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2-Ethoxyethyl Cyanoacetate

    • Product Name 2-Ethoxyethyl Cyanoacetate
    • Alias Ethylglycol cyanoacetate
    • Einecs 408-030-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    663118

    Chemicalname 2-Ethoxyethyl Cyanoacetate
    Molecularformula C7H11NO3
    Molecularweight 157.17 g/mol
    Casnumber 623-50-7
    Appearance Colorless to pale yellow liquid
    Boilingpoint 255 °C
    Meltingpoint -20 °C
    Density 1.105 g/cm3
    Solubility Soluble in organic solvents
    Purity Typically ≥98%
    Refractiveindex 1.441
    Flashpoint 116 °C

    As an accredited 2-Ethoxyethyl Cyanoacetate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 2-Ethoxyethyl Cyanoacetate, 500g, supplied in a tightly sealed amber glass bottle with chemical-resistant cap, labeled with hazard warnings.
    Shipping 2-Ethoxyethyl Cyanoacetate is shipped in tightly sealed containers, typically made of glass or high-density polyethylene, to prevent leaks and contamination. It should be transported under cool, dry conditions and protected from direct sunlight. Proper labeling and compliance with local, national, and international regulations for chemicals are required during shipping.
    Storage 2-Ethoxyethyl Cyanoacetate should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from sources of ignition, heat, and direct sunlight. Keep it separate from incompatible substances such as strong oxidizers and acids. Proper labeling and secure storage are essential to prevent accidental exposure, spills, or contamination. Store at recommended temperature guidelines specified by the manufacturer.
    Application of 2-Ethoxyethyl Cyanoacetate

    Applications of 2-Ethoxyethyl Cyanoacetate in Industrial Manufacturing

    2-Ethoxyethyl Cyanoacetate is a specialized chemical intermediate employed by select industries for its cyano and ester functional groups, contributing to molecular modification processes downstream. Our manufacturing expertise ensures every batch meets stringent purity levels, helping manufacturers achieve process consistency and compliant finished goods across regulated environments. Below we outline verified industrial application segments, providing detailed insight into real-world standards, incorporation practices, process integration, and tangible product outcomes.

    1. Active Pharmaceutical Ingredient Intermediate Synthesis

    Many pharmaceutical companies source this compound as a key building block during the multi-step synthesis of complex APIs, especially for antiepileptic and vasodilator drug classes. Its controlled reactivity and solubility characteristics allow chemists to achieve high selectively in Knoevenagel condensation reactions, often under strictly validated process conditions.

    Industry compliance standards

    • Current Good Manufacturing Practice (cGMP, 21 CFR Parts 210 and 211)
    • ICH Q7 Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients
    • European Pharmacopoeia Monograph 2.9.10 (related substance purity control)
    • Validation protocols under FDA/EMA regulatory guidance

    Typical usage ratio

    • 0.3% - 1.2% w/w of the total API synthesis batch, ratio selected based on target yield and byproduct minimization during condensation and alkylation steps

    Downstream process integration

    • Charged into the reaction vessel post-initial base formation, usually dissolved in polar aprotic solvents such as DMF or DMSO, entering during anhydrous conditions to facilitate subsequent carbon-carbon bond formation

    Final product types

    • Intermediates for pyridine or pyrimidine-based APIs
    • Precursors to ion channel modulators or central nervous system medications
    • Specialty fine chemicals used in investigational pharmaceutical research

    2. Crop Protection Active Ingredient Manufacturing

    Plant protection manufacturers employ this ester as a cyanoacetate donor in the synthesis of select herbicide and insecticide molecules requiring electron-withdrawing group introduction. Controlled addition enables customization of biological activity and environmental degradation profiles in the finished agrochemical actives.

    Industry compliance standards

    • FAO/WHO Pesticide Specifications
    • ISO 9001:2015 Quality Management for agrochemical intermediates
    • REACH Regulation (EC) No 1907/2006—chemical registration and safety evaluation
    • National agrochemical registration programs—EPA (USA), ICAMA (China)

    Typical usage ratio

    • 0.5% - 2.5% by mass depending on the active’s backbone modification step; rate adjusted according to molecular conversion efficiency and regulatory limits for impurities

    Downstream process integration

    • Introduced in the pre-crystallization phase within closed synthesis reactors, often following initial halogenation or nitration reactions, facilitating the installation of the cyano group via nucleophilic substitution or condensation

    Final product types

    • Precursor actives for post-emergence weed control agents
    • Intermediate molecules for synthetic pyrethroid insecticides
    • Active cores for fungicide formulations with customized degradation rates

    3. Liquid Crystal Display (LCD) Intermediate Components

    The electronics sector uses this cyanoester during the manufacture of liquid crystal materials. Its integration allows downstream engineers to modulate dielectric anisotropy and phase transition temperatures required for precise display performance, supporting formulators of specialty liquid crystal compounds.

