sequence scale-up.

    Polymer researchers have reported success using our product in the development of specialty resins and advanced coatings, where both the electronic and structural properties of the molecule add flexibility to design. The brief, yet effective, methoxy group’s electron-donating feature supports both stability and functionalization, helping avoid the stability pitfalls that frequently trouble unsubstituted or easily oxidized furan derivatives.

    Clear Points of Difference: Experience on the Shop Floor Shows What’s Real

    Taking a close look at 2-Methoxyfuran’s performance against other chemicals in the same family, the serious distinctions become clear. Unlike plain furan, which arrives on site as a highly flammable, easily polymerizing liquid, 2-Methoxyfuran provides greater shelf stability and reduced tendency for runaway exotherms during storage or reaction. Technicians report less hassle handling this product, which shows resilience during prolonged storage and resists the sticky residues and off-odors we remember from our early days working with low-purity furan stocks.

    Methylfuran has a lower boiling point and less selective reactivity, which can force downstream purification steps and bring unpredictable side reactions. By contrast, the methoxy substitution in our product shields the furan ring, opens cleaner reaction spaces, and brings synthetic flexibility—particularly attractive for chemists tired of post-purification headaches and unexpected isomers in their HPLC runs.

    As the manufacturer, we've watched our quality control data over many years, noticing that batch-to-batch consistency with 2-Methoxyfuran beats most alternatives. Our approach focuses on preventative maintenance, demanding training, and a simple rule: if a batch doesn’t meet spec, it doesn’t ship. We take particular pride in our in-house research efforts, which have tested common substitutions and catalogued yield differences, impurity profiles, and safety concerns. This hands-on process gives us a unique view of which molecules help customers finish their projects faster, safer, and more cost effectively.

    Safety, Handling, and Sustainability—Manufacturers See What Works

    Most of the trade stories about chemical sustainability skip over the difficult choices that chemical manufacturers face. As a direct producer, we’ve learned that investing in internal containment systems, double-layered drum jackets, and robust venting isn’t just an environmental checkbox—it’s the only approach that keeps quality reliable across all seasons. Subtle changes in raw materials, atmospheric pressure during fill, or a rushed transfer session can create batches that never reach the spec desk.

    We train every operator on the smell, flash point, and visual appearance of 2-Methoxyfuran. Beyond the published technical data, there’s a team of people checking every shipment before it leaves the warehouse. Some of our partner labs offer their own third-party verification, and our records invite them to cross-check results. Real-world safety comes down to more than just SDS sheets and compliance memos—the safest chemical is the one made with pride and consistency by people who know every detail about its behavior.

    On the sustainability front, recent years have ramped up the push to adopt green chemistry principles, including minimizing waste, reducing solvent volumes, and reusing recovered byproducts. Our pilot plant produces 2-Methoxyfuran from carefully sourced feedstocks, and our team recycles all process water through a closed-loop scrubber. Analysts review carbon impact metrics for each production run. This focus satisfies not just regulatory requirements but reflects the real-world accountability that comes from seeing the impact of waste, odor, or inefficiency every single day.

    Weighing the Real Advantages for Chemists and Operators

    Few things frustrate a plant foreman or lab manager more than downtime due to variable chemical supplies. With 2-Methoxyfuran, we have aimed for stability at every step—from procurement of raw materials down to the labeling for shipment. We take pride when production chemists report that their syntheses work the same in March as in October, that their yields hold up, and that unplanned shutdowns become rare. That comes from our story, not just process data: every tweak we’ve made has come from someone on the line who has spent years watching what works and what doesn’t.

    Feedback from hundreds of QA and R&D teams points to a simple fact—2-Methoxyfuran solves specific reactivity and selectivity challenges that arise with more commonly available alternatives. In pharmaceutical routes, medicinal teams have built complex heterocycles and fused-ring scaffolds using this product, reporting higher yields and cleaner conversions than with methylated or unsubstituted furan starting points. This isn’t sales talk: our records back up these trends, and our own research has tested these claims at the kilo lab level before signing off on routine production.

    From an engineering standpoint, the relatively high boiling point reduces evaporation losses during solvent-intensive transformations, bringing either improved mass balance in scaled reactors or easier containment during pilot runs. The inertness of the methoxy group under normal handling conditions means longer shelf life and a reduced need for special storage, which takes strain off receiving crews and lets operators focus on moving lots instead of managing exceptions.

