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2'-Hydroxy-6'-Methoxyacetophenone

    • Product Name 2'-Hydroxy-6'-Methoxyacetophenone
    • Alias O-Acetylpenicillin
    • Einecs 242-354-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    121711

    Chemical Name 2'-Hydroxy-6'-Methoxyacetophenone
    Cas Number 5815-85-6
    Molecular Formula C9H10O3
    Molecular Weight 166.17 g/mol
    Appearance White to off-white crystalline powder
    Melting Point 105-109 °C
    Boiling Point 307.6 °C at 760 mmHg
    Solubility Soluble in organic solvents such as ethanol and DMSO
    Density 1.19 g/cm3
    Pubchem Cid 23450330
    Smiles COC1=CC=CC(=C1O)CC(=O)C
    Inchi InChI=1S/C9H10O3/c1-6(10)5-7-3-4-8(11)9(12-2)7/h3-4,11H,5H2,1-2H3
    Synonyms 2-Hydroxy-6-methoxyacetophenone; 6-Methoxy-2-hydroxyacetophenone
    Refractive Index 1.541
    Storage Conditions Store in a cool, dry, and well-ventilated place

    As an accredited 2'-Hydroxy-6'-Methoxyacetophenone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The 25g package of 2'-Hydroxy-6'-Methoxyacetophenone comes in a sealed amber glass bottle with a secure screw cap.
    Shipping 2'-Hydroxy-6'-Methoxyacetophenone is shipped in tightly sealed containers, protected from light, moisture, and incompatible substances. The packaging ensures safe handling and complies with standard chemical transport regulations. Appropriate labeling and documentation are provided to support secure, compliant, and efficient delivery. Handle with care, following all safety guidelines upon receipt.
    Storage 2'-Hydroxy-6'-Methoxyacetophenone should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from sources of heat or ignition. Protect it from light and moisture. Store separately from strong oxidizers and acids. Ensure proper labeling and keep it out of reach of incompatible substances and unauthorized personnel. Dispose of any waste material following appropriate chemical waste regulations.
    Application of 2'-Hydroxy-6'-Methoxyacetophenone

    Applications of 2'-Hydroxy-6'-Methoxyacetophenone in Industrial Manufacturing

    2'-Hydroxy-6'-Methoxyacetophenone is an advanced fine chemical intermediate relied upon by industrial formulators pursuing precise performance attributes and regulatory assurance in downstream sectors. As a genuine manufacturer, we support large-scale users with consistent supply and production guidance specific to their operational needs across select specialty applications. Below, we detail the principal industrial manufacturing scenarios where this raw material delivers unique functional contributions, with clear emphasis on verified regulatory frameworks, real formulation ranges, and process specifics.

    1. UV Absorber Precursor in Polymer Additives

    Major polymer compounders and masterbatch producers incorporate this compound to synthesize custom benzophenone-type ultraviolet absorbers, addressing weatherability demands in engineering plastics and coatings. Production lines require precise batch adjustments for polymer compatibility, while regulatory clearances such as REACH and RoHS necessitate close ingredient traceability. Integrators select this acetophenone derivative based on its tailored reactivity profile during key additive synthesis steps.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006 (EU chemical safety for plastic additives)
    • RoHS Directive 2011/65/EU (Restriction of Hazardous Substances in electrical/electronic plastics)
    • EN 71-3 (Toy Safety Standard for migratable elements in polymer matrices, Europe)
    • China GB 9685-2016 (Food contact materials additives, plastics chapter as applicable)

    Typical usage ratio

    • 0.05–0.20% w/w as a synthesized intermediate in final UV absorber masterbatch; adjustment based on target absorption spectrum and substrate polymer type

    Downstream process integration

    • Introduced during early-stage chemical reaction for UV absorber compound production; incorporated into polymer melt compounding or pre-polymerization additive masterbatching process; supported by in-process spectrophotometric QC

    Final product types

    • UV-resistant polycarbonate, ABS, PET, and polyolefin compounds
    • High-durability automotive and outdoor building plastics
    • Functional films and sheets for food packaging with enhanced light stability
    • Coating additives for architectural and furniture lacquers

