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HS Code |
121711 |
| Chemical Name | 2'-Hydroxy-6'-Methoxyacetophenone |
| Cas Number | 5815-85-6 |
| Molecular Formula | C9H10O3 |
| Molecular Weight | 166.17 g/mol |
| Appearance | White to off-white crystalline powder |
| Melting Point | 105-109 °C |
| Boiling Point | 307.6 °C at 760 mmHg |
| Solubility | Soluble in organic solvents such as ethanol and DMSO |
| Density | 1.19 g/cm3 |
| Pubchem Cid | 23450330 |
| Smiles | COC1=CC=CC(=C1O)CC(=O)C |
| Inchi | InChI=1S/C9H10O3/c1-6(10)5-7-3-4-8(11)9(12-2)7/h3-4,11H,5H2,1-2H3 |
| Synonyms | 2-Hydroxy-6-methoxyacetophenone; 6-Methoxy-2-hydroxyacetophenone |
| Refractive Index | 1.541 |
| Storage Conditions | Store in a cool, dry, and well-ventilated place |
As an accredited 2'-Hydroxy-6'-Methoxyacetophenone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | The 25g package of 2'-Hydroxy-6'-Methoxyacetophenone comes in a sealed amber glass bottle with a secure screw cap. |
| Shipping | 2'-Hydroxy-6'-Methoxyacetophenone is shipped in tightly sealed containers, protected from light, moisture, and incompatible substances. The packaging ensures safe handling and complies with standard chemical transport regulations. Appropriate labeling and documentation are provided to support secure, compliant, and efficient delivery. Handle with care, following all safety guidelines upon receipt. |
| Storage | 2'-Hydroxy-6'-Methoxyacetophenone should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from sources of heat or ignition. Protect it from light and moisture. Store separately from strong oxidizers and acids. Ensure proper labeling and keep it out of reach of incompatible substances and unauthorized personnel. Dispose of any waste material following appropriate chemical waste regulations. |
Applications of 2'-Hydroxy-6'-Methoxyacetophenone in Industrial Manufacturing2'-Hydroxy-6'-Methoxyacetophenone is an advanced fine chemical intermediate relied upon by industrial formulators pursuing precise performance attributes and regulatory assurance in downstream sectors. As a genuine manufacturer, we support large-scale users with consistent supply and production guidance specific to their operational needs across select specialty applications. Below, we detail the principal industrial manufacturing scenarios where this raw material delivers unique functional contributions, with clear emphasis on verified regulatory frameworks, real formulation ranges, and process specifics. 1. UV Absorber Precursor in Polymer AdditivesMajor polymer compounders and masterbatch producers incorporate this compound to synthesize custom benzophenone-type ultraviolet absorbers, addressing weatherability demands in engineering plastics and coatings. Production lines require precise batch adjustments for polymer compatibility, while regulatory clearances such as REACH and RoHS necessitate close ingredient traceability. Integrators select this acetophenone derivative based on its tailored reactivity profile during key additive synthesis steps. Industry compliance standards
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2. Synthesis of Pharmaceutical IntermediatesAPI manufacturers utilize this raw material as a selective starting point for the construction of complex aromatic structures required in small molecule drugs. Its ortho-hydroxy and methoxy reactive groups enable regioselective transformations, making it central to syntheses under GMP environments. Carefully validated sourcing and traceability are vital to meet international pharmacopeia standards for human and veterinary API manufacturing. Industry compliance standards
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3. Fragrance Ingredient Synthesis for Fine ChemicalsIndustrial fragrance compounders employ this phenolic acetophenone as a crucial intermediate for producing methoxy-phenolic base notes and masking agents found in detergents, air care, and personal care fragrances. Its molecular structure enables targeted etherification and esterification steps, tailored for high-volume captive use and contract blending under strict olfactory and safety criteria. Industry compliance standards
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4. Photographic Chemical ManufacturingManufacturers of specialty photographic chemicals utilize this material as an intermediate for custom-organic developer agents, where precise electron donor profiles and purity determine imaging performance for silver halide processes. Integration relies on rigorous QC and batch documentation conforming to international photo industry chemical protocols. Industry compliance standards
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5. High-Purity Laboratory Reagent ProductionProducers of analytical-grade reagents and certified reference materials use this particular acetophenone derivative in trace analysis solutions owing to its well-defined chromatographic attributes. Formulators require batch-level documentation and full traceability to meet global laboratory reagent quality demands, supporting critical diagnostics, research, and calibration standards. Industry compliance standards
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Every kilogram of 2’-Hydroxy-6’-Methoxyacetophenone we manufacture leaves our facility matching strict quality standards. We have focused on this compound for years, refining every production cycle and raw material selection. Each batch receives detailed analytical attention, which secures high content, low impurity, and stability under varied storage conditions. Our model correlates with its reference number in international chemical databases, and our tracking system guarantees full traceability, an approach that supports laboratories and producers who depend on repeatable, real-world results.