    Lessons Learned from Manufacturing Practice

    Over decades of scale-up, every change in our 2-Methoxyfuran operation has surfaced from real-world challenges. We’ve adjusted our process in response to where earlier standard grades struggled—issues like product darkening after a month in storage, peroxide formation in returned partial drums, or inconsistent freezing during winter shipments. Having direct responsibility for every stage means we see the failures as sharply as the successes.

    Real improvements have included installing in-line scavenging beds to capture trace acidity before final filtration, automating water analysis at multiple points in the run, and applying stricter control over nitrogen blanketing to prevent partial oxidation. Not every competitor takes these extra steps, but our years of troubleshooting tell us they make the difference during audits, customer inquiries, and performance troubleshooting. Every hour spent on maintenance, every update to our operator logs—these show up in the clear, consistent product pouring from our lines.

    When industry shifts or new regulations land, our team adapts—and so does our approach to 2-Methoxyfuran. We engage partner labs to challenge our assumptions and keep documentation ready for every production campaign. Feedback from large-scale project users has led to tighter limits on trace metals and improved purification steps. Instead of resting on a legacy process, we’re constantly learning from every QC outlier, shipment delay, or unexpected chromatographic finding.

    Practical Advice for Real Users

    Having supplied 2-Methoxyfuran to both specialized and multi-product plants, we advise users to invest in understanding the limits of their own systems. In the early years, we saw some clients approach the product as a drop-in replacement for furan or methylfuran. Many soon discovered that the methoxy group opens new selectivity opportunities and unlocks different reaction windows—but it pays to run pilot studies and compare performance head-to-head with older reagents. Our technical team often collaborates directly with user sites to adapt guidelines and help troubleshoot first runs, sharing insights gained over years of plant-scale experience.

    For storage, we keep our packaging in rust-free, dry containers and regularly rotate inventory. Customers who do the same rarely run into issues, though heat and moisture can shorten shelf life for any sensitive organic. Routine on-site sample testing—smell, water content, clarity—prevents surprises. When you see a clear, odor-free fill, you know every process variable has stayed within its limits.

    We encourage proper handling of all furan derivatives, including ours. Inexperienced users occasionally underestimate the potential for strong exotherms with certain reagents. For this reason, we provide extra process details during onboarding and recommend local exhaust or sealed-system operation. Staff with a history of handling ethers or furans catch on quickly, reporting that 2-Methoxyfuran falls within predictable safety limits on both small and large scales.

    Long-Term Outlook—What We See Ahead for 2-Methoxyfuran

    Chemical manufacturing never stands still. Advances in catalysis, green chemistry, and medicine all point toward higher demand for reliable, functionalized building blocks. As more research groups and process plants push into new heterocyclic scaffolds or smarter polymer backbones, the need for consistently pure, well-documented materials like 2-Methoxyfuran is only growing. Experience tells us unpredictability comes not from the chemistry, but from inconsistent practices—so we keep pressing for better internal systems and honest feedback from our network.

    Open conversations with research chemists, process developers, and engineering managers will continue shaping our protocols. We've seen firsthand how projects succeed when there's a direct line between the manufacturer and the user—the feedback loop keeps both sides accountable and helps drive improvement. For decades, this approach has made our 2-Methoxyfuran a favorite choice among specialists who know that technical reliability matters more than hot marketing.

    Looking forward, we invest in every technology that keeps our product out front in both performance and compliance. Our R&D team targets process safety, reductions in waste, and traceability, so that every batch shares the same reliability as the last. The input of practical users—those actually running reactions and pumping batches through reactors—remains our gold standard for change and improvement.

    Built on Direct Experience—A Manufacturer’s Promise

    We have stood in the shoes of chemists and operators alike, solving real problems as they arise, learning what works and improving it year by year. Our 2-Methoxyfuran isn't a commodity—it’s a specialty tool for both upstream and downstream applications, borne of rigorous effort and close working relationships with end users. Each improvement we make responds to a direct need on the ground, and every bottle we ship carries the weight of that hard-earned knowledge.

    From synthesis to shipment, we focus on transparency, reliability, and collaboration. Our team’s collective years on the shop floor—coping with the grind of 24-hour schedules, adapting to new methods, following up on customer feedback—tell us this is the only way to make chemicals that support real innovation and lasting progress.

    So, for labs and plants taking on their next generation of research or production, our 2-Methoxyfuran arrives as more than a rare specialty. It’s a partner for those who measure their success vial by vial, batch by batch. That’s what keeps us moving, bottle after bottle, year after year.