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2-Ethoxypropene

    • Product Name 2-Ethoxypropene
    • Alias 1-propenyl ethyl ether
    • Einecs 216-415-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry sales7@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    606811

    Cas Number 926-94-5
    Iupac Name 2-ethoxyprop-1-ene
    Molecular Formula C5H10O
    Molar Mass 86.13 g/mol
    Appearance Colorless liquid
    Boiling Point 57-59 °C
    Density 0.76 g/cm3
    Flash Point -17 °C
    Refractive Index 1.400
    Solubility In Water Slightly soluble

    As an accredited 2-Ethoxypropene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 2-Ethoxypropene is packaged in a 500 mL amber glass bottle with a secure plastic cap, labeled with safety and hazard information.
    Shipping 2-Ethoxypropene should be shipped in tightly sealed containers, under inert gas such as nitrogen to prevent polymerization. Store and transport in a cool, well-ventilated area away from heat, sparks, and open flames. Comply with hazardous materials regulations, as this chemical is flammable and may pose health risks if inhaled or exposed to skin.
    Storage 2-Ethoxypropene should be stored in a cool, dry, and well-ventilated area away from heat, sparks, open flames, and incompatible substances such as acids and oxidizers. The container must be tightly closed and properly labeled. Avoid exposure to moisture. Use pressure-resistant containers if necessary, and store away from direct sunlight to prevent degradation and hazardous vapor release.
    Application of 2-Ethoxypropene

    Applications of 2-Ethoxypropene in Industrial Manufacturing

    2-Ethoxypropene serves as a key intermediate in various chemical manufacturing sectors. Its efficient alkylating and blocking capabilities enable specialty downstream reactions and product development. Below, we detail major application fields, process details, and end product pathways based on our direct production and technical service experience.

    1. Pharmaceutical Intermediate Synthesis

    In active pharmaceutical ingredient (API) synthesis, 2-ethoxypropene functions as a protecting group for hydroxy compounds during multi-step reactions, specifically for ketalization and acetalization steps. Research and commercial production often utilize it to temporarily mask functional groups, thereby improving yield and selectivity in complex molecule assembly. Critical applications include the manufacture of antibiotics, antiviral agents, and other fine chemicals where controlled deprotection and compatibility with reaction conditions are required. Stringent quality and traceability requirements mandate batch-specific documentation from upstream raw material through to validated downstream process completion.

    Industry compliance standards

    • ICH Q7 GMP guidelines for active pharmaceutical ingredient manufacturing
    • USP, EP, and JP pharmacopoeial standards for residual solvents and process impurities
    • 21 CFR Parts 210/211 U.S. FDA cGMP for finished pharmaceuticals
    • EU EudraLex Volume 4, Annex 13 for investigational medicinal products

    Typical usage ratio

    • 0.9–1.2 molar equivalents relative to substrate; ratios determined by substrate reactivity and downstream hydrolysis tolerance

    Downstream process integration

    • Added at protection step in multi-stage synthesis after initial substrate preparation and prior to key functionalization reactions; removed during final deprotection using acid or base catalysis

    Final product types

    • Anti-infective API intermediates
    • Central nervous system drug intermediates
    • Hormone precursor intermediates
    • Antiviral compound intermediates

    2. Agrochemical Compound Development

    Manufacturers in the agrochemical sector use 2-ethoxypropene during the synthesis of pesticide, herbicide, and fungicide actives, particularly when transient protection of aldehyde or ketone groups is necessary to enable selective downstream modifications. The high reactivity with carbonyl compounds improves intermediate yield, especially in processes involving stepwise alkylation or condensation reactions. Native residue monitoring and safe handling protocols remain essential due to regulatory controls over process chemicals and environmental release.

    Industry compliance standards

    • FAO/WHO JMPR guidelines for pesticides
    • OECD guidelines for chemical testing and GLP compliance
    • REACH (EC 1907/2006) for registration of agrochemical intermediates in Europe
    • EPA 40 CFR Parts 150–189 for U.S. pesticide manufacturing

    Typical usage ratio

    • 0.8–1.0 molar equivalents per functional group; adjusted for specific protection duration and subsequent deprotection efficiency

    Downstream process integration

    • Introduced during intermediate protection steps prior to heterocyclic ring closure or electrophilic substitution; monitored for completion before next synthetic transformation

    Final product types

    • Pesticide intermediates (organophosphates, carbamates)
    • Herbicide intermediates
    • Fungicide precursor compounds
    • Plant growth regulator raw materials

    3. Polymer and Resin Manufacturing

    Specialty polymers and resins producers incorporate 2-ethoxypropene as a reactant for modifying polyols and enhancing crosslinking efficiency during copolymerization. The intermediate structure allows precise molecular weight adjustment and installation of pendant functional groups in resins destined for high-performance coatings and adhesives. Consistency of purity and controlled introduction are vital for batch reproducibility, as any variation can impact physical properties, film formation, and curing behavior of downstream end products.

