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2-Methoxybenzyl Alcohol

    • Product Name 2-Methoxybenzyl Alcohol
    • Alias o-Anisyl alcohol
    • Einecs 227-842-1
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    333039

    Cas Number 612-16-8
    Molecular Formula C8H10O2
    Molecular Weight 138.17 g/mol
    Iupac Name 2-Methoxybenzyl alcohol
    Synonyms o-Anisyl alcohol, ortho-Methoxybenzyl alcohol
    Appearance Colorless to pale yellow liquid
    Boiling Point 246-247 °C
    Melting Point 6-8 °C
    Density 1.098 g/cm³ at 25 °C
    Solubility In Water Slightly soluble
    Flash Point 110 °C
    Refractive Index 1.543 at 20 °C

    As an accredited 2-Methoxybenzyl Alcohol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing A 500 mL amber glass bottle, labeled “2-Methoxybenzyl Alcohol,” with safety warnings, screw cap, and tamper-evident seal.
    Shipping 2-Methoxybenzyl Alcohol is shipped in tightly sealed containers to prevent leakage and contamination. It should be stored in a cool, dry, and well-ventilated area away from sources of ignition. Proper labeling and documentation, including safety data sheets, are required during transport. Handle with protective equipment as specified by shipping regulations.
    Storage 2-Methoxybenzyl alcohol should be stored in a tightly closed container, in a cool, dry, and well-ventilated area, away from heat sources and incompatible substances such as acids and oxidizing agents. Protect it from light and moisture. Ensure proper labeling, and store at room temperature or as specified by the manufacturer. Follow all safety guidelines for handling organic chemicals.
    Application of 2-Methoxybenzyl Alcohol

    Applications of 2-Methoxybenzyl Alcohol in Industrial Manufacturing

    2-Methoxybenzyl Alcohol is a specialty aromatic alcohol utilized by manufacturers as an intermediate and modifier across key chemical process routes. Its unique reactivity and solubility profile enable controlled incorporation in high-value synthesis pathways. We supply this raw material for regulated sectors with precise documentation and technical backing from our plant operations.

    1. Pharmaceutical Intermediate Production

    Pharmaceutical manufacturers source 2-Methoxybenzyl Alcohol as a key intermediate for active pharmaceutical ingredient (API) synthesis, especially in creating molecules containing the methoxybenzyl group. In step-growth procedures, chemists employ it for benzylation reactions and as a precursor for various ethers and esters used in drug development. Tight batch records and analytical verification ensure trace residues do not carry into finished APIs or intermediates, meeting the high compliance thresholds.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • United States Pharmacopeia (USP) for relevant intermediates
    • European Pharmacopoeia monographs (Ph. Eur.)
    • FDA cGMP (21 CFR Part 210/211) for pharmaceutical manufacturing sites

    Typical usage ratio

    • 0.5–5% molar equivalents per reaction step
    • Adjusted based on target molecule’s functional group needs and reaction stoichiometry

    Downstream process integration

    • Introduced during protected intermediate synthesis phases for benzyl group installation
    • Applied in alkylation, etherification or acylation reactions conducted at elevated temperatures under inert atmosphere
    • Subsequent removal and purification through distillation and chromatographic steps

    Final product types

    • Beta-blockers (e.g., atenolol intermediates)
    • Antihistamine APIs with methoxy-substituted aromatic cores
    • CMO-supplied NCE libraries for clinical trial studies
    • Branded or generic APIs requiring methoxybenzyl moieties

    2. Agrochemical Synthesis

    2-Methoxybenzyl Alcohol is incorporated by crop protection manufacturers as an intermediate in selective herbicide and fungicide production. It serves as a building block in the synthesis of agrochemicals featuring methoxybenzyl or methoxyphenyl functionalities. Large-scale reactors handle batchwise reactions, while QC labs confirm minimal trace impurities before downstream formulation. Use aligns with local chemical registration and environmental handling protocols.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • ISO 9001:2015 certified process controls in synthesis plants
    • REACH registration (EC No. 202-077-1) for European sales
    • EPA TSCA Inventory Listing for US-supplied intermediates