    Industry compliance standards

    • IEC 61249-2-21 (Materials for printed boards and other connecting structures – Sectional specification for non-halogenated products)
    • JIS C6109-1 (Testing methods for liquid crystal materials)
    • ISO/TS 16419:2013 (LCD test procedures)
    • RoHS Directive (Restriction of Hazardous Substances, EU 2011/65/EU)

    Typical usage ratio

    • 0.7% - 2% of the liquid crystal batch formulation; precise fraction determined by dielectric and optical requirements in the end-use application

    Downstream process integration

    • Dosed during the early-stage molecular blending tank prior to column purification and alignment treatment, before final compounding with other nematic and smectic monomers

    Final product types

    • Liquid crystal compounds for TFT and OLED flat-panel displays
    • Intermediate mixtures for specialty optical films
    • Electronic-grade fluid crystals for e-paper devices

    4. Photographic and Imaging Chemical Synthesis

    Imaging material producers utilize this compound as a cyano-functional intermediate for synthesizing light-sensitive dye couplers and stabilizers. Its high purity ensures minimal background signal and reliable color formation in professional photographic film and printing applications.

    Industry compliance standards

    • ISO 9001 for imaging chemicals
    • ISO 18902: Imaging materials - Processed imaging materials - Albums, framing and storage
    • ANSI IT9.2 - Photographic Processing Chemicals
    • Cleanroom GMP for photographic chemical filling

    Typical usage ratio

    • 0.4% - 1.1% by total chemical mixture weight, adjusted depending on target dye intensity and batch volume in coupler and developer formulations

    Downstream process integration

    • Added post-initial condensation, directly into color coupler synthesis reactors, typically managed under controlled temperature and pH to maximize coupling efficiency and minimize discoloration byproducts

    Final product types

    • Color dye coupler intermediates for professional photographs
    • Stabilizer ingredients for digital printing inks
    • Specialty imaging reagent kits for scientific analysis films

    5. Specialty Polymer and Resin Additive Formulation

    Chemical formulators in the advanced polymer sector employ this cyanoacetate during the functionalization of acrylic and vinyl chloride resins where polarity modification or chain extension properties are required. Its use supports performance tuning for specific surface, barrier, or flexibility characteristics in the final resin product.

    Industry compliance standards

    • ISO 9001:2015 for polymer additives
    • ASTM D256 (Standard Test Methods for Impact Resistance of Plastics and Electrical Insulating Materials)
    • REACH compliance for polymer additives
    • RoHS Directive for electronic-grade resins

    Typical usage ratio

    • 0.2% - 1.5% of total monomer mass, optimized during pre-polymerization blends; dosage dependent on target impact strength and compatibility with downstream modifiers

    Downstream process integration

    • Included in the reactor feedstock prior to catalyst addition, reacting during bulk or emulsion polymerization to enable molecular grafting or polar side-chain installation

    Final product types

    • Film-forming resins for protective coatings
    • Additive-modified acrylic sheets for optical panels
    • Flexible PVC compounds for specialty cable coatings
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    Certification & Compliance
    More Introduction

    2-Ethoxyethyl Cyanoacetate: Direct From the Manufacturer’s Floor

    Introducing Genuine 2-Ethoxyethyl Cyanoacetate

    Walking through our facility, the sharp yet clean aroma of esters mixes with the hum of reactors that have been serving the chemical industry for years. Among the esters that fill our flasks, 2-Ethoxyethyl Cyanoacetate stands out for good reason. We don’t just batch this molecule for a margin; we’ve tracked its path for decades, studied its behavior through seasons, and supported research teams struggling for purity and yield. From our experience, this compound deserves more recognition—not just as a stock line entry, but as a workhorse in complex organic synthesis.

    What Sets 2-Ethoxyethyl Cyanoacetate Apart

    Our production line for 2-Ethoxyethyl Cyanoacetate often runs alongside classic methyl and ethyl esters of cyanoacetic acid. Chemists call for these core intermediates daily, but those who know their toolbox well recognize why the 2-ethoxyethyl group earns a spot on the rack. Chemically, the 2-ethoxyethyl group brings a different blend of solubility and reactivity compared with shorter chains like methyl or ethyl. Sometimes the difference shows up in reaction rates, sometimes in easier work-up or separation. This matters when scale goes from grams on the bench top to kilos or tons in sealed vessels.

    We’ve seen our own team, and partners at clients’ labs, benefit from this ester’s practical solubility in polar and non-polar solvents—helpful for routes that jam with more stubborn esters. That small 2-ethoxyethyl tail can clear product out of the mixer fast after a reaction, so time on the floor isn’t lost to delays at the extraction step.