    Industry compliance standards

    • ISO 9001 quality management for resin and polymer manufacturing
    • REACH Annex XVII restrictions (Europe)
    • ASTM D7767 for monomer content in adhesives
    • RoHS 2 Directive (2011/65/EU) for electronic and electrical adhesives/resins

    Typical usage ratio

    • 2–8% w/w relative to total monomer feed; percentage based on target glass transition temperature and crosslink density

    Downstream process integration

    • Dosed into pre-polymerization mixture before catalyst addition; controlled addition limits volatilization and ensures uniform block formation

    Final product types

    • High-solids acrylic resins
    • Polyurethane crosslinkers
    • Epoxy adhesive modifiers
    • Low-VOC coating resins

    4. Flavors and Fragrances Ingredient Synthesis

    2-ethoxypropene offers a rapid and selective route for protecting hydroxy- and carbonyl-functionalized building blocks in specialty ester and aldehyde production for the flavors and fragrances sector. Downstream manufacturers employ it to maximize desired isomer production while minimizing unwanted side reactions, enabling high-purity aroma compound synthesis compliant with global food contact and cosmetic regulatory standards. All lots must be free of undesired residuals and measurable by validated GC-MS techniques.

    Industry compliance standards

    • IFRA Standards for fragrance materials
    • FCC (Food Chemicals Codex) for food ingredient safety
    • 21 CFR 172 Subpart F (FDA) for flavoring substances
    • EU Regulation No 1334/2008 on flavorings and certain food ingredients

    Typical usage ratio

    • 0.95–1.05 molar equivalents per functional group; tightly controlled to minimize unreacted reagent and facilitate clean final product purification

    Downstream process integration

    • Used for masking reactive sites prior to oxidation or esterification; removed enzymatically or chemically to yield pure aroma compounds in the final stage

    Final product types

    • Fruit ester intermediates for flavor blends
    • Aldehyde building blocks for fragrance bases
    • Complex natural-identical aroma molecules
    • Floral and citrus top notes for perfumery
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    Certification & Compliance
    More Introduction

    2-Ethoxypropene: Precision Chemistry Backed by Hands-On Manufacturing

    Understanding 2-Ethoxypropene from a Manufacturer’s Perspective

    We have spent years watching chemists and process engineers reach for 2-ethoxypropene when they need clean results and predictable performance in tough reaction steps. Questions about purity, stability, and handling land on our desks almost every week, and the same themes keep coming up—chemists want greater control, fewer side reactions, and reagents that won’t derail unstable substrates. Those needs steer the way we manufacture 2-ethoxypropene and shape every lot we release.

    Product Profile: Model, Appearance, and Physical Qualities

    Our 2-ethoxypropene (sometimes described as ethyl isopropenyl ether) enters the world as a clear, colorless liquid with a sharp, distinctive odor. At room temperature, it stays fluid and manageable, with a boiling range that supports easy fractionation and minimal risk of product loss during transfer. We keep strict control on methyl vinyl ether, acetone, and ethanol levels left behind after synthesis, because overlooked residues throw off high-precision applications such as pharmaceutical synthesis or polymer manufacture. Each lot falls inside narrow purity targets—customers have told us their chromatography data consistently confirms our technical figures. Rigorous gas chromatography monitoring and moisture controls support this repeatability batch after batch.

    Application Experience: Where 2-Ethoxypropene Makes a Difference

    The first place our customers head with 2-ethoxypropene is acetal and ketal formation. Laboratory teams working with temperature- or moisture-sensitive aldehydes mention how classic acid-catalyzed protection reactions respond reliably with our product, while competing ethers struggle to match the selectivity and gentle reaction conditions. Synthetic chemists processing multi-step libraries have pushed us for tighter packaging and smaller containers. On their side, smaller aliquots allow cleaner sampling lines, less exposure to air, and better storage times without repeated transfers that risk peroxide build-up.