    Typical usage ratio

    • 1–7% of formula weight of total actives per specific agrochemical route
    • Proportion varies depending on substitution pattern and required yield of downstream active ingredient

    Downstream process integration

    • Enters synthesis via O-alkylation or selective reduction process streams
    • Handled in glass-lined or stainless-steel reactors with temperature control (60–140°C)
    • Purification follows using vacuum distillation and phase separation

    Final product types

    • Pre-emergent herbicides derived from methoxybenzyl intermediates
    • Fungicidal active compounds for cereal and fruit applications
    • Seed treatment chemicals containing aromatic ether fragments
    • Blended technical concentrates for custom agrochem packs

    3. Fragrance and Flavor Ingredient Manufacturing

    Aromatics processors utilize 2-Methoxybenzyl Alcohol for synthesis of specialty fragrances and flavoring agents. It brings a mild, sweet-anisic note and acts as a precursor in forming more complex aroma molecules. Usage is governed by food contact materials regulations, as well as strict organoleptic and chemical purity parameters defined by flavor houses and perfumer labs.

    Industry compliance standards

    • IFRA (International Fragrance Association) Amendment guidelines
    • FEMA (Flavor and Extract Manufacturers Association) GRAS Evaluations
    • European Commission Regulation (EC) No 1334/2008 for food flavorings
    • Kosher and Halal Ingredient Certifications based on plant process control

    Typical usage ratio

    • 0.01–0.2% w/w in flavor or fragrance concentrate blends
    • Adjusted according to end-use application’s flavor/aroma threshold and matrix compatibility

    Downstream process integration

    • Solubilized into carrier solvents or compounded directly into fragrance oils
    • Subjected to distillation and blending in stainless steel reactors with real-time GC analysis
    • QC sample release on both olfactory purity and contaminant limits

    Final product types

    • Personal care fragrance bases (fine fragrances, soaps, haircare)
    • Flavoring composites for baked goods or beverage syrups
    • Industrial deodorizer and air care formulations
    • Custom perfumery accords for niche and mass market launches

    4. Dye and Pigment Intermediate Manufacture

    Producers in the colorant industry rely on this raw material as a functional intermediate during synthesis of methoxy-substituted dyes. Its role includes supplying the methoxybenzyl group through etherification or condensation chemistry, allowing process flexibility in shifting chromophore absorption. Plants retain full traceability throughout the batch, and operators scale handling by hazard class and environmental permitting.

    Industry compliance standards

    • OEKO-TEX® Standard 100 (relevant for textile dyes)
    • ISO 14001:2015 environmental management during synthesis
    • Restricted Substance Lists (e.g., ZDHC MRSL) for pigment intermediates
    • Global Harmonized System (GHS) Safety Data Sheet conformity

    Typical usage ratio

    • 2–10% by weight relative to total dye batch mass
    • Optimized per specific pigment structure and target depth of shade

    Downstream process integration

    • Added during condensation with aromatic amines or aldehydes
    • Reactor feed via metered batch dosing under closed system
    • Downstream purification by liquid-liquid extraction and fine filtration

    Final product types

    • Azo dyestuff intermediates for synthetics and cellulose fibers
    • Disperse dyes for polyester and blended fabrics
    • Specialty pigments for printing inks and plastic coloration
    • Custom blended colorants for automotive or industrial coatings

    5. Polymer and Resin Modifier Sourcing

    Chemical formulators deploy 2-Methoxybenzyl Alcohol within resin and polymer modification, using its aromatic structure to impart flexibility and impact resistance in finished materials. During alkyd or epoxy synthesis, it acts as a monomeric chain modifier or capping agent. Operations integrate batch controls to ensure downstream performance consistency and product regulatory status for end-use markets.