We select our starting phenolic substances based on their verified purity, favoring those from longstanding partners with controlled upstream processes. This way, we minimize by-products and assure colorless or near-colorless crystalline output. If you’ve handled batches from different sources, you know how small differences in synthetic route or purification can affect melting point, odor, or solubility. With our approach, those inconsistencies disappear.
Lab staff working with 2’-Hydroxy-6’-Methoxyacetophenone demand more than technical specs—they need experience-backed reliability. Many products on the market carry impressive-sounding labels, but with varying solvent inclusion, moisture, or packaging debris. By controlling each lot in-house—right down to the way temperature stabilizes before packaging—we prevent those minor but troublesome variances.
Customers in fragrance synthesis, pharmaceutical development, and advanced materials all share the same complaint about lower-grade products: unpredictable background odors or yellowing over time. We track oxidation at every stage, ensure hermetic packing, and fill each order per requirement—scaled from grams to tons, so researchers and manufacturers get exactly what they specify. The difference in yield, processing speed, or even color in the finished product becomes clear right away.
Our 2’-Hydroxy-6’-Methoxyacetophenone ships at ≥99% content, with polymorphic testing confirming a single crystal form. End users in analytical labs count on that. Processors in the flavor sector opt for this grade because trace impurities tend to distort aroma. In pharma and specialty synthesis, a single unknown can force reruns or invalidate a batch.
Difference lies in more than purity. Water content and foreign matter, while often listed as minor, have significant impact in downstream processing. Our moisture threshold holds under 0.2%, as determined by Karl Fischer titration. Any material exceeding visual clarity requirements undergoes additional recrystallization. These parameters, though sometimes overlooked, keep reaction times steady and reduce off-target side reactions. Since our own pilot plant requires consistent behavior, we have engineered every processing step around predictable performance.
Perfume formulators turn to 2’-Hydroxy-6’-Methoxyacetophenone as a valued modifier. Its unique substitution pattern creates a mild, balsamic base note—longer-lasting than plain hydroxyacetophenones and far less harsh than common ether derivatives. Working with end-users, we’ve seen many products fail shelf-life or sensory tests because they rely on poorly purified material, leading to sourness or background haze in formulation.
For pharmaceutical research, this molecule’s hydroxyl and methoxy groups enable targeted derivatization—forming the backbone for exploring new actives or intermediates. Working from our consistent batches, medicinal chemists minimize false leads when running screens, since there are no surprises due to contaminant peaks in their NMR or GC-MS results.
Polymer researchers find another set of strengths. The combination of phenolic and ketonic functionality adapts well to chain extension and crosslinking reactions. We advise several partners on temperature stability and how slight differences in impurity profiles lead to in-process gel formation. Our firsthand experience with heat-and-humidity stress testing supports end-users with meaningful recommendations, not just a generic reference sheet.
Finally, in agricultural formulation and analytical standards supply, reliability in content and form ensures robust calibration and minimal batch-to-batch variation in experimental results. We share methods openly so labs can compare our material to others, rather than rely on wishful reading of a data sheet.
Many customers come to us after struggling with lookalike materials, asking why their outcomes deviate from expectations. We’ve run countless parallel tests using 2’-Hydroxyacetophenone, 4’-Methoxyacetophenone, and other isomeric compounds. Their variant reactivity, melting points, and even interaction with solvents create pitfalls if material origin isn’t verified.
2’-Hydroxy-6’-Methoxyacetophenone features hydroxy at the ortho position and methoxy at the meta—leading to marked variance in electrophilic substitution and hydrogen bonding. Compared to its para-methoxy relative, ours yields a smoother integration in fine fragrance applications and inhibits peroxidation more effectively in storage. These aren’t theoretical benefits. By focusing on structural consistency and robust packaging, we reduce complaints and maintain performance batch after batch.
Some users report sticking or slow dissolution in scaled-up synthesis when using older lots or less rigorously prepared products. Through hands-on process adjustments, we learned early that controlling for residual metals and solvent carryover is crucial. Whether a customer employs it as an API precursor or modifier, consistent granulometry and minimal dust pay off, allowing seamless transfer and metering—even at automatic dosing lines.
Direct handling counts. We store 2’-Hydroxy-6’-Methoxyacetophenone under cool, dry, inert conditions, using packaging that prevents both light and atmospheric ingress. Choices range from high-barrier polyethylene bottles for small lots to lined fiber drums for tonnage orders. Our packing crew strips away any material that falls short of visual or mechanical integrity, since microplastic or fibrous contamination causes headaches during downstream milling or blending.
Shipping always matches the volatility and hazard category of the substance. We draw on our own history with temperature excursions, employing insulated transports or desiccant-packed containers if needed. Our logistics partners receive real-time feedback from site to dock, so delays or damages get resolved before delivery upsets a customer’s timeline. We realize small delivery details can snowball into major project delays, so our logistics team tests every shipping option before rolling out changes.
Direct technical support stems from everyday production reality. We don’t recommend generic blends or off-the-shelf solutions unless they solve a real problem observed in our own workshops. Our chemists stay in touch with R&D and scale-up partners, sharing application notes, not just technical sheets.