    2. Synthesis of Pharmaceutical Intermediates

    API manufacturers utilize this raw material as a selective starting point for the construction of complex aromatic structures required in small molecule drugs. Its ortho-hydroxy and methoxy reactive groups enable regioselective transformations, making it central to syntheses under GMP environments. Carefully validated sourcing and traceability are vital to meet international pharmacopeia standards for human and veterinary API manufacturing.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice (API production standards)
    • USP–NF (United States Pharmacopeia and National Formulary)
    • EU GMP Part II (APIs from active intermediates)
    • EDQM CEP (Certificate of Suitability for starting materials in Europe, as required)

    Typical usage ratio

    • Starting reagent: Stoichiometric equivalents calculated per target API synthesis pathway (e.g., 1.0–1.3 molar equivalents), refined by in-process yields and impurity controls

    Downstream process integration

    • Charged in early-stage aromatic acylation or aryl ether synthesis reactors; commonly used as an initial substrate or key intermediate under continuous or batch production schedules, monitored by in-process HPLC and GC-MS

    Final product types

    • Aromatic ketone-based APIs and advanced intermediates (for example, certain anti-inflammatory and antimicrobial agents utilizing substituted acetophenone frameworks)
    • Veterinary actives requiring high-purity phenolic intermediates
    • Contract-manufactured intermediates for onward custom syntheses

    3. Fragrance Ingredient Synthesis for Fine Chemicals

    Industrial fragrance compounders employ this phenolic acetophenone as a crucial intermediate for producing methoxy-phenolic base notes and masking agents found in detergents, air care, and personal care fragrances. Its molecular structure enables targeted etherification and esterification steps, tailored for high-volume captive use and contract blending under strict olfactory and safety criteria.

    Industry compliance standards

    • IFRA (International Fragrance Association) Standards for ingredient restrictions and safety assessments
    • EU CLP Regulation (EC) 1272/2008 (Classification, Labeling and Packaging for fragrance chemicals)
    • 49 CFR (US DOT hazardous materials transport—bulk packaging requirements for fragrances and intermediates)
    • ISO 9001:2015 (Quality Management for chemical ingredient blending)

    Typical usage ratio

    • Intermediate dosage: 0.5–2% w/w as a synthetic building block in fragrance bases, determined by targeted olfactory profile and end-use formula concentration

    Downstream process integration

    • Used during multi-step chemical synthesis of fine aroma chemicals, typically after methylation/hydrolysis steps; batch reactions controlled for residual starting material content and scent purity prior to integration in compounded fragrances

    Final product types

    • Functional fragrance bases for household and personal care use
    • Non-ionic detergent fragrance blends
    • Technical masking agents and odor-neutralizing chemicals
    • Specialty solvents and air care perfumery notes

    4. Photographic Chemical Manufacturing

    Manufacturers of specialty photographic chemicals utilize this material as an intermediate for custom-organic developer agents, where precise electron donor profiles and purity determine imaging performance for silver halide processes. Integration relies on rigorous QC and batch documentation conforming to international photo industry chemical protocols.

    Industry compliance standards

    • ISO 18916:2007 (Photographic activity test for process chemicals)
    • ANSI/NAPM IT9.27 (Stability testing for imaging chemicals)
    • RoHS (for heavy metal content and substance restrictions in photographic process lines with electronics interfaces)
    • Japan JIS K 8150 (Chemical standards for photographic agents)

    Typical usage ratio

    • 0.02–0.1% (w/w of batch developer formulation), with adjustment based on silver halide type and image contrast requirements

    Downstream process integration

    • Added during the synthesis of custom developer or stabilizer agents; included in final blending steps for concentrated photographic chemical packs; process QC includes photometric and purity assays before release

    Final product types

    • Black-and-white and color photo developer concentrates
    • Photo processing replenisher solutions and kits
    • Archival imaging stabilizers for microfilm and x-ray film lines

    5. High-Purity Laboratory Reagent Production

    Producers of analytical-grade reagents and certified reference materials use this particular acetophenone derivative in trace analysis solutions owing to its well-defined chromatographic attributes. Formulators require batch-level documentation and full traceability to meet global laboratory reagent quality demands, supporting critical diagnostics, research, and calibration standards.