    Industry compliance standards

    • ISO 9001:2015 certified QC for polymer batch release
    • ASTM D3418 (Differential Scanning Calorimetry of Polymers)
    • RoHS/WEEE checks for consumer-facing polymer applications
    • UL Yellow Card status for some resin systems

    Typical usage ratio

    • 0.5–3.5% by weight in resin or polymer backbone
    • Fine-tuned based on impact on glass transition temperature (Tg) and processing viscosity

    Downstream process integration

    • Batch-fed into prepolymer mixing or esterification reactors
    • Integrated at specific temperature ramps for controlled molecular weight distribution
    • QC release contingent on FTIR/DSC confirmation of structural modification

    Final product types

    • Modified alkyd and acrylic resins for architectural coatings
    • Epoxy systems for adhesives and electronics encapsulation
    • Phenolic resin modified materials for automotive friction surfaces
    • Industrial-grade plastics for molded components
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    Certification & Compliance
    More Introduction

    2-Methoxybenzyl Alcohol: Direct from Our Production Floor

    At our facility, the manufacturing of 2-Methoxybenzyl Alcohol continues to provide reliable quality for a diverse set of applications, including pharmaceutical synthesis, fragrance intermediates, and specialized organic synthesis. After years spent refining our process, we understand the compound as more than a set of numbers on a data sheet—it’s a reliable building block that allows chemists and product developers to push boundaries while keeping purity and consistency in sharp focus.

    Model and Specifications from an Operator’s View

    We produce 2-Methoxybenzyl Alcohol at a purity level of 99%. Our team prefers a focused, inward approach to ensure each batch reaches clear, colorless standards free from residual solvents or yellowing. Internal checks include GC purity above 99.0%, water below 0.2%, and refractive index at 1.534 to 1.537. These checkpoints do not exist for their own sake—we find most customers notice directly on the line if there’s any deviation, particularly those running large batch productions or looking to avoid rework later on.

    The usual lot size, determined by our own reactor volumes and logistics experience, clocks in at 200 kg per drum. We verify every batch across quality assurance for acid value, color index, and moisture content, habits drilled in after years noticing how minor spec lapses create headaches in downstream reactions. This focus on practical checkpoints—appearance, melting point, odor threshold—stems from feedback: if a compound lingers with off-odors or tints, downstream users lose both trust and time.

    In-the-Field Use: Not Just on Paper

    In the last decade, the spotlight on 2-Methoxybenzyl Alcohol grew mainly due to its position in pharmaceutical intermediate chains, fragrance development, and agricultural synthesis. Labs choose this molecule as a starting reagent for antihistamines, active pharmaceutical ingredients, and specialty aroma compounds. The compound’s ether functionality resists hydrolysis under acidic conditions, while the benzyl structure enables smooth transitions via oxidation or protection-deprotection steps.

    As a manufacturer, we supply directly to researchers who ask for batch-level documentation, as well as to process engineers scaling up fragrances or high-purity intermediates. Our long-term clients create pharmaceutical building blocks, such as antihistamine analogs and selective serotonin reuptake inhibitor precursors. Some use our product to synthesize compounds needing gentle protection of reactive aldehydes. Formulators in niche fragrance applications tell us that the consistency in odor and color profile is critical for their end product profile—blending fluctuations from other suppliers force them to recalibrate, so they keep coming back to our direct deliveries.

    2-Methoxybenzyl Alcohol’s moderate boiling point near 249°C and a flash point above 100°C suit it well for controlled bulk synthesis, while its solubility characteristics enable predictable work-ups for separation and purification. Customers working with continuous reactors often mention their appreciation for clean phase separations and low “gumming” in transfer lines—these are details only regular users notice, and ones that rule out many inconsistent suppliers.

    How 2-Methoxybenzyl Alcohol Stands Apart

    We have processed and worked with benzyl alcohol, 4-methoxybenzyl alcohol, and their derivatives for a generation, so the distinctions in reactivity, safety, and end-use aren’t abstract for us—they become obvious from the demands of our own equipment and customer feedback. Compared to benzyl alcohol, 2-Methoxybenzyl Alcohol offers enhanced stability in acid-catalyzed environments, which researchers find useful for challenging acylation and alkylation reactions. Its methoxy group at the ortho-position prevents unwanted side reactions seen with unsubstituted analogs.