    For those new to it: a molecule like 2-Ethoxyethyl Cyanoacetate doesn’t just serve as another link in the chain. It sets the tone for downstream chemistry, especially where selective alkylation or condensation comes into play. The cyano and ester groups naturally pull in skilled organic chemists, but the 2-ethoxyethyl group itself gives extra leverage in method development. You won’t find this benefit in plain methyl or ethyl cyanoacetate.

    Consistent Specifications, Purposeful Manufacturing

    On our floor, preparation always starts with careful selection of feedstocks and routine calibration of our reactors. We target high purity, not just because paperwork demands it, but because any side reaction or impurity cuts into downstream yield—and headaches in QA cost far more than bull runs in the market. We check parameters from color to water content, but our pride lies in tight control over acid value and residual solvent. This pays off for customers aiming for high-value pharmaceuticals or specialty polymers, where even small contaminants can spell major loss.

    Our most common batch sizes range from pilot-scale drums to full production, but what unites them is reliable delivery of a clear, colorless to pale yellow liquid. Typical GC shows purity in the high nineties. Moisture checks are routine. We understand that solvent residues carry through final products if not kept low, so GC-MS and Karl Fischer titration show up in everyday QC routines. We keep our methods transparent so every partner can focus on chemistry, not uncertainty.

    Real-World Usage Drives Our Approach

    Walk into any synthetic lab using complex nitriles, and there’s a good chance our cyanoacetate finds a role. The molecule offers both nucleophilic and electrophilic handles, which often means it gets the call for Knoevenagel condensations, alkylations, or Michael additions. We hear from partners making pharmaceutical intermediates—pyridines, piperidines, and heterocycles of all stripes—who choose this particular ester for the slightly higher boiling point and easier manageability during reaction quenching and purification.

    In coatings and specialty materials, we see polymer makers gravitate to 2-ethoxyethyl cyanoacetate where flexibility in solvent compatibility cuts weeks from development time. The role it plays in matching monomers with different solubility profiles often becomes the hidden hero in pilot plant troubleshooting sessions. Chemists can cleanly incorporate the molecule where other esters create phase separation headaches or sluggish emulsions. We build our process knowledge on stories like these, not just certificate readings.

    We’ve seen direct feedback: a plant running acrylic polymers switched from ethyl cyanoacetate to our 2-ethoxyethyl version and shaved hours off their process, thanks to improved solubility and less foaming. These aren’t claims built on speculation—they’re results from partners working inside real-world constraints like production volume, batch cycling, and customer deadlines.

    Common Challenges, Practical Solutions

    Every production run brings its own set of surprises, but a few challenges come up again and again with esters like this. Shelf-life, storage, and shipment top the worry list. Over years of manufacturing and delivery, we’ve learned to work closely with transport teams and warehouse staff to lock down the best combination of drum linings and temperature control. We support partners to keep containers tightly closed, shielded from moisture and light.

    Even small leaks in packaging, or exposure to high temperatures, can push minor by-product formation. Old warehouse habits die hard, but our regular site visits and training keep basics sharp, from double-sealed bungs on containers to outloading directly onto temperature-monitored trucks. Many headaches—crystallization, off-spec color, or unexplained turbidity—originate from distribution missteps more than lab errors. We’re candid on this: small investments in reliable packaging systems pay bigger dividends in satisfaction than chasing minor tweaks to process controls.

    Comparisons from Practical Experience

    We run the comparison tests ourselves. In our hands, 2-ethoxyethyl cyanoacetate offers markedly better solution behavior in solvents like ethanol, acetone, and several common glycols than methyl or ethyl derivatives. During batch testing, this translates to smoother operation of both continuous and batch reactors, less scraping or sticking inside vessels, and reduced solvent loss from unnecessary purging.

    Anecdotes from our technical support calls highlight that 2-ethoxyethyl cyanoacetate often improves crystallization profiles for some intermediates. Easier product wash translates to cleaner isolations and less time spent troubleshooting semi-solids. We’ve even heard molders note how the final polymer structure benefits, with less haze or fewer bubbles, when this ester replaces shorter analogs.

    Some customers enter conversations weighing the higher cost or specialized handling needs of this ester. We bring them into our lab, let them run side-by-side batches, and show firsthand that yield improvements and labor savings on separation or purification quickly close the price gap. We don’t shy from the facts: For some bulk applications where highest solvent power isn’t needed, cheaper methyl or ethyl versions make sense. But anyone facing tough separations, or seeking more forgiving process windows, finds the investment in 2-ethoxyethyl pays off.