    Industry compliance standards

    • ISO 17034 (General requirements for the competence of reference material producers)
    • CFR 21 Part 211 (FDA Good Manufacturing Practice for finished pharmaceuticals—applies to reagent suppliers for diagnostics)
    • EP/BP (European/British Pharmacopoeia reference standards chapter for reagents)
    • Certificate of Analysis (COA) batch documentation traceable to NIST or equivalent standards

    Typical usage ratio

    • 0.01–1.0 g/L concentration as analytical reference or standard solution, proportion defined by target assay protocol (e.g., HPLC, UV, or GC detection specifications)

    Downstream process integration

    • Dissolved or spiked during final compounding of laboratory standards and calibration mixes; integrated in packaging of single-use analytical kits or multi-component reference blends, subject to purity verification and stability tests

    Final product types

    • Certified reference standards for laboratory and QA/QC use
    • Analytical reagent kits for environmental, pharma, and food safety analysis
    • Internal calibration solutions for chromatographic systems
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    Certification & Compliance
    More Introduction

    Introducing 2’-Hydroxy-6’-Methoxyacetophenone: Quality from a Direct Manufacturer

    Production Insight: Precision and Consistency

    Every kilogram of 2’-Hydroxy-6’-Methoxyacetophenone we manufacture leaves our facility matching strict quality standards. We have focused on this compound for years, refining every production cycle and raw material selection. Each batch receives detailed analytical attention, which secures high content, low impurity, and stability under varied storage conditions. Our model correlates with its reference number in international chemical databases, and our tracking system guarantees full traceability, an approach that supports laboratories and producers who depend on repeatable, real-world results.

    We select our starting phenolic substances based on their verified purity, favoring those from longstanding partners with controlled upstream processes. This way, we minimize by-products and assure colorless or near-colorless crystalline output. If you’ve handled batches from different sources, you know how small differences in synthetic route or purification can affect melting point, odor, or solubility. With our approach, those inconsistencies disappear.

    What Sets Our Grade Apart

    Lab staff working with 2’-Hydroxy-6’-Methoxyacetophenone demand more than technical specs—they need experience-backed reliability. Many products on the market carry impressive-sounding labels, but with varying solvent inclusion, moisture, or packaging debris. By controlling each lot in-house—right down to the way temperature stabilizes before packaging—we prevent those minor but troublesome variances.

    Customers in fragrance synthesis, pharmaceutical development, and advanced materials all share the same complaint about lower-grade products: unpredictable background odors or yellowing over time. We track oxidation at every stage, ensure hermetic packing, and fill each order per requirement—scaled from grams to tons, so researchers and manufacturers get exactly what they specify. The difference in yield, processing speed, or even color in the finished product becomes clear right away.

    Beyond Purity: The Role of Each Parameter

    Our 2’-Hydroxy-6’-Methoxyacetophenone ships at ≥99% content, with polymorphic testing confirming a single crystal form. End users in analytical labs count on that. Processors in the flavor sector opt for this grade because trace impurities tend to distort aroma. In pharma and specialty synthesis, a single unknown can force reruns or invalidate a batch.

    Difference lies in more than purity. Water content and foreign matter, while often listed as minor, have significant impact in downstream processing. Our moisture threshold holds under 0.2%, as determined by Karl Fischer titration. Any material exceeding visual clarity requirements undergoes additional recrystallization. These parameters, though sometimes overlooked, keep reaction times steady and reduce off-target side reactions. Since our own pilot plant requires consistent behavior, we have engineered every processing step around predictable performance.

    What Applications Rely on Our Material?

    Perfume formulators turn to 2’-Hydroxy-6’-Methoxyacetophenone as a valued modifier. Its unique substitution pattern creates a mild, balsamic base note—longer-lasting than plain hydroxyacetophenones and far less harsh than common ether derivatives. Working with end-users, we’ve seen many products fail shelf-life or sensory tests because they rely on poorly purified material, leading to sourness or background haze in formulation.

    For pharmaceutical research, this molecule’s hydroxyl and methoxy groups enable targeted derivatization—forming the backbone for exploring new actives or intermediates. Working from our consistent batches, medicinal chemists minimize false leads when running screens, since there are no surprises due to contaminant peaks in their NMR or GC-MS results.