    Organizations attempting the same steps with methyl vinyl ether or dimethoxypropene share different complaint lists: toughness in handling and occasional difficult removal of by-products. 2-Ethoxypropene stands out for its neat volatility and ability to drive transformations without leaving tricky residues. That lighter footprint reduces the clean-up burden, makes automated reactors easier to run, and cuts solvent washing costs, especially at scale.

    Handling in the Plant: Safety and Stability Must Come First

    Our experience has taught us the importance of airtight containment at every transfer point. 2-ethoxypropene reacts quickly with acids and some bases, and open containers in humid air pick up water, which turns into unwanted hydrolysis. We have implemented customized nitrogen-purged filling lines and storage tanks equipped with desiccators. These cost more in up-front equipment, but they reduce lost product and extend usable shelf life, which matters once a chemist opens a container for routine sampling. Operators inspect gaskets, valves, and stoppers several times every shift. Our training programs emphasize rapid sealing after each use and never leaving containers half-opened. Losses from simple carelessness can lead to expensive product returns and, worse, compromised chemistry in customer plants.

    Even after years of production, we still find new subtleties in managing 2-ethoxypropene waste streams. Many facilities struggle to neutralize acidic residues safely without aggressive hydrolysis, and we suggest dedicated catch drums equipped to handle decomposed vapors. Teams using traditional glassware setups in universities sometimes forget how strongly this ether attacks certain polymers and adhesives. For repeatable results, we recommend using well-documented, tested labware and never improvising sealants or transfer lines.

    How We Keep Quality High: From Batch Production to Delivery

    A manufacturer’s reputation hinges on scrutiny at every step. We opted for continuous distillation, not batchwise separation, after watching how batch approaches can leave heavy-end contaminants or accumulate peroxide impurities over time. Our process uses a sequence of distillation columns, each equipped with automated sensors that fine-tune temperature and flow. These real-time checks minimize operator error and ensure tight control over final purity. QA analysts take random samples from every drum, using infrared spectroscopy and wet chemistry to confirm absence of detectable peroxides and verify exact levels of the parent compound.

    Packaging grew into its own challenge. Old habits—reusing drums, relying on common stoppers, mixing labels—caused mistakes that appeared months later as returned shipments or legal concerns. Today, finished 2-ethoxypropene leaves our facility only in newly lined drums, with inert atmosphere overlays. Smaller volumes travel in certified aluminum bottles tested for chemical compatibility—years of field feedback warned us that cheap caps and untested plastics break down quickly and contaminate high-purity reactions. Detailed labels, tamper-evident seals, and batch numbers link every delivery back to the raw material depot. We train logistics teams in the product’s specific hazards and the need for prompt, temperature-stable transit, especially in summer.

    Use Cases that Shape our Product: Voices from Industry and Academia

    Pharmaceutical groups developing small-scale screening libraries call for high consistency from bottle to bottle, since even minor variation can sabotage kinetic studies. Our production lines hit their stride meeting these requests with no detectable stabilizer residues (such as BHT or hydroquinone), so as not to add unknowns to sensitive reactions. We field questions about shelf life weekly; our results show stability above 98 percent after six months when unopened and stored away from direct sunlight. Chemists prefer to work with recently packaged material, so we schedule staggered runs instead of long-term holding.

    Polymer manufacturers head in a different direction. They use 2-ethoxypropene as a comonomer or a transient blocking agent, looking for a clean incorporation into backbone chains and smooth cleavage under acidic conditions. They want no mechanical surprises: no bubbly foams, uneven viscosity, or trace metallic residues from plant lines. Factories scaling up have asked us repeatedly how to maximize every drop—tracked by total solids remaining and analytical GC for side products. Our close communication loop with their process engineers led us to fine-tune pre-delivery clean-room inspection and double-filtration, eliminating recurring problems with micro-residues from valve lubricants or warehouse dust.

    Academic research groups contribute feedback as well. Synthesis teams exploring new derivatives contact us about stability under mild acid or heat, especially as acetals grown from 2-ethoxypropene become inputs for further functionalization. They seek longer shelf life and containers that prevent air ingress between repetitive micro-scale experiments. These researchers notice any deviation from the norm, so even tiny inconsistencies in color, odor, or reactivity quickly generate detailed feedback for our QA team.