    Responsibility Toward Safety and Regulation

    Years of production in regulated industries trained us to handle cyano compounds with respect for people and the environment. We maintain strict controls, keep proper ventilation, and manage waste streams closely for every run. Regulatory agencies periodically inspect our operations, keeping us accountable to both worker safety and external standards.

    From time to time, regional regulations or customer requirements shift on labeling, packaging, or impurity levels. We keep teams updated with monthly workshops and cross-checks with legal staff. We invite auditors, both third-party and customer-chosen, to walk our lines, inspect logs, and ask tough questions. It keeps our standards high and builds the trust that relationships in chemical manufacturing require.

    Our documentation includes transparent traceability from raw material through batch records and final product certificates. We don’t bury shortcomings or miss out on process adjustments learned from years at the reactor. Partners trust us to support them through sudden specification changes, documentation updates, or requests for extra analysis.

    Guidance for New Users

    For labs, pilot plants, or full-scale production teams new to this material, we offer direct advice based on old lessons. Store the ester in sealed drums under dry, cool conditions. Avoid metal containers that might react with trace acid. During product transfer, minimize headspace and limit air or light exposure. Always check compatibility with in-house solvents—routine bench checks ahead of scaled runs avoid surprises downstream.

    On the process side, mixing the ester in with strong bases or nucleophiles should proceed in a controlled manner, keeping temperature moderate and agitation steady. Reactors shouldn’t run too hot, or hydrolysis can accelerate, cutting into yield and leaving downstream workup messier. For scale-up, incremental pilot trials have saved many teams from costly downtime or reprocessing. We encourage technical teams to reach out for hints, not just formal documentation.

    Disposal and effluent management deserve attention. Though this ester is less volatile than shorter esters, it still carries the risks of cyano compounds and must be handled accordingly in spent solutions and wash waters. As local regulations evolve on organonitrile disposal and monitoring, our samples and documentation offer a clear starting point for compliance review.

    Collaborating for Advancement

    Some of the most promising successes with 2-ethoxyethyl cyanoacetate have come from joint development projects. Rather than stick to old recipes, R&D groups work with our technical team to fine-tune reaction conditions, test alternative solvents, or tweak feed rates and process temperatures. We’ve even retooled reactor lines or shifted batch sequencing to accommodate clients’ unique needs. By building process flexibility into our plant, we help shorten the path from bench to production. Exchange of real process data—not just glossy brochures—characterizes our strongest relationships.

    As the market for specialty intermediates grows in sophistication, the demands on purity and process resilience rise too. Older approaches to cyanoacetate chemistry tied production to rigid specifications and slow changeovers. By applying years of plant experience, technical fieldwork, and plenty of learning from mistakes, we turn the production of 2-ethoxyethyl cyanoacetate from routine commodity work into a collaborative platform. Teams on both sides know the value of a supplier who listens, adapts, and learns as chemistry evolves.

    Insights from the Shop Floor

    Behind each shipment, the faces of our operators and chemists tell a story—routine, in some ways, but always subject to innovation. We trust our teams with real responsibility, not just because procedures call for it, but because repeatable, safe chemistry depends on the instincts developed running hundreds of batches. We keep lines of communication open from plant floor to customer site, steadily improving documentation, anticipating delivery hiccups, and solving the day-to-day issues that chemical manufacturing inevitably brings.

    We’ve watched projects stall on factors like shipment delays, last-minute spec changes, or lab-scale observations ignored by remote headquarters. Years of running real equipment, troubleshooting process upsets, and investing in training pay off in smoother handoffs between teams. Customers who continue sourcing from us know we never push responsibility downhill; we dig into process bottlenecks, work through SOP updates, and even run parallel batches for joint analysis when something goes sideways.

    Looking Forward: The Role of 2-Ethoxyethyl Cyanoacetate

    Markets change, and so do chemical processes. Where traditional intermediates often fall short in advanced synthesis, 2-ethoxyethyl cyanoacetate brings a blend of chemical properties and hands-on manageability that we’ve come to depend on. It doesn’t just fill a need on a spreadsheet—it bridges production and innovation, allowing research teams and plant operators to push projects ahead with fewer roadblocks.

    We stand behind this product not because it’s the only ester out there, but because practical experience, evolving applications, and decades of shop-floor know-how give us confidence in what we ship. We take pride in running a lean operation that delivers consistent results batch after batch—not through luck or unthinking repetition, but by applying lessons learned the hard way, listening to customers’ changing needs, and keeping an eye on every detail from raw material check-in to final delivery.

    Whether ramping up a new synthesis line or tackling tough scale-up problems, the real-world strengths of 2-ethoxyethyl cyanoacetate come clear in the hands of chemists who see the difference between “good enough” and “built for purpose.” We’ll continue refining our processes, working across borders, and keeping this versatile ester front and center for the industries and innovators who count on it.