    Those using 4-methoxybenzyl alcohol will notice sharper volatility and a shift in melting point, changing how they purify and store materials. Our product sees less volatility loss and offers better long-term storage in standard steel drums, holding up under the humid and variable temperature conditions common in Asian and European warehouses. The electron-donating methoxy group at the two position also confers greater resilience to oxidation compared to para variants, giving pharmaceutical and aroma compound production a process-friendly window.

    Why Purity Drives Consistency

    In organic synthesis, even small deviations from expected purity generate unexpected outcomes. Several years ago, a client’s multi-step Grignard synthesis ground to a halt; only after close inspection did we find trace-level contaminants in their feedstock benzyl alcohol. From then on, our lab increased the batch-level tracking of impurities in our 2-Methoxybenzyl Alcohol lines, especially aldehyde and peroxides levels, to well below the limits found in broader “technical grade” markets.

    Some producers chase volume with less filtration and quality control. We have taken the opposite route because of repeated instances where impurities left by faster processes burn out glassware, foul reactors, or complicate product isolation. By running rigorous microfiltration and column purification, and favoring closed transfer lines, we have achieved batches that leave less than 0.2% water—meeting the needs of pharmaceutical-grade users who value dry, dust-free, non-yellowing material. We test each drum pre-shipment, with team members keen to catch small changes before bulk transport, as no one wants to receive a 200 kg barrel with layered or clouded liquid after weeks in transit.

    Handling, Transport, and Warehouse Lessons

    Over time, we learned that packaging and onsite warehousing shape the long-term reputation of this product almost as much as raw chemical quality. Poly-lined steel drums prevent slow solvent leaching far better than open-top containers and avoid the off-odors and darkening that can mar older stock. Our warehouse sits climate-controlled year-round, minimizing exposure spikes above 27°C that push up peroxide levels and degrade product aroma over time.

    Routine quality rechecks are built into our handling cycle. One case years ago—when a consignment spent extra weeks in port storage—drove home how variable warehouse standards can ruin product even when chemical specs are met at shipping. Now, we work only with logistics partners who guarantee covered, dry handling without triple stacking. Documentation travels alongside every batch, detailed on origin, testing, and tracking, to keep users firmly in the loop and avoid ambiguous sourcing claims that plague parts of the specialty organic chemicals world.

    Consistent bottling is only part of this. Reports from new customers occasionally recall receiving drums elsewhere with varying fill levels, split closures, or unclear labelling. Tight controls over filling minimize oxygen ingress and avoid “headspace” oxidation during transit, so those formulating for pharmaceutical or food-related use spend less time tracking product changes. Issues get solved here before they reach partners or clients experiencing delays or downtime as a result.

    Product Integration as Told by Users

    Direct feedback from regular users sharpens our approach just as much as in-house R&D. Pharmaceutical intermediates producers describe how 2-Methoxybenzyl Alcohol helps them create stable, isolatable protecting groups without introducing flavor or aroma contamination. The reactivity profile translates to controlled transformation in both small pilot and several ton scales.

    Fragrance customers share that the compound, while not commonly used as the final top note itself, detours through many subtle blends, particularly where light floral or almond backnotes develop. Their standards for byproduct content run stricter than in many bulk chemical operations—minor shifts in odor or color can disqualify an entire lot. Recognizing this, we take great pain to limit extraneous alcohols and aromatic aldehydes through extra-stage purification.

    Researchers developing customized intermediates in agrochemicals look for predictability rather than any breakthrough property. Having batches match reactivity profile year in and out reduces troubleshooting and shortens development cycles. They swap insights on which ketones or acids the compound modifies most efficiently, improvements that we feed back into process optimization for both speed and minimum waste generation.

    Process Knowledge from Hands-on Experience

    Standard industry practice can encourage shortcuts that cost more in long-term headaches. We favor longer residence time for reaction stages during methylation and benzylation, based on yield loss we observed in early production runs that moved too quickly to maximize throughput. Instead, we adapted equipment setup to prioritize conversion completeness, purging side products before bottling. Small details—checked isolation pH, higher-grade glass column media, complete nitrogen blanketing—may not win awards but keep complaints from surfacing, which always find their way to the production office faster than praise.