    Comparing 2-Ethoxypropene to Other Ethers in Real-World Reactions

    Customers often ask how 2-ethoxypropene performs beside methyl vinyl ether, ethyl vinyl ether, or acrolein derivatives. We have watched hands-on trials in pilot plants show the same trend: 2-ethoxypropene resists hydrolysis and extends the range of sensitive transformations, especially for base-labile or acid-labile building blocks. In our experience, competing ethers either don’t fully evaporate during work-up—which increases time and solvent use—or split off reactive by-products that complicate purification. Methyl vinyl ether, for example, hydrolyzes quickly, skipping over the delicate controlled-release many chemists want from their ketal-forming reagent. Our product runs clean, and the distinctive odor signals both presence and loss during venting—a simple but practical handling checkpoint.

    Long-term storage brings more surprises. 2-ethoxypropene, once stabilized under dry gas, beats many other vinyl ethers in keeping color and odor stable for half a year or more. This outlasts ethyl vinyl ether, which picks up acrolein odor, and extends beyond dimethoxypropene, prone to slow breakdown even under tight seals. We built this experience into our storage guidelines, shipping only under nitrogen flush and advising end users to draw off the smallest practical aliquots each session. Our batch records and time-stamped log sheets let users track changes, catch problems quickly, and keep paperwork tight for regulatory audits.

    Challenges, Solutions, and Ongoing Improvements

    Production cost increases remain a reality for materials this volatile. The market for acetals in drug development or crop protection pulls on limited supply, so raw input pricing can swing sharply. We counteract market shocks by locking in long-term contracts with ethanol suppliers and updating our distillation systems to recover off-spec material where feasible. Feedback from plant operators led us to install automated leak detection and vapor recovery, which helped recapture valuable solvent and reduce air emissions from fill lines.

    Handling safety never fades into the background. Early mishaps with peroxide formation taught us not to leave drums unmonitored or improperly purged. Every operator on our floor learns to label opened containers with date and user, and we only store filled drums indoors, away from bright light sources. Training covers the signs of incipient degradation—changes in smell, slight yellowing, tendency to form sticky coatings—and encourages immediate isolation and investigation before rework or disposal.

    We once watched a university team lose an entire series of experiments because local air moisture entered an inadequately sealed sample. The lesson stuck. Now, we work closely with packaging suppliers to develop tighter-sealing containers and recommend that every end user keep desiccant packs or dry inert gas at hand—the extra cost prevents far greater losses down the line.

    Analytical innovation has pushed us to stay ahead. As high-resolution spectrometers and wet chemistry become routine at every scale, our customers notice and report minor trends: lingering traces of ethanol, transient yellow coloration, unexpected volatility changes. We use these reports to adapt production parameters quarterly, reviewing each stage from raw input to filling and shipment. Every lot that leaves our docks carries not just a set of numbers, but also experience reflected in handling notes, recommended lab techniques, and advice about both traditional and emerging reaction applications.

    Why 2-Ethoxypropene Remains a Go-To Building Block—and What Sets Our Manufacturing Apart

    Our years of experience with 2-ethoxypropene taught us its true worth lies in the predictability it brings to demanding syntheses. The reliability of our internal QC procedures gets reflected downstream by consistent customer results, fewer surprises during scale-up, and a smaller gap between laboratory discovery and production reality. Unlike off-standard ethers that demand workaround steps to overcome instability, our product delivers clean, reproducible reactions because the batch-to-batch consistency is never an afterthought—every small improvement in storage, filling, or QA supports that goal.

    Real chemistry, at laboratory or manufacturing scale, can unravel over the smallest overlooked variable—be it unwanted hydrolysis, troublesome by-products, or unstable containers. Decades of hands-on effort taught us the only way to guarantee purity and ease-of-use is by controlling every factor directly, from raw materials to finished drum. Our ongoing conversations with chemists, scale-up managers, and logistics teams supply an unending feedback loop, so each year’s process embodies dozens of improvements made, measured, and banked on the plant floor.

    2-Ethoxypropene remains the preferred choice for acetal formation and protection steps in laboratories and commercial plants alike. Broad adoption grew out of side-by-side comparisons, where performance, handling, and reliability outweighed theoretical purity figures on a page. Through years of attention to practical details—tight storage, real-time analytic checks, custom packaging—we see our product continue to drive cleaner results and easier chemistry. Every drum shipped carries not just our name, but also the accumulated knowledge of chemists, plant hands, and researchers worldwide.