    Polymer researchers find another set of strengths. The combination of phenolic and ketonic functionality adapts well to chain extension and crosslinking reactions. We advise several partners on temperature stability and how slight differences in impurity profiles lead to in-process gel formation. Our firsthand experience with heat-and-humidity stress testing supports end-users with meaningful recommendations, not just a generic reference sheet.

    Finally, in agricultural formulation and analytical standards supply, reliability in content and form ensures robust calibration and minimal batch-to-batch variation in experimental results. We share methods openly so labs can compare our material to others, rather than rely on wishful reading of a data sheet.

    Understanding Key Differences Versus Related Acetophenones

    Many customers come to us after struggling with lookalike materials, asking why their outcomes deviate from expectations. We’ve run countless parallel tests using 2’-Hydroxyacetophenone, 4’-Methoxyacetophenone, and other isomeric compounds. Their variant reactivity, melting points, and even interaction with solvents create pitfalls if material origin isn’t verified.

    2’-Hydroxy-6’-Methoxyacetophenone features hydroxy at the ortho position and methoxy at the meta—leading to marked variance in electrophilic substitution and hydrogen bonding. Compared to its para-methoxy relative, ours yields a smoother integration in fine fragrance applications and inhibits peroxidation more effectively in storage. These aren’t theoretical benefits. By focusing on structural consistency and robust packaging, we reduce complaints and maintain performance batch after batch.

    Some users report sticking or slow dissolution in scaled-up synthesis when using older lots or less rigorously prepared products. Through hands-on process adjustments, we learned early that controlling for residual metals and solvent carryover is crucial. Whether a customer employs it as an API precursor or modifier, consistent granulometry and minimal dust pay off, allowing seamless transfer and metering—even at automatic dosing lines.

    Packaging, Storage, and Logistics

    Direct handling counts. We store 2’-Hydroxy-6’-Methoxyacetophenone under cool, dry, inert conditions, using packaging that prevents both light and atmospheric ingress. Choices range from high-barrier polyethylene bottles for small lots to lined fiber drums for tonnage orders. Our packing crew strips away any material that falls short of visual or mechanical integrity, since microplastic or fibrous contamination causes headaches during downstream milling or blending.

    Shipping always matches the volatility and hazard category of the substance. We draw on our own history with temperature excursions, employing insulated transports or desiccant-packed containers if needed. Our logistics partners receive real-time feedback from site to dock, so delays or damages get resolved before delivery upsets a customer’s timeline. We realize small delivery details can snowball into major project delays, so our logistics team tests every shipping option before rolling out changes.

    Bridging Lab and Plant: Value of Manufacturer Experience

    Direct technical support stems from everyday production reality. We don’t recommend generic blends or off-the-shelf solutions unless they solve a real problem observed in our own workshops. Our chemists stay in touch with R&D and scale-up partners, sharing application notes, not just technical sheets.

    We offer on-site or remote troubleshooting for formulation and analytical issues. If trouble arises—a yield drop, color change, or crystallization hiccup—our production records and batch reserve samples enable rapid cross-checks. This working partnership, developed across years of feedback, pays off. Many long-term customers rely on our lot reserves to re-benchmark their own process troubleshooting.

    Even for customers scaling from development to full production, we share batch history and offer advice on adjusting for any transitions, rather than leaving users with a static spec sheet. We trust our familiarity with each lot, knowing exactly how minor shifts can echo down the supply chain.

    Supporting Advanced Synthesis and Research Goals

    Our R&D team understands the experimental pressure researchers face. False readings or unexplained byproducts frustrate method validation. By maintaining high-purity, reproducibility, and up-to-date certificates of analysis, we help laboratories remain compliant with ISO, GMP, or internal audit requirements. Downstream, our documented impurity profiles stay current with the latest regulatory frameworks, supporting customers querying REACH or other authority databases.

    We routinely handle special requests—altering physical form, particle size reduction, or customized blending—provided these modifications do not compromise main grade integrity. With the equipment on hand for micronization and inert packaging, we bring that flexibility to projects where solution behavior or surface area impact matters. That kind of hands-on knowledge rarely comes from distributors or traders outside real production floors.