    Our operators note the importance of regular turnover in stock to guard against aging or accumulation of moisture, especially during seasonal humidity swings. Product delivered within two weeks of synthesis preserves the natural clarity and odor profile far more dependably than holding inventory for months at a time. Making the best use of close supplier relationships for toluene and methylating agents keeps replenishment swift, just as buyers expect our stock to run “fresh” for their demanding applications.

    We maintain tight feedback loops between production, QA, and packing; each team sees the critical checks as a safeguard not just for customer confidence, but for the validity of our own processes. Inspection records aren’t filed away—they circulate as working documents, letting us pinpoint if a minor post-filtration tweak improved color index, or if a specific batch of sealing gaskets minimized oxygen exposure. We believe this open-circle approach outruns the rigid checklists that allow problems to fester.

    Ongoing Improvements and Industry Realities

    Our outlook isn’t shaped in isolation from market realities. Price pressures, changing environmental regulations, and increased scrutiny around provenance mean that new process improvements remain a constant focus. We regularly replace older solvent stocks and re-train staff against batch “shortcuts” that creep into established routines. Implementing full traceability from raw material to drum fill takes effort. While this sounds like an industry buzz phrase, in our experience it means quickly identifying any root cause if an issue surfaces. Long-term, transparent records form a counter to cheapened materials or dubious purity claims from offshore brokers—clients quickly spot who cuts corners and who puts in the time.

    The global market now demands disclosure of potential allergens, trace contaminants, and origin of every material that ends up in consumer goods. Early adoption of detailed batch logs, GC-MS impurity traces, and offsite storage tracking keeps us in step with these shifts, while others scramble to react to regulatory demands. Our team works hands-on to cut unnecessary hazardous steps—especially chlorinated solvents—out of synthesis pathways where possible, heeding both staff safety and downstream user requirements. Where a safer green alternative delivers, we implement it. Our clients have never been shy to share which contaminants create product rejection or regulatory delays; those lessons stick with us, shaping how the next batch gets made.

    Solutions for Long-Term Partnerships

    Maintaining trust means anticipating practical needs before they become stumbling blocks. Direct shipment to customers’ blending or reaction sites, scheduled QA lab visits and consultation on storage protocols have helped several long-term partners avoid production downtime. We’ve found real value in open tech discussions with clients—sharing yield improvement ideas, helping model downstream losses, and advising on product handling in transitional weather has built partnerships that last through volatile market cycles.

    Smaller users, especially in specialty synthesis, often lack the in-house checks available to multinationals. We act as an extension of their QC, catching issues before they emerge in their systems. Larger buyers sometimes require small, periodic pre-shipment samples to test against in-situ product needs; flexible sampling and batch reservation solutions have kept those relationships steady. We recognize the incremental costs of missed orders, off-spec batches, or mis-shipments—once confidence erodes, winning it back takes more than a single flawless batch.

    To those who’ve recently joined our user base, or those revisiting after setbacks elsewhere, we offer not only product but direct insight on what makes batches reliable, usable, and fit for tough regulatory environments. Input from groups working in cosmetic intermediates, veterinary APIs, or niche pesticide research now feeds back into our plant improvements—driving not only the final product, but the operational culture that sustains it.

    The Value of Manufacturer Expertise

    We don’t view ourselves simply as a box-ticking source of material. The years spent working with 2-Methoxybenzyl Alcohol, troubleshooting real-world technical snags, and refining both process and packaging, define how and why we deliver this compound in its current form. Each batch integrates lessons learned not from trade shows or specification sheets, but from daily production experiences—watching for color drifts, sniffing out off-odors, learning the efficiency loss from even tiny process missteps. The trust our partners show relies on this grounded, practiced attention; it’s reinforced every time an order ships out on time and meets the needs stated in the beginning.