We offer on-site or remote troubleshooting for formulation and analytical issues. If trouble arises—a yield drop, color change, or crystallization hiccup—our production records and batch reserve samples enable rapid cross-checks. This working partnership, developed across years of feedback, pays off. Many long-term customers rely on our lot reserves to re-benchmark their own process troubleshooting.
Even for customers scaling from development to full production, we share batch history and offer advice on adjusting for any transitions, rather than leaving users with a static spec sheet. We trust our familiarity with each lot, knowing exactly how minor shifts can echo down the supply chain.
Our R&D team understands the experimental pressure researchers face. False readings or unexplained byproducts frustrate method validation. By maintaining high-purity, reproducibility, and up-to-date certificates of analysis, we help laboratories remain compliant with ISO, GMP, or internal audit requirements. Downstream, our documented impurity profiles stay current with the latest regulatory frameworks, supporting customers querying REACH or other authority databases.
We routinely handle special requests—altering physical form, particle size reduction, or customized blending—provided these modifications do not compromise main grade integrity. With the equipment on hand for micronization and inert packaging, we bring that flexibility to projects where solution behavior or surface area impact matters. That kind of hands-on knowledge rarely comes from distributors or traders outside real production floors.
Our operational approach centers on real-world correction and learning, not just compliance. Every return, query, or complaint becomes a basis for an action plan—refining synthesis, updating protocols, or retraining staff instead of making excuses. Meeting regulatory and green chemistry standards happens in parallel with improving operator safety and reducing waste, because that’s how efficient manufacturers survive.
Feedback loops include direct reports from users—how the compound performs at the lab bench, how it stores during hot weather, how it processes in automated lines or with unusual solvents. Over multiple years, these reports have shaped our practices more than abstract industry trends or market reports. Recent improvements in filtration, thermal stabilization, and packaging emerged directly from such feedback.
We undergo yearly recertification under global chemical quality systems, not for a marketing badge but because those checks catch overlooked risks. The detailed audit trail guarantees supply chain security, critical in a climate of rising concern about cross-border authenticity and traceability. New entrants to the space might focus on price or branding, only to cut corners in storage or batch segregation—issues we learned to correct the hard way.
Our safety standards reflect both regulatory frameworks and operator experience. Procedures adapt as hazard assessments change. We publish accessible handling guides and work with customers on risk-reducing packaging—whether in reclosable bottles for small labs or UN-rated drums for industrial users. All outbound shipments include transport and emergency recommendations that reflect real hazard exposure, not wishes or the minimum technical requirement.
Our operation includes solvent recycling, solid waste reduction, and continuous monitoring for fugitive emissions. We’ve retrofitted sections of our plant, drawing from industry-proven practices to lower energy intensity and water consumption. Waste heat recapture and closed-loop chillers cut both carbon footprint and cost, so our product offers a smaller environmental burden than generic or offshore alternatives. Regular audits keep us ahead of tightening industry and local requirements.
Customers count on verifiable statements of product stewardship. We provide chain-of-custody transparency and maintain compliance with evolving frameworks on hazardous substances and lifecycle assessments. We work to build evidence-based trust, supported by live audits and published environmental track records.
The gap between flop and success in specialty chemicals often comes down to service attitude from the source. As direct manufacturers, we see recurring pain points—delayed shipments, lack of application guidance, inconsistent product quality—from users burned by indirect supply chains. We keep our lines open from lab bench to loading dock, preferring to solve problems before they turn into expensive hold-ups.
Every order is traceable down to raw material lots, and any logistics snags receive immediate investigation—not canned apologies. Clients point to this hands-on support as the deciding factor when tight project timelines or regulatory filings are on the line.
We maintain a full archive of validated analytical methods for our product—HPLC, LCMS, NMR, and even physical testing such as DSC and TGA. This transparency eliminates guesswork and facilitates direct method transfer for customers seeking quick integration into secondary processes. Whenever new usage trends emerge, our technical team collaborates openly to validate extraction or modification protocols, something only a genuine manufacturer can consistently offer.
Continuous market shifts call for flexibility in scale, purity, and logistics. We invest in scalable synthesis and adaptive stock management, so expanding projects can ramp up without major requalification. And instead of relying on a marketing partner’s filtered product info, clients deal with the real production source, leading to a smoother rollout and far fewer surprises along the way.
Empirical learning and repeat partnership drive our evolution. Every year, we implement incremental improvements uncovered through direct user feedback, internal audits, and advances in process control technology. By investing early in methods that pay off for the user, we ensure long-term viability for both our company and each project that relies on our product.
2’-Hydroxy-6’-Methoxyacetophenone stands out because every batch comes direct from our hands. Our blend of quality control, technical service, logistical flexibility, and sustainable practice makes a difference for end-users, project managers, and researchers who cannot afford to gamble with consistency. Customers who have run side-by-side trials attest to the transformation: fewer reworks, stronger process yields, simpler documentation, and much greater confidence adapting to new market or regulatory demands. Each delivery brings more than raw material—it brings the accumulated know-how of a dedicated manufacturer ready to stand behind every shipment.