    Values and Continuous Improvement

    Our operational approach centers on real-world correction and learning, not just compliance. Every return, query, or complaint becomes a basis for an action plan—refining synthesis, updating protocols, or retraining staff instead of making excuses. Meeting regulatory and green chemistry standards happens in parallel with improving operator safety and reducing waste, because that’s how efficient manufacturers survive.

    Feedback loops include direct reports from users—how the compound performs at the lab bench, how it stores during hot weather, how it processes in automated lines or with unusual solvents. Over multiple years, these reports have shaped our practices more than abstract industry trends or market reports. Recent improvements in filtration, thermal stabilization, and packaging emerged directly from such feedback.

    Certifications, Safety, and Regulatory Standing

    We undergo yearly recertification under global chemical quality systems, not for a marketing badge but because those checks catch overlooked risks. The detailed audit trail guarantees supply chain security, critical in a climate of rising concern about cross-border authenticity and traceability. New entrants to the space might focus on price or branding, only to cut corners in storage or batch segregation—issues we learned to correct the hard way.

    Our safety standards reflect both regulatory frameworks and operator experience. Procedures adapt as hazard assessments change. We publish accessible handling guides and work with customers on risk-reducing packaging—whether in reclosable bottles for small labs or UN-rated drums for industrial users. All outbound shipments include transport and emergency recommendations that reflect real hazard exposure, not wishes or the minimum technical requirement.

    Environmental Impact and Sustainability Efforts

    Our operation includes solvent recycling, solid waste reduction, and continuous monitoring for fugitive emissions. We’ve retrofitted sections of our plant, drawing from industry-proven practices to lower energy intensity and water consumption. Waste heat recapture and closed-loop chillers cut both carbon footprint and cost, so our product offers a smaller environmental burden than generic or offshore alternatives. Regular audits keep us ahead of tightening industry and local requirements.

    Customers count on verifiable statements of product stewardship. We provide chain-of-custody transparency and maintain compliance with evolving frameworks on hazardous substances and lifecycle assessments. We work to build evidence-based trust, supported by live audits and published environmental track records.

    Service, Not Just Supply

    The gap between flop and success in specialty chemicals often comes down to service attitude from the source. As direct manufacturers, we see recurring pain points—delayed shipments, lack of application guidance, inconsistent product quality—from users burned by indirect supply chains. We keep our lines open from lab bench to loading dock, preferring to solve problems before they turn into expensive hold-ups.

    Every order is traceable down to raw material lots, and any logistics snags receive immediate investigation—not canned apologies. Clients point to this hands-on support as the deciding factor when tight project timelines or regulatory filings are on the line.

    Technical Data Transparency

    We maintain a full archive of validated analytical methods for our product—HPLC, LCMS, NMR, and even physical testing such as DSC and TGA. This transparency eliminates guesswork and facilitates direct method transfer for customers seeking quick integration into secondary processes. Whenever new usage trends emerge, our technical team collaborates openly to validate extraction or modification protocols, something only a genuine manufacturer can consistently offer.

    Looking Forward: Partnership and Progress

    Continuous market shifts call for flexibility in scale, purity, and logistics. We invest in scalable synthesis and adaptive stock management, so expanding projects can ramp up without major requalification. And instead of relying on a marketing partner’s filtered product info, clients deal with the real production source, leading to a smoother rollout and far fewer surprises along the way.

    Empirical learning and repeat partnership drive our evolution. Every year, we implement incremental improvements uncovered through direct user feedback, internal audits, and advances in process control technology. By investing early in methods that pay off for the user, we ensure long-term viability for both our company and each project that relies on our product.

    Conclusion: Practical Value Through Real Production

    2’-Hydroxy-6’-Methoxyacetophenone stands out because every batch comes direct from our hands. Our blend of quality control, technical service, logistical flexibility, and sustainable practice makes a difference for end-users, project managers, and researchers who cannot afford to gamble with consistency. Customers who have run side-by-side trials attest to the transformation: fewer reworks, stronger process yields, simpler documentation, and much greater confidence adapting to new market or regulatory demands. Each delivery brings more than raw material—it brings the accumulated know-how of a dedicated manufacturer ready to stand behind every shipment.